ES2135398T3 - Compuesto y composiciones de inhibicion de la resorcion osea. - Google Patents
Compuesto y composiciones de inhibicion de la resorcion osea.Info
- Publication number
- ES2135398T3 ES2135398T3 ES92900438T ES92900438T ES2135398T3 ES 2135398 T3 ES2135398 T3 ES 2135398T3 ES 92900438 T ES92900438 T ES 92900438T ES 92900438 T ES92900438 T ES 92900438T ES 2135398 T3 ES2135398 T3 ES 2135398T3
- Authority
- ES
- Spain
- Prior art keywords
- pct
- bone resorption
- inhibition
- compositions
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 230000030991 negative regulation of bone resorption Effects 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 102000043299 Parathyroid hormone-related Human genes 0.000 abstract 2
- 101710123753 Parathyroid hormone-related protein Proteins 0.000 abstract 2
- 208000006386 Bone Resorption Diseases 0.000 abstract 1
- 125000001429 N-terminal alpha-amino-acid group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000024279 bone resorption Effects 0.000 abstract 1
- 208000037765 diseases and disorders Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 229920001184 polypeptide Polymers 0.000 abstract 1
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physical Education & Sports Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Endocrinology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Transceivers (AREA)
- Mobile Radio Communication Systems (AREA)
Abstract
SE DEMUESTRA QUE FRAGMENTOS TERMINALES DE CARBOXILO DE PTHRP TAMBIEN CONOCIDOS POR EL NOMBRE DE FACTOR DE ESTIMULACION DE CICLASA DE ADENILATO [ACSF] Y FACTOR DE LIBERACION OSEA [BRF] POSEEN UNA ACTIVIDAD INHIBITORIA DE RESORCION OSEA QUE ES UNA ACTIVIDAD OPUESTA A LA REALIZADA POR LA SECUENCIA PTHRP COMPLETA Y FRAGMENTOS N-TERMINAL DE LA MISMA. SE DESCRIBEN COMPUESTOS QUE TIENEN ACTIVIDAD INHIBITORIA DE RESORCION OSEA QUE COMPRENDEN UN FRAGMENTO TERMINAL DE CARBOXI DE PTHRP QUE CONSTA DE AL MENOS AMINOACIDOS 107-111 DE PTHRP, O UN DERIVADO DEL MISMO. TAMBIEN SE DESCRIBEN METODOS PARA LA INHIBICION DE RESORCION OSEA, Y METODOS PARA EL TRATAMIENTO DE ENFERMEDADES CARACTERIZADAS POR EL EXCESO DE RESORCION OSEA, CUYOS METODOS COMPRENDEN LA ADMINISTRACION A UN SUJETO QUE NECESITE TAL TRATAMIENTO UNA CANTIDAD EFECTIVA INHIBITORIA DE RESORCION OSEA DE UN FRAGMENTO TERMINAL DE CARBOXI DE PTHRP QUE CONSTE DE AL MENOS AMINOACIDOS 107-111 DE PTHRP O UN DERIVADO DEL MISMO OPCIONALMENTE EN ASOCIACION CON UN PORTADOR O EXCIPIENTE FARMACOLOGICAMENTE ACEPTABLE.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AUPK387990 | 1990-12-13 | ||
| AUPK956791 | 1991-11-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2135398T3 true ES2135398T3 (es) | 1999-11-01 |
Family
ID=25643990
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES92900438T Expired - Lifetime ES2135398T3 (es) | 1990-12-13 | 1991-12-13 | Compuesto y composiciones de inhibicion de la resorcion osea. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5688760A (es) |
| EP (1) | EP0561877B1 (es) |
| JP (1) | JP3280021B2 (es) |
| AT (1) | ATE181336T1 (es) |
| AU (1) | AU666838B2 (es) |
| CA (1) | CA2096933C (es) |
| DE (1) | DE69131355T2 (es) |
| DK (1) | DK0561877T3 (es) |
| ES (1) | ES2135398T3 (es) |
| GR (1) | GR3030947T3 (es) |
| HU (1) | HUT64565A (es) |
| WO (1) | WO1992010511A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2158762A1 (en) * | 1993-04-08 | 1994-10-27 | Hans Rink | Cyclic compounds and compositions which inhibit bone resorption |
| GB9425582D0 (en) * | 1994-12-19 | 1995-02-15 | Iaf Biochem Int | Peptides having immunomodulatory activity |
| WO1996025944A1 (fr) * | 1995-02-20 | 1996-08-29 | Yukio Kato | Remedes contre la polyarthrite rhumatoide et les affections articulaires inflammatoires |
| BR9607857A (pt) * | 1995-03-20 | 1998-06-30 | Shell Int Research | Processo para regeneração de partículas de catalisador usado contaminadas com materiais contendo enxofre e/ou carbonados |
| EP0902036A1 (en) * | 1997-09-05 | 1999-03-17 | Roche Diagnostics GmbH | Peptide containing an arginine mimetic for the treatment of osteoporosis, their production, and drugs containing these compounds |
| WO1999046283A1 (en) * | 1998-03-09 | 1999-09-16 | Zealand Pharmaceuticals A/S | Pharmacologically active peptide conjugates having a reduced tendency towards enzymatic hydrolysis |
| MXPA04006728A (es) * | 2002-01-10 | 2005-08-19 | Osteotrophin Llc | Tratamiento de desordenes oseos con medicamentos anabolicos esqueleticos. |
| EP1585535A2 (en) * | 2002-08-15 | 2005-10-19 | Osteotrophin LLC | Pthrp-derived modulators of smooth muscle proliferation |
| JP2010538978A (ja) * | 2007-09-11 | 2010-12-16 | モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト | 治療剤としてのオクトレオチドの使用 |
| ES2605813B1 (es) * | 2015-09-16 | 2018-01-17 | Fundación Instituto De Investigación Sanitaria Fundación Jiménez Díaz | Uso de osteostatina en la preparación de un medicamento para el tratamiento de artrosis |
| WO2018215831A2 (en) * | 2017-05-22 | 2018-11-29 | National Hellenic Research Foundation | Macrocyclic modulators of disease associated protein misfolding and aggregation |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL78342A (en) * | 1985-04-04 | 1991-06-10 | Gen Hospital Corp | Pharmaceutical composition for treatment of osteoporosis in humans comprising a parathyroid hormone or a fragment thereof |
| JPS63259972A (ja) * | 1987-04-17 | 1988-10-27 | Fuji Electric Co Ltd | 燃料電池設備 |
| US5312810A (en) * | 1987-05-20 | 1994-05-17 | The University Of Melbourne | Method and compositions for making ACSF and ACSF antagonists |
| DE3885752T2 (de) * | 1987-05-20 | 1994-06-16 | Genentech Inc | Methode und verbindungen zur herstellung von acsf und acsf-antagonisten. |
| US4819504A (en) * | 1987-05-27 | 1989-04-11 | Sampson Sports, Inc. | Self contained braking system for bicycle pedals |
| DE68921665T2 (de) * | 1988-05-09 | 1995-09-21 | Merck & Co Inc | Hemmer vom flüssigen kalziumerhöhenden Faktor. |
| JP2752987B2 (ja) * | 1988-06-01 | 1998-05-18 | 株式会社東芝 | リン酸型燃料電池発電プラント |
-
1991
- 1991-12-13 HU HU9301726A patent/HUT64565A/hu unknown
- 1991-12-13 EP EP92900438A patent/EP0561877B1/en not_active Expired - Lifetime
- 1991-12-13 ES ES92900438T patent/ES2135398T3/es not_active Expired - Lifetime
- 1991-12-13 DK DK92900438T patent/DK0561877T3/da active
- 1991-12-13 WO PCT/AU1991/000580 patent/WO1992010511A1/en active IP Right Grant
- 1991-12-13 CA CA002096933A patent/CA2096933C/en not_active Expired - Lifetime
- 1991-12-13 AT AT92900438T patent/ATE181336T1/de not_active IP Right Cessation
- 1991-12-13 US US08/064,111 patent/US5688760A/en not_active Expired - Lifetime
- 1991-12-13 AU AU90632/91A patent/AU666838B2/en not_active Expired
- 1991-12-13 DE DE69131355T patent/DE69131355T2/de not_active Expired - Lifetime
- 1991-12-13 JP JP50160992A patent/JP3280021B2/ja not_active Expired - Lifetime
-
1999
- 1999-08-10 GR GR990402028T patent/GR3030947T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO1992010511A1 (en) | 1992-06-25 |
| ATE181336T1 (de) | 1999-07-15 |
| DE69131355D1 (de) | 1999-07-22 |
| HUT64565A (en) | 1994-01-28 |
| GR3030947T3 (en) | 1999-11-30 |
| CA2096933C (en) | 2003-05-13 |
| US5688760A (en) | 1997-11-18 |
| JP3280021B2 (ja) | 2002-04-30 |
| CA2096933A1 (en) | 1992-06-14 |
| HU9301726D0 (en) | 1993-10-28 |
| EP0561877A1 (en) | 1993-09-29 |
| EP0561877A4 (es) | 1994-03-23 |
| DE69131355T2 (de) | 1999-12-30 |
| EP0561877B1 (en) | 1999-06-16 |
| JPH06503330A (ja) | 1994-04-14 |
| AU9063291A (en) | 1992-07-08 |
| DK0561877T3 (da) | 1999-12-27 |
| AU666838B2 (en) | 1996-02-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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