MX2009008980A - Base de minociclina cristalina y procesos para su preparacion. - Google Patents

Base de minociclina cristalina y procesos para su preparacion.

Info

Publication number
MX2009008980A
MX2009008980A MX2009008980A MX2009008980A MX2009008980A MX 2009008980 A MX2009008980 A MX 2009008980A MX 2009008980 A MX2009008980 A MX 2009008980A MX 2009008980 A MX2009008980 A MX 2009008980A MX 2009008980 A MX2009008980 A MX 2009008980A
Authority
MX
Mexico
Prior art keywords
minocycline base
processes
preparation
crystalline
crystalline minocycline
Prior art date
Application number
MX2009008980A
Other languages
English (en)
Inventor
William Heggie
Zita Mendes
Jose Rafael Antunes
Susana Marto
Original Assignee
Hovione Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hovione Int Ltd filed Critical Hovione Int Ltd
Publication of MX2009008980A publication Critical patent/MX2009008980A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

La presente invención se refiere a una base de minociclina cristalina. En particular, se proporcionan tres formas polimórficas cristalinas, designadas Forma I, Forma II y Forma III, de base de minociclina. Son caracterizadas por datos de XRD e IR. También se proporcionan procesos para preparar las nuevas formas polimórficas. Por ejemplo, la Forma I se prepara por disolución y/o suspensión de la base de minociclina amorfa en un solvente orgánico elegido de éteres seguido por cristalización de la mezcla.
MX2009008980A 2007-02-23 2008-02-22 Base de minociclina cristalina y procesos para su preparacion. MX2009008980A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PT103661A PT103661B (pt) 2007-02-23 2007-02-23 Processo de preparação de minociclina base cristalina
PCT/GB2008/000625 WO2008102161A2 (en) 2007-02-23 2008-02-22 Crystalline minocycline base and processes for its preparation

Publications (1)

Publication Number Publication Date
MX2009008980A true MX2009008980A (es) 2009-11-11

Family

ID=39432804

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2009008980A MX2009008980A (es) 2007-02-23 2008-02-22 Base de minociclina cristalina y procesos para su preparacion.
MX2012005474A MX340539B (es) 2007-02-23 2009-08-21 Base de minociclina cristalina y procesos para su preparacion.

Family Applications After (1)

Application Number Title Priority Date Filing Date
MX2012005474A MX340539B (es) 2007-02-23 2009-08-21 Base de minociclina cristalina y procesos para su preparacion.

Country Status (20)

Country Link
US (2) US8258327B2 (es)
EP (1) EP2125705B1 (es)
JP (4) JP2010519247A (es)
KR (1) KR101391132B1 (es)
CN (1) CN101679218B (es)
AU (1) AU2008217619B2 (es)
BR (2) BRPI0807319B1 (es)
CA (2) CA2722496C (es)
DK (1) DK2125705T3 (es)
ES (1) ES2610434T3 (es)
HU (1) HUE033030T2 (es)
IL (1) IL200544A0 (es)
MX (2) MX2009008980A (es)
NO (1) NO20092960L (es)
NZ (1) NZ579626A (es)
PL (1) PL2125705T3 (es)
PT (1) PT103661B (es)
RU (2) RU2485095C2 (es)
WO (1) WO2008102161A2 (es)
ZA (1) ZA200906517B (es)

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US10117812B2 (en) 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US20080138296A1 (en) 2002-10-25 2008-06-12 Foamix Ltd. Foam prepared from nanoemulsions and uses
CA2502986C (en) 2002-10-25 2011-08-23 Foamix Ltd. Cosmetic and pharmaceutical foam
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
US7700076B2 (en) 2002-10-25 2010-04-20 Foamix, Ltd. Penetrating pharmaceutical foam
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US8722650B1 (en) 2005-06-24 2014-05-13 Medicis Pharmaceutical Corporation Extended-release minocycline dosage forms
US9192615B2 (en) 2008-08-06 2015-11-24 Medicis Pharmaceutical Corporation Method for the treatment of acne and certain dosage forms thereof
US20080242642A1 (en) 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US20080260655A1 (en) 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
PT103661B (pt) 2007-02-23 2010-09-07 Hovione Farmaciencia S A Processo de preparação de minociclina base cristalina
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
US9439857B2 (en) 2007-11-30 2016-09-13 Foamix Pharmaceuticals Ltd. Foam containing benzoyl peroxide
WO2009072007A2 (en) 2007-12-07 2009-06-11 Foamix Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
PT104350A (pt) * 2009-01-23 2010-07-23 Hovione Farmaci Ncia S A Processo de isolamento de tigeciclina
WO2010125470A2 (en) 2009-04-28 2010-11-04 Foamix Ltd. Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
PT104644B (pt) 2009-06-26 2012-11-06 Hovione Farmaciencia S A Formulação tópica contendo uma tetraciclina e método de tratamento de infecções cutâneas usando a mesma
CA2769625C (en) 2009-07-29 2017-04-11 Foamix Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
CA2769677A1 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
WO2011039637A2 (en) 2009-10-02 2011-04-07 Foamix Ltd. Surfactant-free water-free foamable compositions, breakable foams and gels and their uses
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
US9561241B1 (en) 2011-06-28 2017-02-07 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for minocycline
PT106063B (pt) * 2011-12-19 2017-05-30 Inst Superior Técnico Minociclina cristalina termorresistente produzida por recristalização com dióxido de carbono
CN104151186B (zh) * 2014-08-11 2016-06-15 重庆福安药业(集团)股份有限公司 替加环素杂质的立体选择性制备方法
PT108223B (pt) * 2015-02-13 2018-05-08 Hovione Farm S A Novas formas polimórficas de minociclina base e processos para a sua preparação
TW201705962A (zh) 2015-03-23 2017-02-16 生物製藥Ｘ公司 皮膚用四環素醫藥組成物
WO2017097891A1 (en) * 2015-12-10 2017-06-15 Sandoz Ag Crystalline eravacycline
MX2020012139A (es) 2016-09-08 2021-01-29 Vyne Pharmaceuticals Inc Composiciones y metodos para tratar rosacea y acne.
WO2021191273A1 (en) 2020-03-24 2021-09-30 Hovione Scientia Limited Compositions for use in treating meibomian gland dysfunction
US20220062308A1 (en) 2020-08-27 2022-03-03 Hovione Scientia Limited Methods and compositions for treating rosacea

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PT103661B (pt) 2007-02-23 2010-09-07 Hovione Farmaciencia S A Processo de preparação de minociclina base cristalina

Also Published As

Publication number Publication date
US20100286417A1 (en) 2010-11-11
EP2125705A2 (en) 2009-12-02
CN101679218B (zh) 2013-10-30
JP2017039742A (ja) 2017-02-23
JP2014169319A (ja) 2014-09-18
MX340539B (es) 2016-07-13
US8258327B2 (en) 2012-09-04
PT103661B (pt) 2010-09-07
WO2008102161A3 (en) 2009-01-08
BR122021000846B1 (pt) 2021-08-10
RU2009135403A (ru) 2011-03-27
CA2835788C (en) 2018-03-27
ZA200906517B (en) 2010-09-29
IL200544A0 (en) 2010-05-17
NZ579626A (en) 2011-12-22
ES2610434T3 (es) 2017-04-27
PT103661A (pt) 2008-08-25
BRPI0807319A2 (pt) 2017-05-02
RU2013112021A (ru) 2014-09-27
CA2722496C (en) 2014-06-10
EP2125705B1 (en) 2016-10-12
BRPI0807319B1 (pt) 2021-08-10
WO2008102161A2 (en) 2008-08-28
JP2010519247A (ja) 2010-06-03
AU2008217619A1 (en) 2008-08-28
PL2125705T3 (pl) 2017-02-28
US9416097B2 (en) 2016-08-16
CN101679218A (zh) 2010-03-24
US20130030195A1 (en) 2013-01-31
WO2008102161A9 (en) 2008-11-13
HUE033030T2 (hu) 2017-11-28
NO20092960L (no) 2009-11-20
KR20100014520A (ko) 2010-02-10
AU2008217619B2 (en) 2013-01-10
JP2019142882A (ja) 2019-08-29
DK2125705T3 (en) 2017-01-16
CA2722496A1 (en) 2008-08-28
RU2485095C2 (ru) 2013-06-20
KR101391132B1 (ko) 2014-05-02
RU2577331C2 (ru) 2016-03-20
CA2835788A1 (en) 2008-08-28

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