BR112016018548A2 - composto, ácido, medicamento, e, uso de um composto. - Google Patents

composto, ácido, medicamento, e, uso de um composto.

Info

Publication number
BR112016018548A2
BR112016018548A2 BR112016018548A BR112016018548A BR112016018548A2 BR 112016018548 A2 BR112016018548 A2 BR 112016018548A2 BR 112016018548 A BR112016018548 A BR 112016018548A BR 112016018548 A BR112016018548 A BR 112016018548A BR 112016018548 A2 BR112016018548 A2 BR 112016018548A2
Authority
BR
Brazil
Prior art keywords
compound
acid
medicine
prophylaxis
obesity
Prior art date
Application number
BR112016018548A
Other languages
English (en)
Inventor
Kikuchi Fumiaki
Kakegawa Keiko
Sasaki Minoru
Nishikawa Yoichi
Ikeda Zenichi
Original Assignee
Takeda Pharmaceuticals Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceuticals Co filed Critical Takeda Pharmaceuticals Co
Publication of BR112016018548A2 publication Critical patent/BR112016018548A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

composto, ácido, medicamento, e, uso de um composto são fornecidos um composto heterocíclico fundido tendo uma ação inibitória de enteropeptidase e uso do composto como um medicamento para o tratamento ou a profilaxia de obesidade, diabetes melito, etc. especificamente, são fornecidos um composto representado pela seguinte fórmula (i): em que cada símbolo é conforme aqui definido, ou um sal do mesmo, e uso do composto como um medicamento para o tratamento ou a profilaxia de obesidade, diabetes melito, etc.
BR112016018548A 2014-02-13 2015-02-12 composto, ácido, medicamento, e, uso de um composto. BR112016018548A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2014025944 2014-02-13
PCT/JP2015/000640 WO2015122188A1 (en) 2014-02-13 2015-02-12 Heterocyclic compound

Publications (1)

Publication Number Publication Date
BR112016018548A2 true BR112016018548A2 (pt) 2019-01-15

Family

ID=52589730

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112016018548A BR112016018548A2 (pt) 2014-02-13 2015-02-12 composto, ácido, medicamento, e, uso de um composto.

Country Status (22)

Country Link
US (2) US9428470B2 (pt)
EP (1) EP3105228B1 (pt)
JP (1) JP6458054B2 (pt)
KR (1) KR20160113299A (pt)
CN (1) CN106170487A (pt)
AR (1) AR099399A1 (pt)
AU (1) AU2015216439A1 (pt)
BR (1) BR112016018548A2 (pt)
CA (1) CA2939675A1 (pt)
CL (1) CL2016002023A1 (pt)
CR (1) CR20160368A (pt)
EA (1) EA201691624A1 (pt)
EC (1) ECSP16067163A (pt)
IL (1) IL247018A0 (pt)
MA (1) MA39247B1 (pt)
MX (1) MX2016010561A (pt)
PE (1) PE20161396A1 (pt)
PH (1) PH12016501614A1 (pt)
SG (1) SG11201606176YA (pt)
TW (1) TW201609677A (pt)
UY (1) UY35995A (pt)
WO (1) WO2015122188A1 (pt)

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PT3104939T (pt) 2014-02-10 2024-07-17 Fred Hutchinson Cancer Center Tratamento de ataque cardíaco e lesão isquémica com iodeto de sódio
US9346776B2 (en) 2014-02-13 2016-05-24 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
US9428470B2 (en) 2014-02-13 2016-08-30 Takeda Pharmaceutical Company Limited Heterocyclic compound
US9670210B2 (en) 2014-02-13 2017-06-06 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
WO2015123437A1 (en) 2014-02-13 2015-08-20 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
TWI720451B (zh) 2014-02-13 2021-03-01 美商英塞特控股公司 作為lsd1抑制劑之環丙胺
US9695167B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted triazolo[1,5-a]pyridines and triazolo[1,5-a]pyrazines as LSD1 inhibitors
WO2016007736A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Imidazopyrazines as lsd1 inhibitors
TWI687419B (zh) 2014-07-10 2020-03-11 美商英塞特公司 作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪
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BR112020022790A2 (pt) 2018-05-09 2021-02-02 Lg Chem, Ltd novo composto que exibe atividade inibitória de enteropeptidase
US20210403420A1 (en) * 2018-08-27 2021-12-30 Scohia Pharma, Inc. Benzoate compound
WO2020047198A1 (en) 2018-08-31 2020-03-05 Incyte Corporation Salts of an lsd1 inhibitor and processes for preparing the same
US20220281866A1 (en) 2019-07-19 2022-09-08 Janssen Pharmaceutica Nv 5,8-disubstituted-[1,2,4]triazolo[1,5-a]pyridinyl and 5,8-disubstituted-imidazo[1,2-a]pyridine derivatives useful as inhibitors of enteropeptidase
JP7327788B2 (ja) * 2019-08-06 2023-08-16 学校法人福岡大学 糖化産物生成抑制剤及び医薬組成物
JP2023500702A (ja) * 2019-11-04 2023-01-10 ファラデイ ファーマシューティカルズ， インコーポレイテッド 化学療法に関連した悪液質および心毒性の治療ならびに予防のためのヨウ化化合物の使用
WO2021166899A1 (ja) * 2020-02-17 2021-08-26 宇部興産株式会社 インクレチン様物質と組み合わせて使用するための消化管プロテアーゼ阻害剤を含む薬剤
CN111803652B (zh) * 2020-08-04 2021-09-14 南通康是美生物科技有限公司 治疗痤疮的化合物在制备治疗痤疮的药物组合物或化妆品组合物中的用途

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Also Published As

Publication number Publication date
MA39247B1 (fr) 2018-04-30
EP3105228A1 (en) 2016-12-21
CN106170487A (zh) 2016-11-30
TW201609677A (zh) 2016-03-16
MX2016010561A (es) 2016-11-16
JP6458054B2 (ja) 2019-01-23
KR20160113299A (ko) 2016-09-28
EA201691624A1 (ru) 2017-05-31
UY35995A (es) 2015-08-31
AU2015216439A1 (en) 2016-08-11
US20150225354A1 (en) 2015-08-13
EP3105228B1 (en) 2018-09-26
PE20161396A1 (es) 2017-01-10
US10023544B2 (en) 2018-07-17
WO2015122188A1 (en) 2015-08-20
SG11201606176YA (en) 2016-08-30
PH12016501614A1 (en) 2017-02-06
JP2017505823A (ja) 2017-02-23
CA2939675A1 (en) 2015-08-20
CL2016002023A1 (es) 2017-03-24
US9428470B2 (en) 2016-08-30
MA39247A1 (fr) 2017-11-30
US20160347724A1 (en) 2016-12-01
ECSP16067163A (es) 2017-10-31
CR20160368A (es) 2016-12-01
IL247018A0 (en) 2016-09-29
AR099399A1 (es) 2016-07-20

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