BR9809484A - Formulação farmacêutica oral revestida entérica, processo para a manufatura da mesma, uso de uma qualidade de hidroxipropil metilcelulose (hpmc) de baixa viscosidade, e, processo para o tratamento de doenças gastrointestinais em mamìferos, incluindo o homem. - Google Patents
Formulação farmacêutica oral revestida entérica, processo para a manufatura da mesma, uso de uma qualidade de hidroxipropil metilcelulose (hpmc) de baixa viscosidade, e, processo para o tratamento de doenças gastrointestinais em mamìferos, incluindo o homem.Info
- Publication number
- BR9809484A BR9809484A BR9809484-0A BR9809484A BR9809484A BR 9809484 A BR9809484 A BR 9809484A BR 9809484 A BR9809484 A BR 9809484A BR 9809484 A BR9809484 A BR 9809484A
- Authority
- BR
- Brazil
- Prior art keywords
- hpmc
- low viscosity
- hydroxypropyl methylcellulose
- pharmaceutical formulation
- omeprazole
- Prior art date
Links
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 title abstract 5
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 title abstract 5
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 title abstract 5
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 title abstract 5
- 238000000034 method Methods 0.000 title abstract 5
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 239000008203 oral pharmaceutical composition Substances 0.000 title abstract 3
- 208000018522 Gastrointestinal disease Diseases 0.000 title abstract 2
- 241000124008 Mammalia Species 0.000 title abstract 2
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 abstract 3
- 239000004480 active ingredient Substances 0.000 abstract 3
- 229960000381 omeprazole Drugs 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 239000011162 core material Substances 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- 159000000011 group IA salts Chemical class 0.000 abstract 2
- 239000010410 layer Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 239000011230 binding agent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 239000002702 enteric coating Substances 0.000 abstract 1
- 238000009505 enteric coating Methods 0.000 abstract 1
- SUBDBMMJDZJVOS-DEOSSOPVSA-N esomeprazole Chemical compound C([S@](=O)C1=NC2=CC=C(C=C2N1)OC)C1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-DEOSSOPVSA-N 0.000 abstract 1
- 229960004770 esomeprazole Drugs 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE9702000A SE9702000D0 (sv) | 1997-05-28 | 1997-05-28 | New pharmaceutical formulation |
| PCT/SE1998/000922 WO1998053803A1 (en) | 1997-05-28 | 1998-05-18 | Pharmaceutical formulation of omeprazole |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9809484A true BR9809484A (pt) | 2000-06-20 |
Family
ID=20407122
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9809484-0A BR9809484A (pt) | 1997-05-28 | 1998-05-18 | Formulação farmacêutica oral revestida entérica, processo para a manufatura da mesma, uso de uma qualidade de hidroxipropil metilcelulose (hpmc) de baixa viscosidade, e, processo para o tratamento de doenças gastrointestinais em mamìferos, incluindo o homem. |
Country Status (40)
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6645988B2 (en) | 1996-01-04 | 2003-11-11 | Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US5840737A (en) | 1996-01-04 | 1998-11-24 | The Curators Of The University Of Missouri | Omeprazole solution and method for using same |
| US6699885B2 (en) * | 1996-01-04 | 2004-03-02 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and methods of using same |
| US6489346B1 (en) * | 1996-01-04 | 2002-12-03 | The Curators Of The University Of Missouri | Substituted benzimidazole dosage forms and method of using same |
| US6174548B1 (en) * | 1998-08-28 | 2001-01-16 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
| US6096340A (en) | 1997-11-14 | 2000-08-01 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
| CA2298823C (en) * | 1998-04-20 | 2011-06-07 | Eisai Co., Ltd. | Stabilized composition comprising a benzimidazole type compound |
| SE9803772D0 (sv) * | 1998-11-05 | 1998-11-05 | Astra Ab | Pharmaceutical formulation |
| SE9902386D0 (sv) * | 1999-06-22 | 1999-06-22 | Astra Ab | New formulation |
| US6245913B1 (en) | 1999-06-30 | 2001-06-12 | Wockhardt Europe Limited | Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole |
| ES2168043B1 (es) | 1999-09-13 | 2003-04-01 | Esteve Labor Dr | Forma farmaceutica solida oral de liberacion modificada que contiene un compuesto de bencimidazol labil en medio acido. |
| MXPA02003762A (es) | 1999-10-20 | 2002-09-30 | Eisai Co Ltd | Metodos para estabilizar compuestos basados en benzimidazol. |
| US20040092511A1 (en) * | 1999-12-10 | 2004-05-13 | Billstein Stephan Anthony | Pharmaceutical combinations and their use in treating gastrointestinal and abdominal viscera disorders |
| US20020192299A1 (en) * | 2000-12-28 | 2002-12-19 | Rajneesh Taneja | Pharmaceutical compositions of a non-enteric coated proton pump inhibitor with a carbonate salt and bicarbonate salt combination |
| JP2002234842A (ja) * | 2001-02-09 | 2002-08-23 | Kyowa Yakuhin Kogyo Kk | 内服腸溶性製剤 |
| US20040006111A1 (en) * | 2002-01-25 | 2004-01-08 | Kenneth Widder | Transmucosal delivery of proton pump inhibitors |
| US20040082618A1 (en) * | 2002-07-03 | 2004-04-29 | Rajneesh Taneja | Liquid dosage forms of acid labile drugs |
| FR2843121B3 (fr) | 2002-08-02 | 2004-09-10 | Rhodia Chimie Sa | Agent ignifugeant, procede de preparation et l'utilisation de cet agent |
| US20070243251A1 (en) * | 2002-12-20 | 2007-10-18 | Rajneesh Taneja | Dosage Forms Containing A PPI, NSAID, and Buffer |
| US20040121004A1 (en) * | 2002-12-20 | 2004-06-24 | Rajneesh Taneja | Dosage forms containing a PPI, NSAID, and buffer |
| US20040146558A1 (en) * | 2003-01-28 | 2004-07-29 | Kyowa Pharmaceutical Co., Ltd. | Oral enteric-coated preparation |
| JP4567340B2 (ja) * | 2003-01-29 | 2010-10-20 | 武田薬品工業株式会社 | 被覆製剤の製造方法 |
| ZA200506397B (en) * | 2003-01-29 | 2006-11-29 | Takeda Pharmaceutical | Process for producing coated preparation |
| RU2359671C2 (ru) * | 2003-01-29 | 2009-06-27 | Такеда Фармасьютикал Компани Лимитед | Способ получения препарата с покрытием |
| MXPA05007883A (es) | 2003-01-29 | 2005-09-21 | Takeda Pharmaceutical | Proceso para producir una preparacion recubierta. |
| US20040248942A1 (en) * | 2003-02-20 | 2004-12-09 | Bonnie Hepburn | Novel formulation, omeprazole antacid complex-immediate release for rapid and sustained suppression of gastric acid |
| US20050042277A1 (en) * | 2003-07-17 | 2005-02-24 | Irukulla Srinivas | Pharmaceutical compositions having a swellable coating |
| US8993599B2 (en) | 2003-07-18 | 2015-03-31 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| US20070292498A1 (en) * | 2003-11-05 | 2007-12-20 | Warren Hall | Combinations of proton pump inhibitors, sleep aids, buffers and pain relievers |
| CN1311824C (zh) * | 2004-04-21 | 2007-04-25 | 常州市第四制药厂有限公司 | 奥美拉唑肠溶微粒制剂及制备方法 |
| US8906940B2 (en) * | 2004-05-25 | 2014-12-09 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| US8815916B2 (en) * | 2004-05-25 | 2014-08-26 | Santarus, Inc. | Pharmaceutical formulations useful for inhibiting acid secretion and methods for making and using them |
| ES2324354T3 (es) * | 2005-07-29 | 2009-08-05 | Rottapharm S.P.A. | Combinacion terapeutica de itriglumida e inhibidores de la bomba de protones en el tratamiento de trastornos gastrointestinales y relacionados. |
| AU2007266574A1 (en) * | 2006-06-01 | 2007-12-06 | Dexcel Pharma Technologies Ltd. | Multiple unit pharmaceutical formulation |
| KR101436516B1 (ko) * | 2007-07-23 | 2014-09-02 | 주식회사태평양제약 | 코팅된 펠렛을 함유하는 현탁정 및 이의 제조방법 |
| CN103126998A (zh) * | 2007-09-28 | 2013-06-05 | 西梯茜生命工学股份有限公司 | 一种固态分散体和含有埃索美拉唑的药物组合物 |
| RU2477123C2 (ru) * | 2008-03-28 | 2013-03-10 | Феррер Интернасионал, С.А. | Капсула и лекарственное средство для профилактики сердечно-сосудистых заболеваний |
| HRP20140640T1 (hr) | 2008-08-19 | 2014-11-21 | Xenoport, Inc. | Prolijekovi monometil estera fumarne kiseline, farmaceutski sastavi iz toga i postupci njihove uporabe |
| US10945984B2 (en) | 2012-08-22 | 2021-03-16 | Arbor Pharmaceuticals, Llc | Methods of administering monomethyl fumarate and prodrugs thereof having reduced side effects |
| AU2013305684B2 (en) | 2012-08-22 | 2016-11-24 | Xenoport, Inc. | Oral dosage forms of methyl hydrogen fumarate and prodrugs thereof |
| CN102961356A (zh) * | 2012-12-11 | 2013-03-13 | 山西云鹏制药有限公司 | 一种含奥美拉唑的蓝色肠溶片剂的制备方法 |
| WO2014160633A1 (en) | 2013-03-24 | 2014-10-02 | Xenoport, Inc. | Pharmaceutical compositions of dimethyl fumarate |
| EP3041467A1 (en) | 2013-09-06 | 2016-07-13 | XenoPort, Inc. | Crystalline forms of (n,n-diethylcarbamoyl)methyl methyl (2e)but-2-ene-1,4-dioate, methods of synthesis and use |
| US20150079180A1 (en) * | 2013-09-18 | 2015-03-19 | Xenoport, Inc. | Nanoparticle compositions of dimethyl fumarate |
| US9999672B2 (en) | 2014-03-24 | 2018-06-19 | Xenoport, Inc. | Pharmaceutical compositions of fumaric acid esters |
| WO2016174664A1 (en) | 2015-04-29 | 2016-11-03 | Dexcel Pharma Technologies Ltd. | Orally disintegrating compositions |
| US10076494B2 (en) | 2016-06-16 | 2018-09-18 | Dexcel Pharma Technologies Ltd. | Stable orally disintegrating pharmaceutical compositions |
| US20230058473A1 (en) | 2020-01-27 | 2023-02-23 | Towa Pharmaceutical Co., Ltd. | Esomeprazole oral preparation and method for producing the same |
| KR102432084B1 (ko) | 2021-11-16 | 2022-08-12 | 알리코제약(주) | S-오메프라졸을 함유하는 안정성이 개선되고 소형화된 정제 |
| JP2025532389A (ja) | 2022-10-04 | 2025-09-29 | ザビリュク，アルセニー | 大動脈弁の石灰化の抑制 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE7804231L (sv) * | 1978-04-14 | 1979-10-15 | Haessle Ab | Magsyrasekretionsmedel |
| SE8301182D0 (sv) * | 1983-03-04 | 1983-03-04 | Haessle Ab | Novel compounds |
| GB2189698A (en) * | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
| YU48263B (sh) * | 1991-06-17 | 1997-09-30 | Byk Gulden Lomberg Chemische Fabrik Gmbh. | Postupak za dobijanje farmaceutskog preparata na bazi pantoprazola |
| JPH05255088A (ja) * | 1991-11-05 | 1993-10-05 | Yoshitomi Pharmaceut Ind Ltd | 抗潰瘍剤含有製剤 |
| JP2669446B2 (ja) * | 1992-03-23 | 1997-10-27 | 信越化学工業株式会社 | 医薬品コーティング液用原料粉粒体 |
| FR2692146B1 (fr) * | 1992-06-16 | 1995-06-02 | Ethypharm Sa | Compositions stables de microgranules d'omeprazole gastro-protégés et leur procédé d'obtention. |
| JPH0733659A (ja) * | 1992-07-17 | 1995-02-03 | Yoshitomi Pharmaceut Ind Ltd | 抗潰瘍剤含有製剤 |
| SE9301830D0 (sv) * | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
| SE9302396D0 (sv) * | 1993-07-09 | 1993-07-09 | Ab Astra | A novel compound form |
| SE9302395D0 (sv) * | 1993-07-09 | 1993-07-09 | Ab Astra | New pharmaceutical formulation |
| EE03305B1 (et) * | 1994-07-08 | 2000-12-15 | Astra Aktiebolag | Paljuosaline tableteeritud annusvorm I |
| SE9500422D0 (sv) * | 1995-02-06 | 1995-02-06 | Astra Ab | New oral pharmaceutical dosage forms |
-
1997
- 1997-05-28 SE SE9702000A patent/SE9702000D0/xx unknown
-
1998
- 1998-05-14 AR ARP980102246A patent/AR012698A1/es not_active Application Discontinuation
- 1998-05-14 HR HR980260A patent/HRP980260B1/xx not_active IP Right Cessation
- 1998-05-15 MA MA25077A patent/MA26497A1/fr unknown
- 1998-05-15 TW TW87107541A patent/TW575435B/zh not_active IP Right Cessation
- 1998-05-18 SI SI9830433T patent/SI0984773T1/xx unknown
- 1998-05-18 JP JP50056299A patent/JP4649001B2/ja not_active Expired - Fee Related
- 1998-05-18 EE EEP199900540A patent/EE03903B1/xx not_active IP Right Cessation
- 1998-05-18 PT PT98924700T patent/PT984773E/pt unknown
- 1998-05-18 TR TR1999/02890T patent/TR199902890T2/xx unknown
- 1998-05-18 BR BR9809484-0A patent/BR9809484A/pt not_active Application Discontinuation
- 1998-05-18 ID IDW991448A patent/ID24654A/id unknown
- 1998-05-18 AU AU76803/98A patent/AU722879B2/en not_active Ceased
- 1998-05-18 UA UA99116247A patent/UA71541C2/uk unknown
- 1998-05-18 RS YUP-608/99A patent/RS49629B/sr unknown
- 1998-05-18 KR KR1019997011083A patent/KR100540721B1/ko not_active Expired - Fee Related
- 1998-05-18 DK DK98924700T patent/DK0984773T3/da active
- 1998-05-18 ZA ZA984178A patent/ZA984178B/xx unknown
- 1998-05-18 DE DE69812089T patent/DE69812089T2/de not_active Expired - Lifetime
- 1998-05-18 PL PL98337237A patent/PL194634B1/pl unknown
- 1998-05-18 SK SK1590-99A patent/SK286625B6/sk not_active IP Right Cessation
- 1998-05-18 CA CA002290531A patent/CA2290531C/en not_active Expired - Lifetime
- 1998-05-18 RU RU99126869/14A patent/RU2207121C2/ru not_active IP Right Cessation
- 1998-05-18 US US09/077,717 patent/US6090827A/en not_active Expired - Lifetime
- 1998-05-18 NZ NZ500886A patent/NZ500886A/en not_active IP Right Cessation
- 1998-05-18 AT AT98924700T patent/ATE234078T1/de active
- 1998-05-18 HU HU0002182A patent/HU229154B1/hu not_active IP Right Cessation
- 1998-05-18 CZ CZ0420299A patent/CZ298972B6/cs not_active IP Right Cessation
- 1998-05-18 IL IL13289598A patent/IL132895A0/xx not_active IP Right Cessation
- 1998-05-18 ES ES98924700T patent/ES2195342T3/es not_active Expired - Lifetime
- 1998-05-18 WO PCT/SE1998/000922 patent/WO1998053803A1/en not_active Ceased
- 1998-05-18 CN CN98805564A patent/CN1123338C/zh not_active Expired - Fee Related
- 1998-05-18 EP EP98924700A patent/EP0984773B1/en not_active Expired - Lifetime
- 1998-05-18 DZ DZ980104A patent/DZ2494A1/xx active
- 1998-05-21 TN TNTNSN98068A patent/TNSN98068A1/fr unknown
- 1998-05-25 EG EG56898A patent/EG24044A/xx active
- 1998-05-27 MY MYPI98002355A patent/MY122298A/en unknown
- 1998-07-19 SA SA98190304A patent/SA98190304B1/ar unknown
-
1999
- 1999-11-11 IS IS5245A patent/IS2856B/is unknown
- 1999-11-26 NO NO19995809A patent/NO328100B1/no not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9809484A (pt) | Formulação farmacêutica oral revestida entérica, processo para a manufatura da mesma, uso de uma qualidade de hidroxipropil metilcelulose (hpmc) de baixa viscosidade, e, processo para o tratamento de doenças gastrointestinais em mamìferos, incluindo o homem. | |
| BR9915087A (pt) | Formulação farmacêutica oral revestida entérica, uso de uma qualidade de hidroxipropil celulose (hpc), processo para a munufatura de uma formulação farmacêutica oral revestida entérica, uso de uma formulação farmacêutica, e, método para o tratamento de doenças gastrointestinais em mamìferos, incluindo o homem | |
| PT1308159E (pt) | Composicao farmaceutica contendo um omeprazole labil a acidos e processo para a sua preparacao | |
| DK122291A (da) | Benzimidazolderivat og fysiologisk acceptable salte heraf samt fremgangsmaade til fremstilling af samme | |
| CL2009000805A1 (es) | Composicion farmaceutica que comprende a una sal sodica del enantiomero (-) de 5-metoxi-2[[(4-metoxi-3,5-dimetil-2-piridinil)metil]sulfinil]-1h-bencimidazol ((-)-omeprazol); y su uso en la inhibicion de la secrecion de acido gastrico y para tratar enfermedades inflamatorias gastrointestinales. (divisional solicitud 3570-00). | |
| RU99126869A (ru) | Фармацевтический препарат омепразола | |
| BR0011894A (pt) | Forma de dosagem oral, processo para a fabricação de forma de dosagem, uso de forma de dosagem farmacêutica oral, e, métodos para aumentar inibição de secreção do ácido gástrico e para aumentar o efeito terapêutico no tratamento de distúrbios gastrointestinais associados com excesso de secreção ácida | |
| DE69906518D1 (de) | Arzneistoff-abgabesystem enthaltend eine festgepackte, feste arzneistoffbasis | |
| YU36700A (sh) | Oralni farmaceutski oblik za doziranje sa produženim oslobađanjem | |
| HUP0100347A2 (hu) | Gyomorvédett omeprazol mikrogranulátumok, eljárás előállításukra és ezeket tartalmazó gyógyászati készítmények | |
| ATE110379T1 (de) | Therapeutisch aktive substituierte benzimidazole und verfahren zu ihrer herstellung. | |
| NO178336C (no) | Analogifremgangsmåte for fremstilling av en terapeutisk aktiv benzimidazolforbindelse og mellomprodukter | |
| ES2172343T3 (es) | 14,15-ciclopropano-androstanos insaturados, procedimiento para su preparacion y formulaciones farmaceuticas que contienen estos compuestos. | |
| AR014096A1 (es) | 17 alfa,8,9-deshidroestradiol y 17 beta delta 8,9 deshidroestradiol, el uso de los mismos para la manufactura de un medicamento, una composicionfarmaceutica que los comprende y un procedimiento para su preparacion. | |
| TH8139A (th) | ซับสทิทิวเทดเบนซิมิดาโซลที่ว่องไวในการรักษาและ?กรรมวิธีสำหรับเตรียมสารนั้น |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PRESENTE PEDIDO, UMA VEZ QUE O MESMO NAO ATENDE AO DISPOSTO NOS ARTIGOS 8O E 13 DA LPI |
|
| B15K | Others concerning applications: alteration of classification |
Free format text: ALTERADA DA INT. CL: A61K 9/28; A61K 47/38; A61K 31/4439; A61P 1/04 Ipc: A61K 9/28 (2008.04) |
|
| B12B | Appeal against refusal [chapter 12.2 patent gazette] |