DK3773589T3 - RET-inhibitor til anvendelse i behandling af cancer med en RET-ændring - Google Patents

RET-inhibitor til anvendelse i behandling af cancer med en RET-ændring Download PDF

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Publication number
DK3773589T3
DK3773589T3 DK19718531.7T DK19718531T DK3773589T3 DK 3773589 T3 DK3773589 T3 DK 3773589T3 DK 19718531 T DK19718531 T DK 19718531T DK 3773589 T3 DK3773589 T3 DK 3773589T3
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Prior art keywords
ret
treating cancer
alteration
inhibitor
ret inhibitor
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DK19718531.7T
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Danish (da)
English (en)
Inventor
Raab Erica Evans
Beni B Wolf
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Blueprint Medicines Corp
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK19718531.7T 2018-04-03 2019-04-03 RET-inhibitor til anvendelse i behandling af cancer med en RET-ændring DK3773589T3 (da)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201862652284P 2018-04-03 2018-04-03
US201862656297P 2018-04-11 2018-04-11
US201862657605P 2018-04-13 2018-04-13
US201862741683P 2018-10-05 2018-10-05
PCT/US2019/025655 WO2019195471A1 (en) 2018-04-03 2019-04-03 Ret inhibitor for use in treating cancer having a ret alteration

Publications (1)

Publication Number Publication Date
DK3773589T3 true DK3773589T3 (da) 2024-01-29

Family

ID=66223846

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Application Number Title Priority Date Filing Date
DK19718531.7T DK3773589T3 (da) 2018-04-03 2019-04-03 RET-inhibitor til anvendelse i behandling af cancer med en RET-ændring

Country Status (26)

Country Link
US (5) US20210100795A1 (https=)
EP (2) EP3773589B1 (https=)
JP (3) JP7422084B2 (https=)
KR (1) KR20200139749A (https=)
AU (1) AU2019247766A1 (https=)
BR (1) BR112020020273A2 (https=)
CA (1) CA3096043A1 (https=)
CL (1) CL2020002544A1 (https=)
CR (1) CR20200522A (https=)
DK (1) DK3773589T3 (https=)
ES (1) ES2970041T3 (https=)
FI (1) FI3773589T3 (https=)
HR (1) HRP20240124T1 (https=)
HU (1) HUE065374T2 (https=)
IL (1) IL277629A (https=)
LT (1) LT3773589T (https=)
MX (1) MX2020010417A (https=)
MY (1) MY203645A (https=)
PE (1) PE20210096A1 (https=)
PL (1) PL3773589T3 (https=)
PT (1) PT3773589T (https=)
RS (1) RS65127B1 (https=)
SG (1) SG11202009681YA (https=)
SI (1) SI3773589T1 (https=)
WO (1) WO2019195471A1 (https=)
ZA (1) ZA202006072B (https=)

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US11666570B2 (en) * 2019-07-11 2023-06-06 The Board Of Trustees Of The Leland Stanford Junior University Diagnosis and regulation of epidermal differentiation and cancer cell activity
EP4157829A1 (en) 2020-05-29 2023-04-05 Blueprint Medicines Corporation Solid forms of pralsetinib
US11946935B2 (en) * 2020-08-25 2024-04-02 Regents Of The University Of Minnesota Circulating tumor markers for meningiomas
JP1746261S (ja) * 2022-10-17 2023-06-14 量子暗号鍵伝送機

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US11872192B2 (en) 2024-01-16
CA3096043A1 (en) 2019-10-10
HRP20240124T1 (hr) 2024-04-12
SI3773589T1 (sl) 2024-03-29
BR112020020273A2 (pt) 2021-04-06
MY203645A (en) 2024-07-11
CR20200522A (es) 2021-02-17
EP4353317A3 (en) 2024-05-08
EP3773589B1 (en) 2023-11-01
US20250041297A1 (en) 2025-02-06
US20220175773A1 (en) 2022-06-09
AU2019247766A1 (en) 2020-10-15
CL2020002544A1 (es) 2021-06-11
EP3773589A1 (en) 2021-02-17
RU2020135917A (ru) 2022-05-04
IL277629A (en) 2020-11-30
PL3773589T3 (pl) 2024-04-02
US11963958B2 (en) 2024-04-23
ZA202006072B (en) 2024-01-31
PE20210096A1 (es) 2021-01-12
WO2019195471A1 (en) 2019-10-10
US20210100799A1 (en) 2021-04-08
EP4353317A2 (en) 2024-04-17
US12539303B2 (en) 2026-02-03
SG11202009681YA (en) 2020-10-29
JP7422084B2 (ja) 2024-01-25
PT3773589T (pt) 2024-02-06
ES2970041T3 (es) 2024-05-24
LT3773589T (lt) 2024-02-12
US20210100795A1 (en) 2021-04-08
JP2021520349A (ja) 2021-08-19
FI3773589T3 (fi) 2024-02-01
US20210085680A1 (en) 2021-03-25
JP2023165937A (ja) 2023-11-17
RS65127B1 (sr) 2024-02-29
KR20200139749A (ko) 2020-12-14
HUE065374T2 (hu) 2024-05-28
MX2020010417A (es) 2021-01-08
JP2022022391A (ja) 2022-02-03
US11273160B2 (en) 2022-03-15

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