BR112020020273A2 - Inibidor de ret para uso no tratamento de câncer tendo uma alteração de ret - Google Patents

Inibidor de ret para uso no tratamento de câncer tendo uma alteração de ret Download PDF

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Publication number
BR112020020273A2
BR112020020273A2 BR112020020273-8A BR112020020273A BR112020020273A2 BR 112020020273 A2 BR112020020273 A2 BR 112020020273A2 BR 112020020273 A BR112020020273 A BR 112020020273A BR 112020020273 A2 BR112020020273 A2 BR 112020020273A2
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BR
Brazil
Prior art keywords
cancer
ret
fact
individual
amino acid
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BR112020020273-8A
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English (en)
Portuguese (pt)
Inventor
Erica Evans Raab
Beni B. Wolf
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Blueprint Medicines Corporation
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Application filed by Blueprint Medicines Corporation filed Critical Blueprint Medicines Corporation
Publication of BR112020020273A2 publication Critical patent/BR112020020273A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
BR112020020273-8A 2018-04-03 2019-04-03 Inibidor de ret para uso no tratamento de câncer tendo uma alteração de ret BR112020020273A2 (pt)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US201862652284P 2018-04-03 2018-04-03
US62/652,284 2018-04-03
US201862656297P 2018-04-11 2018-04-11
US62/656,297 2018-04-11
US201862657605P 2018-04-13 2018-04-13
US62/657,605 2018-04-13
US201862741683P 2018-10-05 2018-10-05
US62/741,683 2018-10-05
PCT/US2019/025655 WO2019195471A1 (en) 2018-04-03 2019-04-03 Ret inhibitor for use in treating cancer having a ret alteration

Publications (1)

Publication Number Publication Date
BR112020020273A2 true BR112020020273A2 (pt) 2021-04-06

Family

ID=66223846

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112020020273-8A BR112020020273A2 (pt) 2018-04-03 2019-04-03 Inibidor de ret para uso no tratamento de câncer tendo uma alteração de ret

Country Status (26)

Country Link
US (5) US20210100795A1 (https=)
EP (2) EP3773589B1 (https=)
JP (3) JP7422084B2 (https=)
KR (1) KR20200139749A (https=)
AU (1) AU2019247766A1 (https=)
BR (1) BR112020020273A2 (https=)
CA (1) CA3096043A1 (https=)
CL (1) CL2020002544A1 (https=)
CR (1) CR20200522A (https=)
DK (1) DK3773589T3 (https=)
ES (1) ES2970041T3 (https=)
FI (1) FI3773589T3 (https=)
HR (1) HRP20240124T1 (https=)
HU (1) HUE065374T2 (https=)
IL (1) IL277629A (https=)
LT (1) LT3773589T (https=)
MX (1) MX2020010417A (https=)
MY (1) MY203645A (https=)
PE (1) PE20210096A1 (https=)
PL (1) PL3773589T3 (https=)
PT (1) PT3773589T (https=)
RS (1) RS65127B1 (https=)
SG (1) SG11202009681YA (https=)
SI (1) SI3773589T1 (https=)
WO (1) WO2019195471A1 (https=)
ZA (1) ZA202006072B (https=)

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PE20210096A1 (es) 2018-04-03 2021-01-12 Blueprint Medicines Corp Inhibidor de ret para uso en tratar cancer que tiene una alteracion de ret
US11666570B2 (en) * 2019-07-11 2023-06-06 The Board Of Trustees Of The Leland Stanford Junior University Diagnosis and regulation of epidermal differentiation and cancer cell activity
EP4157829A1 (en) 2020-05-29 2023-04-05 Blueprint Medicines Corporation Solid forms of pralsetinib
US11946935B2 (en) * 2020-08-25 2024-04-02 Regents Of The University Of Minnesota Circulating tumor markers for meningiomas
JP1746261S (ja) * 2022-10-17 2023-06-14 量子暗号鍵伝送機

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KR20230113612A (ko) 2020-12-04 2023-07-31 블루프린트 메디신즈 코포레이션 프랄세티닙의 제조 방법

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