BR112015023398A8 - Métodos para amplificar ácidos nucléicos - Google Patents

Métodos para amplificar ácidos nucléicos

Info

Publication number
BR112015023398A8
BR112015023398A8 BR112015023398A BR112015023398A BR112015023398A8 BR 112015023398 A8 BR112015023398 A8 BR 112015023398A8 BR 112015023398 A BR112015023398 A BR 112015023398A BR 112015023398 A BR112015023398 A BR 112015023398A BR 112015023398 A8 BR112015023398 A8 BR 112015023398A8
Authority
BR
Brazil
Prior art keywords
methods
nucleic acids
amplify nucleic
compositions
amplifying nucleic
Prior art date
Application number
BR112015023398A
Other languages
English (en)
Other versions
BR112015023398A2 (pt
Inventor
Belhocine Kamila
Lee Josephine
Patel Pranav
Richardson Aaron
Tabakman Scott
Original Assignee
Theranos Inc
Theranos Ip Co Llc
Labrador Diagnostics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Theranos Inc, Theranos Ip Co Llc, Labrador Diagnostics Llc filed Critical Theranos Inc
Publication of BR112015023398A2 publication Critical patent/BR112015023398A2/pt
Publication of BR112015023398A8 publication Critical patent/BR112015023398A8/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates
    • C12P19/28—N-glycosides
    • C12P19/30—Nucleotides
    • C12P19/34—Polynucleotides, e.g. nucleic acids, oligoribonucleotides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]

Abstract

MÉTODOS PARA AMPLIFICAR ÁCIDOS NUCLÉICOS. Métodos e composições para amplificar ácidos nucléicos e geração de concatemeros são revelados. Os métodos de aplicação propiciados aqui podem ser realizados sob condições isotérmicas. Métodos e composições podem incluir reagentes tais como polimerases de ácidos nucléicos e primers.
BR112015023398A 2013-03-15 2014-03-15 Métodos para amplificar ácidos nucléicos BR112015023398A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361800606P 2013-03-15 2013-03-15
PCT/US2014/030034 WO2014145296A2 (en) 2013-03-15 2014-03-15 Nuclei acid amplification

Publications (2)

Publication Number Publication Date
BR112015023398A2 BR112015023398A2 (pt) 2017-07-18
BR112015023398A8 true BR112015023398A8 (pt) 2022-08-23

Family

ID=51538449

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015023398A BR112015023398A8 (pt) 2013-03-15 2014-03-15 Métodos para amplificar ácidos nucléicos

Country Status (13)

Country Link
US (6) US9725760B2 (pt)
EP (2) EP2971123B1 (pt)
JP (3) JP2016521120A (pt)
KR (1) KR20150132481A (pt)
CN (2) CN116334193A (pt)
AU (1) AU2014233150A1 (pt)
BR (1) BR112015023398A8 (pt)
CA (1) CA2906805A1 (pt)
ES (1) ES2881080T3 (pt)
IL (1) IL241269B (pt)
MX (1) MX365323B (pt)
SG (1) SG11201507272RA (pt)
WO (1) WO2014145296A2 (pt)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2934220C (en) 2007-10-02 2019-11-05 Theranos, Inc. Modular point-of-care devices and uses thereof
AR085087A1 (es) 2011-01-21 2013-09-11 Theranos Inc Sistemas y metodos para maximizar el uso de muestras
US8475739B2 (en) 2011-09-25 2013-07-02 Theranos, Inc. Systems and methods for fluid handling
US9664702B2 (en) 2011-09-25 2017-05-30 Theranos, Inc. Fluid handling apparatus and configurations
US20140170735A1 (en) 2011-09-25 2014-06-19 Elizabeth A. Holmes Systems and methods for multi-analysis
US8840838B2 (en) 2011-09-25 2014-09-23 Theranos, Inc. Centrifuge configurations
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US9268915B2 (en) 2011-09-25 2016-02-23 Theranos, Inc. Systems and methods for diagnosis or treatment
US10012664B2 (en) 2011-09-25 2018-07-03 Theranos Ip Company, Llc Systems and methods for fluid and component handling
US9810704B2 (en) 2013-02-18 2017-11-07 Theranos, Inc. Systems and methods for multi-analysis
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
MX365323B (es) 2013-03-15 2019-05-29 Theranos Ip Co Llc Amplificación de ácidos nucléicos.
WO2014145298A1 (en) 2013-03-15 2014-09-18 Theranos, Inc. Nucleic acid amplification
US10450595B2 (en) 2013-03-15 2019-10-22 Theranos Ip Company, Llc Nucleic acid amplification
AU2014233145A1 (en) 2013-03-15 2015-09-17 Theranos Ip Company, Llc Nucleic acid amplification
CN105683751B (zh) 2013-09-06 2020-01-17 赛拉诺斯知识产权有限责任公司 用于接收拭子的装置、系统、方法和套件
EP3042208A4 (en) 2013-09-06 2017-04-19 Theranos, Inc. Systems and methods for detecting infectious diseases
JP2017531424A (ja) 2014-09-17 2017-10-26 セラノス， インコーポレイテッドＴｈｅｒａｎｏｓ， Ｉｎｃ． ハイブリッド多元ステップ核酸増幅
US10822648B1 (en) 2016-07-29 2020-11-03 Labrador Diagnostics Llc Hybrid multi-step nucleic acid amplification
BR102018010733A2 (pt) 2018-05-25 2019-12-10 Caio Pompeia sistema de lastro baseado em uso de água e veículo híbrido compreendendo o referido sistema
WO2020028989A1 (en) * 2018-08-08 2020-02-13 Deep Genomics Incorporated Systems and methods for determining effects of therapies and genetic variation on polyadenylation site selection

Family Cites Families (110)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK171161B1 (da) 1985-03-28 1996-07-08 Hoffmann La Roche Fremgangsmåde til påvisning af forekomst eller fravær af mindst én specifik nukleinsyresekvens i en prøve eller til skelnen mellem to forskellige nukleinsyresekvenser i denne prøve
US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
WO1992001813A1 (en) 1990-07-25 1992-02-06 Syngene, Inc. Circular extension for generating multiple nucleic acid complements
JP3084733B2 (ja) 1990-09-19 2000-09-04 東洋紡績株式会社 標的核酸の増幅方法、検出方法およびそのためのキット
WO1994003624A1 (en) 1992-08-04 1994-02-17 Auerbach Jeffrey I Methods for the isothermal amplification of nucleic acid molecules
US7135312B2 (en) 1993-04-15 2006-11-14 University Of Rochester Circular DNA vectors for synthesis of RNA and DNA
US5714320A (en) 1993-04-15 1998-02-03 University Of Rochester Rolling circle synthesis of oligonucleotides and amplification of select randomized circular oligonucleotides
JPH0716094A (ja) 1993-06-15 1995-01-20 Toyobo Co Ltd Ｒｎａポリメラーゼのプロモーター配列をもつ１本鎖オリゴヌクレオチドを製造する方法
JPH0767646A (ja) 1993-08-27 1995-03-14 Toyobo Co Ltd 試料中に含まれる特定ｒｎａ配列を鋳型とする核酸配列の増幅方法
US5928905A (en) 1995-04-18 1999-07-27 Glaxo Group Limited End-complementary polymerase reaction
US5834252A (en) * 1995-04-18 1998-11-10 Glaxo Group Limited End-complementary polymerase reaction
FR2721945B1 (fr) * 1994-07-04 1996-10-18 David Fabrice Accroissement genique, un procede d'amplicication genique isotherme et ses applications
FR2726277B1 (fr) 1994-10-28 1996-12-27 Bio Merieux Oligonucleotide utilisable comme amorce dans une methode d'amplification basee sur une replication avec deplacement de brin
AT402203B (de) 1995-06-13 1997-03-25 Himmler Gottfried Dipl Ing Dr Verfahren zur transkriptionsfreien amplifizierung von nucleinsäuren
WO1997004131A1 (en) 1995-07-21 1997-02-06 Forsyth Dental Infirmary For Children Single primer amplification of polynucleotide hairpins
DK0938320T3 (da) 1996-03-26 2010-10-18 Michael S Kopreski Metode til at ud af plasma eller serum tilvejebringe ekstraheret ekstracellulært RNA for at detektere, overvåge eller vurdere cancer
EP2369007B1 (en) 1996-05-29 2015-07-29 Cornell Research Foundation, Inc. Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions
US6117635A (en) 1996-07-16 2000-09-12 Intergen Company Nucleic acid amplification oligonucleotides with molecular energy transfer labels and methods based thereon
US6054274A (en) 1997-11-12 2000-04-25 Hewlett-Packard Company Method of amplifying the signal of target nucleic acid sequence analyte
WO1999035281A1 (en) 1998-01-09 1999-07-15 University Of Utah Research Foundation Method for in vitro amplification of circular dna
US8445664B2 (en) 1998-06-24 2013-05-21 Enzo Diagnostics, Inc. Kits for amplifying and detecting nucleic acid sequences
US6743605B1 (en) 1998-06-24 2004-06-01 Enzo Life Sciences, Inc. Linear amplification of specific nucleic acid sequences
JP2002525078A (ja) 1998-09-15 2002-08-13 イェール ユニバーシティ 人工的長末端反復配列
US6235502B1 (en) 1998-09-18 2001-05-22 Molecular Staging Inc. Methods for selectively isolating DNA using rolling circle amplification
DE69937223T3 (de) 1998-11-09 2011-05-05 Eiken Kagaku K.K. Verfahren zur synthese von nukleinsäuren
AU2410500A (en) 1999-01-11 2000-08-01 President And Fellows Of Harvard College Isothermal amplification of dna
WO2000047812A1 (en) 1999-02-15 2000-08-17 Kiram Ab Process for oxygen pulping of lignocellulosic material and recovery of pulping chemicals
NZ516278A (en) 1999-06-22 2004-03-26 Invitrogen Corp Improved primers and methods for the detection and discrimination of nucleic acids
US6194179B1 (en) 1999-07-20 2001-02-27 The Rockefeller University Method for preparing polynucleotide sequences and uses thereof
CA2390309C (en) 1999-11-08 2012-09-25 Eiken Kagaku Kabushiki Kaisha Method for synthesizing the nucleic acid
AU2001244677A1 (en) * 2000-04-07 2001-10-23 Eiken Kagaku Kabushiki Kaisha Method of amplifying nucleic acid by using double-stranded nucleic acid as template
US6605451B1 (en) 2000-06-06 2003-08-12 Xtrana, Inc. Methods and devices for multiplexing amplification reactions
US7993839B2 (en) 2001-01-19 2011-08-09 General Electric Company Methods and kits for reducing non-specific nucleic acid amplification
IL141392A0 (en) 2001-02-12 2002-03-10 Gene Bio Applic Ltd Orientation-directed construction of plasmids
JP2004526442A (ja) 2001-02-27 2004-09-02 ビルコ・ビーブイビーエイ エネルギー転移プライマーを用いる環状プローブ増幅（ｃｐａ）
US6977148B2 (en) 2001-10-15 2005-12-20 Qiagen Gmbh Multiple displacement amplification
US7297485B2 (en) 2001-10-15 2007-11-20 Qiagen Gmbh Method for nucleic acid amplification that results in low amplification bias
US7399590B2 (en) 2002-02-21 2008-07-15 Asm Scientific, Inc. Recombinase polymerase amplification
ATE400663T1 (de) 2002-02-21 2008-07-15 Asm Scient Inc Rekombinase-polymerase-amplifikation
JP3867926B2 (ja) 2002-10-29 2007-01-17 独立行政法人理化学研究所 核酸の増幅法
US7955795B2 (en) 2003-06-06 2011-06-07 Qiagen Gmbh Method of whole genome amplification with reduced artifact production
US6977153B2 (en) 2002-12-31 2005-12-20 Qiagen Gmbh Rolling circle amplification of RNA
EP1590470A4 (en) 2003-02-03 2006-09-27 Ge Healthcare Bio Sciences AMPLIFICATION OF cDNA FOR THE FORMATION OF EXPRESSION PROFILES
WO2005003304A2 (en) 2003-06-20 2005-01-13 Illumina, Inc. Methods and compositions for whole genome amplification and genotyping
TWI333977B (en) 2003-09-18 2010-12-01 Symphogen As Method for linking sequences of interest
CA2540087A1 (en) 2003-09-26 2005-04-07 Circleamp, Inc. Amplification of polynucleotides by rolling circle amplification
US7282333B2 (en) 2003-10-20 2007-10-16 Promega Corporation Methods and compositions for nucleic acid analysis
JP4379087B2 (ja) 2003-11-07 2009-12-09 トヨタ自動車株式会社 ゲラニルゲラニル二リン酸合成酵素及びゲラニルゲラニオールの製造方法
WO2005059178A1 (en) 2003-12-10 2005-06-30 Bio Trove, Inc. Improved selective ligation and amplification assay
WO2005063977A1 (ja) 2003-12-25 2005-07-14 Riken 核酸の増幅法およびこれを利用した変異核酸の検出法
US8440404B2 (en) 2004-03-08 2013-05-14 Rubicon Genomics Methods and compositions for generating and amplifying DNA libraries for sensitive detection and analysis of DNA methylation
US20100075384A1 (en) 2004-03-25 2010-03-25 New England Biolabs, Inc. Helicase-dependent amplification of circular nucleic acids
JP2005333920A (ja) 2004-05-28 2005-12-08 Aisin Seiki Co Ltd 等温増幅可能な鎖置換ｄｎａポリメラーゼを用いたテンプレートｄｎａ分子の増幅方法
JP5249581B2 (ja) 2004-08-09 2013-07-31 ジェネレイション バイオテック リミテッド ライアビリティ カンパニー 核酸の単離および増幅方法
US20060194214A1 (en) 2005-02-28 2006-08-31 George Church Methods for assembly of high fidelity synthetic polynucleotides
EP2319940A1 (en) 2005-01-04 2011-05-11 Hitachi Chemical Company, Ltd. Primer generation rolling circle amplification
GB0504774D0 (en) * 2005-03-08 2005-04-13 Lingvitae As Method
WO2006119066A2 (en) 2005-04-29 2006-11-09 The J. Craig Venter Institute Amplification and cloning of single dna molecules using rolling circle amplification
EP1924704B1 (en) 2005-08-02 2011-05-25 Rubicon Genomics, Inc. Compositions and methods for processing and amplification of dna, including using multiple enzymes in a single reaction
AU2006287548A1 (en) 2005-09-06 2007-03-15 Gen-Probe Incorporated Methods, compositions and kits for isothermal amplification of nucleic acids
CN1834261A (zh) 2005-11-15 2006-09-20 北京博奥生物芯片有限责任公司 基因分型芯片及其制备方法与应用
US8137936B2 (en) 2005-11-29 2012-03-20 Macevicz Stephen C Selected amplification of polynucleotides
US7368265B2 (en) 2006-01-23 2008-05-06 Compass Genetics, Llc Selective genome amplification
GB0614825D0 (en) 2006-07-26 2006-09-06 Medical Res Council Method for amplification of ligation reactions
GB0618046D0 (en) * 2006-09-13 2006-10-25 Lingvitae As Method
US7910302B2 (en) * 2006-10-27 2011-03-22 Complete Genomics, Inc. Efficient arrays of amplified polynucleotides
CA2691360A1 (en) 2007-06-22 2008-12-31 Stephen A. Brown Specific amplification of tumor specific dna sequences
US8435741B2 (en) 2007-07-26 2013-05-07 Fujifilm Corporation Isothermal nucleic acid amplification method using surfactant
JP2009048280A (ja) 2007-08-15 2009-03-05 Nikon Corp 機構解析プログラム
CA2934220C (en) 2007-10-02 2019-11-05 Theranos, Inc. Modular point-of-care devices and uses thereof
KR101414713B1 (ko) 2007-10-11 2014-07-03 삼성전자주식회사 리가제 및 엔도뉴클레아제의 존재하에서 롤링서클 증폭에의하여 표적 핵산을 증폭하는 방법
US8420323B2 (en) 2007-11-14 2013-04-16 Fujifilm Corporation Nucleic acid amplification method
WO2009120374A2 (en) 2008-03-28 2009-10-01 Pacific Biosciences Of California, Inc. Methods and compositions for nucleic acid sample preparation
JP2011515102A (ja) 2008-03-28 2011-05-19 パシフィック バイオサイエンシーズ オブ カリフォルニア， インコーポレイテッド 核酸シーケンシング用組成物及び方法
EP3249056B1 (en) 2008-06-11 2019-04-10 GeneForm Technologies Limited Method of atp regeneration in a recombinase reaction
US7863222B2 (en) 2008-08-01 2011-01-04 Rigel Pharmaceuticals, Inc. shRNA library
EP2719774B8 (en) * 2008-11-07 2020-04-22 Adaptive Biotechnologies Corporation Methods of monitoring conditions by sequence analysis
JP5616584B2 (ja) 2009-01-09 2014-10-29 富士フイルム株式会社 核酸配列の複製方法
US8986958B2 (en) 2009-03-30 2015-03-24 Life Technologies Corporation Methods for generating target specific probes for solution based capture
GB0910302D0 (en) * 2009-06-15 2009-07-29 Lumora Ltd Nucleic acid amplification
EP2529026B1 (en) * 2010-01-25 2013-11-13 Rd Biosciences Inc. Self-folding amplification of target nucleic acid
CA2790342C (en) 2010-02-19 2019-10-01 The Ohio State University Primers and methods for nucleic acid amplification
WO2012012037A1 (en) 2010-07-19 2012-01-26 New England Biolabs, Inc. Oligonucleotide adaptors: compositions and methods of use
GB201013153D0 (en) 2010-08-04 2010-09-22 Touchlight Genetics Ltd Primer for production of closed linear DNA
CN101906488B (zh) 2010-08-09 2012-10-24 宁波大学 传染性脾肾坏死病毒的超分支滚环扩增检测方法
US10392726B2 (en) * 2010-10-08 2019-08-27 President And Fellows Of Harvard College High-throughput immune sequencing
EP2689028B1 (en) 2011-03-23 2017-08-30 Pacific Biosciences Of California, Inc. Isolation of polymerase-nucleic acid complexes and loading onto substrates
US9074204B2 (en) 2011-05-20 2015-07-07 Fluidigm Corporation Nucleic acid encoding reactions
WO2013003585A2 (en) 2011-06-29 2013-01-03 The Johns Hopkins University Enrichment of nucleic acids by complimentary capture
EP4219740A3 (en) 2011-09-06 2023-08-16 Gen-Probe Incorporated Closed nucleic acid structures
JP5299981B1 (ja) 2011-09-08 2013-09-25 独立行政法人理化学研究所 プライマーセット及びそれを用いた標的核酸配列の増幅方法並びに変異核酸の検出方法
US8435738B2 (en) 2011-09-25 2013-05-07 Theranos, Inc. Systems and methods for multi-analysis
US9619627B2 (en) 2011-09-25 2017-04-11 Theranos, Inc. Systems and methods for collecting and transmitting assay results
US9632102B2 (en) 2011-09-25 2017-04-25 Theranos, Inc. Systems and methods for multi-purpose analysis
US8380541B1 (en) 2011-09-25 2013-02-19 Theranos, Inc. Systems and methods for collecting and transmitting assay results
JP2014530358A (ja) 2011-09-25 2014-11-17 セラノス， インコーポレイテッド 多重分析のためのシステム及び方法
US9250229B2 (en) 2011-09-25 2016-02-02 Theranos, Inc. Systems and methods for multi-analysis
KR101329563B1 (ko) 2011-12-13 2013-11-15 연세대학교 산학협력단 신체 유체 채취용 디바이스
US9267168B2 (en) 2012-06-12 2016-02-23 Pacific Biosciences Of California, Inc. Methods and compositions for isolating template nucleic acids
CN104640637B (zh) 2012-07-18 2018-09-18 赛拉诺斯知识产权有限责任公司 用于小样本容量的高速小型离心机
EP2692870A1 (en) 2012-08-03 2014-02-05 Alacris Theranostics GmbH Method for nucleic acid amplification
WO2014025337A1 (en) 2012-08-06 2014-02-13 The Government Of The United States Of America As Represented By The Secretary Of The Department Of Methods and reagents for amplifying nucleic acids
US9476089B2 (en) 2012-10-18 2016-10-25 President And Fellows Of Harvard College Methods of making oligonucleotide probes
US10011862B2 (en) 2013-03-14 2018-07-03 Cornell University Method for relative quantification of changes in DNA methylation, using combined nuclease, ligation, and polymerase reactions
AU2014233145A1 (en) 2013-03-15 2015-09-17 Theranos Ip Company, Llc Nucleic acid amplification
PL2970922T3 (pl) 2013-03-15 2018-06-29 Theranos, Inc. Termostabilna ligaza łącząca tępe końce i sposoby jej wykorzystania
WO2014145298A1 (en) 2013-03-15 2014-09-18 Theranos, Inc. Nucleic acid amplification
MX365323B (es) 2013-03-15 2019-05-29 Theranos Ip Co Llc Amplificación de ácidos nucléicos.
US10450595B2 (en) 2013-03-15 2019-10-22 Theranos Ip Company, Llc Nucleic acid amplification
US9290800B2 (en) 2013-03-15 2016-03-22 Pacific Biosciences Of California, Inc. Targeted rolling circle amplification

Also Published As

Publication number Publication date
US10131939B2 (en) 2018-11-20
CN106715710A (zh) 2017-05-24
US20140295440A1 (en) 2014-10-02
CN106715710B (zh) 2022-10-25
JP2021129582A (ja) 2021-09-09
AU2014233150A1 (en) 2015-09-17
BR112015023398A2 (pt) 2017-07-18
US20190203278A1 (en) 2019-07-04
US10745745B2 (en) 2020-08-18
EP2971123A2 (en) 2016-01-20
CA2906805A1 (en) 2014-09-18
EP3943610A1 (en) 2022-01-26
MX365323B (es) 2019-05-29
US9551027B2 (en) 2017-01-24
US11649487B2 (en) 2023-05-16
EP2971123B1 (en) 2021-05-05
WO2014145296A2 (en) 2014-09-18
ES2881080T3 (es) 2021-11-26
US20180094306A1 (en) 2018-04-05
IL241269B (en) 2019-11-28
KR20150132481A (ko) 2015-11-25
EP2971123A4 (en) 2017-03-08
US20210024987A1 (en) 2021-01-28
JP2019141058A (ja) 2019-08-29
MX2015011435A (es) 2016-06-06
US11603558B2 (en) 2023-03-14
WO2014145296A3 (en) 2014-11-27
IL241269A0 (en) 2015-11-30
JP2016521120A (ja) 2016-07-21
CN116334193A (zh) 2023-06-27
US20160068895A1 (en) 2016-03-10
SG11201507272RA (en) 2015-10-29
US9725760B2 (en) 2017-08-08
US20150140567A1 (en) 2015-05-21

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