BR112018008546A2 - métodos para detecção de tamanho de ácido nucleico de sequências de repetição - Google Patents
métodos para detecção de tamanho de ácido nucleico de sequências de repetiçãoInfo
- Publication number
- BR112018008546A2 BR112018008546A2 BR112018008546A BR112018008546A BR112018008546A2 BR 112018008546 A2 BR112018008546 A2 BR 112018008546A2 BR 112018008546 A BR112018008546 A BR 112018008546A BR 112018008546 A BR112018008546 A BR 112018008546A BR 112018008546 A2 BR112018008546 A2 BR 112018008546A2
- Authority
- BR
- Brazil
- Prior art keywords
- nucleic acid
- methods
- repeat sequences
- detecting nucleic
- acid size
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 108020004707 nucleic acids Proteins 0.000 title abstract 4
- 150000007523 nucleic acids Chemical class 0.000 title abstract 4
- 102000039446 nucleic acids Human genes 0.000 title abstract 4
- 108091081062 Repeated sequence (DNA) Proteins 0.000 title 1
- 230000003321 amplification Effects 0.000 abstract 1
- 238000004458 analytical method Methods 0.000 abstract 1
- 238000003199 nucleic acid amplification method Methods 0.000 abstract 1
- 238000004513 sizing Methods 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6858—Allele-specific amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6851—Quantitative amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2525/00—Reactions involving modified oligonucleotides, nucleic acids, or nucleotides
- C12Q2525/10—Modifications characterised by
- C12Q2525/151—Modifications characterised by repeat or repeated sequences, e.g. VNTR, microsatellite, concatemer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2545/00—Reactions characterised by their quantitative nature
- C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
- C12Q2545/101—Reactions characterised by their quantitative nature the purpose being quantitative analysis with an internal standard/control
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2545/00—Reactions characterised by their quantitative nature
- C12Q2545/10—Reactions characterised by their quantitative nature the purpose being quantitative analysis
- C12Q2545/113—Reactions characterised by their quantitative nature the purpose being quantitative analysis with an external standard/control, i.e. control reaction is separated from the test/target reaction
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/10—Detection mode being characterised by the assay principle
- C12Q2565/125—Electrophoretic separation
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
são aqui descritos sistemas e dispositivos de anotação de cálculo e processamento de dados, e métodos correspondentes, para análise de ácido nucleico. em particular, são aqui descritos métodos para dimensionamento de uma região de repetição de uma amostra de ácido nucleico. por exemplo, os métodos descritos neste documento utilizam uma escala de produtos de amplificação para determinar o tamanho do ácido nucleico.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562250476P | 2015-11-03 | 2015-11-03 | |
PCT/US2016/060389 WO2017079478A1 (en) | 2015-11-03 | 2016-11-03 | Methods for nucleic acid size detection of repeat sequences |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112018008546A2 true BR112018008546A2 (pt) | 2018-10-30 |
Family
ID=58635460
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112018008546A BR112018008546A2 (pt) | 2015-11-03 | 2016-11-03 | métodos para detecção de tamanho de ácido nucleico de sequências de repetição |
Country Status (10)
Country | Link |
---|---|
US (2) | US20170121763A1 (pt) |
EP (1) | EP3371330A4 (pt) |
JP (1) | JP7003035B2 (pt) |
KR (1) | KR20180064544A (pt) |
CN (1) | CN108431236B (pt) |
AU (1) | AU2016349391B2 (pt) |
BR (1) | BR112018008546A2 (pt) |
CA (1) | CA3002088A1 (pt) |
IL (1) | IL258727B2 (pt) |
WO (1) | WO2017079478A1 (pt) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9355167B2 (en) * | 2012-05-18 | 2016-05-31 | California Institute Of Technology | Systems and methods for the distributed categorization of source data |
US11449788B2 (en) | 2017-03-17 | 2022-09-20 | California Institute Of Technology | Systems and methods for online annotation of source data using skill estimation |
WO2021155114A1 (en) * | 2020-01-30 | 2021-08-05 | Laboratory Corporation Of America Holdings | Fragile x syndrome agg interruption genotyping |
CA3191872A1 (en) * | 2020-08-15 | 2022-02-24 | Life Technologies Corporation | Dna analyzer with synthetic allelic ladder library |
WO2024010875A1 (en) * | 2022-07-06 | 2024-01-11 | The Regents Of The University Of California | Repeat-aware profiling of cell-free rna |
CN118136119B (zh) * | 2024-04-30 | 2024-08-06 | 宁波海尔施基因科技股份有限公司 | 一种用于Sanger测序的毛细管电泳迁移率校正方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5853995A (en) * | 1997-01-07 | 1998-12-29 | Research Development Foundation | Large scale genotyping of diseases and a diagnostic test for spinocerebellar ataxia type 6 |
CA2453360A1 (en) * | 2001-07-11 | 2003-01-23 | Applera Corporation | Internal calibration standards for electrophoretic analyses |
US8409805B2 (en) | 2009-02-13 | 2013-04-02 | Asuragen, Inc. | Method of amplification of GC-rich DNA templates |
AU2010229334B2 (en) | 2009-03-24 | 2015-08-20 | Asuragen, Inc. | PCR methods for characterizing the 5' untranslated region of the FMR1 and FMR2 genes |
BR112013010585B1 (pt) | 2010-10-29 | 2020-12-01 | Asuragen, Inc. | método de caracterização de um locus de fmr1 ou um locus de frm2 em uma amostra de dna e método de análise de um locus fmr1 ou um locus fmr2 de uma amostra de dna humana |
WO2014015273A1 (en) | 2012-07-20 | 2014-01-23 | Asuragen, Inc. | Comprehensive fmr1 genotyping |
US10497463B2 (en) | 2013-11-13 | 2019-12-03 | Myriad Women's Health, Inc. | Automated nucleic acid repeat count calling methods |
-
2016
- 2016-11-03 CN CN201680074751.5A patent/CN108431236B/zh active Active
- 2016-11-03 EP EP16862998.8A patent/EP3371330A4/en active Pending
- 2016-11-03 IL IL258727A patent/IL258727B2/en unknown
- 2016-11-03 BR BR112018008546A patent/BR112018008546A2/pt active Search and Examination
- 2016-11-03 WO PCT/US2016/060389 patent/WO2017079478A1/en active Application Filing
- 2016-11-03 JP JP2018522783A patent/JP7003035B2/ja active Active
- 2016-11-03 KR KR1020187015047A patent/KR20180064544A/ko not_active Application Discontinuation
- 2016-11-03 CA CA3002088A patent/CA3002088A1/en active Pending
- 2016-11-03 US US15/343,057 patent/US20170121763A1/en not_active Abandoned
- 2016-11-03 AU AU2016349391A patent/AU2016349391B2/en active Active
-
2019
- 2019-08-23 US US16/549,684 patent/US11913068B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
WO2017079478A1 (en) | 2017-05-11 |
US20170121763A1 (en) | 2017-05-04 |
CN108431236A (zh) | 2018-08-21 |
AU2016349391B2 (en) | 2022-12-08 |
AU2016349391A1 (en) | 2018-05-10 |
IL258727A (en) | 2018-06-28 |
IL258727B1 (en) | 2023-09-01 |
KR20180064544A (ko) | 2018-06-14 |
IL258727B2 (en) | 2024-01-01 |
US11913068B2 (en) | 2024-02-27 |
CN108431236B (zh) | 2022-11-15 |
EP3371330A1 (en) | 2018-09-12 |
CA3002088A1 (en) | 2017-05-11 |
JP2019502367A (ja) | 2019-01-31 |
US20200048696A1 (en) | 2020-02-13 |
JP7003035B2 (ja) | 2022-02-10 |
EP3371330A4 (en) | 2019-06-26 |
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B09A | Decision: intention to grant [chapter 9.1 patent gazette] |