BR112017022045A2 - composição e kits para matrizes de microgel pseudoplástico - Google Patents
composição e kits para matrizes de microgel pseudoplásticoInfo
- Publication number
- BR112017022045A2 BR112017022045A2 BR112017022045A BR112017022045A BR112017022045A2 BR 112017022045 A2 BR112017022045 A2 BR 112017022045A2 BR 112017022045 A BR112017022045 A BR 112017022045A BR 112017022045 A BR112017022045 A BR 112017022045A BR 112017022045 A2 BR112017022045 A2 BR 112017022045A2
- Authority
- BR
- Brazil
- Prior art keywords
- microgel
- pseudoplastic
- kits
- arrays
- composition
- Prior art date
Links
- 238000003491 array Methods 0.000 title 1
- 239000002245 particle Substances 0.000 abstract 4
- 239000012736 aqueous medium Substances 0.000 abstract 1
- 230000010261 cell growth Effects 0.000 abstract 1
- 230000004663 cell proliferation Effects 0.000 abstract 1
- 230000003833 cell viability Effects 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 229920002521 macromolecule Polymers 0.000 abstract 1
- 239000011159 matrix material Substances 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
Classifications
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/225—Fibrin; Fibrinogen
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
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- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/24—Collagen
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/26—Mixtures of macromolecular compounds
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- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/362—Skin, e.g. dermal papillae
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- A—HUMAN NECESSITIES
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- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3625—Vascular tissue, e.g. heart valves
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3633—Extracellular matrix [ECM]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
- A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
- A61L27/3834—Cells able to produce different cell types, e.g. hematopoietic stem cells, mesenchymal stem cells, marrow stromal cells, embryonic stem cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/404—Biocides, antimicrobial agents, antiseptic agents
- A61L2300/406—Antibiotics
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- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/06—Flowable or injectable implant compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/12—Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/34—Materials or treatment for tissue regeneration for soft tissue reconstruction
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Botany (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Biophysics (AREA)
- Developmental Biology & Embryology (AREA)
- Hematology (AREA)
- Dispersion Chemistry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Preparation (AREA)
- Materials For Medical Uses (AREA)
- Polymers & Plastics (AREA)
- Peptides Or Proteins (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Abstract
essa invenção se refere, de modo geral, as partículas de microgel peguiladas, reticuladas, deformáveis e intumescíveis em água porém insolúveis em água e as macromoléculas com base em proteína que são pseudoplásticas (desbaste de cisalhamento) e fluem no meio aquoso sob cisalhamento e que podem ser injetadas ou tornadas fluidas, em que as partículas de microgel podem ser reformadas em um grupo de partículas de microgel quando o cisalhamento é removido. as partículas de microgel funcionam como uma matriz para sustentar o crescimento da célula, viabilidade e proliferação.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14/689,625 US20160303281A1 (en) | 2015-04-17 | 2015-04-17 | Composition and kits for pseudoplastic microgel matrices |
US14/689,625 | 2015-04-17 | ||
PCT/US2016/027131 WO2016168196A1 (en) | 2015-04-17 | 2016-04-12 | Composition and kits for pseudoplastic microgel matrices |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112017022045A2 true BR112017022045A2 (pt) | 2018-07-03 |
BR112017022045B1 BR112017022045B1 (pt) | 2023-11-28 |
Family
ID=57126813
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112017022045-8A BR112017022045B1 (pt) | 2015-04-17 | 2016-04-12 | Composição para matrizes de microgel pseudoplástico |
Country Status (14)
Country | Link |
---|---|
US (2) | US20160303281A1 (pt) |
EP (1) | EP3283057B1 (pt) |
JP (1) | JP6930733B2 (pt) |
KR (1) | KR102592242B1 (pt) |
CN (1) | CN107708675B (pt) |
AU (1) | AU2016250012B2 (pt) |
BR (1) | BR112017022045B1 (pt) |
CA (1) | CA2982352A1 (pt) |
DK (1) | DK3283057T3 (pt) |
ES (1) | ES2895947T3 (pt) |
HK (1) | HK1245663A1 (pt) |
MX (1) | MX2017013002A (pt) |
PT (1) | PT3283057T (pt) |
WO (1) | WO2016168196A1 (pt) |
Families Citing this family (51)
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IL282559B (en) | 2014-07-17 | 2022-07-01 | Univ California | Self-reinforced and controllable microgel particles for biomedical applications |
WO2017142879A1 (en) | 2016-02-16 | 2017-08-24 | The Regents Of The University Of California | Methods for immune system modulation with microporous annealed particle gels |
EP3562523A4 (en) * | 2016-12-29 | 2020-09-30 | Tempo Therapeutics, Inc. | PROCESSES AND SYSTEMS FOR THE TREATMENT OF A MEDICAL IMPLANT SITE |
IT201700087978A1 (it) * | 2017-07-31 | 2019-01-31 | Univ Degli Studi Genova | Scaffold di idrogel tridimensionale per colture cellulari e metodo per la sua produzione |
KR102172222B1 (ko) * | 2017-12-29 | 2020-10-30 | 서울대학교산학협력단 | 단백질 약물 전달용 광가교 마이크로젤 및 그의 제조 방법 |
CN111886031B (zh) * | 2018-01-10 | 2022-10-14 | G2G生物公司 | 含胶原蛋白肽的聚己内酯微球填充物及其制备方法 |
US20190240335A1 (en) * | 2018-02-07 | 2019-08-08 | Promedon S.A. | Biocompatible Hydrogel Compositions |
CN110193094A (zh) * | 2018-02-24 | 2019-09-03 | 上海优先生物医学工程有限公司 | 一种软组织填充修复材料及其制备方法和用途 |
US10335421B1 (en) | 2018-02-26 | 2019-07-02 | Aisha Chaudhry | Topical wound care formulation |
KR102090576B1 (ko) * | 2018-02-26 | 2020-03-18 | 주식회사 엔도비전 | 상처치료용 다층 드레싱재 |
CN108653196A (zh) * | 2018-04-11 | 2018-10-16 | 燕山大学 | 一种脂质体复合双响应载药水凝胶的制备方法 |
CN110402918A (zh) * | 2018-04-27 | 2019-11-05 | 庄明华 | 一种保存骨组织材料的方法 |
US20210402061A1 (en) | 2018-05-09 | 2021-12-30 | The Johns Hopkins University | Nanofiber-hydrogel composites for cell and tissue delivery |
CN108715833B (zh) * | 2018-06-01 | 2021-09-14 | 天晴干细胞股份有限公司 | 一种负载血小板裂解液的微球制备方法 |
GB201810925D0 (en) * | 2018-07-03 | 2018-08-15 | Blueberry Therapeutics Ltd | Compositions and methods of treatment |
CN109224123B (zh) * | 2018-10-11 | 2021-04-09 | 成都迪康中科生物医学材料有限公司 | 具有抑制肿瘤作用的纳米羟基磷灰石复合材料及制备方法 |
CN109298180A (zh) * | 2018-11-19 | 2019-02-01 | 中南大学 | 一种检测鼠伤寒沙门氏菌的方法 |
GB201820021D0 (en) * | 2018-12-07 | 2019-01-23 | Univ Birmingham | Ocular hydrogel compositions |
GB201820018D0 (en) * | 2018-12-07 | 2019-01-23 | Univ Birmingham | Therapeutic hydrogel compositions |
CN109481739B (zh) * | 2018-12-12 | 2021-07-30 | 四川大学华西医院 | 一种骨关节润滑剂及其制备方法 |
US11832879B2 (en) * | 2019-03-08 | 2023-12-05 | Neuwave Medical, Inc. | Systems and methods for energy delivery |
US11065188B2 (en) | 2019-05-29 | 2021-07-20 | Av Laboratories Llc | Applications and formulations of optimized, modified human embryonic fertility culture media with biguanides and/or functional equivalents |
AU2020286067A1 (en) * | 2019-05-31 | 2022-01-06 | Sumitomo Chemical Company, Limited | Liquid suspension concentrate formulation comprising mefentrifluconazole |
CN110721344B (zh) * | 2019-11-21 | 2020-12-11 | 北京帝康医药投资管理有限公司 | 一种用于促进心肌修复的可注射生物凝胶及其制备方法 |
CN110898250B (zh) * | 2019-11-28 | 2020-11-13 | 浙江大学 | 一种用于皮肤移植的自降解水凝胶粘合剂材料及其制备方法 |
US20210244846A1 (en) * | 2020-02-07 | 2021-08-12 | Nanyang Technological University | Biofunctional hydrogel for wound healing |
WO2021174008A1 (en) * | 2020-02-28 | 2021-09-02 | University Of Florida Research Foundation | Compositions, methods, kits, and systems relating to charge-neutral microgels for 3d cell culture and printing |
AU2021237731A1 (en) * | 2020-03-20 | 2022-09-29 | Bard Peripheral Vascular, Inc. | Reactive hydrogel forming formulations and related methods |
CN111840654B (zh) * | 2020-08-04 | 2021-05-25 | 李双宏 | 一种改性透明质酸复合美容整形材料的制备方法 |
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CN112708594B (zh) * | 2021-01-26 | 2022-02-25 | 中科博生生物工程有限公司 | 脐带间充质干细胞复苏培养基及其制备方法和应用 |
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JP6930733B2 (ja) | 2021-09-01 |
AU2016250012A1 (en) | 2017-11-02 |
AU2016250012B2 (en) | 2020-12-03 |
US11590259B2 (en) | 2023-02-28 |
JP2018511622A (ja) | 2018-04-26 |
HK1245663A1 (zh) | 2018-08-31 |
KR20170140274A (ko) | 2017-12-20 |
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