BR9606768A - Cloridreto de valaciclovir uso do mesmo e processo para o tratamento de infecção virótica de herpes em um ser humano e para a produção de cloridreto de valaciclovir na forma cristalina anidra - Google Patents

Cloridreto de valaciclovir uso do mesmo e processo para o tratamento de infecção virótica de herpes em um ser humano e para a produção de cloridreto de valaciclovir na forma cristalina anidra

Info

Publication number
BR9606768A
BR9606768A BR9606768A BR9606768A BR9606768A BR 9606768 A BR9606768 A BR 9606768A BR 9606768 A BR9606768 A BR 9606768A BR 9606768 A BR9606768 A BR 9606768A BR 9606768 A BR9606768 A BR 9606768A
Authority
BR
Brazil
Prior art keywords
valacyclovir hydrochloride
human
treatment
production
viral infection
Prior art date
Application number
BR9606768A
Other languages
English (en)
Portuguese (pt)
Inventor
Barry Howard Carter
Jane Muse Partin
Peter Gregory Varlashkin
Richard Augustus Winnikie
William Bayne Grubb
Gregory Allan Conway
Philip George Lake
David Michael Skinner
David James Whatrup
Original Assignee
Wellcome Found
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=10768347&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9606768(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Wellcome Found filed Critical Wellcome Found
Publication of BR9606768A publication Critical patent/BR9606768A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A61P31/22—Antivirals for DNA viruses for herpes viruses

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BR9606768A 1995-01-20 1996-01-19 Cloridreto de valaciclovir uso do mesmo e processo para o tratamento de infecção virótica de herpes em um ser humano e para a produção de cloridreto de valaciclovir na forma cristalina anidra BR9606768A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9501178.9A GB9501178D0 (en) 1995-01-20 1995-01-20 Guanine derivative
PCT/GB1996/000117 WO1996022291A1 (en) 1995-01-20 1996-01-19 Guanine derivative

Publications (1)

Publication Number Publication Date
BR9606768A true BR9606768A (pt) 1997-12-30

Family

ID=10768347

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9606768A BR9606768A (pt) 1995-01-20 1996-01-19 Cloridreto de valaciclovir uso do mesmo e processo para o tratamento de infecção virótica de herpes em um ser humano e para a produção de cloridreto de valaciclovir na forma cristalina anidra

Country Status (40)

Country Link
US (1) US6107302A (enEXAMPLES)
EP (1) EP0804436B1 (enEXAMPLES)
JP (1) JP3176633B2 (enEXAMPLES)
KR (1) KR100376074B1 (enEXAMPLES)
CN (1) CN1049893C (enEXAMPLES)
AP (1) AP662A (enEXAMPLES)
AR (1) AR002270A1 (enEXAMPLES)
AT (1) ATE302777T1 (enEXAMPLES)
AU (1) AU702794B2 (enEXAMPLES)
BG (1) BG63393B1 (enEXAMPLES)
BR (1) BR9606768A (enEXAMPLES)
CA (1) CA2210799C (enEXAMPLES)
CY (1) CY2531B1 (enEXAMPLES)
CZ (1) CZ297065B6 (enEXAMPLES)
DE (1) DE69635106T2 (enEXAMPLES)
DK (1) DK0804436T3 (enEXAMPLES)
EA (1) EA000364B1 (enEXAMPLES)
EE (1) EE03528B1 (enEXAMPLES)
ES (1) ES2248806T3 (enEXAMPLES)
FI (1) FI973063L (enEXAMPLES)
GB (1) GB9501178D0 (enEXAMPLES)
GE (1) GEP20001940B (enEXAMPLES)
HR (1) HRP960024B1 (enEXAMPLES)
HU (1) HU222993B1 (enEXAMPLES)
IL (1) IL116831A (enEXAMPLES)
IN (1) IN182468B (enEXAMPLES)
IS (1) IS2268B (enEXAMPLES)
NO (1) NO315558B1 (enEXAMPLES)
NZ (1) NZ298851A (enEXAMPLES)
OA (1) OA10499A (enEXAMPLES)
PL (1) PL182175B1 (enEXAMPLES)
RO (1) RO118693B1 (enEXAMPLES)
RS (1) RS49518B (enEXAMPLES)
SI (1) SI0804436T1 (enEXAMPLES)
SK (1) SK285329B6 (enEXAMPLES)
TR (1) TR199700656T1 (enEXAMPLES)
UA (1) UA46001C2 (enEXAMPLES)
UY (1) UY25779A1 (enEXAMPLES)
WO (1) WO1996022291A1 (enEXAMPLES)
ZA (1) ZA96449B (enEXAMPLES)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9501178D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Guanine derivative
EP0874631B1 (en) * 1996-01-19 2003-11-19 Glaxo Group Limited Use of valaciclovir for the manufacture of a medicament for the treatment of genital herpes by a single daily application
IT1283447B1 (it) * 1996-07-18 1998-04-21 Ind Chimica Srl Processo di preparazione del valaciclovir e relativi intermedi
CN1250449A (zh) * 1997-01-17 2000-04-12 味之素株式会社 新型z－伐昔洛韦结晶
GB0010446D0 (en) * 2000-04-28 2000-06-14 Glaxo Wellcome Kk Pharmaceutical formulation
RS55023B1 (sr) * 2001-02-24 2016-11-30 Boehringer Ingelheim Pharma Derivati ksantina, njihovo dobijanje i njihova primena kao lekova
KR100774271B1 (ko) * 2001-09-07 2007-11-08 테바 파마슈티컬 인더스트리즈 리미티드 발라사이클로비르 염산염의 결정질 형태
AU2002348022B2 (en) * 2001-11-05 2006-06-15 Glaxo Group Limited Anhydrous crystal form of valaciclovir hydrochloride
PL371732A1 (en) * 2001-11-14 2005-06-27 Teva Pharmaceutical Industries Ltd. Synthesis and purification of valacyclovir
AU2003240213A1 (en) * 2002-06-24 2004-01-06 Ranbaxy Laboratories Limited Process for the preparation of robust formulations of valacyclovir hydrochloride tablets
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
US20050043329A1 (en) * 2002-09-06 2005-02-24 Shlomit Wizel Crystalline forms of valacyclovir hydrochloride
AU2003277433A1 (en) * 2002-10-16 2004-05-04 Teva Pharmaceutical Industries Ltd. Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
US20050059684A1 (en) * 2002-10-16 2005-03-17 Ben-Zion Dolitzky Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
EP1575953A1 (en) * 2002-12-09 2005-09-21 Texcontor Etablissement Anhydrous crystalline form of valacyclovir hydrochloride
AU2003232719A1 (en) * 2003-05-30 2005-01-21 Eos Eczacibasi Ozgun Kimyasal Urunler Sanayi Ve Ticaret A.S. Novel crystalline forms of valacyclovir hydrochloride
US20050085491A1 (en) * 2003-06-02 2005-04-21 Igor Lifshitz Novel crystalline forms of valacyclovir hydrochloride
KR20060117355A (ko) * 2004-01-21 2006-11-16 테바 파마슈티컬 인더스트리즈 리미티드 발라시클로버 염산염의 제조 방법
US7501426B2 (en) 2004-02-18 2009-03-10 Boehringer Ingelheim International Gmbh 8-[3-amino-piperidin-1-yl]-xanthines, their preparation and their use as pharmaceutical compositions
CA2572268A1 (en) * 2004-06-30 2006-02-02 Teva Pharmaceutical Industries Ltd. Method for reducing residual alcohols in crystalline valacyclovir hydrochloride
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
US20060178512A1 (en) * 2005-02-04 2006-08-10 Cheruthur Govindan Method for preparing amino acid esters of nucleoside analogues
EP1891071B1 (en) * 2005-05-25 2012-02-22 Eli Lilly And Company Cyclopropanecarboxylate esters of acyclovir
EP1746098A1 (en) * 2005-07-21 2007-01-24 SOLMAG S.p.A. Valacyclovir polymorphs and a process for the preparation thereof
DE102005035891A1 (de) * 2005-07-30 2007-02-08 Boehringer Ingelheim Pharma Gmbh & Co. Kg 8-(3-Amino-piperidin-1-yl)-xanthine, deren Herstellung und deren Verwendung als Arzneimittel
US20070112193A1 (en) * 2005-11-14 2007-05-17 Khunt Mayur D Valacyclovir process
BRPI0711558A2 (pt) 2006-05-04 2011-11-08 Boeringer Ingelheim Internat Gmbh polimorfos
EP1852108A1 (en) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG DPP IV inhibitor formulations
PE20080251A1 (es) 2006-05-04 2008-04-25 Boehringer Ingelheim Int Usos de inhibidores de dpp iv
CN1903854B (zh) * 2006-08-09 2012-05-23 丽珠医药集团股份有限公司 一种合成盐酸伐昔洛韦的方法
US20080167325A1 (en) * 2006-12-27 2008-07-10 Bs Praveen Kumar Valacyclovir compositions
US20080281099A1 (en) * 2007-05-07 2008-11-13 Mayur Devjibhai Khunt Process for purifying valacyclovir hydrochloride and intermediates thereof
GB0710277D0 (en) * 2007-05-30 2007-07-11 Univ Birmingham Use of antivirals in the treatment of medical disorders
KR101610005B1 (ko) * 2007-08-17 2016-04-08 베링거 인겔하임 인터내셔날 게엠베하 Ｆａｂ 관련 질환의 치료에 사용하기 위한 푸린 유도체
WO2009031576A1 (ja) * 2007-09-03 2009-03-12 Ajinomoto Co., Inc. バラシクロビル塩酸塩結晶の製造方法
US20090076039A1 (en) * 2007-09-14 2009-03-19 Protia, Llc Deuterium-enriched valacyclovir
PE20140960A1 (es) * 2008-04-03 2014-08-15 Boehringer Ingelheim Int Formulaciones que comprenden un inhibidor de dpp4
PE20100156A1 (es) * 2008-06-03 2010-02-23 Boehringer Ingelheim Int Tratamiento de nafld
UY32030A (es) 2008-08-06 2010-03-26 Boehringer Ingelheim Int "tratamiento para diabetes en pacientes inapropiados para terapia con metformina"
KR20190016601A (ko) 2008-08-06 2019-02-18 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
AU2009281122C1 (en) * 2008-08-15 2016-04-21 Boehringer Ingelheim International Gmbh Purin derivatives for use in the treatment of fab-related diseases
EP2344195A2 (en) 2008-09-10 2011-07-20 Boehringer Ingelheim International GmbH Combination therapy for the treatment of diabetes and related conditions
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
NZ592924A (en) 2008-12-23 2014-05-30 Boehringer Ingelheim Int Salt forms of a xanthine derivative
AR074990A1 (es) 2009-01-07 2011-03-02 Boehringer Ingelheim Int Tratamiento de diabetes en pacientes con un control glucemico inadecuado a pesar de la terapia con metformina
KR20240090632A (ko) 2009-11-27 2024-06-21 베링거 인겔하임 인터내셔날 게엠베하 리나글립틴과 같은 ｄｐｐ－ｉｖ 억제제를 사용한 유전자형 검사된 당뇨병 환자의 치료
US9186392B2 (en) 2010-05-05 2015-11-17 Boehringer Ingelheim International Gmbh Combination therapy
WO2011158252A1 (en) 2010-06-15 2011-12-22 Matrix Laboratories Ltd Process for the preparation of valacyclovir hydrochloride polymorphic form ii
EP3725325B1 (en) 2010-06-24 2023-05-31 Boehringer Ingelheim International GmbH Diabetes therapy
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
CN102584825B (zh) * 2011-01-17 2014-04-02 四川科伦药物研究有限公司 一种合成盐酸伐昔洛韦的方法
CN103781788B (zh) 2011-07-15 2016-08-17 勃林格殷格翰国际有限公司 经取代的喹唑啉、其制备及其在药物组合物中的用途
US20140296520A1 (en) * 2011-11-25 2014-10-02 Piramal Enterprises Limited Process for the preparation of valacyclovir hydrochloride
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
ES2929025T3 (es) 2012-05-14 2022-11-24 Boehringer Ingelheim Int Linagliptina, un derivado de xantina como inhibidor de dpp-4, para su uso en el tratamiento del SRIS y/o de la septicemia
EP2849755A1 (en) 2012-05-14 2015-03-25 Boehringer Ingelheim International GmbH A xanthine derivative as dpp -4 inhibitor for use in the treatment of podocytes related disorders and/or nephrotic syndrome
WO2013174767A1 (en) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh A xanthine derivative as dpp -4 inhibitor for use in modifying food intake and regulating food preference
JP6615109B2 (ja) 2014-02-28 2019-12-04 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｄｐｐ−４阻害薬の医学的使用
KR102391564B1 (ko) 2016-06-10 2022-04-29 베링거 인겔하임 인터내셔날 게엠베하 리나글립틴 및 메트포르민의 병용물
CN110437231B (zh) * 2019-09-04 2022-04-29 上药康丽（常州）药业有限公司 一种盐酸伐昔洛韦无水晶型ⅰ的制备方法
WO2021209563A1 (en) 2020-04-16 2021-10-21 Som Innovation Biotech, S.A. Compounds for use in the treatment of viral infections by respiratory syndrome-related coronavirus

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AP55A (en) * 1987-08-15 1989-09-26 The Wellcome Foundation Ltd Therapeutic Acyclic Nucleosides
ES2157259T3 (es) * 1993-06-10 2001-08-16 Rolabo Sl Procedimiento para preparar esteres de aminoacidos y analogos de nucleosidos.
GB9501178D0 (en) * 1995-01-20 1995-03-08 Wellcome Found Guanine derivative

Also Published As

Publication number Publication date
HRP960024B1 (en) 2005-08-31
EP0804436A1 (en) 1997-11-05
IS4527A (is) 1997-07-15
IL116831A0 (en) 1996-05-14
FI973063A7 (fi) 1997-09-18
RS49518B (sr) 2006-10-27
EA000364B1 (ru) 1999-06-24
SK285329B6 (sk) 2006-11-03
JP3176633B2 (ja) 2001-06-18
AR002270A1 (es) 1998-03-11
CN1179159A (zh) 1998-04-15
YU3396A (sh) 1998-12-23
SK96597A3 (en) 1998-02-04
CZ229497A3 (en) 1997-12-17
GB9501178D0 (en) 1995-03-08
DE69635106D1 (de) 2005-09-29
BG101833A (bg) 1998-04-30
KR19980701525A (ko) 1998-05-15
OA10499A (en) 2002-04-10
TR199700656T1 (xx) 1998-03-21
NO973326L (no) 1997-09-16
US6107302A (en) 2000-08-22
IN182468B (enEXAMPLES) 1999-04-17
FI973063L (fi) 1997-09-18
PL182175B1 (pl) 2001-11-30
AP9701058A0 (en) 1997-10-31
SI0804436T1 (sl) 2006-02-28
WO1996022291A1 (en) 1996-07-25
CA2210799C (en) 2008-06-10
AP662A (en) 1998-08-19
AU702794B2 (en) 1999-03-04
HU222993B1 (hu) 2004-01-28
ES2248806T3 (es) 2006-03-16
PL321326A1 (en) 1997-12-08
EP0804436B1 (en) 2005-08-24
HUP9801836A2 (hu) 1999-05-28
CZ297065B6 (cs) 2006-08-16
IL116831A (en) 1998-10-30
DE69635106T2 (de) 2006-06-08
CY2531B1 (en) 2006-04-12
UA46001C2 (uk) 2002-05-15
RO118693B1 (ro) 2003-09-30
MX9705462A (es) 1997-10-31
JPH11503718A (ja) 1999-03-30
FI973063A0 (fi) 1997-07-18
KR100376074B1 (ko) 2003-06-02
AU4453996A (en) 1996-08-07
HRP960024A2 (en) 1997-10-31
CA2210799A1 (en) 1996-07-25
EE03528B1 (et) 2001-10-15
ZA96449B (en) 1996-08-07
CN1049893C (zh) 2000-03-01
NO315558B1 (no) 2003-09-22
ATE302777T1 (de) 2005-09-15
UY25779A1 (es) 2000-08-21
HUP9801836A3 (en) 1999-06-28
NO973326D0 (no) 1997-07-18
BG63393B1 (bg) 2001-12-29
EE9700175A (et) 1998-02-16
DK0804436T3 (da) 2005-12-27
GEP20001940B (en) 2000-02-05
IS2268B (is) 2007-07-15
NZ298851A (en) 1999-01-28
EA199700124A1 (ru) 1997-12-30

Similar Documents

Publication Publication Date Title
BR9606768A (pt) Cloridreto de valaciclovir uso do mesmo e processo para o tratamento de infecção virótica de herpes em um ser humano e para a produção de cloridreto de valaciclovir na forma cristalina anidra
PT737199E (pt) Processo de preparacao de compostos de silicio biologicamente activos sob a forma concentrada
PT96321A (pt) Processo para a preparacao de nucleosidos de purina
BR9107115A (pt) Processo para a preparacao continua de sulfatos de glicerideos parciais
FI953981A7 (fi) 2-Bentsyyli-polysykliset guaniinijohdannaiset ja menetelmä niiden valmistamiseksi
BR9406750A (pt) Processo para a fabricaçao de artigo ferramental mestre para replicaçao e artigo obtido
BR9205517A (pt) Processo para a preparacao continua de mosto e processo para preparar cerveja
BR9708533A (pt) Limitado retrorreflexivo artigo e processo para produzir um limitado retrorreflexivo
BR9402087A (pt) Processo para a produção de isocianatos puros e utilização
BR8806958A (pt) Composicao de limpeza na forma de gel e processo para a limpeza de substratos
BR9004421A (pt) Composicoes anti-estaticas e amaciantes de tecidos e processo para amaciar e prover um acabamento anti-estatico a tecidos
BR9406737A (pt) Instrumento cirúrgico a processo para remover tumores neurológicos
BR9000731A (pt) Processo para separacao de sais em agua do mar
BR8800841A (pt) Laminador de cilindros axialmente deslocaveis e processo de regulagem de perfil de cilindro axialmente deslocaveis em um laminador
BR8902425A (pt) Composicao anti-estatica e de amaciamento de tecido e processo para amaciar e prover acabamento anti-estatico a tecidos
BR9303876A (pt) Processo para a preparacao de pirrol-(2,3-d)-pirimidinas substituidas na posicao 5 e composto obtido
BR9100196A (pt) Composicao herbicida e processo para produzir derivados de uracil
BR9005438A (pt) Poliaminas e seu processo de preparacao
BR9006776A (pt) Produto para o tratamento dos cabelos na forma de espuma e processo para a sua preparacao
BR9507494A (pt) Processo para a preparação de famciclovi de 2-amino-6-cloro purina e processo para a preparação de penciclovi de 2-amino-6- cloro purina
EE9600020A (et) 9-asendatud 2-(2-n-alkoksüfenüül)puriin-6-oonid, nende valmistamismeetod, kasutamine ravimite valmistamiseks ja nimetatud ühendeid sisaldavad ravimid
PT721453E (pt) Processo para a preparacao den-metil-3-(1-metil-4-piperidinil)-1h-indole-5-etanossulfonamida
PT89809A (pt) Processo para a preparacao de pirimidinas substituidas
AU6748090A (en) Use of caffeine in the treatment of herpes simplex virus infections
PT97130A (pt) Processo para a preparacao de beta-cetoesteres uteis na preparacao de antibioticos quinolona

Legal Events

Date Code Title Description
FB36 Technical and formal requirements: requirement - article 36 of industrial property law
HJEG Technical examination (opinion): technical examination (opinion) related to article 229 of industrial property law
FF Decision: intention to grant
FG9A Patent or certificate of addition granted
B17A Notification of administrative nullity (patentee has 60 days time to reply to this notification)

Free format text: NATURE S PLUS FARMACEUTICA LTDA.