BR9608640A - Utilização de agonistas específicos do receptor cb2 humano compostos e composição farmacêutica - Google Patents
Utilização de agonistas específicos do receptor cb2 humano compostos e composição farmacêuticaInfo
- Publication number
- BR9608640A BR9608640A BR9608640A BR9608640A BR9608640A BR 9608640 A BR9608640 A BR 9608640A BR 9608640 A BR9608640 A BR 9608640A BR 9608640 A BR9608640 A BR 9608640A BR 9608640 A BR9608640 A BR 9608640A
- Authority
- BR
- Brazil
- Prior art keywords
- group
- alkyl
- hydrogen
- halogen
- atom
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9507438A FR2735774B1 (fr) | 1995-06-21 | 1995-06-21 | Utilisation de composes agonistes du recepteur cb2 humain pour la preparation de medicaments immunomodulateurs, nouveaux composes agonistes du recepteur cb2 et les compositions pharmaceutiques les contenant |
PCT/FR1996/000959 WO1997000860A1 (fr) | 1995-06-21 | 1996-06-20 | Composes agonistes du recepteur cb¿2? |
Publications (1)
Publication Number | Publication Date |
---|---|
BR9608640A true BR9608640A (pt) | 1999-05-18 |
Family
ID=9480236
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR9608640A BR9608640A (pt) | 1995-06-21 | 1996-06-20 | Utilização de agonistas específicos do receptor cb2 humano compostos e composição farmacêutica |
Country Status (30)
Country | Link |
---|---|
US (1) | US6013648A (pt) |
EP (1) | EP0833818B1 (pt) |
JP (1) | JP3417566B2 (pt) |
KR (1) | KR19990028272A (pt) |
CN (1) | CN1150166C (pt) |
AT (1) | ATE207054T1 (pt) |
AU (1) | AU717858B2 (pt) |
BR (1) | BR9608640A (pt) |
CA (1) | CA2225379A1 (pt) |
CZ (1) | CZ292630B6 (pt) |
DE (1) | DE69616056T2 (pt) |
DK (1) | DK0833818T3 (pt) |
EE (1) | EE9700345A (pt) |
ES (1) | ES2165986T3 (pt) |
FR (1) | FR2735774B1 (pt) |
HK (1) | HK1005093A1 (pt) |
HU (1) | HUP9900019A3 (pt) |
IL (1) | IL122637A0 (pt) |
IS (1) | IS4637A (pt) |
MX (1) | MX9710251A (pt) |
NO (1) | NO975989L (pt) |
NZ (1) | NZ312161A (pt) |
PL (1) | PL185598B1 (pt) |
PT (1) | PT833818E (pt) |
RU (1) | RU2200736C2 (pt) |
SI (1) | SI0833818T1 (pt) |
SK (1) | SK283660B6 (pt) |
TR (1) | TR199701660T1 (pt) |
UA (1) | UA67717C2 (pt) |
WO (1) | WO1997000860A1 (pt) |
Families Citing this family (85)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2735774B1 (fr) * | 1995-06-21 | 1997-09-12 | Sanofi Sa | Utilisation de composes agonistes du recepteur cb2 humain pour la preparation de medicaments immunomodulateurs, nouveaux composes agonistes du recepteur cb2 et les compositions pharmaceutiques les contenant |
ES2224658T3 (es) * | 1998-05-04 | 2005-03-01 | The University Of Connecticut | Nuevos canabinoides selectivos hacia el receptor cb2. |
CA2340445A1 (en) * | 1998-05-04 | 1999-11-11 | The University Of Connecticut | Novel analgesic and immunomodulatory cannabinoids |
US7589220B2 (en) | 1998-06-09 | 2009-09-15 | University Of Connecticut | Inhibitors of the anandamide transporter |
US7897598B2 (en) | 1998-06-09 | 2011-03-01 | Alexandros Makriyannis | Inhibitors of the anandamide transporter |
DE19837627A1 (de) * | 1998-08-19 | 2000-02-24 | Bayer Ag | Neue Aminosäureester von Arylsulfonamiden und Analoga |
US7276613B1 (en) | 1998-11-24 | 2007-10-02 | University Of Connecticut | Retro-anandamides, high affinity and stability cannabinoid receptor ligands |
US7161016B1 (en) | 1998-11-24 | 2007-01-09 | University Of Connecticut | Cannabimimetic lipid amides as useful medications |
US6566560B2 (en) | 1999-03-22 | 2003-05-20 | Immugen Pharmaceuticals, Inc. | Resorcinolic compounds |
GB9923314D0 (en) * | 1999-10-01 | 1999-12-08 | Pfizer Ltd | Acylation process |
US7119108B1 (en) | 1999-10-18 | 2006-10-10 | University Of Connecticut | Pyrazole derivatives as cannabinoid receptor antagonists |
EP1702617A1 (en) * | 1999-10-18 | 2006-09-20 | The University Of Connecticut | Cannabimimetic indole derivatives |
US6943266B1 (en) * | 1999-10-18 | 2005-09-13 | University Of Connecticut | Bicyclic cannabinoid agonists for the cannabinoid receptor |
US8084467B2 (en) | 1999-10-18 | 2011-12-27 | University Of Connecticut | Pyrazole derivatives as cannabinoid receptor antagonists |
US7393842B2 (en) | 2001-08-31 | 2008-07-01 | University Of Connecticut | Pyrazole analogs acting on cannabinoid receptors |
US6900236B1 (en) * | 1999-10-18 | 2005-05-31 | University Of Connecticut | Cannabimimetic indole derivatives |
JP2003512326A (ja) * | 1999-10-18 | 2003-04-02 | ユニヴァーシティ オブ コネチカット | カンナビノイド相似インドール誘導体 |
US7741365B2 (en) | 1999-10-18 | 2010-06-22 | University Of Connecticut | Peripheral cannabinoid receptor (CB2) selective ligands |
DE60033834T2 (de) | 1999-10-18 | 2007-11-15 | The University Of Connecticut, Farmington | Für periphäre cannabinoid-rezeptoren selektive liganden |
IL132661A (en) | 1999-10-31 | 2008-11-26 | Raphael Mechoulam | Agonists specific for peripheral cannabinoid receptors |
JP2004502642A (ja) * | 2000-02-11 | 2004-01-29 | ブリストル−マイヤーズ スクイブ カンパニー | カンナビノイドレセプターモジュレーター、それらの製造方法、および呼吸系および非呼吸系疾患の処置のためのカンナビノイドレセプターモジュレーターの使用 |
US6974568B2 (en) * | 2000-05-23 | 2005-12-13 | The Regents Of The University Of California | Treatment for cough |
CA2415742A1 (en) | 2000-07-25 | 2002-01-31 | Merck & Co., Inc. | N-substituted indoles useful in the treatment of diabetes |
US20020137802A1 (en) * | 2000-09-28 | 2002-09-26 | Travis Craig R. | Methods and compounds for inhibiting eicosanoid metabolism and platelet aggregation |
US6541510B2 (en) * | 2000-09-28 | 2003-04-01 | Immugen Pharmaceuticals, Inc. | Antiviral methods and compounds |
FR2814678B1 (fr) * | 2000-10-04 | 2002-12-20 | Aventis Pharma Sa | Association d'un antagoniste du recepteur cb1 et de sibutramine, les compositions pharmaceutiques les contenant et leur utilisation pour la traitement de l'obesite |
AUPR118000A0 (en) * | 2000-11-02 | 2000-11-23 | Amrad Operations Pty. Limited | Therapeutic molecules and methods |
FR2816938B1 (fr) * | 2000-11-22 | 2003-01-03 | Sanofi Synthelabo | Derives de 3-aroylindole, leur procede de preparation et les compositions pharmaceutiques en contenant |
CA2435409A1 (en) | 2001-01-26 | 2002-08-01 | University Of Connecticut | Novel cannabimimetic ligands |
EP1363632B1 (en) | 2001-01-29 | 2010-08-25 | The University of Connecticut | Receptor selective cannabimimetic aminoalkylindoles |
US7067539B2 (en) * | 2001-02-08 | 2006-06-27 | Schering Corporation | Cannabinoid receptor ligands |
US7507767B2 (en) * | 2001-02-08 | 2009-03-24 | Schering Corporation | Cannabinoid receptor ligands |
JP4312594B2 (ja) | 2001-07-13 | 2009-08-12 | ユニバーシティ オブ コネチカット | 新規な二環式及び三環式カンナビノイド |
EP1406576B2 (en) * | 2001-07-18 | 2011-06-29 | Unilever PLC | Hair and/or scalp treatment compositions |
WO2003035005A2 (en) | 2001-10-26 | 2003-05-01 | University Of Connecticut | Heteroindanes: a new class of potent cannabimimetic ligands |
MXPA04004674A (es) * | 2001-11-14 | 2004-08-12 | Schering Corp | Ligados de los receptors de los canabinodies. |
TW200407110A (en) * | 2001-11-23 | 2004-05-16 | Astrazeneca Ab | New use for the treatment of gastroesophageal reflux disease |
EP1461027A4 (en) * | 2001-12-07 | 2005-09-07 | Univ Virginia Commonwealth | TREATMENT OF NEOPLASIA |
US7528165B2 (en) * | 2001-12-13 | 2009-05-05 | National Health Research Institutes | Indole compounds |
TWI317634B (en) * | 2001-12-13 | 2009-12-01 | Nat Health Research Institutes | Aroyl indoles compounds |
US7632955B2 (en) * | 2001-12-13 | 2009-12-15 | National Health Research Institutes | Indole compounds |
US20040171613A1 (en) * | 2001-12-27 | 2004-09-02 | Japan Tobacco Inc. | Therapeutic agent for non-immediate type allergic diseases |
WO2003061699A1 (fr) * | 2001-12-27 | 2003-07-31 | Japan Tobacco, Inc. | Remedes pour affections allergiques |
RU2337909C2 (ru) | 2002-02-01 | 2008-11-10 | Ф.Хоффманн-Ля Рош Аг | Замещенные индолы и фармацевтическая композиция, обладающая агонистической активностью в отношении альфа-1a/l адренорецептора |
ATE447971T1 (de) | 2002-02-19 | 2009-11-15 | Shionogi & Co | Antipruriginosa |
NZ535349A (en) | 2002-03-08 | 2007-01-26 | Signal Pharm Inc | JNK inhibitors with chemotherapeutic agents in a combination therapy for treating or preventing cancer and other proliferative disorders in refractory patients in particular |
CN1652766A (zh) * | 2002-03-18 | 2005-08-10 | 免疫力药品有限公司 | 间苯二酚和大麻素的局部制剂及其施用方法 |
FR2839718B1 (fr) | 2002-05-17 | 2004-06-25 | Sanofi Synthelabo | Derives d'indole, leur procede de preparation et les compositions pharmaceutiques en contenant |
JP2005533809A (ja) * | 2002-06-19 | 2005-11-10 | シェーリング コーポレイション | カンナビノイドレセプタアゴニスト |
EP1545502A4 (en) | 2002-08-23 | 2008-12-24 | Univ Connecticut | KETO CANNABINOIDS WITH THERAPEUTIC INDICATIONS |
DE60328033D1 (de) | 2002-11-25 | 2009-07-30 | Schering Corp | Cannabinoid-rezeptorliganden |
AR043633A1 (es) | 2003-03-20 | 2005-08-03 | Schering Corp | Ligandos de receptores de canabinoides |
WO2005007111A2 (en) | 2003-07-11 | 2005-01-27 | Bristol-Myers Squibb Company | Tetrahydroquinoline derivatives as cannabinoid receptor modulators |
US7326706B2 (en) | 2003-08-15 | 2008-02-05 | Bristol-Myers Squibb Company | Pyrazine modulators of cannabinoid receptors |
IL160420A0 (en) | 2004-02-16 | 2004-07-25 | Yissum Res Dev Co | Treating or preventing diabetes with cannabidiol |
EP1768667B1 (en) * | 2004-06-22 | 2009-09-30 | Schering Corporation | Cannabinoid receptor ligands |
US7517991B2 (en) * | 2004-10-12 | 2009-04-14 | Bristol-Myers Squibb Company | N-sulfonylpiperidine cannabinoid receptor 1 antagonists |
WO2006069196A1 (en) * | 2004-12-21 | 2006-06-29 | Abbott Laboratories | 3-cycloalkylcarbonyl indoles as cannabinoid receptor ligands |
US7456289B2 (en) * | 2004-12-31 | 2008-11-25 | National Health Research Institutes | Anti-tumor compounds |
FR2893615B1 (fr) | 2005-11-18 | 2008-03-07 | Sanofi Aventis Sa | Derives de 3-acylindole, leur preparation et leur application en therapeutique |
JP2009538933A (ja) | 2006-05-31 | 2009-11-12 | アボット・ラボラトリーズ | カンナビノイド受容体リガンドとしての化合物およびその使用 |
US8841334B2 (en) | 2006-05-31 | 2014-09-23 | Abbvie Inc. | Compounds as cannabinoid receptor ligands and uses thereof |
JP2010522760A (ja) | 2007-03-28 | 2010-07-08 | アボット・ラボラトリーズ | カンナビノイド受容体リガンドとしての1,3−チアゾール−2(3h)−イリデン化合物 |
US7872033B2 (en) | 2007-04-17 | 2011-01-18 | Abbott Laboratories | Compounds as cannabinoid receptor ligands |
CA2683086A1 (en) | 2007-05-18 | 2008-11-18 | Abbott Laboratories | Color tunable light source |
US7943658B2 (en) * | 2007-07-23 | 2011-05-17 | Bristol-Myers Squibb Company | Indole indane amide compounds useful as CB2 agonists and method |
US9193713B2 (en) | 2007-10-12 | 2015-11-24 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
FR2933697B1 (fr) | 2008-07-11 | 2010-08-13 | Sanofi Aventis | Derives de 1-benzyl-cinnolin-4-(1h)-one substitues, leur preparation et leur application en therapeutique |
US8846730B2 (en) | 2008-09-08 | 2014-09-30 | Abbvie Inc. | Compounds as cannabinoid receptor ligands |
CA2737199A1 (en) | 2008-09-16 | 2010-03-25 | Abbott Laboratories | Novel compounds as cannabinoid receptor ligands |
PA8854001A1 (es) | 2008-12-16 | 2010-07-27 | Abbott Lab | Compuestos novedosos como ligandos de receptores de canabinoides |
WO2011009883A1 (en) | 2009-07-23 | 2011-01-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Selective cb2 receptor agonists for use in the prevention or treatment of alcoholic liver disease |
FR2950055A1 (fr) | 2009-09-17 | 2011-03-18 | Sanofi Aventis | Derives de 3-amino-cinnolin-4(1h)-one substitues, leur preparation et leur application en therapeutique |
ES2530629T3 (es) | 2010-08-20 | 2015-03-04 | Univ Washington Ct Commerciali | Composición y métodos para tratar glioblastomas |
US9173887B2 (en) | 2010-12-22 | 2015-11-03 | Abbvie Inc. | Hepatitis C inhibitors and uses thereof |
FR2983859B1 (fr) | 2011-12-12 | 2014-01-17 | Sanofi Sa | Derives de 1,3,5-triazine-2-amine, leur preparation et leur application en diagnostique et en therapeutique |
US9416103B2 (en) * | 2012-01-09 | 2016-08-16 | The Board Of Trustees Of The University Of Arkansas | Use of the aminoalkylindole JWH-073-M4 and related compounds as neutral CB1 receptor antagonists for the treatment of alcoholism, drug abuse, obesity, and obesity-related diseases |
WO2014015298A1 (en) | 2012-07-20 | 2014-01-23 | The Regents Of The University Of California | Peripherally-acting cannabinoid receptor agonists for chronic pain |
KR20150102511A (ko) * | 2014-02-28 | 2015-09-07 | 주식회사 아세아텍 | 베일러용 드로우 |
CZ2014985A3 (cs) * | 2014-12-31 | 2016-03-09 | Vysoká škola chemicko- technologická v Praze | Derivát syntetického kanabinoidu, způsob jeho přípravy a použití |
CZ306547B6 (cs) * | 2014-12-31 | 2017-03-01 | Vysoká škola chemicko - technologická v Praze | Derivát syntetického kanabinoidu, způsob jeho přípravy a použití |
CN109715152A (zh) * | 2016-04-29 | 2019-05-03 | 柯巴斯医药有限公司 | 医治感染的方法 |
CN108794379A (zh) * | 2017-04-26 | 2018-11-13 | 华东师范大学 | 1h-吲哚-2-甲酰胺衍生物及其制备方法和应用 |
WO2019144126A1 (en) | 2018-01-22 | 2019-07-25 | Pascal Biosciences Inc. | Cannabinoids and derivatives for promoting immunogenicity of tumor and infected cells |
IL295374A (en) | 2020-02-04 | 2022-10-01 | Mindset Pharma Inc | 3-pyrrolidine indole derivatives as serotonergic psychedelics for the treatment of central nervous system disorders |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RO77049A2 (ro) * | 1980-08-08 | 1981-06-22 | Institutul De Cercetari Chimico-Farmaceutice,Ro | Derivati de 2-metil-3-etilindol si procedeu de preparare a acestora |
RO90049A2 (ro) * | 1984-12-25 | 1986-08-30 | Centrala Industriala De Medicamente Cosmetice,Coloranti Si Lacuri,Ro | Procedeu de preparare a clorhidratului hidrat de 1-(p-clorbenzoil)3-/2-(di-n-propilamino) etil/5-metoxi-2-metilindol |
US5068234A (en) * | 1990-02-26 | 1991-11-26 | Sterling Drug Inc. | 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles |
US5081122A (en) * | 1990-03-05 | 1992-01-14 | Sterling Drug Inc. | Antiglaucoma compositions containing 4-arylcarbonyl-1-(4-morpholinyl)-lower-alkyl)-1H-indoles and method of use thereof |
US5013837A (en) * | 1990-03-08 | 1991-05-07 | Sterling Drug Inc. | 3-Arylcarbonyl-1H-indole-containing compounds |
US4973587A (en) * | 1990-03-08 | 1990-11-27 | Sterling Drug Inc. | 3-arylcarbonyl-1-aminoalkyl-1H-indole-containing antiglaucoma method |
FR2735774B1 (fr) * | 1995-06-21 | 1997-09-12 | Sanofi Sa | Utilisation de composes agonistes du recepteur cb2 humain pour la preparation de medicaments immunomodulateurs, nouveaux composes agonistes du recepteur cb2 et les compositions pharmaceutiques les contenant |
-
1995
- 1995-06-21 FR FR9507438A patent/FR2735774B1/fr not_active Expired - Fee Related
-
1996
- 1996-06-20 UA UA97126177A patent/UA67717C2/uk unknown
- 1996-06-20 DK DK96922962T patent/DK0833818T3/da active
- 1996-06-20 SK SK1735-97A patent/SK283660B6/sk unknown
- 1996-06-20 SI SI9630401T patent/SI0833818T1/xx unknown
- 1996-06-20 CA CA002225379A patent/CA2225379A1/en not_active Abandoned
- 1996-06-20 HU HU9900019A patent/HUP9900019A3/hu unknown
- 1996-06-20 BR BR9608640A patent/BR9608640A/pt not_active Application Discontinuation
- 1996-06-20 CN CNB961961260A patent/CN1150166C/zh not_active Expired - Fee Related
- 1996-06-20 CZ CZ19974143A patent/CZ292630B6/cs not_active IP Right Cessation
- 1996-06-20 EP EP96922962A patent/EP0833818B1/fr not_active Expired - Lifetime
- 1996-06-20 AT AT96922962T patent/ATE207054T1/de not_active IP Right Cessation
- 1996-06-20 TR TR97/01660T patent/TR199701660T1/xx unknown
- 1996-06-20 PT PT96922962T patent/PT833818E/pt unknown
- 1996-06-20 KR KR1019970709586A patent/KR19990028272A/ko active IP Right Grant
- 1996-06-20 EE EE9700345A patent/EE9700345A/xx unknown
- 1996-06-20 RU RU98101097/14A patent/RU2200736C2/ru not_active IP Right Cessation
- 1996-06-20 PL PL96324185A patent/PL185598B1/pl not_active IP Right Cessation
- 1996-06-20 ES ES96922962T patent/ES2165986T3/es not_active Expired - Lifetime
- 1996-06-20 MX MX9710251A patent/MX9710251A/es not_active IP Right Cessation
- 1996-06-20 DE DE69616056T patent/DE69616056T2/de not_active Expired - Fee Related
- 1996-06-20 JP JP50362997A patent/JP3417566B2/ja not_active Expired - Fee Related
- 1996-06-20 AU AU63632/96A patent/AU717858B2/en not_active Ceased
- 1996-06-20 WO PCT/FR1996/000959 patent/WO1997000860A1/fr active IP Right Grant
- 1996-06-20 NZ NZ312161A patent/NZ312161A/xx unknown
- 1996-06-20 IL IL12263796A patent/IL122637A0/xx not_active IP Right Cessation
-
1997
- 1997-12-19 IS IS4637A patent/IS4637A/is unknown
- 1997-12-19 NO NO975989A patent/NO975989L/no not_active Application Discontinuation
- 1997-12-22 US US08/995,902 patent/US6013648A/en not_active Expired - Fee Related
-
1998
- 1998-05-19 HK HK98104304A patent/HK1005093A1/xx not_active IP Right Cessation
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR9608640A (pt) | Utilização de agonistas específicos do receptor cb2 humano compostos e composição farmacêutica | |
NO982330D0 (no) | Pyrazolderivater, fremgangsmÕte for fremstilling derav og farmas÷ytiske preparater inneholdende nevnte derivater | |
DE69813896D1 (de) | Alpha-aminoamidderivate die als analgetische mittel nützlich sind | |
HUP0300922A2 (hu) | Új vegyületek, eljárás az előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk | |
HUP9802866A2 (hu) | 2,4,5-Triszubsztituált-fenil-keto-enol-származékok, intermedierjeik, a vegyületeket hatóanyagként tartalmazó inszekticid, akaricid és herbicid készítmények, valamint eljárás a vegyületek és készítmények előállítására és alkalmazására | |
HUP0303652A2 (hu) | Ciklikus származékok, mint kemokin receptor aktivitás modulátorai és ezeket tartalmazó gyógyszerkészítmények | |
HUP0300527A2 (hu) | Pirrolopirimidinon-származékok, a vegyületek előállítása és alkalmazása | |
HUP0301329A2 (hu) | Béta3 Adrenergiás agonisták, valamint ezen vegyületeket tartalmazó gyógyászati készítmények és eljárás e vegyületek előállítására | |
KR950704328A (ko) | 5-HT₄ 수용체 길항제로서의 피페리딘 유도체(Piperidine Derivatives as 5-HT₄ Receptor Antagonists) | |
HUP9901613A2 (hu) | Szubsztituált tetraciklusos kondenzált furán-amin-származékok, eljárás előállításukra, alkalmazásuk és az ezeket tartalmazó gyógyszerkészítmények | |
HUP9900501A2 (hu) | Muszkarin receptor antagonista hatású oxa- és tiadiazolszármazékok, intermedierjeik, előállításuk és alkalmazásuk, a vegyületeket tartalmazó gyógyászati készítmények | |
IE862630L (en) | 3-VINYL AND 3-ETHYNYL-ß-CARBOLINES | |
ATE168991T1 (de) | Substituierte arylalkoxybenzyl-aminopropanamide, ihre herstellung und verwendung als antiepileptische, neuroprotektive und antidepressive mittel | |
ES8207525A1 (es) | Un procedimiento para la preparacion de nuevos derivados de la quinoleina. | |
NO901083D0 (no) | Fremgangsmaate for fremstilling av nye 1,7-kondenserte 1h-indol-2-carboxylsyre-n-(1,4-benzodiazepin)-3-yl)amider. | |
IL100212A (en) | Pyrroline compounds, a process for their preparation, their use to prepare pyrrole products and pyrrole products made by said process | |
HUP9802407A1 (hu) | Eljárás kamptotecinszármazékok előállítására, valamint a közbenső termékként szolgáló vegyületek | |
WO1999021848A3 (en) | Novel 1-(n'-(arylalkylaminoalkyl))aminoisoindoles; a new class of dopamine receptor subtype specific ligands | |
DE69402935D1 (de) | Substituierte arylalkylaminobenzyl-aminopropanamide, ihre herstellung und verwendung als antiepileptische, neuroprotektive und antidepressive mittel | |
HUP0203695A2 (hu) | Szubsztituált pirrol Mannichbázisok, előállításuk, alkalmazásuk és ilyent tartalmazó gyógyászati készítmény | |
ES483162A1 (es) | Un procedimiento para peparar nuevas ureas sustituidas. | |
HUP0204149A2 (hu) | Új szulfoniloxazolamin-származékok, ezeket tartalmazó gyógyszerkészítmények és eljárás a vegyületek előállítására | |
DK0419360T3 (da) | Phenothiazinderivater, deres fremstilling og farmaceutiske præparater indeholdende disse | |
HUP9901139A2 (hu) | Melatonin agonisták alkalmazása jóindulatú prosztata hiperplázia kezelésére alkalmas gyógyászati készítmények előállítására | |
SE7701843L (sv) | Forfarande for framstellning av nya derivat av ditiepino-(1,4)(2,3-c)-pyrrol |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
TE | Change of address | ||
PC | Transfer |
Free format text: SANOFI-SYNTHELABO (FR) |
|
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: INDEFIRO O PRESENTE PEDIDO DE PATENTE DE ACORDO COM ART. 8O DA LPI |