TR200101492T2 - IGF-I ve II 'yi engelleyen GH-RH'nın antagonistik analogları - Google Patents

IGF-I ve II 'yi engelleyen GH-RH'nın antagonistik analogları

Info

Publication number
TR200101492T2
TR200101492T2 TR2001/01492T TR200101492T TR200101492T2 TR 200101492 T2 TR200101492 T2 TR 200101492T2 TR 2001/01492 T TR2001/01492 T TR 2001/01492T TR 200101492 T TR200101492 T TR 200101492T TR 200101492 T2 TR200101492 T2 TR 200101492T2
Authority
TR
Turkey
Prior art keywords
analogs
inhibits igf
hgh
antagonistic analogues
antagonistic
Prior art date
Application number
TR2001/01492T
Other languages
English (en)
Inventor
V. Schally Andrew
Varga Jozsef
Zarandi Marta
Original Assignee
The Administrators Of The Tulane Educational Fund
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by The Administrators Of The Tulane Educational Fund filed Critical The Administrators Of The Tulane Educational Fund
Publication of TR200101492T2 publication Critical patent/TR200101492T2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/60—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
    • A61P5/08—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH for decreasing, blocking or antagonising the activity of the anterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

hGH-RH(1-29)NH2 'nin sentetik analoglarinin yeni bir dizisi ortaya konulmaktadir. Bu analoglar endojen hGH-RH'nin aktivitesini engeller ve dolayisiyla da büyüme hormonunun serbest birakilmasini önler. Geçmiste tarif edilmis olanlara kiyasla, yeni, analoglarin daha kuvvetli olan engelleyici potanslari muhtelif amino asitlerin degistirilmesi sonucu husule gelir.
TR2001/01492T 1998-11-25 1999-11-23 IGF-I ve II 'yi engelleyen GH-RH'nın antagonistik analogları TR200101492T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/199,381 US6057422A (en) 1998-11-25 1998-11-25 Antagonistic analogs of GH-RH inhibiting IGF-I and -II

Publications (1)

Publication Number Publication Date
TR200101492T2 true TR200101492T2 (tr) 2001-11-21

Family

ID=22737273

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01492T TR200101492T2 (tr) 1998-11-25 1999-11-23 IGF-I ve II 'yi engelleyen GH-RH'nın antagonistik analogları

Country Status (29)

Country Link
US (2) US6057422A (tr)
EP (1) EP1133522B1 (tr)
JP (1) JP2002530432A (tr)
KR (1) KR100629013B1 (tr)
CN (1) CN100422211C (tr)
AR (1) AR022392A1 (tr)
AT (1) ATE332310T1 (tr)
AU (1) AU757222B2 (tr)
BG (1) BG65137B1 (tr)
BR (1) BR9915512A (tr)
CA (1) CA2351665C (tr)
CO (1) CO5180565A1 (tr)
CZ (1) CZ20011794A3 (tr)
DE (1) DE69932255T2 (tr)
DK (1) DK1133522T3 (tr)
ES (1) ES2264279T3 (tr)
HK (1) HK1036461A1 (tr)
HU (1) HUP0105094A3 (tr)
IL (1) IL142899A0 (tr)
NO (1) NO20012489L (tr)
NZ (1) NZ511307A (tr)
PL (1) PL197471B1 (tr)
PT (1) PT1133522E (tr)
RU (1) RU2235099C2 (tr)
SK (1) SK7252001A3 (tr)
TR (1) TR200101492T2 (tr)
TW (1) TW585873B (tr)
UA (1) UA68407C2 (tr)
WO (1) WO2000031136A1 (tr)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1412477A4 (en) * 2001-07-12 2005-12-14 Exelixis Inc GLYPICANS (GPC) USEFUL AS MODIFIERS OF IRRTK AND P21 MECHANISMS, METHODS OF USE THEREOF
US20040121407A1 (en) * 2002-09-06 2004-06-24 Elixir Pharmaceuticals, Inc. Regulation of the growth hormone/IGF-1 axis
CN1688696A (zh) * 2002-09-18 2005-10-26 蒙特利尔大学医疗中心 Ghrh类似物
TW200517400A (en) * 2003-08-05 2005-06-01 Univ Tulane Antagonistic analogs of GH-RH (2003)
CA2718146C (en) * 2008-03-28 2016-09-20 The University Of Miami Novel n- and c-terminal substituted antagonistic analogs of gh-rh
US8691942B2 (en) 2008-03-28 2014-04-08 University Of Miami N- and C- terminal substituted antagonistic analogs of GH-RH
KR101642363B1 (ko) 2008-06-12 2016-07-25 입센 바이오이노베이션 리미티드 신경내분비계 질환의 억제
CN102083451A (zh) 2008-06-12 2011-06-01 赛恩泰新公司 癌症的抑制
GB0820970D0 (en) 2008-11-17 2008-12-24 Syntaxin Ltd Suppression of cancer
US8227421B2 (en) 2009-09-17 2012-07-24 University Of Miami Fluorinated GHRH antagonists
CN103547591A (zh) 2011-04-21 2014-01-29 瑟瑞技术公司 生长激素释放因子(grf)类似物及其用途
US9079974B2 (en) * 2011-12-21 2015-07-14 The University Of Miami GH-RH analogs with potent agonistic effects
US9855312B2 (en) 2012-12-21 2018-01-02 University Of Miami GHRH agonists for the treatment of ischemic disorders
WO2014100816A2 (en) 2012-12-21 2014-06-26 University Of Miami Ghrh agonists for islet cell transplantation and function and the treatment of diabetes
US10350273B2 (en) 2014-11-12 2019-07-16 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Treatment of hormonal disorders of growth
EP3920961A4 (en) 2019-02-08 2022-12-14 United States Government as represented by the Department of Veterans Affairs GROWTH HORMONE RELEASING HORMONE ANTAGONISTS AND THEIR USES

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659693A (en) * 1984-04-30 1987-04-21 Syntex (U.S.A.) Inc. N,N'-dialkyl substituted guanidino amino acyl residue substituted GRF-analog peptides
JPH06502618A (ja) * 1990-05-04 1994-03-24 ジ・アドミニストレイターズ・オブ・ザ・テュレイン・エデュケイショナル・ファンド 新規な合成ｇｒｆ類似物
US5550212A (en) * 1993-12-17 1996-08-27 The Administrators Of The Tulane Educational Fund Analogues of hGH-RH(1-29)NH2 having antagonistic activity
US5942489A (en) * 1996-05-03 1999-08-24 The Administrators Of The Tulane Educational Fund HGH-RH(1-29)NH2 analogues having antagonistic activity

Also Published As

Publication number Publication date
CN100422211C (zh) 2008-10-01
PL349877A1 (en) 2002-09-23
WO2000031136A9 (en) 2001-07-19
AU2029100A (en) 2000-06-13
CA2351665A1 (en) 2000-06-02
BG65137B1 (bg) 2007-03-30
SK7252001A3 (en) 2002-02-05
BG105638A (en) 2002-01-31
HK1036461A1 (en) 2002-01-04
HUP0105094A2 (hu) 2002-04-29
EP1133522A1 (en) 2001-09-19
HUP0105094A3 (en) 2002-05-28
EP1133522B1 (en) 2006-07-05
NZ511307A (en) 2005-01-28
KR100629013B1 (ko) 2006-09-26
DK1133522T3 (da) 2006-11-06
ATE332310T1 (de) 2006-07-15
ES2264279T3 (es) 2006-12-16
DE69932255T2 (de) 2007-05-31
AU757222B2 (en) 2003-02-06
TW585873B (en) 2004-05-01
CN1328570A (zh) 2001-12-26
CA2351665C (en) 2008-09-02
UA68407C2 (en) 2004-08-16
CZ20011794A3 (cs) 2002-02-13
JP2002530432A (ja) 2002-09-17
BR9915512A (pt) 2001-08-07
AR022392A1 (es) 2002-09-04
PT1133522E (pt) 2006-11-30
NO20012489L (no) 2001-07-04
RU2235099C2 (ru) 2004-08-27
US7026281B1 (en) 2006-04-11
DE69932255D1 (de) 2006-08-17
CO5180565A1 (es) 2002-07-30
NO20012489D0 (no) 2001-05-21
PL197471B1 (pl) 2008-04-30
IL142899A0 (en) 2002-04-21
US6057422A (en) 2000-05-02
WO2000031136A1 (en) 2000-06-02
KR20010101079A (ko) 2001-11-14

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