BR112018009105A8 - método para detectar anomalia cromossómica em embrião usando cultura de blastocisto - Google Patents

método para detectar anomalia cromossómica em embrião usando cultura de blastocisto

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BR112018009105A8
BR112018009105A8 BR112018009105A BR112018009105A BR112018009105A8 BR 112018009105 A8 BR112018009105 A8 BR 112018009105A8 BR 112018009105 A BR112018009105 A BR 112018009105A BR 112018009105 A BR112018009105 A BR 112018009105A BR 112018009105 A8 BR112018009105 A8 BR 112018009105A8
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embryo
blastocyst culture
chromosomal abnormality
culture
blastocyst
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BR112018009105A
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BR112018009105A2 (pt
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Yao Bing
Cai Liyi
Lu Sijia
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Xukang Medical Science & Tech Suzhou Co Ltd
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Publication of BR112018009105A2 publication Critical patent/BR112018009105A2/pt
Publication of BR112018009105A8 publication Critical patent/BR112018009105A8/pt

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Abstract

um método fornecido é para detectar uma anormalia cromossômica em um embrião usando cultura de blastocisto. o método compreende: detectar dna livre de células embrionárias circulantes em cultura in vitro embrionária inicial, isto é, cultura de blastocisto, realizando amplificação uniforme completa do genoma em dna traço, e então usando um método, como sequenciamento de próxima geração, para realizar análises no produto de dna amplificado, de modo a determinar uma condição cromossômica de um embrião, ou seja, se ocorre aneuploidia ou aneuploidia parcial de cormossomas.
BR112018009105A 2015-11-05 2016-11-04 método para detectar anomalia cromossómica em embrião usando cultura de blastocisto BR112018009105A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN201510746098.XA CN105368936B (zh) 2015-11-05 2015-11-05 一种利用囊胚培养液检测胚胎染色体异常的方法
PCT/CN2016/104753 WO2017076359A1 (zh) 2015-11-05 2016-11-04 一种利用囊胚培养液检测胚胎染色体异常的方法

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BR112018009105A2 BR112018009105A2 (pt) 2018-11-06
BR112018009105A8 true BR112018009105A8 (pt) 2019-02-26

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BR112018009105A BR112018009105A8 (pt) 2015-11-05 2016-11-04 método para detectar anomalia cromossómica em embrião usando cultura de blastocisto

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US (1) US20180327821A1 (pt)
EP (1) EP3372690A4 (pt)
JP (2) JP2019506873A (pt)
KR (2) KR20200118221A (pt)
CN (2) CN105368936B (pt)
AU (2) AU2016351034B2 (pt)
BR (1) BR112018009105A8 (pt)
TW (1) TWI622651B (pt)
WO (1) WO2017076359A1 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105368936B (zh) * 2015-11-05 2021-07-30 序康医疗科技（苏州）有限公司 一种利用囊胚培养液检测胚胎染色体异常的方法
CN111621548A (zh) * 2016-04-26 2020-09-04 序康医疗科技（苏州）有限公司 扩增dna的方法
CN106086199A (zh) * 2016-07-05 2016-11-09 上海序康医疗科技有限公司 一种利用不含透明带的囊胚培养液检测胚胎染色体异常的方法
CN107190101A (zh) * 2017-08-01 2017-09-22 安诺优达基因科技(北京)有限公司 一种用于胚胎植入前染色体异常检测的方法及试剂盒
CN107760773A (zh) * 2017-10-26 2018-03-06 北京中仪康卫医疗器械有限公司 一种对胚胎培养液进行scRRBS分析的方法
CN110317862A (zh) * 2018-03-28 2019-10-11 顶探科技(北京)有限公司 一种利用哺乳动物胚胎培养液检测小rna的方法
WO2020061637A1 (en) * 2018-09-27 2020-04-02 Monash Ivf Group Limited Dna from cell-free medium
CN109402238A (zh) * 2018-12-19 2019-03-01 广州海思医疗科技有限公司 用于血液、口腔拭子进行pcr的裂解液及试剂盒
CN109628566A (zh) * 2018-12-28 2019-04-16 北京中仪康卫医疗器械有限公司 利用RAD-seq对胚胎进行PGS分析的方法
CN109536581B (zh) * 2018-12-29 2022-02-01 序康医疗科技（苏州）有限公司 一种利用囊胚培养液检测胚胎健康状况的方法和产品
CN109609445A (zh) * 2019-01-07 2019-04-12 安徽农业大学 一种囊胚中单个卵裂球的分离方法
CN109629009B (zh) * 2019-01-10 2022-02-22 北京中科遗传与生殖医学研究院有限责任公司 一种基于RAD-seq对胚胎进行无创PGS的方法
CN110964690A (zh) * 2019-01-16 2020-04-07 北京大学深圳医院 辅助生殖技术实施过程中防止配子错配的方法
CN112094840A (zh) * 2019-06-17 2020-12-18 南京尧顺禹生物科技有限公司 一种用于基因组片段扩增的微量动物样品基因组dna模板的快速制备方法
CN110283904A (zh) * 2019-07-31 2019-09-27 阿吉安(福州)基因医学检验实验室有限公司 同时进行pgt-a和pgt-m的检测方法及其试剂盒
CN110423801A (zh) * 2019-09-06 2019-11-08 北京协和洛克生物技术有限责任公司 Mthfr和mtrr基因多态性检测引物、探针、试剂盒及应用
CN110669724A (zh) * 2019-11-08 2020-01-10 广州达瑞生殖技术有限公司 一种囊胚培养液及其制备方法
CN111172259A (zh) * 2020-03-09 2020-05-19 云南省第一人民医院 一种胚胎培养液的卵裂球期的胚胎染色体检测方法
CN111440857B (zh) * 2020-03-11 2023-03-21 阿吉安(福州)基因医学检验实验室有限公司 用于无创胚胎植入前遗传性检测的方法
CN112582022B (zh) * 2020-07-21 2021-11-23 序康医疗科技（苏州）有限公司 用于无创胚胎移植优先级评级的系统和方法
CN112592886A (zh) * 2021-01-04 2021-04-02 首都医科大学附属北京朝阳医院 一种收集ivf-et患者胚胎培养液的方法及其应用
KR102310223B1 (ko) * 2021-07-21 2021-10-08 주식회사 에이아이더뉴트리진 랩온페이퍼칩을 포함하는 구조물에 적용하기 위한 세포용해용 조성물
CN113957131B (zh) * 2021-10-17 2024-03-19 合肥金域医学检验实验室有限公司 一种废旧芯片重新处理再利用的方法
CN116103280B (zh) * 2022-12-28 2024-03-15 上海亿康医学检验所有限公司 样本保存液及其在染色体非整倍体筛查和/或转录组检测中的应用
CN117721222B (zh) * 2024-02-07 2024-05-10 北京大学第三医院（北京大学第三临床医学院） 一种单细胞转录组预测胚胎着床的方法及应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010044937A1 (en) * 1999-12-17 2001-11-22 Gerald Schatten Methods for producing transgenic animals
JP2006087394A (ja) * 2004-09-27 2006-04-06 Wako Pure Chem Ind Ltd 核酸抽出方法および核酸抽出キット
JP2008017851A (ja) * 2007-09-10 2008-01-31 Toyobo Co Ltd Ｄｎａ合成反応を促進する添加剤
WO2012166425A2 (en) * 2011-05-27 2012-12-06 President And Fellows Of Harvard College Methods of amplifying whole genome of a single cell
AT512417A1 (de) * 2012-02-10 2013-08-15 Ivf Zentren Prof Zech Bregenz Gmbh Verfahren zur analyse fetaler nukleinsäuren
EP4036250A1 (en) * 2013-06-18 2022-08-03 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods for determining the quality of an embryo
GB201319779D0 (en) * 2013-11-08 2013-12-25 Cartagenia N V Genetic analysis method
ES2796224T3 (es) * 2014-01-30 2020-11-26 Pecsi Tudomanyegyetem Evaluación de embriones previa a la implantación a través de la detección de ADN embrionario libre
CN105368936B (zh) * 2015-11-05 2021-07-30 序康医疗科技（苏州）有限公司 一种利用囊胚培养液检测胚胎染色体异常的方法

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