SI3371171T1 - Inhibitorji ret - Google Patents
Inhibitorji retInfo
- Publication number
- SI3371171T1 SI3371171T1 SI201631796T SI201631796T SI3371171T1 SI 3371171 T1 SI3371171 T1 SI 3371171T1 SI 201631796 T SI201631796 T SI 201631796T SI 201631796 T SI201631796 T SI 201631796T SI 3371171 T1 SI3371171 T1 SI 3371171T1
- Authority
- SI
- Slovenia
- Prior art keywords
- ret
- inhibitors
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/30—Halogen atoms or nitro radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/34—One oxygen atom
- C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562249784P | 2015-11-02 | 2015-11-02 | |
US201662367960P | 2016-07-28 | 2016-07-28 | |
EP16794885.0A EP3371171B1 (en) | 2015-11-02 | 2016-11-01 | Inhibitors of ret |
PCT/US2016/059879 WO2017079140A1 (en) | 2015-11-02 | 2016-11-01 | Inhibitors of ret |
Publications (1)
Publication Number | Publication Date |
---|---|
SI3371171T1 true SI3371171T1 (sl) | 2024-03-29 |
Family
ID=57286889
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI201631796T SI3371171T1 (sl) | 2015-11-02 | 2016-11-01 | Inhibitorji ret |
Country Status (29)
Country | Link |
---|---|
US (4) | US10030005B2 (sl) |
EP (3) | EP4292594A3 (sl) |
JP (3) | JP6807385B2 (sl) |
KR (1) | KR20180073689A (sl) |
CN (2) | CN108473468B (sl) |
AU (1) | AU2016348402B2 (sl) |
BR (1) | BR112018008877B1 (sl) |
CA (1) | CA3003721C (sl) |
CL (1) | CL2018001181A1 (sl) |
DK (1) | DK3371171T3 (sl) |
EA (1) | EA038890B1 (sl) |
FI (1) | FI3371171T3 (sl) |
HK (1) | HK1259287A1 (sl) |
HR (1) | HRP20231681T1 (sl) |
IL (3) | IL288519B2 (sl) |
LT (1) | LT3371171T (sl) |
MX (1) | MX2018005528A (sl) |
MY (1) | MY194262A (sl) |
NZ (1) | NZ742351A (sl) |
PH (1) | PH12018500907A1 (sl) |
PL (1) | PL3371171T3 (sl) |
PT (1) | PT3371171T (sl) |
RS (1) | RS65069B1 (sl) |
SA (1) | SA518391496B1 (sl) |
SG (1) | SG11201803653QA (sl) |
SI (1) | SI3371171T1 (sl) |
TW (2) | TWI757256B (sl) |
WO (1) | WO2017079140A1 (sl) |
ZA (1) | ZA201803050B (sl) |
Families Citing this family (60)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MX365251B (es) | 2010-05-20 | 2019-05-28 | Array Biopharma Inc | Compuestos macrocíclicos como inhibidores de trk cinasa. |
KR102163776B1 (ko) | 2012-07-11 | 2020-10-12 | 블루프린트 메디신즈 코포레이션 | 섬유아세포 성장인자 수용체의 저해제 |
WO2014160521A1 (en) | 2013-03-15 | 2014-10-02 | Blueprint Medicines Corporation | Piperazine derivatives and their use as kit modulators |
CN105658652B (zh) | 2013-10-17 | 2019-04-12 | 蓝图药品公司 | 可用于治疗与kit相关的病症的组合物 |
PL3395814T3 (pl) | 2013-10-25 | 2022-08-22 | Blueprint Medicines Corporation | Inhibitory receptora czynników wzrostu fibroblastów |
US9695165B2 (en) | 2014-01-15 | 2017-07-04 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
US10202365B2 (en) | 2015-02-06 | 2019-02-12 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors |
PL3322706T3 (pl) | 2015-07-16 | 2021-07-19 | Array Biopharma, Inc. | Podstawione związki pirazolo[1,5-a]pirydynowe jako inhibitory kinazy ret |
KR20180048635A (ko) | 2015-07-24 | 2018-05-10 | 블루프린트 메디신즈 코포레이션 | Kit 및 pdgfr에 관련된 장애를 치료하는데 유용한 조성물 |
WO2017035354A1 (en) | 2015-08-26 | 2017-03-02 | Blueprint Medicines Corporation | Compounds and compositions useful for treating disorders related to ntrk |
PT3371171T (pt) | 2015-11-02 | 2024-01-24 | Blueprint Medicines Corp | Inibidores de ret |
RU2018122089A (ru) | 2015-11-19 | 2019-12-25 | Блюпринт Медсинс Корпорейшн | Соединения и композиции, подходящие для лечения расстройств, связанных с ntrk |
WO2017161269A1 (en) | 2016-03-17 | 2017-09-21 | Blueprint Medicines Corporation | Inhibitors of ret receptor tyrosine kinases |
ES2957233T3 (es) | 2016-04-15 | 2024-01-15 | Blueprint Medicines Corp | Inhibidores de quinasa tipo receptor de activina |
CN109996556A (zh) | 2016-05-13 | 2019-07-09 | 分子医学研究院 | 治疗与ilc3细胞相关之疾病的方法 |
WO2018017983A1 (en) * | 2016-07-22 | 2018-01-25 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to ret |
WO2018022761A1 (en) * | 2016-07-27 | 2018-02-01 | Blueprint Medicines Corporation | Substituted cyclopentane-amides for treating disorders related to ret |
TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
WO2018136661A1 (en) | 2017-01-18 | 2018-07-26 | Andrews Steven W | SUBSTITUTED PYRAZOLO[1,5-a]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS |
JOP20190213A1 (ar) | 2017-03-16 | 2019-09-16 | Array Biopharma Inc | مركبات حلقية ضخمة كمثبطات لكيناز ros1 |
US11040979B2 (en) | 2017-03-31 | 2021-06-22 | Blueprint Medicines Corporation | Substituted pyrrolo[1,2-b]pyridazines for treating disorders related to KIT and PDGFR |
US20210290620A1 (en) * | 2017-05-15 | 2021-09-23 | Blueprint Medicines Corporation | Combinations of RET Inhibitors and mTORC1 Inhibitors and Uses Thereof for the Treatment of Cancer Mediated by Aberrant RET Activity |
TWI812649B (zh) | 2017-10-10 | 2023-08-21 | 美商絡速藥業公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物 |
TWI791053B (zh) | 2017-10-10 | 2023-02-01 | 美商亞雷生物製藥股份有限公司 | 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物 |
ES2931537T3 (es) | 2017-10-18 | 2022-12-30 | Blueprint Medicines Corp | Pirrolopiridinas sustituidas como inhibidores de la quinasa similar al receptor de activina |
TW201932464A (zh) | 2018-01-18 | 2019-08-16 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑基[4,3-c]吡啶化合物 |
TWI802635B (zh) | 2018-01-18 | 2023-05-21 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡咯并[2,3-d]嘧啶化合物 |
US11524963B2 (en) | 2018-01-18 | 2022-12-13 | Array Biopharma Inc. | Substituted pyrazolo[3,4-d]pyrimidines as RET kinase inhibitors |
AU2019247766A1 (en) | 2018-04-03 | 2020-10-15 | Blueprint Medicines Corporation | RET inhibitor for use in treating cancer having a RET alteration |
EP3833372A4 (en) | 2018-08-10 | 2022-06-08 | Blueprint Medicines Corporation | TREATMENT OF EGFR MUTANT CANCER |
WO2020035065A1 (zh) * | 2018-08-17 | 2020-02-20 | 南京明德新药研发有限公司 | 作为ret抑制剂的吡唑衍生物 |
ES2922314T3 (es) | 2018-09-10 | 2022-09-13 | Array Biopharma Inc | Compuestos heterocíclicos condensados como inhibidores de cinasa RET |
WO2020114474A1 (zh) * | 2018-12-06 | 2020-06-11 | 苏州信诺维医药科技有限公司 | 一种杂环化合物、其应用及含其的药物组合物 |
CN111285882B (zh) * | 2018-12-07 | 2022-12-02 | 四川科伦博泰生物医药股份有限公司 | 稠环化合物、包含其的药物组合物及其制备方法和用途 |
CN111484479B (zh) * | 2019-01-25 | 2023-06-13 | 四川科伦博泰生物医药股份有限公司 | 氮杂环化合物、包含其的药物组合物及其制备方法和用途 |
CN111499613B (zh) * | 2019-01-31 | 2023-05-12 | 浙江海正药业股份有限公司 | N-甲酰胺衍生物、其制备方法及其在医药上的用途 |
BR112021016299A2 (pt) | 2019-02-19 | 2021-10-13 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Composto heterocíclico, composição farmacêutica compreendendo o mesmo, método de preparação do mesmo e uso do mesmo |
WO2020200314A1 (zh) * | 2019-04-03 | 2020-10-08 | 南京明德新药研发有限公司 | 作为ret抑制剂的含氮螺环衍生物 |
CN111808077B (zh) * | 2019-04-12 | 2023-05-02 | 浙江海正药业股份有限公司 | 哌嗪酰胺衍生物,其制备方法及其在医药上的用途 |
HUE064283T2 (hu) | 2019-04-12 | 2024-02-28 | Blueprint Medicines Corp | Az (S)-1-(4-fluorofenil)-1-(2-(4-(6-(1-metil-1H-pirazol-4-il)pirrolo[2,1-f][1,2,4]triazin-4-il) piperazinil)-pirimidin-5-il)etán-1-amin kristályos formái és elõállítási eljárásai |
CN111961034A (zh) * | 2019-05-20 | 2020-11-20 | 浙江同源康医药股份有限公司 | 用作ret激酶抑制剂的化合物及其应用 |
US11666570B2 (en) * | 2019-07-11 | 2023-06-06 | The Board Of Trustees Of The Leland Stanford Junior University | Diagnosis and regulation of epidermal differentiation and cancer cell activity |
CN113121524B (zh) | 2019-12-31 | 2023-04-25 | 南京创济生物医药有限公司 | 杂环亚砜亚胺化合物及其中间体、制备方法和应用 |
CN113135896A (zh) * | 2020-01-18 | 2021-07-20 | 正大天晴药业集团股份有限公司 | 作为ret抑制剂的甲基吡唑类衍生物 |
CN111362923A (zh) * | 2020-03-25 | 2020-07-03 | 魏威 | 制备ret抑制剂普拉塞替尼的方法、以及普拉塞替尼的中间体及其制备方法 |
CN111440151A (zh) * | 2020-03-25 | 2020-07-24 | 魏威 | 制备抗肿瘤药普拉赛替尼的方法 |
CN111269229B (zh) * | 2020-03-27 | 2021-02-12 | 苏州信诺维医药科技有限公司 | 一种治疗癌症的化合物 |
US20230234954A1 (en) * | 2020-05-20 | 2023-07-27 | Tyk Medicines, Inc. | Compound used as ret kinase inhibitor and application thereof |
BR112022024382A2 (pt) | 2020-05-29 | 2023-05-02 | Blueprint Medicines Corp | Formas sólidas de pralsetinibe |
BR112022024374A2 (pt) * | 2020-05-29 | 2023-05-02 | Blueprint Medicines Corp | Composições farmacêuticas de pralsetinibe |
CN111777595A (zh) * | 2020-07-22 | 2020-10-16 | 上海希迈医药科技有限公司 | 一种环己烷甲酰胺类化合物的新晶型及其制备方法 |
WO2022086899A1 (en) | 2020-10-19 | 2022-04-28 | Teva Pharmaceuticals International Gmbh | Solid state forms of pralsetinib and process for preparation thereof |
WO2022117448A1 (en) | 2020-12-03 | 2022-06-09 | Sandoz Ag | Crystalline forms of pralsetinib |
KR20230113612A (ko) | 2020-12-04 | 2023-07-31 | 블루프린트 메디신즈 코포레이션 | 프랄세티닙의 제조 방법 |
CN113072541B (zh) * | 2021-04-02 | 2022-07-08 | 山东四环药业股份有限公司 | 一种靶向药物blu-667的制备方法 |
CA3222177A1 (en) | 2021-06-03 | 2022-12-08 | Fundacao D. Anna De Sommer Champalimaud E Dr. Carlos Montez Champalimaud | Neuro-mesenchyme units control ilc2 and obesity via a brain-adipose circuit |
CN115057822B (zh) * | 2022-07-14 | 2023-05-02 | 上海优合贝德医药科技有限公司 | 一种普拉替尼中间体2097133-31-6的新合成方法 |
CN117466901A (zh) * | 2022-07-23 | 2024-01-30 | 浙江海正药业股份有限公司 | 哌嗪酰胺衍生物的晶型及其制备方法和用途 |
Family Cites Families (84)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001060816A1 (en) | 2000-02-17 | 2001-08-23 | Amgen Inc. | Kinase inhibitors |
BR0312873A (pt) | 2002-07-24 | 2005-06-28 | Univ Cincinnati | 4-(4-metilpiperazin-1-ilmetil)-n-[4-metil-3-(4-piridin-3-il) pirimidin-2-ilamino)fenil] benzamida para tratamento de doenças associadas com ret cinase mutante |
EP1696920B8 (en) | 2003-12-19 | 2015-05-06 | Plexxikon Inc. | Compounds and methods for development of ret modulators |
US8227455B2 (en) * | 2005-04-18 | 2012-07-24 | Rigel Pharmaceuticals, Inc. | Methods of treating cell proliferative disorders |
US20100047777A1 (en) | 2005-05-26 | 2010-02-25 | The Johns Hopkins University | Methods for identifying mutations in coding and non-coding dna |
WO2007023382A2 (en) | 2005-08-25 | 2007-03-01 | Pfizer Inc. | Pyrimidine amino pyrazole compounds, potent kinase inhibitors |
EP1978958A4 (en) | 2006-01-24 | 2009-12-02 | Merck & Co Inc | INHIBITION OF TYROSINE KINASE RET |
WO2008061201A1 (en) * | 2006-11-15 | 2008-05-22 | Rigel Pharmaceuticals, Inc. | Methods for treating renal tumors using 2,4-pyrimidinediamine drug and prodrug compounds |
WO2009003136A1 (en) * | 2007-06-26 | 2008-12-31 | Rigel Pharmaceuticals, Inc. | Substituted pyrimidine-2, 4 -diamines for treating cell proliferative disorders |
AR067478A1 (es) | 2007-07-09 | 2009-10-14 | Astrazeneca Ab | Compuestos derivados de morfolina pirimidina |
JP5241834B2 (ja) | 2007-07-19 | 2013-07-17 | メルク・シャープ・アンド・ドーム・コーポレーション | プロテインキナーゼ阻害剤としての複素環アミド化合物 |
AU2008282156B2 (en) * | 2007-07-31 | 2014-07-17 | Vertex Pharmaceuticals Incorporated | Process for preparing 5-fluoro-1H-pyrazolo [3, 4-b] pyridin-3-amine and derivatives thereof |
WO2009100536A1 (en) | 2008-02-15 | 2009-08-20 | Methylgene Inc. | Inhibitors of kinase activity with 1,2-di-cyclyl substituted alkyne structures |
CA2730190A1 (en) | 2008-07-14 | 2010-01-21 | Queen's University At Kingston | Pharmaceutical compositions comprising ret inhibitors and methods for the treatment of cancer |
US8367690B2 (en) | 2009-03-24 | 2013-02-05 | Vertex Pharmaceuticals Inc. | Aminopyridine derivatives having aurora a selective inhibitory action |
AU2010258964B2 (en) | 2009-06-09 | 2014-09-11 | Nantbio, Inc. | Benzyl substituted triazine derivatives and their therapeutical applications |
WO2011053938A1 (en) | 2009-10-30 | 2011-05-05 | Ariad Pharmaceuticals, Inc. | Methods and compositions for treating cancer |
CA2780892C (en) | 2009-11-13 | 2017-02-14 | Genosco | Kinase inhibitors |
CN103764676A (zh) | 2011-08-04 | 2014-04-30 | 日本国立癌症研究中心 | Kif5b基因和ret基因的融合基因、以及以该融合基因为目标的判断癌症治疗有效性的方法 |
DK2748192T3 (en) | 2011-08-23 | 2019-02-25 | Found Medicine Inc | KIF5B-RET-FUSION MOLECULES AND APPLICATIONS THEREOF |
JP6342805B2 (ja) | 2011-09-02 | 2018-06-13 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 置換ピラゾロ[3,4−d]ピリミジンおよびその用途 |
US20130096136A1 (en) | 2011-09-30 | 2013-04-18 | Methylgene Inc. | Inhibitors of Protein Tyrosine Kinase Activity |
US10023855B2 (en) | 2011-10-31 | 2018-07-17 | Macrogen, Inc. | Fusion protein comprising C-terminal domain of RET protein and use thereof as a diagnosing marker |
EP2776420A1 (en) | 2011-11-09 | 2014-09-17 | Vertex Pharmaceuticals Incorporated | Pyrazine compounds useful as inhibitors of atr kinase |
JP2015109806A (ja) | 2012-03-22 | 2015-06-18 | アステラス製薬株式会社 | 新規ret融合体の検出法 |
RU2646754C2 (ru) * | 2012-04-25 | 2018-03-07 | Раквалиа Фарма Инк. | Производные пирролопиридинона в качестве ttx-s блокаторов |
JP2015516439A (ja) | 2012-05-10 | 2015-06-11 | シンタ ファーマシューティカルズ コーポレーション | Hsp90阻害化合物で癌を治療すること |
KR102163776B1 (ko) | 2012-07-11 | 2020-10-12 | 블루프린트 메디신즈 코포레이션 | 섬유아세포 성장인자 수용체의 저해제 |
JPWO2014017491A1 (ja) | 2012-07-26 | 2016-07-11 | 国立研究開発法人国立がん研究センター | Cep55遺伝子とret遺伝子との融合遺伝子 |
EP2892532B1 (en) | 2012-09-07 | 2019-02-13 | Exelixis, Inc. | Inhibitors of met, vegfr and ret for use in the treatment of lung adenocarcinoma |
CA3077553C (en) * | 2012-09-25 | 2022-08-02 | Chugai Seiyaku Kabushiki Kaisha | Ret inhibitor |
CN108047219A (zh) | 2012-11-07 | 2018-05-18 | 内尔维阿诺医学科学有限公司 | 取代的嘧啶基和吡啶基吡咯并吡啶酮类、其制备方法及其作为激酶抑制剂的用途 |
TWI629266B (zh) | 2012-12-28 | 2018-07-11 | 藍印藥品公司 | 纖維母細胞生長因子受體之抑制劑 |
CN105102468A (zh) | 2013-02-25 | 2015-11-25 | 百时美施贵宝公司 | 用于治疗hiv的c-3烷基和烯基修饰的桦木酸衍生物 |
SI2970191T1 (sl) | 2013-03-15 | 2017-04-26 | GlaxoSmithKline International Property Development Limited | Piridinski derivati kot inhibitorji kinaze, prerazporejeni med transfekcijo (ret) |
WO2014160521A1 (en) | 2013-03-15 | 2014-10-02 | Blueprint Medicines Corporation | Piperazine derivatives and their use as kit modulators |
WO2015006875A1 (en) | 2013-07-18 | 2015-01-22 | Methylgene Inc. | Process for the preparation of substituted pyrimidines |
WO2015025866A1 (ja) | 2013-08-20 | 2015-02-26 | 独立行政法人国立がん研究センター | 肺がんで見出された新規融合遺伝子 |
CN105658652B (zh) | 2013-10-17 | 2019-04-12 | 蓝图药品公司 | 可用于治疗与kit相关的病症的组合物 |
WO2015058129A1 (en) | 2013-10-17 | 2015-04-23 | Blueprint Medicines Corporation | Compositions useful for treating disorders related to kit |
PL3395814T3 (pl) | 2013-10-25 | 2022-08-22 | Blueprint Medicines Corporation | Inhibitory receptora czynników wzrostu fibroblastów |
GB201321146D0 (en) | 2013-11-29 | 2014-01-15 | Cancer Rec Tech Ltd | Quinazoline compounds |
US9695165B2 (en) | 2014-01-15 | 2017-07-04 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
US9688680B2 (en) | 2014-08-04 | 2017-06-27 | Blueprint Medicines Corporation | Compositions useful for treating disorders related to kit |
MY181913A (en) | 2014-09-10 | 2021-01-14 | Glaxosmithkline Ip Dev Ltd | Pyridone derivatives as rearranged during transfection (ret) kinase inhibitors |
EP3191449B1 (en) | 2014-09-10 | 2020-07-01 | GlaxoSmithKline Intellectual Property Development Limited | Compounds as rearranged during transfection (ret) inhibitors |
PL3218378T3 (pl) | 2014-11-14 | 2020-10-19 | Nerviano Medical Sciences S.R.L. | Pochodne 6-amino-7-bicyklo-7-deazapuryny jako inhibitory kinaz białkowych |
US10202365B2 (en) | 2015-02-06 | 2019-02-12 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors |
PL3322706T3 (pl) | 2015-07-16 | 2021-07-19 | Array Biopharma, Inc. | Podstawione związki pirazolo[1,5-a]pirydynowe jako inhibitory kinazy ret |
KR20180048635A (ko) | 2015-07-24 | 2018-05-10 | 블루프린트 메디신즈 코포레이션 | Kit 및 pdgfr에 관련된 장애를 치료하는데 유용한 조성물 |
WO2017035354A1 (en) | 2015-08-26 | 2017-03-02 | Blueprint Medicines Corporation | Compounds and compositions useful for treating disorders related to ntrk |
CN105255927B (zh) | 2015-09-30 | 2018-07-27 | 温州医科大学附属第一医院 | 一种kiaa1217-ret融合基因 |
TW201722985A (zh) | 2015-11-02 | 2017-07-01 | 戊瑞治療有限公司 | Cd80胞外域多肽及其用於癌症治療 |
PT3371171T (pt) | 2015-11-02 | 2024-01-24 | Blueprint Medicines Corp | Inibidores de ret |
CN108431042A (zh) | 2015-11-02 | 2018-08-21 | 詹森药业有限公司 | 抗-il1rap抗体,结合il1rap和cd3的双特异性抗原结合分子及其用途 |
RU2018122089A (ru) | 2015-11-19 | 2019-12-25 | Блюпринт Медсинс Корпорейшн | Соединения и композиции, подходящие для лечения расстройств, связанных с ntrk |
WO2017145050A1 (en) | 2016-02-23 | 2017-08-31 | Glaxosmithkline Intellectual Property Development Limited | Pyridylpyridone derivative useful as a ret kinase inhibitor in the treatment of ibs and cancer |
WO2017161269A1 (en) | 2016-03-17 | 2017-09-21 | Blueprint Medicines Corporation | Inhibitors of ret receptor tyrosine kinases |
CN109069512B (zh) | 2016-04-01 | 2022-06-14 | 西格诺药品有限公司 | 取代的氨基嘌呤化合物、其组合物以及相关治疗方法 |
ES2957233T3 (es) | 2016-04-15 | 2024-01-15 | Blueprint Medicines Corp | Inhibidores de quinasa tipo receptor de activina |
EP3442980B1 (en) | 2016-04-15 | 2021-06-09 | Cancer Research Technology Limited | Heterocyclic compounds as ret kinase inhibitors |
PL3442535T3 (pl) | 2016-04-15 | 2022-10-24 | Cancer Research Technology Limited | Związki heterocykliczne jako inhibitory kinazy ret |
WO2018017983A1 (en) | 2016-07-22 | 2018-01-25 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to ret |
WO2018022761A1 (en) | 2016-07-27 | 2018-02-01 | Blueprint Medicines Corporation | Substituted cyclopentane-amides for treating disorders related to ret |
US20190192522A1 (en) | 2016-09-08 | 2019-06-27 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor 4 in combination with cyclin-dependent kinase inhibitors |
JP2018052878A (ja) | 2016-09-29 | 2018-04-05 | 第一三共株式会社 | ピリジン化合物 |
CN106749231B (zh) | 2016-10-09 | 2019-03-01 | 南京纳丁菲医药科技有限公司 | 萘啶化合物和药物组合物及它们的应用 |
TWI704148B (zh) | 2016-10-10 | 2020-09-11 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物 |
JOP20190077A1 (ar) | 2016-10-10 | 2019-04-09 | Array Biopharma Inc | مركبات بيرازولو [1، 5-a]بيريدين بها استبدال كمثبطات كيناز ret |
US10799503B2 (en) | 2016-12-01 | 2020-10-13 | Ignyta, Inc. | Methods for the treatment of cancer |
WO2018136661A1 (en) | 2017-01-18 | 2018-07-26 | Andrews Steven W | SUBSTITUTED PYRAZOLO[1,5-a]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS |
WO2018136663A1 (en) | 2017-01-18 | 2018-07-26 | Array Biopharma, Inc. | Ret inhibitors |
US11040979B2 (en) | 2017-03-31 | 2021-06-22 | Blueprint Medicines Corporation | Substituted pyrrolo[1,2-b]pyridazines for treating disorders related to KIT and PDGFR |
GB201705971D0 (en) | 2017-04-13 | 2017-05-31 | Cancer Res Tech Ltd | Inhibitor compounds |
US20210290620A1 (en) | 2017-05-15 | 2021-09-23 | Blueprint Medicines Corporation | Combinations of RET Inhibitors and mTORC1 Inhibitors and Uses Thereof for the Treatment of Cancer Mediated by Aberrant RET Activity |
US10934300B2 (en) | 2017-06-23 | 2021-03-02 | San Diego State University (Sdsu) Foundation | Atropisomerism for enhanced kinase inhibitor selectivity |
CN109180677A (zh) | 2017-06-30 | 2019-01-11 | 厦门大学 | 取代芳基醚类化合物、其制备方法、药用组合物及其应用 |
WO2019008172A1 (en) | 2017-07-07 | 2019-01-10 | Nipd Genetics Public Company Limited | ENRICHED MULTIPLEXED PARALLEL ANALYSIS IN TARGET FOR TUMOR BIOMARKER EVALUATION |
PL3728271T3 (pl) | 2017-12-19 | 2023-01-23 | Turning Point Therapeutics, Inc. | Związki makrocykliczne do leczenia chorób |
US11524963B2 (en) | 2018-01-18 | 2022-12-13 | Array Biopharma Inc. | Substituted pyrazolo[3,4-d]pyrimidines as RET kinase inhibitors |
TW201932464A (zh) | 2018-01-18 | 2019-08-16 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡唑基[4,3-c]吡啶化合物 |
TWI802635B (zh) | 2018-01-18 | 2023-05-21 | 美商亞雷生物製藥股份有限公司 | 作為ret激酶抑制劑之經取代吡咯并[2,3-d]嘧啶化合物 |
AU2019247766A1 (en) | 2018-04-03 | 2020-10-15 | Blueprint Medicines Corporation | RET inhibitor for use in treating cancer having a RET alteration |
EP3833372A4 (en) | 2018-08-10 | 2022-06-08 | Blueprint Medicines Corporation | TREATMENT OF EGFR MUTANT CANCER |
-
2016
- 2016-11-01 PT PT167948850T patent/PT3371171T/pt unknown
- 2016-11-01 SG SG11201803653QA patent/SG11201803653QA/en unknown
- 2016-11-01 FI FIEP16794885.0T patent/FI3371171T3/fi active
- 2016-11-01 BR BR112018008877-3A patent/BR112018008877B1/pt active IP Right Grant
- 2016-11-01 LT LTEPPCT/US2016/059879T patent/LT3371171T/lt unknown
- 2016-11-01 IL IL288519A patent/IL288519B2/en unknown
- 2016-11-01 CN CN201680076816.XA patent/CN108473468B/zh active Active
- 2016-11-01 WO PCT/US2016/059879 patent/WO2017079140A1/en active Application Filing
- 2016-11-01 MX MX2018005528A patent/MX2018005528A/es unknown
- 2016-11-01 EA EA201891087A patent/EA038890B1/ru unknown
- 2016-11-01 RS RS20240044A patent/RS65069B1/sr unknown
- 2016-11-01 EP EP23201915.8A patent/EP4292594A3/en active Pending
- 2016-11-01 PL PL16794885.0T patent/PL3371171T3/pl unknown
- 2016-11-01 CA CA3003721A patent/CA3003721C/en active Active
- 2016-11-01 TW TW105135376A patent/TWI757256B/zh active
- 2016-11-01 JP JP2018521916A patent/JP6807385B2/ja active Active
- 2016-11-01 CN CN202010391097.9A patent/CN111423416B/zh active Active
- 2016-11-01 EP EP23201930.7A patent/EP4331585A2/en active Pending
- 2016-11-01 TW TW110148980A patent/TWI787018B/zh active
- 2016-11-01 HR HRP20231681TT patent/HRP20231681T1/hr unknown
- 2016-11-01 NZ NZ742351A patent/NZ742351A/en unknown
- 2016-11-01 AU AU2016348402A patent/AU2016348402B2/en active Active
- 2016-11-01 IL IL302209A patent/IL302209B1/en unknown
- 2016-11-01 SI SI201631796T patent/SI3371171T1/sl unknown
- 2016-11-01 KR KR1020187015706A patent/KR20180073689A/ko not_active Application Discontinuation
- 2016-11-01 MY MYPI2018701728A patent/MY194262A/en unknown
- 2016-11-01 DK DK16794885.0T patent/DK3371171T3/da active
- 2016-11-01 EP EP16794885.0A patent/EP3371171B1/en active Active
- 2016-11-01 US US15/340,428 patent/US10030005B2/en active Active
-
2018
- 2018-04-24 IL IL258902A patent/IL258902B/en unknown
- 2018-04-27 PH PH12018500907A patent/PH12018500907A1/en unknown
- 2018-05-02 CL CL2018001181A patent/CL2018001181A1/es unknown
- 2018-05-02 SA SA518391496A patent/SA518391496B1/ar unknown
- 2018-05-09 ZA ZA2018/03050A patent/ZA201803050B/en unknown
- 2018-07-20 US US16/041,719 patent/US10584114B2/en active Active
-
2019
- 2019-01-30 HK HK19101648.3A patent/HK1259287A1/zh unknown
-
2020
- 2020-01-29 US US16/775,646 patent/US11279688B2/en active Active
- 2020-12-07 JP JP2020202520A patent/JP7026196B2/ja active Active
-
2022
- 2022-02-11 US US17/669,785 patent/US20220315560A1/en active Pending
- 2022-02-14 JP JP2022020355A patent/JP2022058976A/ja active Pending
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
IL288519A (en) | inhibitors of ret | |
IL251584B (en) | Dihydropyrrolopyridines ror–gamma inhibitors | |
IL246902A0 (en) | Dihydropyrrolopyridine ror–gamma inhibitors | |
ZA201604272B (en) | Inhibitors of glutaminase | |
SG11201706729SA (en) | Derivatives of sobetirome | |
EP3183255C0 (en) | SPIROPYRROLIDINE AS MDM2 INHIBITORS | |
IL257061A (en) | Inhibitors of ezh2 | |
GB201521059D0 (en) | Inhibitors of metallo-beta-lactamases | |
IL259796A (en) | Aza-benzimidazole inhibitors of pad4 | |
GB201708457D0 (en) | Inhibitors of metallo-beta-lactamases | |
GB201501004D0 (en) | Inhibitors | |
GB201708451D0 (en) | Inhibitors of metallo-beta-lactamases | |
GB201520949D0 (en) | Inhibitors | |
HUP1500506A2 (en) | Salts of palbociclib | |
MA43165A (fr) | Inhibiteurs de ret |