NO20092960L - Krystallinsk minocycline base og framgangsmater for framstilling av denne - Google Patents
Krystallinsk minocycline base og framgangsmater for framstilling av denneInfo
- Publication number
- NO20092960L NO20092960L NO20092960A NO20092960A NO20092960L NO 20092960 L NO20092960 L NO 20092960L NO 20092960 A NO20092960 A NO 20092960A NO 20092960 A NO20092960 A NO 20092960A NO 20092960 L NO20092960 L NO 20092960L
- Authority
- NO
- Norway
- Prior art keywords
- minocycline base
- processes
- preparation
- crystalline
- crystalline minocycline
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/24—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton
- C07C237/26—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring of the carbon skeleton of a ring being part of a condensed ring system formed by at least four rings, e.g. tetracycline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
Oppfinnelsen framskaffer krystallinsk minosyklin-base. Der er særlig framskaffet tre krystallinske polymorfe former av minosyklin, benevnt som form I, form II og form III. Disse er karakterisert ved XRD og IR data. Framgangsmåter for framstilling av de nye polymorfe formene er også framskaffet. For eksempel blir form I framstilt ved å løse og/eller suspendere amorf minosyklin-base i et organisk løsningsmiddel valgt fra etere, etterfulgt av krystallisering fra blandingen.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PT103661A PT103661B (pt) | 2007-02-23 | 2007-02-23 | Processo de preparação de minociclina base cristalina |
PCT/GB2008/000625 WO2008102161A2 (en) | 2007-02-23 | 2008-02-22 | Crystalline minocycline base and processes for its preparation |
Publications (1)
Publication Number | Publication Date |
---|---|
NO20092960L true NO20092960L (no) | 2009-11-20 |
Family
ID=39432804
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
NO20092960A NO20092960L (no) | 2007-02-23 | 2009-09-04 | Krystallinsk minocycline base og framgangsmater for framstilling av denne |
Country Status (20)
Country | Link |
---|---|
US (2) | US8258327B2 (no) |
EP (1) | EP2125705B1 (no) |
JP (4) | JP2010519247A (no) |
KR (1) | KR101391132B1 (no) |
CN (1) | CN101679218B (no) |
AU (1) | AU2008217619B2 (no) |
BR (2) | BRPI0807319B1 (no) |
CA (2) | CA2722496C (no) |
DK (1) | DK2125705T3 (no) |
ES (1) | ES2610434T3 (no) |
HU (1) | HUE033030T2 (no) |
IL (1) | IL200544A0 (no) |
MX (2) | MX2009008980A (no) |
NO (1) | NO20092960L (no) |
NZ (1) | NZ579626A (no) |
PL (1) | PL2125705T3 (no) |
PT (1) | PT103661B (no) |
RU (2) | RU2485095C2 (no) |
WO (1) | WO2008102161A2 (no) |
ZA (1) | ZA200906517B (no) |
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IL152486A0 (en) | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
US20080138296A1 (en) | 2002-10-25 | 2008-06-12 | Foamix Ltd. | Foam prepared from nanoemulsions and uses |
CA2502986C (en) | 2002-10-25 | 2011-08-23 | Foamix Ltd. | Cosmetic and pharmaceutical foam |
US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
US7704518B2 (en) | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
US7700076B2 (en) | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
US8722650B1 (en) | 2005-06-24 | 2014-05-13 | Medicis Pharmaceutical Corporation | Extended-release minocycline dosage forms |
US9192615B2 (en) | 2008-08-06 | 2015-11-24 | Medicis Pharmaceutical Corporation | Method for the treatment of acne and certain dosage forms thereof |
US20080242642A1 (en) | 2007-04-02 | 2008-10-02 | Medicis Pharmaceutical Corporation | Minocycline oral dosage forms for the treatment of acne |
US20080260655A1 (en) | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
PT103661B (pt) | 2007-02-23 | 2010-09-07 | Hovione Farmaciencia S A | Processo de preparação de minociclina base cristalina |
US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
US9439857B2 (en) | 2007-11-30 | 2016-09-13 | Foamix Pharmaceuticals Ltd. | Foam containing benzoyl peroxide |
WO2009072007A2 (en) | 2007-12-07 | 2009-06-11 | Foamix Ltd. | Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof |
PT104350A (pt) * | 2009-01-23 | 2010-07-23 | Hovione Farmaci Ncia S A | Processo de isolamento de tigeciclina |
WO2010125470A2 (en) | 2009-04-28 | 2010-11-04 | Foamix Ltd. | Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof |
PT104644B (pt) | 2009-06-26 | 2012-11-06 | Hovione Farmaciencia S A | Formulação tópica contendo uma tetraciclina e método de tratamento de infecções cutâneas usando a mesma |
CA2769625C (en) | 2009-07-29 | 2017-04-11 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
CA2769677A1 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
WO2011039637A2 (en) | 2009-10-02 | 2011-04-07 | Foamix Ltd. | Surfactant-free water-free foamable compositions, breakable foams and gels and their uses |
US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
US9561241B1 (en) | 2011-06-28 | 2017-02-07 | Medicis Pharmaceutical Corporation | Gastroretentive dosage forms for minocycline |
PT106063B (pt) * | 2011-12-19 | 2017-05-30 | Inst Superior Técnico | Minociclina cristalina termorresistente produzida por recristalização com dióxido de carbono |
CN104151186B (zh) * | 2014-08-11 | 2016-06-15 | 重庆福安药业(集团)股份有限公司 | 替加环素杂质的立体选择性制备方法 |
PT108223B (pt) * | 2015-02-13 | 2018-05-08 | Hovione Farm S A | Novas formas polimórficas de minociclina base e processos para a sua preparação |
TW201705962A (zh) | 2015-03-23 | 2017-02-16 | 生物製藥X公司 | 皮膚用四環素醫藥組成物 |
WO2017097891A1 (en) * | 2015-12-10 | 2017-06-15 | Sandoz Ag | Crystalline eravacycline |
MX2020012139A (es) | 2016-09-08 | 2021-01-29 | Vyne Pharmaceuticals Inc | Composiciones y metodos para tratar rosacea y acne. |
WO2021191273A1 (en) | 2020-03-24 | 2021-09-30 | Hovione Scientia Limited | Compositions for use in treating meibomian gland dysfunction |
US20220062308A1 (en) | 2020-08-27 | 2022-03-03 | Hovione Scientia Limited | Methods and compositions for treating rosacea |
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US299111A (en) * | 1884-05-27 | Process of and apparatus | ||
US3148212A (en) * | 1961-12-22 | 1964-09-08 | American Cyanamid Co | Reductive alkylation process |
USRE26253E (en) * | 1963-05-17 | 1967-08-15 | And z-alkylamino-g-deoxytetracycline | |
US3526629A (en) * | 1968-04-02 | 1970-09-01 | American Cyanamid Co | Beta-hydroxyethylpiperazinocarboxymethyl - 7 - dimethylamino - 6 - deoxy-6-demethyltetracycline |
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IL136460A0 (en) | 1997-12-22 | 2001-06-14 | Schering Corp | Molecular dispersion composition with enhanced bioavailability |
WO2000032119A1 (en) * | 1998-12-01 | 2000-06-08 | Atropos Limited | A medical device comprising an evertable sleeve |
CL2004001884A1 (es) * | 2003-08-04 | 2005-06-03 | Pfizer Prod Inc | Procedimiento de secado por pulverizacion para la formacion de dispersiones solidas amorfas de un farmaco y polimeros. |
AR057649A1 (es) * | 2005-05-27 | 2007-12-12 | Wyeth Corp | Formas solidas cristalinas de tigeciclina y metodos para preparar las mismas |
EP1910273A2 (en) * | 2005-07-21 | 2008-04-16 | Paratek Pharmaceuticals, Inc. | 10-substituted tetracyclines and methods of use thereof |
PT103661B (pt) | 2007-02-23 | 2010-09-07 | Hovione Farmaciencia S A | Processo de preparação de minociclina base cristalina |
-
2007
- 2007-02-23 PT PT103661A patent/PT103661B/pt active IP Right Grant
-
2008
- 2008-02-22 PL PL08709507T patent/PL2125705T3/pl unknown
- 2008-02-22 NZ NZ579626A patent/NZ579626A/en unknown
- 2008-02-22 KR KR1020097019750A patent/KR101391132B1/ko active IP Right Grant
- 2008-02-22 HU HUE08709507A patent/HUE033030T2/hu unknown
- 2008-02-22 CA CA2722496A patent/CA2722496C/en active Active
- 2008-02-22 JP JP2009550320A patent/JP2010519247A/ja not_active Withdrawn
- 2008-02-22 RU RU2009135403/04A patent/RU2485095C2/ru active
- 2008-02-22 ES ES08709507.1T patent/ES2610434T3/es active Active
- 2008-02-22 EP EP08709507.1A patent/EP2125705B1/en active Active
- 2008-02-22 DK DK08709507.1T patent/DK2125705T3/en active
- 2008-02-22 BR BRPI0807319-8A patent/BRPI0807319B1/pt active IP Right Grant
- 2008-02-22 US US12/528,209 patent/US8258327B2/en active Active
- 2008-02-22 CN CN2008800059328A patent/CN101679218B/zh active Active
- 2008-02-22 CA CA2835788A patent/CA2835788C/en active Active
- 2008-02-22 MX MX2009008980A patent/MX2009008980A/es active IP Right Grant
- 2008-02-22 RU RU2013112021/04A patent/RU2577331C2/ru active
- 2008-02-22 BR BR122021000846-9A patent/BR122021000846B1/pt active IP Right Grant
- 2008-02-22 AU AU2008217619A patent/AU2008217619B2/en not_active Ceased
- 2008-02-22 WO PCT/GB2008/000625 patent/WO2008102161A2/en active Application Filing
-
2009
- 2009-08-21 MX MX2012005474A patent/MX340539B/es unknown
- 2009-08-23 IL IL200544A patent/IL200544A0/en active IP Right Grant
- 2009-09-04 NO NO20092960A patent/NO20092960L/no not_active Application Discontinuation
- 2009-09-18 ZA ZA200906517A patent/ZA200906517B/en unknown
-
2012
- 2012-08-30 US US13/599,116 patent/US9416097B2/en not_active Expired - Fee Related
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2014
- 2014-05-20 JP JP2014104022A patent/JP2014169319A/ja active Pending
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2016
- 2016-09-28 JP JP2016189162A patent/JP2017039742A/ja active Pending
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2019
- 2019-03-27 JP JP2019059559A patent/JP2019142882A/ja active Pending
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
CHAD | Change of the owner's name or address (par. 44 patent law, par. patentforskriften) |
Owner name: HOVIONE SCIENTIA LIMITED, IE |
|
FC2A | Withdrawal, rejection or dismissal of laid open patent application |