NO975989D0 - CB2-reseptor-agonist-forbindelser - Google Patents

CB2-reseptor-agonist-forbindelser

Info

Publication number
NO975989D0
NO975989D0 NO975989A NO975989A NO975989D0 NO 975989 D0 NO975989 D0 NO 975989D0 NO 975989 A NO975989 A NO 975989A NO 975989 A NO975989 A NO 975989A NO 975989 D0 NO975989 D0 NO 975989D0
Authority
NO
Norway
Prior art keywords
group
alkyl
hydrogen
halogen
atom
Prior art date
Application number
NO975989A
Other languages
English (en)
Other versions
NO975989L (no
Inventor
Murielle Rinaldi
Francis Barth
Pierre Casellas
Christian Congy
Didier Oustric
Malcolm R Bell
Amba Thomas E D
Richard E Philion
Original Assignee
Sanofi Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Sa filed Critical Sanofi Sa
Publication of NO975989D0 publication Critical patent/NO975989D0/no
Publication of NO975989L publication Critical patent/NO975989L/no

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5355—Non-condensed oxazines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/538—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with carbocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12—Radicals substituted by oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
NO975989A 1995-06-21 1997-12-19 CB2-reseptor-agonist-forbindelser NO975989L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR9507438A FR2735774B1 (fr) 1995-06-21 1995-06-21 Utilisation de composes agonistes du recepteur cb2 humain pour la preparation de medicaments immunomodulateurs, nouveaux composes agonistes du recepteur cb2 et les compositions pharmaceutiques les contenant
PCT/FR1996/000959 WO1997000860A1 (fr) 1995-06-21 1996-06-20 Composes agonistes du recepteur cb¿2?

Publications (2)

Publication Number Publication Date
NO975989D0 true NO975989D0 (no) 1997-12-19
NO975989L NO975989L (no) 1998-02-19

Family

ID=9480236

Family Applications (1)

Application Number Title Priority Date Filing Date
NO975989A NO975989L (no) 1995-06-21 1997-12-19 CB2-reseptor-agonist-forbindelser

Country Status (30)

Country Link
US (1) US6013648A (no)
EP (1) EP0833818B1 (no)
JP (1) JP3417566B2 (no)
KR (1) KR19990028272A (no)
CN (1) CN1150166C (no)
AT (1) ATE207054T1 (no)
AU (1) AU717858B2 (no)
BR (1) BR9608640A (no)
CA (1) CA2225379A1 (no)
CZ (1) CZ292630B6 (no)
DE (1) DE69616056T2 (no)
DK (1) DK0833818T3 (no)
EE (1) EE9700345A (no)
ES (1) ES2165986T3 (no)
FR (1) FR2735774B1 (no)
HK (1) HK1005093A1 (no)
HU (1) HUP9900019A3 (no)
IL (1) IL122637A0 (no)
IS (1) IS4637A (no)
MX (1) MX9710251A (no)
NO (1) NO975989L (no)
NZ (1) NZ312161A (no)
PL (1) PL185598B1 (no)
PT (1) PT833818E (no)
RU (1) RU2200736C2 (no)
SI (1) SI0833818T1 (no)
SK (1) SK283660B6 (no)
TR (1) TR199701660T1 (no)
UA (1) UA67717C2 (no)
WO (1) WO1997000860A1 (no)

Families Citing this family (85)

* Cited by examiner, † Cited by third party
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FR2735774B1 (fr) * 1995-06-21 1997-09-12 Sanofi Sa Utilisation de composes agonistes du recepteur cb2 humain pour la preparation de medicaments immunomodulateurs, nouveaux composes agonistes du recepteur cb2 et les compositions pharmaceutiques les contenant
ATE277921T1 (de) * 1998-05-04 2004-10-15 Univ Connecticut Selektiv auf den cb2-rezeptor wirkende cannabinoide
DE69910373T2 (de) * 1998-05-04 2004-04-01 The University Of Connecticut, Farmington Analgetische und immunomodulierende cannabinoiden
US7897598B2 (en) 1998-06-09 2011-03-01 Alexandros Makriyannis Inhibitors of the anandamide transporter
US7589220B2 (en) 1998-06-09 2009-09-15 University Of Connecticut Inhibitors of the anandamide transporter
DE19837627A1 (de) * 1998-08-19 2000-02-24 Bayer Ag Neue Aminosäureester von Arylsulfonamiden und Analoga
US7161016B1 (en) 1998-11-24 2007-01-09 University Of Connecticut Cannabimimetic lipid amides as useful medications
US7276613B1 (en) 1998-11-24 2007-10-02 University Of Connecticut Retro-anandamides, high affinity and stability cannabinoid receptor ligands
US6566560B2 (en) 1999-03-22 2003-05-20 Immugen Pharmaceuticals, Inc. Resorcinolic compounds
GB9923314D0 (en) * 1999-10-01 1999-12-08 Pfizer Ltd Acylation process
MXPA02005101A (es) * 1999-10-18 2003-09-25 Alexipharma Inc Derivados de indol canabimimeticos.
US7393842B2 (en) 2001-08-31 2008-07-01 University Of Connecticut Pyrazole analogs acting on cannabinoid receptors
US7119108B1 (en) 1999-10-18 2006-10-10 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
WO2001028329A1 (en) 1999-10-18 2001-04-26 University Of Connecticut Peripheral cannabinoid receptor (cb2) selective ligands
US6943266B1 (en) * 1999-10-18 2005-09-13 University Of Connecticut Bicyclic cannabinoid agonists for the cannabinoid receptor
US6900236B1 (en) * 1999-10-18 2005-05-31 University Of Connecticut Cannabimimetic indole derivatives
EP1702617A1 (en) * 1999-10-18 2006-09-20 The University Of Connecticut Cannabimimetic indole derivatives
US8084467B2 (en) 1999-10-18 2011-12-27 University Of Connecticut Pyrazole derivatives as cannabinoid receptor antagonists
US7741365B2 (en) 1999-10-18 2010-06-22 University Of Connecticut Peripheral cannabinoid receptor (CB2) selective ligands
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US6974568B2 (en) * 2000-05-23 2005-12-13 The Regents Of The University Of California Treatment for cough
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PL2606032T3 (pl) 2010-08-20 2015-07-31 Univ Washington Through Its Center For Commercialization Kompozycja i sposoby terapii glejakaep
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US9416103B2 (en) * 2012-01-09 2016-08-16 The Board Of Trustees Of The University Of Arkansas Use of the aminoalkylindole JWH-073-M4 and related compounds as neutral CB1 receptor antagonists for the treatment of alcoholism, drug abuse, obesity, and obesity-related diseases
US9656981B2 (en) 2012-07-20 2017-05-23 The Regents Of The University Of California Peripherally-acting cannabinoid receptor agonists for chronic pain
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Also Published As

Publication number Publication date
EP0833818A1 (fr) 1998-04-08
TR199701660T1 (xx) 1998-04-21
AU6363296A (en) 1997-01-22
CN1192732A (zh) 1998-09-09
ATE207054T1 (de) 2001-11-15
EE9700345A (et) 1998-06-15
MX9710251A (es) 1998-03-31
ES2165986T3 (es) 2002-04-01
FR2735774B1 (fr) 1997-09-12
BR9608640A (pt) 1999-05-18
KR19990028272A (ko) 1999-04-15
CZ414397A3 (cs) 1998-07-15
JP3417566B2 (ja) 2003-06-16
SK283660B6 (sk) 2003-11-04
CN1150166C (zh) 2004-05-19
AU717858B2 (en) 2000-04-06
PL324185A1 (en) 1998-05-11
PT833818E (pt) 2002-04-29
CZ292630B6 (cs) 2003-11-12
SK173597A3 (en) 1998-11-04
CA2225379A1 (en) 1997-01-09
HUP9900019A3 (en) 2001-03-28
NZ312161A (en) 2000-08-25
HK1005093A1 (en) 1998-12-24
IL122637A0 (en) 1998-08-16
DE69616056T2 (de) 2002-06-20
JPH11507937A (ja) 1999-07-13
EP0833818B1 (fr) 2001-10-17
RU2200736C2 (ru) 2003-03-20
HUP9900019A2 (hu) 1999-10-28
DE69616056D1 (de) 2001-11-22
WO1997000860A1 (fr) 1997-01-09
PL185598B1 (pl) 2003-06-30
IS4637A (is) 1997-12-19
NO975989L (no) 1998-02-19
SI0833818T1 (en) 2002-04-30
FR2735774A1 (fr) 1996-12-27
UA67717C2 (en) 2004-07-15
DK0833818T3 (da) 2002-02-11
US6013648A (en) 2000-01-11

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