BR9812803A - Uma cápsula dupla para administração de princìpios ativos em terapias múltiplas - Google Patents
Uma cápsula dupla para administração de princìpios ativos em terapias múltiplasInfo
- Publication number
- BR9812803A BR9812803A BR9812803-5A BR9812803A BR9812803A BR 9812803 A BR9812803 A BR 9812803A BR 9812803 A BR9812803 A BR 9812803A BR 9812803 A BR9812803 A BR 9812803A
- Authority
- BR
- Brazil
- Prior art keywords
- active ingredients
- administration
- capsule
- dosage form
- pharmaceutical dosage
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
"UMA CáPSULA DUPLA PARA ADMINISTRAçãO DE PRINCìPIOS ATIVOS EM TERAPIAS MúLTIPLAS" Uma forma de dosagem farmacêutica particularmente adequada para a administração de princípios ativos em terapias múltiplas é divulgada. A forma de dosagem farmacêutica é uma cápsula dupla caracterizada pelo fato de uma cápsula ser colocada dentro de uma externa. Cada uma das cápsulas inclui um ou mais princípios ativos. A cápsula dupla de acordo com a invenção é de preferência usada em terapias triplas e quádruplas contra o microorganismo Helicobacter Pylori. As vantagens desta forma de dosagem farmacêutica consistem em fornecer uma simples posologia para administração de dois ou mais princípios ativos, permitindo que os princípios ativos se ativem nos intervalos de tempo corretos e nas quantidades pré-estabelecidas, e impedindo interações entre os princípios ativos. Na configuração preferida da invenção, a forma de dosagem farmacêutica possui uma cápsula externa contendo subcitrato de bismuto e metronidazol, e uma cápsula interna contendo tetraciclina e opcionalmente omeprazol, que é usada na terapia da erradicação da Helicobacter pylori. [Consta nas páginas de número 1, 2, 3, 4, 4a, 13, 14 e 15 do documento original o carimbo de "Folha Retificada". Consta, ainda nas páginas de número 5 a 12 do documento original as inscrições WO 99/30693 e PCT/EP98/08167.]
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT97MI002788A IT1296980B1 (it) | 1997-12-17 | 1997-12-17 | Capsula doppia come forma farmaceutica per la somministrazione di principi attivi in terapie multiple |
PCT/EP1998/008167 WO1999030693A2 (en) | 1997-12-17 | 1998-12-14 | A double capsule for the administration of active principles in multiple therapies |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9812803A true BR9812803A (pt) | 2000-10-03 |
Family
ID=11378381
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9812803-5A BR9812803A (pt) | 1997-12-17 | 1998-12-14 | Uma cápsula dupla para administração de princìpios ativos em terapias múltiplas |
Country Status (26)
Country | Link |
---|---|
US (1) | US6350468B1 (pt) |
EP (1) | EP1037614B1 (pt) |
JP (1) | JP4615713B2 (pt) |
KR (1) | KR100509351B1 (pt) |
CN (1) | CN1147292C (pt) |
AR (1) | AR014126A1 (pt) |
AT (1) | ATE254910T1 (pt) |
AU (1) | AU743090B2 (pt) |
BR (1) | BR9812803A (pt) |
CA (1) | CA2315408C (pt) |
CZ (1) | CZ299181B6 (pt) |
DE (1) | DE69820108T2 (pt) |
DK (1) | DK1037614T3 (pt) |
ES (1) | ES2212391T3 (pt) |
HK (1) | HK1034897A1 (pt) |
HU (1) | HU225690B1 (pt) |
ID (1) | ID26340A (pt) |
IT (1) | IT1296980B1 (pt) |
MY (1) | MY121713A (pt) |
NO (1) | NO329126B1 (pt) |
NZ (1) | NZ505655A (pt) |
PE (1) | PE20000512A1 (pt) |
PL (1) | PL192541B1 (pt) |
PT (1) | PT1037614E (pt) |
TR (1) | TR200001761T2 (pt) |
WO (1) | WO1999030693A2 (pt) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6428809B1 (en) * | 1999-08-18 | 2002-08-06 | Microdose Technologies, Inc. | Metering and packaging of controlled release medication |
GB0017673D0 (en) * | 2000-07-20 | 2000-09-06 | Mw Encap Limited | Delivery device |
AU2001272645A1 (en) * | 2000-07-20 | 2002-02-05 | Mw Encap Limited | Delivery device |
US20040105883A1 (en) * | 2001-04-17 | 2004-06-03 | Ping Gao | Pharmaceutical dosage form capable of maintaining stable dissolution profile upon storage |
US20040105885A1 (en) * | 2001-04-17 | 2004-06-03 | Ping Gao | Gelatin capsule exhibiting reduced cross-linking |
US20040131670A1 (en) * | 2001-04-17 | 2004-07-08 | Ping Gao | Pellicle-resistant gelatin capsule |
US20070087048A1 (en) * | 2001-05-31 | 2007-04-19 | Abrams Andrew L | Oral dosage combination pharmaceutical packaging |
US6726809B2 (en) * | 2001-09-26 | 2004-04-27 | Albany International Corp. | Industrial process fabric |
US7670612B2 (en) | 2002-04-10 | 2010-03-02 | Innercap Technologies, Inc. | Multi-phase, multi-compartment capsular delivery apparatus and methods for using same |
WO2004060379A2 (en) * | 2003-01-03 | 2004-07-22 | Milankovits Marton | Pharmaceutical compositions comprising an antibacterial agent nd antifungal agent and a nitroimidazole for the treatment and prevention of genitourinary infections and their extragenital complications |
US20050053648A1 (en) * | 2003-09-08 | 2005-03-10 | Chalmers Anne Marie | Medication delivery device |
WO2005039474A1 (en) * | 2003-10-21 | 2005-05-06 | Ambo Innovation Llc | Digestible and volume adjustable multi medication delivery device |
US7981908B2 (en) * | 2005-05-11 | 2011-07-19 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion |
US7803817B2 (en) * | 2005-05-11 | 2010-09-28 | Vecta, Ltd. | Composition and methods for inhibiting gastric acid secretion |
CN100350900C (zh) * | 2005-05-23 | 2007-11-28 | 江西本草天工科技有限责任公司 | 复方降香双相胶囊及其制备方法 |
CN100350898C (zh) * | 2005-05-23 | 2007-11-28 | 江西本草天工科技有限责任公司 | 复方三七双相胶囊及其制备方法 |
CN100350899C (zh) * | 2005-05-23 | 2007-11-28 | 江西本草天工科技有限责任公司 | 冠心丹参双相胶囊及其制备方法 |
US8865197B2 (en) * | 2005-09-06 | 2014-10-21 | Israel Oceanographic And Limnological Research Ltd. | Food formulation for aquatic animals with integrated targeted delivery of bioactive agents |
WO2007047371A2 (en) * | 2005-10-14 | 2007-04-26 | Microdose Technologies, Inc. | Pharmaceutical packaging of an oral dosage combination |
CN100393359C (zh) * | 2005-12-13 | 2008-06-11 | 济南百诺医药科技开发有限公司 | 根除幽门螺旋杆菌的多单元组合物 |
US8784886B2 (en) * | 2006-03-09 | 2014-07-22 | GlaxoSmithKline, LLC | Coating capsules with active pharmaceutical ingredients |
EP2081550B2 (en) | 2006-03-09 | 2021-05-26 | Reliant Pharmaceuticals, Inc. | Coating capsules with active pharmaceutical ingredients |
AU2007278986B2 (en) * | 2006-07-25 | 2010-09-16 | Vecta, Ltd. | Compositions and methods for inhibiting gastric acid secretion using derivatives of small dicarboxylic acids in combination with PPI |
US20090087483A1 (en) * | 2007-09-27 | 2009-04-02 | Sison Raymundo A | Oral dosage combination pharmaceutical packaging |
US8439033B2 (en) | 2007-10-09 | 2013-05-14 | Microdose Therapeutx, Inc. | Inhalation device |
CN101513395B (zh) * | 2008-02-20 | 2011-01-12 | 单宝华 | 紫杉醇类双层软胶囊口服制剂药物 |
DE102009001334B4 (de) | 2009-03-04 | 2017-02-23 | Stefan Brosig | Einfache magensaftresistente Verkapselung, z.B. von Ingwer und anderen empfindlichen Stoffen |
CN101607086B (zh) * | 2009-07-21 | 2011-11-02 | 山西安特生物制药股份有限公司 | 一种复方铋剂组合物及其制备方法 |
TWI463998B (zh) | 2009-12-31 | 2014-12-11 | Synmosa Biopharma Corp | Amoxicillin and clomycin have a high absorption rate of pharmaceutical ingredients |
US8991390B2 (en) | 2010-01-05 | 2015-03-31 | Microdose Therapeutx, Inc. | Inhalation device and method |
CN102349887A (zh) * | 2011-08-02 | 2012-02-15 | 天津市嵩锐医药科技有限公司 | 双氯芬酸钠对乙酰氨基酚胃肠型胶囊药物组合物 |
ITMI20120350A1 (it) * | 2012-03-06 | 2013-09-07 | Ultimate Italia S A S Di Levantino Enrico E C | Forma di dosaggio per somministrazione orale di principi attivi |
US20160008371A1 (en) * | 2014-07-14 | 2016-01-14 | Autotelic Llc | Fixed dose combination for pain relief without edema |
US9700514B1 (en) * | 2014-08-20 | 2017-07-11 | Darren Rubin | Single solid oral dosage forms for treating Helicobacter pylori infection and duodenal ulcer disease |
CN105106162A (zh) * | 2015-08-21 | 2015-12-02 | 四川百利药业有限责任公司 | 一种治疗幽门螺杆菌所引起溃疡的复方片剂及其制备方法 |
WO2017223043A1 (en) * | 2016-06-22 | 2017-12-28 | University Of Florida Research Foundation, Inc. | Pharmaceutical capsules for medication adherence monitoring and methods of forming the same |
CN108186968B (zh) * | 2018-01-08 | 2021-07-20 | 江苏聚荣制药集团有限公司 | 温胃舒胶囊 |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3072528A (en) | 1957-07-13 | 1963-01-08 | Med Fabrik Chemisch Pharmazeut | Ingestible dry microorganism preparations |
FR1454013A (fr) * | 1965-08-18 | 1966-07-22 | Pluripharm | Mode de présentation de deux médicaments associés |
DE2729068A1 (de) | 1977-06-28 | 1979-01-11 | Rainer Dr Med Liedtke | Verfahren zur freisetzungssteuerung von arzneimitteln aus kapseln |
CA1143287A (en) * | 1981-08-11 | 1983-03-22 | William C. Stewart | Waterproof edible encapsulation for prophylactic drugs |
DK150008C (da) | 1981-11-20 | 1987-05-25 | Benzon As Alfred | Fremgangsmaade til fremstilling af et farmaceutisk oralt polydepotpraeparat |
US4642233A (en) | 1982-03-22 | 1987-02-10 | Alza Corporation | Gastrointestinal drug delivery system comprising a hydrogel reservoir containing a plurality of tiny pills |
FR2524311A1 (fr) * | 1982-04-05 | 1983-10-07 | Azalbert Gilles | Gelule compartimentee aux fins d'ingestions simultanees a effets differes |
JPS59131355A (ja) | 1983-01-17 | 1984-07-28 | 森下仁丹株式会社 | 多重軟カプセルの製法 |
JPS60193917A (ja) * | 1984-03-14 | 1985-10-02 | R P Shiila- Kk | 多重構造軟カプセル剤 |
US4627808A (en) | 1985-05-31 | 1986-12-09 | Hughes Raymond J | Apparatus for making capsule having plural chambers |
US5256684A (en) | 1985-06-13 | 1993-10-26 | The Procter & Gamble Company | Methods and compositions for the treatment of gastrointestinal disorders |
US4904476A (en) | 1986-03-04 | 1990-02-27 | American Home Products Corporation | Formulations providing three distinct releases |
US4936461A (en) | 1986-09-18 | 1990-06-26 | Makiej Jr Walter J | Multidose capsules |
US4793493A (en) | 1986-09-18 | 1988-12-27 | Makiej Jr Walter J | Multidose capsules |
US4822619A (en) | 1987-02-18 | 1989-04-18 | Ionor, Inc. | Controlled release pharmaceutical preparation containing a gastrointestinal irritant drug |
US5394980A (en) | 1987-06-30 | 1995-03-07 | Tsai; Min H. | Multicompartment mixing capsule |
DE3887353T2 (de) | 1987-10-12 | 1994-05-05 | Exomed Australia Pty Ltd | Behandlungsverfahren für magen-darm-krankheiten. |
US5192752A (en) | 1991-01-14 | 1993-03-09 | The Procter & Gamble Company | Swallowable pharmaceutical compositions containing colloidal bismuth subcitrate |
GB9120131D0 (en) * | 1991-09-20 | 1991-11-06 | Glaxo Group Ltd | Medicaments |
US5582837A (en) | 1992-03-25 | 1996-12-10 | Depomed, Inc. | Alkyl-substituted cellulose-based sustained-release oral drug dosage forms |
US5472695A (en) | 1992-06-25 | 1995-12-05 | Technion Research And Development Foundation Ltd. | Therapeutic application of a thyme extract and in - vitro methods for inhibiting the growth and urease activity of helicobacter pylori |
US5501857A (en) | 1992-07-24 | 1996-03-26 | Midwestern Bio-Ag Products & Services, Inc. | Oral nutritional and dietary composition |
US5310555A (en) | 1992-07-24 | 1994-05-10 | Midwestern Bio-Ag Products And Services, Inc. | Oral nutritional and dietary composition |
DK0686034T3 (da) * | 1993-02-26 | 2001-08-27 | Procter & Gamble | Bisacodyl-doseringsform |
EP0804174A4 (en) | 1993-07-21 | 1998-09-09 | Univ Kentucky Res Found | MULTI-CHAMBER HARD CAPSULES WITH CONTROLLED DELIVERY CHARACTERISTICS |
US5560912A (en) | 1994-06-27 | 1996-10-01 | Technion Research & Development Foundation Ltd. | Method for inhibiting growth of helicobacter pylori |
AUPM695294A0 (en) | 1994-07-20 | 1994-08-11 | Borody, Thomas Julius | Improved combination therapy dose unit |
-
1997
- 1997-12-17 IT IT97MI002788A patent/IT1296980B1/it active IP Right Grant
-
1998
- 1998-12-11 MY MYPI98005603A patent/MY121713A/en unknown
- 1998-12-14 DK DK98966618T patent/DK1037614T3/da active
- 1998-12-14 JP JP2000538676A patent/JP4615713B2/ja not_active Expired - Lifetime
- 1998-12-14 WO PCT/EP1998/008167 patent/WO1999030693A2/en active IP Right Grant
- 1998-12-14 HU HU0100095A patent/HU225690B1/hu unknown
- 1998-12-14 PL PL341737A patent/PL192541B1/pl unknown
- 1998-12-14 US US09/581,721 patent/US6350468B1/en not_active Expired - Lifetime
- 1998-12-14 ES ES98966618T patent/ES2212391T3/es not_active Expired - Lifetime
- 1998-12-14 PT PT98966618T patent/PT1037614E/pt unknown
- 1998-12-14 KR KR10-2000-7006668A patent/KR100509351B1/ko active IP Right Grant
- 1998-12-14 CZ CZ20002231A patent/CZ299181B6/cs not_active IP Right Cessation
- 1998-12-14 ID IDW20001355A patent/ID26340A/id unknown
- 1998-12-14 AU AU24135/99A patent/AU743090B2/en not_active Expired
- 1998-12-14 EP EP98966618A patent/EP1037614B1/en not_active Expired - Lifetime
- 1998-12-14 BR BR9812803-5A patent/BR9812803A/pt not_active Application Discontinuation
- 1998-12-14 TR TR2000/01761T patent/TR200001761T2/xx unknown
- 1998-12-14 CN CNB988130602A patent/CN1147292C/zh not_active Expired - Lifetime
- 1998-12-14 CA CA002315408A patent/CA2315408C/en not_active Expired - Lifetime
- 1998-12-14 NZ NZ505655A patent/NZ505655A/en not_active IP Right Cessation
- 1998-12-14 DE DE69820108T patent/DE69820108T2/de not_active Expired - Lifetime
- 1998-12-14 AT AT98966618T patent/ATE254910T1/de active
- 1998-12-16 AR ARP980106414A patent/AR014126A1/es unknown
- 1998-12-16 PE PE1998001235A patent/PE20000512A1/es not_active IP Right Cessation
-
2000
- 2000-06-16 NO NO20003159A patent/NO329126B1/no not_active IP Right Cessation
-
2001
- 2001-07-27 HK HK01105239A patent/HK1034897A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR9812803A (pt) | Uma cápsula dupla para administração de princìpios ativos em terapias múltiplas | |
DE1001772T1 (de) | Verbesserte verabreichungstechnik für multiple medikamentengaben | |
MX9200992A (es) | Composicion farmaceutica que tiene como ingrediente activo 3-[2-(dimetilamino)etil]-n-metil-1h-indol-5-metanosulfonamida y procedimiento para su preparacion. | |
NO953874L (no) | Farmasöytisk preparat inneholdende lipofile legemidler | |
ES2040232T3 (es) | Preparaciones medicinales para administracion oral conteniendo una sola dosis de 10 a 240 mg de dihidropiridina. | |
ES2191329T3 (es) | Utilizacion de xantofilos en medicamentos para la mejora de la duracion de la funcion muscular o el tratamiento de trastornos o enfermedades musculares. | |
AR240250A1 (es) | Procedimiento para la preparacion de una nueva formualcion farmaceutica oral que contiene omeprazol como ingrediente activo. | |
ES551119A0 (es) | Procedimiento para preparar un agente analgesicamente activo a base de 2-amino-3-carboetoxiamino-6-(4-fluorobencilamino)-piridina y por lo menos un agente antiflogistico no esteroidal | |
AU1935788A (en) | A process for producing an administration and/or dosage form for medically active ingredients of drugs | |
BR9802537A (pt) | Método para anestesiar um paciente humano antes de cirurgias de porte dose unitária e sistema farmacêutico para administração | |
Jensen et al. | Tramadol versus dextropropoxyphene in the treatment of osteoarthritis: A short term double-blind study | |
BR0211198A (pt) | Composições farmacêuticas e seu uso | |
KR970061244A (ko) | 치매 치료용 약학 조성물 | |
RS50298B (sr) | Direktno kompresibilna matrica za kontrolisano oslobađanje pojedinačnih dnevnih doza klaritromicina | |
BR9712964A (pt) | Embalagem para concordância e método para melhorar ou ajudar a concordância do paciente para dietas com remédio complexo. | |
AR019025A1 (es) | Uso de eritropoyetina en bajas dosis para producir un preparado farmaceutico para el tratamiento de hemocromatosis, preparado farmaceutico combinadoutilizado segun dicho uso y envase farmaceutico unitario que contiene al referido preparado farmaceutico combinado | |
ES2062438T3 (es) | Asociacion de vitamina a en dosis fisiologica y de diferentes principios activos que tienen una actividad terapeutica. | |
ATE85218T1 (de) | Oral anzuwendende arzneiform zur einmal taeglichen behandlung der hypertonie mit diltiazemhydrochlorid. | |
JPS6341424A (ja) | 嘔吐等に抗する医薬 | |
HUP0104941A2 (hu) | Több gyógyszerformát tartalmazó bliszter | |
Marder | Risperidone: Efficacy. | |
Gerner | Intractable depression in tertiary care | |
Calligaro | Treatment of acute diarrhea in children | |
TJ | The safety profile, tolerability, and effective dose range of rofecoxib in the treatment of rheumatoid arthritis. Phase II Rofecoxib Rheumatoid Arthritis Study Group | |
Berardinelli et al. | Drug Treatments and Topics: The Year in Review |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
B08H | Application fees: decision cancelled [chapter 8.8 patent gazette] |
Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1741 DE 20040518 POR TER SIDO APRESENTADA COPIA DE GUIA. |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFERIMENTO DO PRESENTE PEDIDO, UMA VEZ QUE O MESMO NAO ATENDE AO ESTABELECIDO NOS ARTIGOS 8O E 13 DA LEI 9279/1996 |
|
B12B | Appeal against refusal [chapter 12.2 patent gazette] |