BR9307348A - Derivados de 5-arilindois - Google Patents
Derivados de 5-arilindoisInfo
- Publication number
- BR9307348A BR9307348A BR9307348A BR9307348A BR9307348A BR 9307348 A BR9307348 A BR 9307348A BR 9307348 A BR9307348 A BR 9307348A BR 9307348 A BR9307348 A BR 9307348A BR 9307348 A BR9307348 A BR 9307348A
- Authority
- BR
- Brazil
- Prior art keywords
- alkyl
- aryl
- hydrogen
- ring
- membered
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97075892A | 1992-11-02 | 1992-11-02 | |
| PCT/US1993/009790 WO1994010171A1 (en) | 1992-11-02 | 1993-10-19 | 5-arylindole derivatives and their use as serotonin (5-ht1) agonists |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9307348A true BR9307348A (pt) | 1999-05-11 |
Family
ID=25517470
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9307348A BR9307348A (pt) | 1992-11-02 | 1993-10-19 | Derivados de 5-arilindois |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US5886008A (enExample) |
| EP (2) | EP0666858B1 (enExample) |
| JP (1) | JP2788551B2 (enExample) |
| KR (1) | KR0163371B1 (enExample) |
| CN (1) | CN1051313C (enExample) |
| AT (1) | ATE202102T1 (enExample) |
| AU (1) | AU685066B2 (enExample) |
| BR (1) | BR9307348A (enExample) |
| CA (2) | CA2340999C (enExample) |
| CZ (1) | CZ283001B6 (enExample) |
| DE (1) | DE69330351T2 (enExample) |
| DK (1) | DK0666858T3 (enExample) |
| EG (1) | EG20396A (enExample) |
| ES (1) | ES2157224T3 (enExample) |
| FI (2) | FI111257B (enExample) |
| GR (1) | GR3036579T3 (enExample) |
| HU (1) | HU222235B1 (enExample) |
| IL (1) | IL107386A (enExample) |
| MY (1) | MY109696A (enExample) |
| NO (1) | NO309652B1 (enExample) |
| NZ (1) | NZ257059A (enExample) |
| PL (1) | PL176091B1 (enExample) |
| PT (1) | PT666858E (enExample) |
| RU (1) | RU2134266C1 (enExample) |
| TW (1) | TW251284B (enExample) |
| WO (1) | WO1994010171A1 (enExample) |
| ZA (1) | ZA938137B (enExample) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9210400D0 (en) * | 1992-05-15 | 1992-07-01 | Merck Sharp & Dohme | Therapeutic agents |
| AU686654B2 (en) * | 1993-08-31 | 1998-02-12 | Pfizer Inc. | 5-arylindole derivatives |
| JP2829788B2 (ja) * | 1994-02-10 | 1998-12-02 | ファイザー インク． | ベンゾジアゼピン受容体部位アゴニスト及びアンタゴニストとしての５−ヘテロアリールインドール誘導体 |
| GB9420529D0 (en) | 1994-10-12 | 1994-11-30 | Pfizer Ltd | Indoles |
| TR199700993T1 (xx) * | 1995-03-20 | 1998-03-21 | Eli Lilly And Company | 5-ikameli-3-(1,2,3,6-tetrahidropridin-4-il)- ve 3-(piperidin-4-il)-1H-indoller: yeni 5-HT1F agonistler. |
| JPH11513666A (ja) * | 1995-10-10 | 1999-11-24 | イーライ・リリー・アンド・カンパニー | Ｎ−［２−置換−３−（２−アミノエチル）−１ｈ−インドール−５−イル］−アミド：新規５−ｈｔ▲下１ｆ▼作動剤 |
| HRP980375A2 (en) | 1997-07-03 | 1999-04-30 | Argyrios Georgios Arvanitis | Imidazopyrimidines and imidazopyridines for the treatment of neurological disorders |
| US6465484B1 (en) | 1997-09-26 | 2002-10-15 | Merck & Co., Inc. | Angiogenesis inhibitors |
| US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
| AU4850199A (en) * | 1998-06-30 | 2000-01-17 | Eli Lilly And Company | Pyrrolidine and pyrroline derivatives having effects on serotonin related systems |
| US6365589B1 (en) | 1998-07-02 | 2002-04-02 | Bristol-Myers Squibb Pharma Company | Imidazo-pyridines, -pyridazines, and -triazines as corticotropin releasing factor antagonists |
| GB9819035D0 (en) * | 1998-09-01 | 1998-10-28 | Cerebrus Res Ltd | Chemical compounds VII |
| US5994352A (en) * | 1998-11-13 | 1999-11-30 | Pfizer Inc. | 5-arylindole derivatives |
| PE20030008A1 (es) | 2001-06-19 | 2003-01-22 | Bristol Myers Squibb Co | Inhibidores duales de pde 7 y pde 4 |
| ATE503483T1 (de) | 2002-10-30 | 2011-04-15 | Merck Sharp & Dohme | Hemmer der akt aktivität |
| US20040102360A1 (en) * | 2002-10-30 | 2004-05-27 | Barnett Stanley F. | Combination therapy |
| US7332508B2 (en) | 2002-12-18 | 2008-02-19 | Novo Nordisk A/S | Substituted homopiperidine, piperidine or pyrrolidine derivatives |
| JP2006524254A (ja) | 2003-04-24 | 2006-10-26 | メルク エンド カムパニー インコーポレーテッド | Ａｋｔ活性の阻害剤 |
| DE10337184A1 (de) | 2003-08-13 | 2005-03-10 | Gruenenthal Gmbh | Substituierte 3-Pyrrolidin-Indol-Derivate |
| US7442709B2 (en) * | 2003-08-21 | 2008-10-28 | Osi Pharmaceuticals, Inc. | N3-substituted imidazopyridine c-Kit inhibitors |
| KR20060119871A (ko) * | 2003-08-21 | 2006-11-24 | 오에스아이 파마슈티컬스, 인코포레이티드 | Ｎ３―치환된 이미다조피리딘 ｃ―ｋｉｔ 억제제 |
| AR046046A1 (es) | 2003-10-03 | 2005-11-23 | 3M Innovative Properties Co | Imidazoquinolinas alcoxi sustituidas. composiciones farmaceuticas. |
| AU2004293078B2 (en) | 2003-11-25 | 2012-01-19 | 3M Innovative Properties Company | Substituted imidazo ring systems and methods |
| DE102004014304A1 (de) | 2004-03-22 | 2005-10-06 | Grünenthal GmbH | Substituierte 1,4,8- Triazaspiro[4,5]decan-2-on-Verbindungen |
| EP1844201B1 (en) | 2005-02-04 | 2016-08-24 | 3M Innovative Properties Company | Aqueous gel formulations containing immune response modifiers |
| ES2346157T3 (es) * | 2006-03-22 | 2010-10-11 | Janssen Pharmaceutica N.V. | Derivados de alquilaminas ciclicas como inhibidores de la interaccion entre mdm2 y p53. |
| EP3610890A1 (en) | 2012-11-14 | 2020-02-19 | The Johns Hopkins University | Methods and compositions for treating schizophrenia |
| WO2014144663A1 (en) | 2013-03-15 | 2014-09-18 | The Johns Hopkins University | Methods and compositions for improving cognitive function |
| US11160785B2 (en) | 2013-03-15 | 2021-11-02 | Agenebio Inc. | Methods and compositions for improving cognitive function |
| WO2016176463A1 (en) | 2015-04-29 | 2016-11-03 | Janssen Pharmaceutica Nv | Indolone compounds and their use as ampa receptor modulators |
| DK3288940T5 (da) | 2015-04-29 | 2021-09-20 | Janssen Pharmaceutica Nv | Azabenzimidazoler og deres anvendelse som ampa-receptormodulatorer |
| JP6800885B2 (ja) | 2015-04-29 | 2020-12-16 | ヤンセン ファーマシューティカ エヌ．ベー． | イミダゾピラジン及びピラゾロピリミジン、並びにａｍｐａ受容体調節物質としてのこれらの使用 |
| CN107635970B (zh) | 2015-04-29 | 2021-03-12 | 詹森药业有限公司 | 苯并咪唑酮和苯并噻唑酮化合物以及它们作为ampa受体调节剂的用途 |
| NZ738682A (en) | 2015-05-22 | 2022-01-28 | Agenebio Inc | Extended release pharmaceutical compositions of levetiracetam |
| WO2017076842A1 (en) | 2015-11-06 | 2017-05-11 | F. Hoffmann-La Roche Ag | Indolin-2-one derivatives |
| JP6857651B2 (ja) | 2015-11-06 | 2021-04-14 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | Ｃｎｓ疾患の処置に有用なインドリン−２−オン誘導体 |
| JP6857662B2 (ja) | 2015-11-06 | 2021-04-14 | エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ | インドリン−２−オン誘導体 |
| WO2017076931A1 (en) | 2015-11-06 | 2017-05-11 | F. Hoffmann-La Roche Ag | Indolin-2-one derivatives for use in the treatment of cns and related disorders |
| CN111822047B (zh) * | 2020-07-17 | 2022-05-27 | 曲阜师范大学 | 一种磁性介孔聚合离子液体负载催化合成吲哚类衍生物的方法 |
| WO2025104491A1 (en) * | 2023-11-14 | 2025-05-22 | Mindset Pharma Inc. | Indole derivatives as serotonergic agents useful for the treatment of disorders related thereto |
| WO2025104490A1 (en) * | 2023-11-14 | 2025-05-22 | Mindset Pharma Inc. | Indole derivatives as serotonergic agents useful for the treatment of disorders related thereto |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA795239B (en) * | 1978-10-12 | 1980-11-26 | Glaxo Group Ltd | Heterocyclic compounds |
| BE889931A (fr) * | 1980-08-12 | 1982-02-11 | Glaxo Group Ltd | Derives indoliques, leur preparation et leurs applications en tant que medicaments |
| US4983622A (en) * | 1984-02-06 | 1991-01-08 | Eli Lilly And Company | 6-substituted-4-dialkylaminotetrahydrobenz(c,d)indoles |
| GB8600397D0 (en) * | 1986-01-08 | 1986-02-12 | Glaxo Group Ltd | Chemical compounds |
| GB8719167D0 (en) * | 1987-08-13 | 1987-09-23 | Glaxo Group Ltd | Chemical compounds |
| GB8724912D0 (en) * | 1987-10-23 | 1987-11-25 | Wellcome Found | Indole derivatives |
| GB8819024D0 (en) * | 1988-08-10 | 1988-09-14 | Glaxo Group Ltd | Chemical compounds |
| IL96891A0 (en) * | 1990-01-17 | 1992-03-29 | Merck Sharp & Dohme | Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them |
| US5340838A (en) * | 1990-05-04 | 1994-08-23 | Eli Lilly And Company | Method of inhibiting gastric acid secretion with 2-phenylcyclopropylamines |
| CA2042295A1 (fr) * | 1990-05-15 | 1991-11-16 | Jacques Chauveau | Derives de mediateurs endogenes, leurs sels, procede de preparation, applications, et compositions les renfermant |
| DE69132691T2 (de) * | 1990-06-07 | 2002-06-20 | Astrazeneca Ab, Soedertaelje | Indolderivate als 5-HT1-like Agonisten |
| DK158590D0 (da) * | 1990-07-02 | 1990-07-02 | Lundbeck & Co As H | Indolderivater |
| PL168919B1 (pl) * | 1990-10-15 | 1996-05-31 | Pfizer | Sposób wytwarzania nowych pochodnych indolu PL PL PL PL |
| CZ283018B6 (cs) * | 1991-02-01 | 1997-12-17 | Merck Sharp And Dohme Limited | Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi |
| FR2672602B1 (fr) * | 1991-02-12 | 1993-06-04 | Centre Nat Rech Scient | Composes derives des beta-carbolines ligands du recepteur des benzodiazepines ayant un effet agoniste inverse et antagoniste vis-a-vis des benzodiazepines et medicaments les contenant. |
| US5229401A (en) * | 1991-09-23 | 1993-07-20 | Hoechst-Roussel Pharmaceuticals Incorporated | Substituted pyridinylamino benzo[b]thiophene compounds |
| US5187159A (en) * | 1991-10-07 | 1993-02-16 | Merck & Co., Inc. | Angiotensin II antagonists incorporating a substituted 1,3-benzodioxole or 1,3-benzodithiole |
| GB9210400D0 (en) * | 1992-05-15 | 1992-07-01 | Merck Sharp & Dohme | Therapeutic agents |
| US5378846A (en) * | 1993-06-11 | 1995-01-03 | Russian-American Institute For New Drug Development | 1,2,3,4-tetrahydropyrrolo-[1,2-a]-pyrazine derivatives |
-
1993
- 1993-10-16 TW TW082108604A patent/TW251284B/zh active
- 1993-10-19 EP EP93923389A patent/EP0666858B1/en not_active Expired - Lifetime
- 1993-10-19 BR BR9307348A patent/BR9307348A/pt not_active Application Discontinuation
- 1993-10-19 RU RU95109927/04A patent/RU2134266C1/ru not_active IP Right Cessation
- 1993-10-19 DK DK93923389T patent/DK0666858T3/da active
- 1993-10-19 AU AU53294/94A patent/AU685066B2/en not_active Ceased
- 1993-10-19 NZ NZ257059A patent/NZ257059A/en unknown
- 1993-10-19 DE DE69330351T patent/DE69330351T2/de not_active Expired - Fee Related
- 1993-10-19 WO PCT/US1993/009790 patent/WO1994010171A1/en not_active Ceased
- 1993-10-19 AT AT93923389T patent/ATE202102T1/de not_active IP Right Cessation
- 1993-10-19 CA CA002340999A patent/CA2340999C/en not_active Expired - Fee Related
- 1993-10-19 PT PT93923389T patent/PT666858E/pt unknown
- 1993-10-19 CZ CZ951108A patent/CZ283001B6/cs not_active IP Right Cessation
- 1993-10-19 KR KR1019950701729A patent/KR0163371B1/ko not_active Expired - Fee Related
- 1993-10-19 CA CA002148380A patent/CA2148380C/en not_active Expired - Fee Related
- 1993-10-19 EP EP00124422A patent/EP1094064A1/en not_active Withdrawn
- 1993-10-19 ES ES93923389T patent/ES2157224T3/es not_active Expired - Lifetime
- 1993-10-19 US US08/424,357 patent/US5886008A/en not_active Expired - Fee Related
- 1993-10-19 JP JP6511101A patent/JP2788551B2/ja not_active Expired - Lifetime
- 1993-10-25 IL IL10738693A patent/IL107386A/en not_active IP Right Cessation
- 1993-11-01 CN CN93120716A patent/CN1051313C/zh not_active Expired - Fee Related
- 1993-11-01 MY MYPI93002280A patent/MY109696A/en unknown
- 1993-11-01 FI FI934825A patent/FI111257B/fi not_active IP Right Cessation
- 1993-11-01 ZA ZA938137A patent/ZA938137B/xx unknown
- 1993-11-02 HU HU9303118A patent/HU222235B1/hu not_active IP Right Cessation
- 1993-11-02 EG EG69793A patent/EG20396A/xx active
-
1995
- 1995-04-28 NO NO951633A patent/NO309652B1/no not_active IP Right Cessation
- 1995-05-01 PL PL93308669A patent/PL176091B1/pl unknown
-
2000
- 2000-11-15 FI FI20002505A patent/FI20002505L/fi unknown
-
2001
- 2001-09-11 GR GR20010401436T patent/GR3036579T3/el not_active IP Right Cessation
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR9307348A (pt) | Derivados de 5-arilindois | |
| ATE110081T1 (de) | Cephalosporinderivate mit in der lage 3 eine thioalkylthiogruppe. | |
| ATE172463T1 (de) | Pyrrolocarbazol | |
| ATE230391T1 (de) | Pyrrolidin derivate, anti-ulcus und antibakterielle arzneimittel | |
| DK0623131T3 (da) | Alkylderivater af trazodon med CNS-aktivitet | |
| ATE340155T1 (de) | Medizinische anwendungen von phenylalkanolen und derivaten davon | |
| DE69128272D1 (de) | Piperazinderivate | |
| ES2112470T3 (es) | Derivados de piridazinona, procedimientos de produccion y utilizacion. | |
| ATE134607T1 (de) | Tetrahydronaphtalenderivate, ihre herstellung und ihre therapeutische verwendung | |
| ES2077697T3 (es) | Derivados de 1-fenoxicarbonil-2-pirrolidinona y agentes nootropicos. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EG | Technical examination (opinion): publication of technical examination (opinion) | ||
| FC | Decision: refusal | ||
| FC | Decision: refusal | ||
| CKFC | Appeal: appeal against refusal |