BR122021000846B1 - Processo para preparar base de minociclina amorfa - Google Patents

Processo para preparar base de minociclina amorfa Download PDF

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Publication number
BR122021000846B1
BR122021000846B1 BR122021000846-9A BR122021000846A BR122021000846B1 BR 122021000846 B1 BR122021000846 B1 BR 122021000846B1 BR 122021000846 A BR122021000846 A BR 122021000846A BR 122021000846 B1 BR122021000846 B1 BR 122021000846B1
Authority
BR
Brazil
Prior art keywords
minocycline
minocycline base
base
crystalline
amorphous
Prior art date
Application number
BR122021000846-9A
Other languages
English (en)
Portuguese (pt)
Inventor
Zita Mendes
Jose Rafael Antunes
Susana Marto
William Heggie
Original Assignee
Hovione Scientia Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hovione Scientia Limited filed Critical Hovione Scientia Limited
Publication of BR122021000846B1 publication Critical patent/BR122021000846B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BR122021000846-9A 2007-02-23 2008-02-22 Processo para preparar base de minociclina amorfa BR122021000846B1 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
PT103661A PT103661B (pt) 2007-02-23 2007-02-23 Processo de preparação de minociclina base cristalina
PT103661 2007-02-23
BRPI0807319-8A BRPI0807319B1 (pt) 2007-02-23 2008-02-22 Base de minociclina cristalina forma 1, processo para preparar base de minociclina cristalina forma i, base de minociclina cristalina forma ii, processo para preparar base de minociclina cristalina forma ii, base de minociclina cristalina forma iii e processo para preparar base de minociclina cristalina forma iii
PCT/GB2008/000625 WO2008102161A2 (en) 2007-02-23 2008-02-22 Crystalline minocycline base and processes for its preparation

Publications (1)

Publication Number Publication Date
BR122021000846B1 true BR122021000846B1 (pt) 2021-08-10

Family

ID=39432804

Family Applications (2)

Application Number Title Priority Date Filing Date
BR122021000846-9A BR122021000846B1 (pt) 2007-02-23 2008-02-22 Processo para preparar base de minociclina amorfa
BRPI0807319-8A BRPI0807319B1 (pt) 2007-02-23 2008-02-22 Base de minociclina cristalina forma 1, processo para preparar base de minociclina cristalina forma i, base de minociclina cristalina forma ii, processo para preparar base de minociclina cristalina forma ii, base de minociclina cristalina forma iii e processo para preparar base de minociclina cristalina forma iii

Family Applications After (1)

Application Number Title Priority Date Filing Date
BRPI0807319-8A BRPI0807319B1 (pt) 2007-02-23 2008-02-22 Base de minociclina cristalina forma 1, processo para preparar base de minociclina cristalina forma i, base de minociclina cristalina forma ii, processo para preparar base de minociclina cristalina forma ii, base de minociclina cristalina forma iii e processo para preparar base de minociclina cristalina forma iii

Country Status (20)

Country Link
US (2) US8258327B2 (https=)
EP (1) EP2125705B1 (https=)
JP (4) JP2010519247A (https=)
KR (1) KR101391132B1 (https=)
CN (1) CN101679218B (https=)
AU (1) AU2008217619B2 (https=)
BR (2) BR122021000846B1 (https=)
CA (2) CA2835788C (https=)
DK (1) DK2125705T3 (https=)
ES (1) ES2610434T3 (https=)
HU (1) HUE033030T2 (https=)
IL (1) IL200544A0 (https=)
MX (2) MX2009008980A (https=)
NO (1) NO20092960L (https=)
NZ (1) NZ579626A (https=)
PL (1) PL2125705T3 (https=)
PT (1) PT103661B (https=)
RU (2) RU2485095C2 (https=)
WO (1) WO2008102161A2 (https=)
ZA (1) ZA200906517B (https=)

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ES2532906T5 (es) 2002-10-25 2022-03-23 Foamix Pharmaceuticals Ltd Espuma cosmética y farmacéutica
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US7700076B2 (en) 2002-10-25 2010-04-20 Foamix, Ltd. Penetrating pharmaceutical foam
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
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US8722650B1 (en) 2005-06-24 2014-05-13 Medicis Pharmaceutical Corporation Extended-release minocycline dosage forms
US20080242642A1 (en) 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US20080260655A1 (en) 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
PT103661B (pt) 2007-02-23 2010-09-07 Hovione Farmaciencia S A Processo de preparação de minociclina base cristalina
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
US9439857B2 (en) 2007-11-30 2016-09-13 Foamix Pharmaceuticals Ltd. Foam containing benzoyl peroxide
WO2009072007A2 (en) 2007-12-07 2009-06-11 Foamix Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
PT104350A (pt) * 2009-01-23 2010-07-23 Hovione Farmaci Ncia S A Processo de isolamento de tigeciclina
WO2010125470A2 (en) 2009-04-28 2010-11-04 Foamix Ltd. Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
PT104644B (pt) 2009-06-26 2012-11-06 Hovione Farmaciencia S A Formulação tópica contendo uma tetraciclina e método de tratamento de infecções cutâneas usando a mesma
CA2769677A1 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
WO2011013009A2 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
WO2011064631A1 (en) 2009-10-02 2011-06-03 Foamix Ltd. Surfactant-free, water-free, foamable compositions and breakable foams and their uses
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
US9561241B1 (en) 2011-06-28 2017-02-07 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for minocycline
PT106063B (pt) 2011-12-19 2017-05-30 Inst Superior Tecnico Minociclina cristalina termorresistente produzida por recristalização com dióxido de carbono
CN104151186B (zh) * 2014-08-11 2016-06-15 重庆福安药业(集团)股份有限公司 替加环素杂质的立体选择性制备方法
PT108223B (pt) * 2015-02-13 2018-05-08 Hovione Farm S A Novas formas polimórficas de minociclina base e processos para a sua preparação
KR20170134514A (ko) 2015-03-23 2017-12-06 바이오팜엑스 인코포레이티드 피부과 사용을 위한 약학 테트라사이클린 조성물
WO2017097891A1 (en) * 2015-12-10 2017-06-15 Sandoz Ag Crystalline eravacycline
US10398641B2 (en) 2016-09-08 2019-09-03 Foamix Pharmaceuticals Ltd. Compositions and methods for treating rosacea and acne
BR112021007969A2 (pt) 2018-10-29 2021-07-27 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. complexos de tetraciclina com atividade controlada
WO2021191273A1 (en) 2020-03-24 2021-09-30 Hovione Scientia Limited Compositions for use in treating meibomian gland dysfunction
WO2022043457A1 (en) 2020-08-27 2022-03-03 Hovione Scientia Limited Methods and compositions for treating rosacea
CN117105812B (zh) * 2023-08-16 2025-09-26 常州市第四制药厂有限公司 一种米诺环素无菌软膏剂及制备方法

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PT103661B (pt) 2007-02-23 2010-09-07 Hovione Farmaciencia S A Processo de preparação de minociclina base cristalina

Also Published As

Publication number Publication date
JP2014169319A (ja) 2014-09-18
US9416097B2 (en) 2016-08-16
RU2485095C2 (ru) 2013-06-20
JP2017039742A (ja) 2017-02-23
US20130030195A1 (en) 2013-01-31
PT103661B (pt) 2010-09-07
MX2009008980A (es) 2009-11-11
BRPI0807319A2 (pt) 2017-05-02
PT103661A (pt) 2008-08-25
CA2722496C (en) 2014-06-10
ZA200906517B (en) 2010-09-29
CA2722496A1 (en) 2008-08-28
JP2019142882A (ja) 2019-08-29
HUE033030T2 (hu) 2017-11-28
PL2125705T3 (pl) 2017-02-28
CN101679218A (zh) 2010-03-24
AU2008217619A1 (en) 2008-08-28
RU2577331C2 (ru) 2016-03-20
RU2013112021A (ru) 2014-09-27
JP2010519247A (ja) 2010-06-03
DK2125705T3 (en) 2017-01-16
KR101391132B1 (ko) 2014-05-02
US20100286417A1 (en) 2010-11-11
KR20100014520A (ko) 2010-02-10
WO2008102161A2 (en) 2008-08-28
BRPI0807319B1 (pt) 2021-08-10
EP2125705B1 (en) 2016-10-12
ES2610434T3 (es) 2017-04-27
CA2835788A1 (en) 2008-08-28
CA2835788C (en) 2018-03-27
NO20092960L (no) 2009-11-20
RU2009135403A (ru) 2011-03-27
MX340539B (es) 2016-07-13
EP2125705A2 (en) 2009-12-02
IL200544A0 (en) 2010-05-17
CN101679218B (zh) 2013-10-30
US8258327B2 (en) 2012-09-04
WO2008102161A3 (en) 2009-01-08
AU2008217619B2 (en) 2013-01-10
NZ579626A (en) 2011-12-22
WO2008102161A9 (en) 2008-11-13

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Legal Events

Date Code Title Description
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/02/2008, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.