BRPI0807319A2 - base de minociclina, base de miniciclina cristalizada, processo para preparar base de minociclina cristalina e processo para preparar base de minociclina amorfa. - Google Patents

base de minociclina, base de miniciclina cristalizada, processo para preparar base de minociclina cristalina e processo para preparar base de minociclina amorfa.

Info

Publication number
BRPI0807319A2
BRPI0807319A2 BRPI0807319A BRPI0807319A BRPI0807319A2 BR PI0807319 A2 BRPI0807319 A2 BR PI0807319A2 BR PI0807319 A BRPI0807319 A BR PI0807319A BR PI0807319 A BRPI0807319 A BR PI0807319A BR PI0807319 A2 BRPI0807319 A2 BR PI0807319A2
Authority
BR
Brazil
Prior art keywords
minocycline base
preparing
base
minocycline
crystallized
Prior art date
Application number
BRPI0807319A
Other languages
English (en)
Inventor
Rafael Antunes Jose
Marto Susana
Heggie William
Mendes Zita
Original Assignee
Hovione Int Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hovione Int Ltd filed Critical Hovione Int Ltd
Priority to BR122021000846-9A priority Critical patent/BR122021000846B1/pt
Publication of BRPI0807319A2 publication Critical patent/BRPI0807319A2/pt
Publication of BRPI0807319B1 publication Critical patent/BRPI0807319B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
    • C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
BRPI0807319-8A 2007-02-23 2008-02-22 Base de minociclina cristalina forma 1, processo para preparar base de minociclina cristalina forma i, base de minociclina cristalina forma ii, processo para preparar base de minociclina cristalina forma ii, base de minociclina cristalina forma iii e processo para preparar base de minociclina cristalina forma iii BRPI0807319B1 (pt)

Priority Applications (1)

Application Number Priority Date Filing Date Title
BR122021000846-9A BR122021000846B1 (pt) 2007-02-23 2008-02-22 Processo para preparar base de minociclina amorfa

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PT103661 2007-02-23
PT103661A PT103661B (pt) 2007-02-23 2007-02-23 Processo de preparação de minociclina base cristalina
PCT/GB2008/000625 WO2008102161A2 (en) 2007-02-23 2008-02-22 Crystalline minocycline base and processes for its preparation

Publications (2)

Publication Number Publication Date
BRPI0807319A2 true BRPI0807319A2 (pt) 2017-05-02
BRPI0807319B1 BRPI0807319B1 (pt) 2021-08-10

Family

ID=39432804

Family Applications (2)

Application Number Title Priority Date Filing Date
BRPI0807319-8A BRPI0807319B1 (pt) 2007-02-23 2008-02-22 Base de minociclina cristalina forma 1, processo para preparar base de minociclina cristalina forma i, base de minociclina cristalina forma ii, processo para preparar base de minociclina cristalina forma ii, base de minociclina cristalina forma iii e processo para preparar base de minociclina cristalina forma iii
BR122021000846-9A BR122021000846B1 (pt) 2007-02-23 2008-02-22 Processo para preparar base de minociclina amorfa

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR122021000846-9A BR122021000846B1 (pt) 2007-02-23 2008-02-22 Processo para preparar base de minociclina amorfa

Country Status (20)

Country Link
US (2) US8258327B2 (pt)
EP (1) EP2125705B1 (pt)
JP (4) JP2010519247A (pt)
KR (1) KR101391132B1 (pt)
CN (1) CN101679218B (pt)
AU (1) AU2008217619B2 (pt)
BR (2) BRPI0807319B1 (pt)
CA (2) CA2722496C (pt)
DK (1) DK2125705T3 (pt)
ES (1) ES2610434T3 (pt)
HU (1) HUE033030T2 (pt)
IL (1) IL200544A0 (pt)
MX (2) MX2009008980A (pt)
NO (1) NO20092960L (pt)
NZ (1) NZ579626A (pt)
PL (1) PL2125705T3 (pt)
PT (1) PT103661B (pt)
RU (2) RU2577331C2 (pt)
WO (1) WO2008102161A2 (pt)
ZA (1) ZA200906517B (pt)

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IL152486A0 (en) 2002-10-25 2003-05-29 Meir Eini Alcohol-free cosmetic and pharmaceutical foam carrier
US9668972B2 (en) 2002-10-25 2017-06-06 Foamix Pharmaceuticals Ltd. Nonsteroidal immunomodulating kit and composition and uses thereof
US9211259B2 (en) 2002-11-29 2015-12-15 Foamix Pharmaceuticals Ltd. Antibiotic kit and composition and uses thereof
US10117812B2 (en) 2002-10-25 2018-11-06 Foamix Pharmaceuticals Ltd. Foamable composition combining a polar solvent and a hydrophobic carrier
US7704518B2 (en) 2003-08-04 2010-04-27 Foamix, Ltd. Foamable vehicle and pharmaceutical compositions thereof
MXPA05004278A (es) 2002-10-25 2005-10-05 Foamix Ltd Espuma cosmetica y farmaceutica.
US20080138296A1 (en) 2002-10-25 2008-06-12 Foamix Ltd. Foam prepared from nanoemulsions and uses
US7700076B2 (en) 2002-10-25 2010-04-20 Foamix, Ltd. Penetrating pharmaceutical foam
US9265725B2 (en) 2002-10-25 2016-02-23 Foamix Pharmaceuticals Ltd. Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof
US8722650B1 (en) 2005-06-24 2014-05-13 Medicis Pharmaceutical Corporation Extended-release minocycline dosage forms
US20080242642A1 (en) 2007-04-02 2008-10-02 Medicis Pharmaceutical Corporation Minocycline oral dosage forms for the treatment of acne
US9192615B2 (en) 2008-08-06 2015-11-24 Medicis Pharmaceutical Corporation Method for the treatment of acne and certain dosage forms thereof
US20080260655A1 (en) 2006-11-14 2008-10-23 Dov Tamarkin Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses
PT103661B (pt) 2007-02-23 2010-09-07 Hovione Farmaciencia S A Processo de preparação de minociclina base cristalina
US8636982B2 (en) 2007-08-07 2014-01-28 Foamix Ltd. Wax foamable vehicle and pharmaceutical compositions thereof
WO2009069006A2 (en) 2007-11-30 2009-06-04 Foamix Ltd. Foam containing benzoyl peroxide
WO2009072007A2 (en) 2007-12-07 2009-06-11 Foamix Ltd. Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof
PT104350A (pt) * 2009-01-23 2010-07-23 Hovione Farmaci Ncia S A Processo de isolamento de tigeciclina
US20120087872A1 (en) 2009-04-28 2012-04-12 Foamix Ltd. Foamable Vehicles and Pharmaceutical Compositions Comprising Aprotic Polar Solvents and Uses Thereof
PT104644B (pt) 2009-06-26 2012-11-06 Hovione Farmaciencia S A Formulação tópica contendo uma tetraciclina e método de tratamento de infecções cutâneas usando a mesma
CA2769677A1 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses
WO2011013009A2 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
BR112012007473A2 (pt) 2009-10-02 2019-05-07 Foamix Ltd composições tópicas de tetraciclina e respectivo método de uso
US9849142B2 (en) 2009-10-02 2017-12-26 Foamix Pharmaceuticals Ltd. Methods for accelerated return of skin integrity and for the treatment of impetigo
US9561241B1 (en) 2011-06-28 2017-02-07 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for minocycline
PT106063B (pt) 2011-12-19 2017-05-30 Inst Superior Técnico Minociclina cristalina termorresistente produzida por recristalização com dióxido de carbono
CN104151186B (zh) * 2014-08-11 2016-06-15 重庆福安药业(集团)股份有限公司 替加环素杂质的立体选择性制备方法
PT108223B (pt) 2015-02-13 2018-05-08 Hovione Farm S A Novas formas polimórficas de minociclina base e processos para a sua preparação
US9918998B2 (en) 2015-03-23 2018-03-20 BioPharmX, Inc. Pharmaceutical tetracycline composition for dermatological use
WO2017097891A1 (en) * 2015-12-10 2017-06-15 Sandoz Ag Crystalline eravacycline
US10398641B2 (en) 2016-09-08 2019-09-03 Foamix Pharmaceuticals Ltd. Compositions and methods for treating rosacea and acne
WO2021191273A1 (en) 2020-03-24 2021-09-30 Hovione Scientia Limited Compositions for use in treating meibomian gland dysfunction
WO2022043457A1 (en) 2020-08-27 2022-03-03 Hovione Scientia Limited Methods and compositions for treating rosacea

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US299111A (en) * 1884-05-27 Process of and apparatus
US3148212A (en) * 1961-12-22 1964-09-08 American Cyanamid Co Reductive alkylation process
USRE26253E (en) * 1963-05-17 1967-08-15 And z-alkylamino-g-deoxytetracycline
US3526629A (en) * 1968-04-02 1970-09-01 American Cyanamid Co Beta-hydroxyethylpiperazinocarboxymethyl - 7 - dimethylamino - 6 - deoxy-6-demethyltetracycline
JPS5245716B1 (pt) * 1970-07-10 1977-11-17
NL158172B (nl) * 1972-09-18 1978-10-16 Farmaceutici Italia Werkwijze voor het bereiden van tetracyclinederivaten met een substituent op de 7-plaats.
CN85101404A (zh) * 1985-05-16 1987-01-17 帝人株式会社 头孢菌素衍生物的生产过程
JPH0737433B2 (ja) * 1987-06-11 1995-04-26 協和醗酵工業株式会社 ７−アミノ−６−デメチル−６−デオキシテトラサイクリンの製造法
US4918208A (en) * 1987-07-28 1990-04-17 Nippon Kayaku Kabushiki Kaisha Process for producing 7-dimethylamino-6-demethyl-6-deoxytetracycline
US5202449A (en) * 1987-07-28 1993-04-13 Nippon Kayaku Kabushiki Kaisha Process for purifying 7-dimethylamino-6-demethyl-6-deoxytetracycline
JPH04235188A (ja) * 1990-06-19 1992-08-24 Takeda Chem Ind Ltd ペネム化合物の結晶、その製造方法および抗菌剤
US5262173A (en) * 1992-03-02 1993-11-16 American Cyanamid Company Pulsatile once-a-day delivery systems for minocycline
DE4235133A1 (de) * 1992-10-19 1994-04-21 Bayer Ag Kristallines (R)-(-)-2-Cycloheptyl-N-methylsulfonyl-[4-(2-chinolinyl-methoxy)-phenyl]-acetamid
JP3623531B2 (ja) * 1993-06-07 2005-02-23 ビーエーエスエフ アクチェンゲゼルシャフト 結晶質ｌ−アスコルビン酸−２−燐酸エステルマグネシウム塩の製造法
IL128862A (en) * 1995-07-17 2007-12-03 Warner Lambert Co [R - (R * R *)] - 2 - (4 - fluorophenyl) - ß, d - dihydroxy - 5 - (1 - methyl - ethyl) 3 - phenyl - 4 - [(phenamino) carbonyl)] - 1H - Pyrol - 1 - Patenoic acid Hydrogen salt Hydrogen crystalline (Atorostatin) Crystalline hydrate
MY126580A (en) 1997-12-22 2006-10-31 Merck Sharp & Dohme Molecular dispersion composition with enchanced bioavailabity
EP1135071A1 (en) * 1998-12-01 2001-09-26 Atropos Limited A medical device comprising an evertable sleeve
CL2004001884A1 (es) * 2003-08-04 2005-06-03 Pfizer Prod Inc Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros.
AR057649A1 (es) * 2005-05-27 2007-12-12 Wyeth Corp Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas
JP2009502809A (ja) * 2005-07-21 2009-01-29 パラテック ファーマシューティカルズ インコーポレイテッド １０−置換テトラサイクリンおよびその使用方法
PT103661B (pt) 2007-02-23 2010-09-07 Hovione Farmaciencia S A Processo de preparação de minociclina base cristalina

Also Published As

Publication number Publication date
EP2125705B1 (en) 2016-10-12
ES2610434T3 (es) 2017-04-27
WO2008102161A2 (en) 2008-08-28
JP2010519247A (ja) 2010-06-03
RU2577331C2 (ru) 2016-03-20
JP2019142882A (ja) 2019-08-29
JP2014169319A (ja) 2014-09-18
EP2125705A2 (en) 2009-12-02
BRPI0807319B1 (pt) 2021-08-10
KR101391132B1 (ko) 2014-05-02
AU2008217619B2 (en) 2013-01-10
WO2008102161A9 (en) 2008-11-13
RU2013112021A (ru) 2014-09-27
WO2008102161A3 (en) 2009-01-08
US8258327B2 (en) 2012-09-04
AU2008217619A1 (en) 2008-08-28
RU2485095C2 (ru) 2013-06-20
KR20100014520A (ko) 2010-02-10
US20100286417A1 (en) 2010-11-11
PT103661A (pt) 2008-08-25
BR122021000846B1 (pt) 2021-08-10
NO20092960L (no) 2009-11-20
DK2125705T3 (en) 2017-01-16
US9416097B2 (en) 2016-08-16
PL2125705T3 (pl) 2017-02-28
NZ579626A (en) 2011-12-22
JP2017039742A (ja) 2017-02-23
HUE033030T2 (hu) 2017-11-28
ZA200906517B (en) 2010-09-29
CN101679218A (zh) 2010-03-24
CA2722496A1 (en) 2008-08-28
IL200544A0 (en) 2010-05-17
US20130030195A1 (en) 2013-01-31
PT103661B (pt) 2010-09-07
CA2835788A1 (en) 2008-08-28
MX340539B (es) 2016-07-13
RU2009135403A (ru) 2011-03-27
MX2009008980A (es) 2009-11-11
CA2835788C (en) 2018-03-27
CN101679218B (zh) 2013-10-30
CA2722496C (en) 2014-06-10

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Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: HOVIONE SCIENTIA LIMITED (IE)

B25A Requested transfer of rights approved

Owner name: HOVIONE SCIENTIA LIMITED (IE)

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 22/02/2008, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.