SG10201912607SA - Compounds and compositions useful for treating disorders related to ntrk - Google Patents
Compounds and compositions useful for treating disorders related to ntrkInfo
- Publication number
- SG10201912607SA SG10201912607SA SG10201912607SA SG10201912607SA SG10201912607SA SG 10201912607S A SG10201912607S A SG 10201912607SA SG 10201912607S A SG10201912607S A SG 10201912607SA SG 10201912607S A SG10201912607S A SG 10201912607SA SG 10201912607S A SG10201912607S A SG 10201912607SA
- Authority
- SG
- Singapore
- Prior art keywords
- ntrk
- compounds
- compositions useful
- disorders related
- treating disorders
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562257476P | 2015-11-19 | 2015-11-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201912607SA true SG10201912607SA (en) | 2020-02-27 |
Family
ID=57517997
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201912607SA SG10201912607SA (en) | 2015-11-19 | 2016-11-18 | Compounds and compositions useful for treating disorders related to ntrk |
| SG11201803920TA SG11201803920TA (en) | 2015-11-19 | 2016-11-18 | Compounds and compositions useful for treating disorders related to ntrk |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201803920TA SG11201803920TA (en) | 2015-11-19 | 2016-11-18 | Compounds and compositions useful for treating disorders related to ntrk |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US10370379B2 (en) |
| EP (1) | EP3377497A1 (en) |
| JP (1) | JP2019500328A (en) |
| KR (1) | KR20180081790A (en) |
| CN (1) | CN108431008A (en) |
| AR (1) | AR106756A1 (en) |
| AU (1) | AU2016355196A1 (en) |
| BR (1) | BR112018010024A8 (en) |
| CA (1) | CA3005741A1 (en) |
| HK (1) | HK1259453A1 (en) |
| IL (1) | IL259164A (en) |
| MX (1) | MX2018006195A (en) |
| PH (1) | PH12018501065A1 (en) |
| RU (1) | RU2018122089A (en) |
| SG (2) | SG10201912607SA (en) |
| TW (1) | TWI733713B (en) |
| WO (1) | WO2017087778A1 (en) |
| ZA (1) | ZA201803530B (en) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NZ703495A (en) | 2012-07-11 | 2018-02-23 | Blueprint Medicines Corp | Inhibitors of the fibroblast growth factor receptor |
| WO2014160521A1 (en) | 2013-03-15 | 2014-10-02 | Blueprint Medicines Corporation | Piperazine derivatives and their use as kit modulators |
| EP3409674B1 (en) | 2013-10-17 | 2022-04-06 | Blueprint Medicines Corporation | Process for preparing compositions useful for treating disorders related to kit |
| WO2015061572A1 (en) | 2013-10-25 | 2015-04-30 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
| WO2015108992A1 (en) | 2014-01-15 | 2015-07-23 | Blueprint Medicines Corporation | Heterobicyclic compounds and their use as fgfr4 receptor inhibitors |
| US10202365B2 (en) | 2015-02-06 | 2019-02-12 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors |
| KR20180048635A (en) | 2015-07-24 | 2018-05-10 | 블루프린트 메디신즈 코포레이션 | Compositions useful for treating disorders related to KIT and PDGFR |
| BR112018003588A2 (en) | 2015-08-26 | 2018-09-25 | Blueprint Medicines Corp | compounds and compositions useful for treating ntrk-related disorders |
| NZ742351A (en) | 2015-11-02 | 2023-03-31 | Blueprint Medicines Corp | Inhibitors of ret |
| CN108431008A (en) | 2015-11-19 | 2018-08-21 | 蓝图药品公司 | It can be used for treating the compound and composition with the relevant illnesss of NTRK |
| US10183928B2 (en) | 2016-03-17 | 2019-01-22 | Blueprint Medicines Corporation | Inhibitors of RET |
| JP7017521B2 (en) | 2016-04-15 | 2022-02-08 | ブループリント メディシンズ コーポレイション | Inhibitor of activin receptor-like kinase |
| US10227329B2 (en) | 2016-07-22 | 2019-03-12 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to RET |
| US10035789B2 (en) | 2016-07-27 | 2018-07-31 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to RET |
| WO2018183712A1 (en) | 2017-03-31 | 2018-10-04 | Blueprint Medicines Corporation | Pyrrolo[1,2-b]pyridazine compounds and compositions useful for treating disorders related to kit and pdgfr |
| US11236086B2 (en) | 2017-10-18 | 2022-02-01 | Blueprint Medicines Corporation | Substituted pyrrolopyridines as inhibitors of activin receptor-like kinase |
| HRP20240124T1 (en) | 2018-04-03 | 2024-04-12 | Blueprint Medicines Corporation | Ret inhibitor for use in treating cancer having a ret alteration |
| US11155560B2 (en) | 2018-10-30 | 2021-10-26 | Kronos Bio, Inc. | Substituted pyrazolo[1,5-a]pyrimidines for modulating CDK9 activity |
| AU2020242287A1 (en) | 2019-03-21 | 2021-09-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A Dbait molecule in combination with kinase inhibitor for the treatment of cancer |
| DK3856341T3 (en) | 2019-04-12 | 2023-12-04 | Blueprint Medicines Corp | CRYSTALLINE FORMS OF (S)-1-(4-FLUORPHENYL)-1-(2-(4-(6-(1-METHYL-1H-PYRAZOL-4-YL)PYRROLO[2,1-F][1, 2,4]TRIAZIN-4-YL)PIPERAZINYL)-PYRIMIDIN-5-YL)ETHAN-1-AMINE AND PROCESSES FOR THEIR PREPARATION |
| CN114761006A (en) | 2019-11-08 | 2022-07-15 | Inserm(法国国家健康医学研究院) | Methods of treating cancer resistant to kinase inhibitors |
| AU2020402942B2 (en) * | 2019-12-13 | 2023-05-11 | Scinnohub Pharmaceutical Co., Ltd | Fluorine-containing heterocyclic derivatives with macrocyclic structure and use thereof |
| CN112979654B (en) * | 2019-12-16 | 2024-03-19 | 赛诺哈勃药业（成都）有限公司 | Heteroaryl fused ring compounds, preparation method and application thereof |
| WO2021148581A1 (en) | 2020-01-22 | 2021-07-29 | Onxeo | Novel dbait molecule and its use |
Family Cites Families (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5251911A (en) | 1992-12-09 | 1993-10-12 | Blake Carlton E | Safety construction for passenger vehicle |
| WO1998014450A1 (en) | 1996-10-02 | 1998-04-09 | Novartis Ag | Pyrimidine derivatives and processes for the preparation thereof |
| PL224879B1 (en) * | 2002-09-04 | 2017-02-28 | Pharmacopeia Drug Discovery Inc | Pyrazolopyrimidines as cyclin-dependent kinase inhibitors |
| US7329662B2 (en) * | 2003-10-03 | 2008-02-12 | Hoffmann-La Roche Inc. | Pyrazolo-pyridine |
| EP2168968B1 (en) | 2004-04-02 | 2017-08-23 | OSI Pharmaceuticals, LLC | 6,6-bicyclic ring substituted heterobicyclic protein kinase inhibitors |
| CA2563699C (en) | 2004-04-23 | 2014-03-25 | Exelixis, Inc. | Kinase modulators and method of use |
| WO2009032694A1 (en) | 2007-08-28 | 2009-03-12 | Dana Farber Cancer Institute | Amino substituted pyrimidine, pyrollopyridine and pyrazolopyrimidine derivatives useful as kinase inhibitors and in treating proliferative disorders and diseases associated with angiogenesis |
| TWI577680B (en) | 2008-10-22 | 2017-04-11 | 亞雷生物製藥股份有限公司 | Substituted pyrazolo[1,5-a]pyrimidine compounds as trk kinase inhibitors |
| AR077468A1 (en) * | 2009-07-09 | 2011-08-31 | Array Biopharma Inc | PIRAZOLO COMPOUNDS (1,5-A) PYRIMIDINE SUBSTITUTED AS TRK-QUINASA INHIBITORS |
| JP2013525481A (en) | 2010-05-05 | 2013-06-20 | バーテックス ファーマシューティカルズ インコーポレイテッド | Tetrasubstituted pyrazolopyrimidines useful as PKC-θ inhibitors |
| UY33597A (en) * | 2010-09-09 | 2012-04-30 | Irm Llc | COMPOUNDS AND COMPOSITIONS AS INHIBITORS OF THE TRK |
| WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
| CN102241678B (en) * | 2011-04-26 | 2014-10-29 | 辽宁利锋科技开发有限公司 | Antitumor effect and application of alicyclic structure-containing compound |
| NZ703495A (en) | 2012-07-11 | 2018-02-23 | Blueprint Medicines Corp | Inhibitors of the fibroblast growth factor receptor |
| JP6223451B2 (en) | 2012-08-31 | 2017-11-01 | ザ リージェンツ オブ ザ ユニヴァーシティ オブ コロラド，ア ボディ コーポレイト | Cancer diagnosis and treatment methods |
| MX2015004151A (en) * | 2012-10-05 | 2015-07-06 | Rigel Pharmaceuticals Inc | Gdf-8 inhibitors. |
| AU2013337277B2 (en) * | 2012-11-05 | 2018-03-08 | Foundation Medicine, Inc. | Novel NTRK1 fusion molecules and uses thereof |
| TWI629266B (en) | 2012-12-28 | 2018-07-11 | 藍印藥品公司 | Inhibitors of the fibroblast growth factor receptor |
| WO2014118226A1 (en) | 2013-02-01 | 2014-08-07 | Bayer Pharma Aktiengesellschaft | Substituted pyrazolopyrimidinylamino-indazoles |
| CN103965199B (en) | 2013-02-02 | 2017-07-07 | 广东东阳光药业有限公司 | A kind of heteroaromatic compounds, the medical composition and its use comprising it |
| SG11201505493QA (en) * | 2013-02-21 | 2015-08-28 | Calitor Sciences Llc | Heteroaromatic compounds as pi3 kinase modulators |
| US20140275092A1 (en) * | 2013-03-13 | 2014-09-18 | Constellation Pharmaceuticals, Inc. | Pyrazolo compounds and uses thereof |
| WO2014160521A1 (en) | 2013-03-15 | 2014-10-02 | Blueprint Medicines Corporation | Piperazine derivatives and their use as kit modulators |
| GB2515785A (en) | 2013-07-03 | 2015-01-07 | Redx Pharma Ltd | Compounds |
| EP3409674B1 (en) | 2013-10-17 | 2022-04-06 | Blueprint Medicines Corporation | Process for preparing compositions useful for treating disorders related to kit |
| US9334263B2 (en) | 2013-10-17 | 2016-05-10 | Blueprint Medicines Corporation | Compositions useful for treating disorders related to kit |
| WO2015061572A1 (en) | 2013-10-25 | 2015-04-30 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor |
| WO2015108328A1 (en) * | 2014-01-14 | 2015-07-23 | 주식회사 엘지생명과학 | Novel ntrk1 fusion gene as colorectal cancer marker and use thereof |
| WO2015108992A1 (en) | 2014-01-15 | 2015-07-23 | Blueprint Medicines Corporation | Heterobicyclic compounds and their use as fgfr4 receptor inhibitors |
| WO2015157093A1 (en) * | 2014-04-08 | 2015-10-15 | Rigel Pharmaceuticals, Inc. | 2,3-disubstituted pyridine compounds as tgf-beta inhibitors and methods of use |
| WO2016022569A1 (en) | 2014-08-04 | 2016-02-11 | Blueprint Medicines Corporation | Compositions useful for treating disorders related to kit |
| KR20240055170A (en) | 2014-12-15 | 2024-04-26 | 주식회사 씨엠지제약 | Fused ring heteroaryl compounds and their use as trk inhibitors |
| US10202365B2 (en) | 2015-02-06 | 2019-02-12 | Blueprint Medicines Corporation | 2-(pyridin-3-yl)-pyrimidine derivatives as RET inhibitors |
| JP6800158B2 (en) | 2015-02-20 | 2020-12-16 | ライジェル ファーマシューティカルズ， インコーポレイテッド | GDF-8 inhibitor |
| KR20180048635A (en) | 2015-07-24 | 2018-05-10 | 블루프린트 메디신즈 코포레이션 | Compositions useful for treating disorders related to KIT and PDGFR |
| BR112018003588A2 (en) | 2015-08-26 | 2018-09-25 | Blueprint Medicines Corp | compounds and compositions useful for treating ntrk-related disorders |
| NZ742351A (en) | 2015-11-02 | 2023-03-31 | Blueprint Medicines Corp | Inhibitors of ret |
| CN108431008A (en) | 2015-11-19 | 2018-08-21 | 蓝图药品公司 | It can be used for treating the compound and composition with the relevant illnesss of NTRK |
| US10183928B2 (en) | 2016-03-17 | 2019-01-22 | Blueprint Medicines Corporation | Inhibitors of RET |
| JP7017521B2 (en) | 2016-04-15 | 2022-02-08 | ブループリント メディシンズ コーポレイション | Inhibitor of activin receptor-like kinase |
| US10227329B2 (en) | 2016-07-22 | 2019-03-12 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to RET |
| US10035789B2 (en) | 2016-07-27 | 2018-07-31 | Blueprint Medicines Corporation | Compounds useful for treating disorders related to RET |
| US20190192522A1 (en) | 2016-09-08 | 2019-06-27 | Blueprint Medicines Corporation | Inhibitors of the fibroblast growth factor receptor 4 in combination with cyclin-dependent kinase inhibitors |
| CN107844168B (en) | 2017-11-23 | 2020-12-01 | 英业达科技有限公司 | Mainboard assembly and fastening device thereof |
-
2016
- 2016-11-18 CN CN201680077637.8A patent/CN108431008A/en active Pending
- 2016-11-18 MX MX2018006195A patent/MX2018006195A/en unknown
- 2016-11-18 RU RU2018122089A patent/RU2018122089A/en not_active Application Discontinuation
- 2016-11-18 SG SG10201912607SA patent/SG10201912607SA/en unknown
- 2016-11-18 BR BR112018010024A patent/BR112018010024A8/en not_active IP Right Cessation
- 2016-11-18 EP EP16808868.0A patent/EP3377497A1/en not_active Withdrawn
- 2016-11-18 WO PCT/US2016/062731 patent/WO2017087778A1/en active Application Filing
- 2016-11-18 KR KR1020187016321A patent/KR20180081790A/en unknown
- 2016-11-18 AR ARP160103546A patent/AR106756A1/en unknown
- 2016-11-18 US US15/355,425 patent/US10370379B2/en active Active
- 2016-11-18 CA CA3005741A patent/CA3005741A1/en not_active Abandoned
- 2016-11-18 AU AU2016355196A patent/AU2016355196A1/en not_active Abandoned
- 2016-11-18 TW TW105137936A patent/TWI733713B/en not_active IP Right Cessation
- 2016-11-18 SG SG11201803920TA patent/SG11201803920TA/en unknown
- 2016-11-18 JP JP2018525688A patent/JP2019500328A/en not_active Ceased
-
2018
- 2018-05-06 IL IL259164A patent/IL259164A/en unknown
- 2018-05-17 PH PH12018501065A patent/PH12018501065A1/en unknown
- 2018-05-28 ZA ZA2018/03530A patent/ZA201803530B/en unknown
-
2019
- 2019-02-01 HK HK19101858.8A patent/HK1259453A1/en unknown
- 2019-07-31 US US16/527,773 patent/US11059827B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| TW201720826A (en) | 2017-06-16 |
| PH12018501065A1 (en) | 2019-01-28 |
| AR106756A1 (en) | 2018-02-14 |
| BR112018010024A2 (en) | 2018-11-21 |
| CA3005741A1 (en) | 2017-05-26 |
| WO2017087778A1 (en) | 2017-05-26 |
| TWI733713B (en) | 2021-07-21 |
| CN108431008A (en) | 2018-08-21 |
| US10370379B2 (en) | 2019-08-06 |
| JP2019500328A (en) | 2019-01-10 |
| ZA201803530B (en) | 2021-08-25 |
| AU2016355196A1 (en) | 2018-06-21 |
| KR20180081790A (en) | 2018-07-17 |
| SG11201803920TA (en) | 2018-06-28 |
| US20190382410A1 (en) | 2019-12-19 |
| BR112018010024A8 (en) | 2019-02-26 |
| IL259164A (en) | 2018-06-28 |
| EP3377497A1 (en) | 2018-09-26 |
| US20170145018A1 (en) | 2017-05-25 |
| HK1259453A1 (en) | 2019-11-29 |
| US11059827B2 (en) | 2021-07-13 |
| RU2018122089A (en) | 2019-12-25 |
| MX2018006195A (en) | 2018-09-05 |
| RU2018122089A3 (en) | 2019-12-30 |
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