UY35995A - Compuesto heterocíclico - Google Patents

Compuesto heterocíclico

Info

Publication number
UY35995A
UY35995A UY0001035995A UY35995A UY35995A UY 35995 A UY35995 A UY 35995A UY 0001035995 A UY0001035995 A UY 0001035995A UY 35995 A UY35995 A UY 35995A UY 35995 A UY35995 A UY 35995A
Authority
UY
Uruguay
Prior art keywords
compound
heterocyclic compound
prophylaxis
obesity
medicament
Prior art date
Application number
UY0001035995A
Other languages
English (en)
Inventor
Nishikawa Yoichi
Sasaki Minoru
Kikuchi Fumiaki
Ikeda Zenichi
Kakegawa Keiko
Original Assignee
Takeda Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Pharmaceutical filed Critical Takeda Pharmaceutical
Publication of UY35995A publication Critical patent/UY35995A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

Se proporciona un compuesto heterocíclico fusionado que tiene una acción inhibidora de la enteropeptidasa, así como el uso del compuesto como medicamento en el tratamiento o la profilaxis de la obesidad, la diabetes mellitus, etc. De forma específic a, se proporciona un compuesto representado por la fórmula (I) que aparece a continuación: en donde cada símbolo es como se lo define en la presente, o una sal de él, así como el uso del compuesto como medicamento en el tratamiento o la profilaxis de la obesidad, la diabetes mellitus, etc.
UY0001035995A 2014-02-13 2015-02-12 Compuesto heterocíclico UY35995A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2014025944 2014-02-13

Publications (1)

Publication Number Publication Date
UY35995A true UY35995A (es) 2015-08-31

Family

ID=52589730

Family Applications (1)

Application Number Title Priority Date Filing Date
UY0001035995A UY35995A (es) 2014-02-13 2015-02-12 Compuesto heterocíclico

Country Status (22)

Country Link
US (2) US9428470B2 (es)
EP (1) EP3105228B1 (es)
JP (1) JP6458054B2 (es)
KR (1) KR20160113299A (es)
CN (1) CN106170487A (es)
AR (1) AR099399A1 (es)
AU (1) AU2015216439A1 (es)
BR (1) BR112016018548A2 (es)
CA (1) CA2939675A1 (es)
CL (1) CL2016002023A1 (es)
CR (1) CR20160368A (es)
EA (1) EA201691624A1 (es)
EC (1) ECSP16067163A (es)
IL (1) IL247018A0 (es)
MA (1) MA39247B1 (es)
MX (1) MX2016010561A (es)
PE (1) PE20161396A1 (es)
PH (1) PH12016501614A1 (es)
SG (1) SG11201606176YA (es)
TW (1) TW201609677A (es)
UY (1) UY35995A (es)
WO (1) WO2015122188A1 (es)

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LT2975023T (lt) 2013-03-13 2018-08-10 Takeda Pharmaceutical Company Limited Guanidinbenzoinės rūgšties esterio junginys
KR102304113B1 (ko) 2014-02-10 2021-09-24 프레드 헛친슨 켄서 리서치 센터 심장마비 및 허혈성 손상의 할로겐 치료
WO2015123437A1 (en) 2014-02-13 2015-08-20 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
US9428470B2 (en) 2014-02-13 2016-08-30 Takeda Pharmaceutical Company Limited Heterocyclic compound
PE20161573A1 (es) 2014-02-13 2017-01-19 Incyte Corp Ciclopropilamina como inhibidor de la lsd1
US9493450B2 (en) 2014-02-13 2016-11-15 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
US9346776B2 (en) 2014-02-13 2016-05-24 Takeda Pharmaceutical Company Limited Fused heterocyclic compound
TWI687419B (zh) 2014-07-10 2020-03-11 美商英塞特公司 作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪
US9695180B2 (en) 2014-07-10 2017-07-04 Incyte Corporation Substituted imidazo[1,2-a]pyrazines as LSD1 inhibitors
WO2016007722A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
JP2018080109A (ja) * 2015-03-16 2018-05-24 武田薬品工業株式会社 治療剤
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SG10202001219UA (en) 2015-08-12 2020-03-30 Incyte Corp Salts of an lsd1 inhibitor
CN111542511A (zh) 2017-11-02 2020-08-14 宇部兴产株式会社 蛋白分解酶的双头型抑制剂
UA126099C2 (uk) 2018-05-09 2022-08-10 ЕлДжи КЕМ, ЛТД. Сполука, яка виявляє інгібувальну активність відносно ентеропептидази
JP6773938B2 (ja) * 2018-08-27 2020-10-21 株式会社スコヒアファーマ 安息香酸エステル化合物
WO2020047198A1 (en) 2018-08-31 2020-03-05 Incyte Corporation Salts of an lsd1 inhibitor and processes for preparing the same
US12268672B2 (en) 2018-10-23 2025-04-08 Japan Science And Technology Agency PPARδ activator
WO2021013742A1 (en) 2019-07-19 2021-01-28 Janssen Pharmaceutica Nv 5,8-disubstituted-[1,2,4]triazolo[1,5-a]pyridinyl and 5,8-disubstituted-imidazo[1,2-a]pyridine derivatives useful as inhibitors of enteropeptidase
JP7327788B2 (ja) * 2019-08-06 2023-08-16 学校法人福岡大学 糖化産物生成抑制剤及び医薬組成物
CN114929246A (zh) * 2019-11-04 2022-08-19 法拉第制药公司 碘化物化合物用于治疗和预防化学疗法相关的恶病质和心脏毒性的用途
WO2021166899A1 (ja) * 2020-02-17 2021-08-26 宇部興産株式会社 インクレチン様物質と組み合わせて使用するための消化管プロテアーゼ阻害剤を含む薬剤
CN111803652B (zh) * 2020-08-04 2021-09-14 南通康是美生物科技有限公司 治疗痤疮的化合物在制备治疗痤疮的药物组合物或化妆品组合物中的用途
US12029718B2 (en) 2021-11-09 2024-07-09 Cct Sciences, Llc Process for production of essentially pure delta-9-tetrahydrocannabinol

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Also Published As

Publication number Publication date
US9428470B2 (en) 2016-08-30
JP2017505823A (ja) 2017-02-23
MA39247B1 (fr) 2018-04-30
MA39247A1 (fr) 2017-11-30
AU2015216439A1 (en) 2016-08-11
PE20161396A1 (es) 2017-01-10
CL2016002023A1 (es) 2017-03-24
KR20160113299A (ko) 2016-09-28
US10023544B2 (en) 2018-07-17
JP6458054B2 (ja) 2019-01-23
CA2939675A1 (en) 2015-08-20
CN106170487A (zh) 2016-11-30
EP3105228B1 (en) 2018-09-26
US20160347724A1 (en) 2016-12-01
TW201609677A (zh) 2016-03-16
EA201691624A1 (ru) 2017-05-31
SG11201606176YA (en) 2016-08-30
EP3105228A1 (en) 2016-12-21
AR099399A1 (es) 2016-07-20
PH12016501614A1 (en) 2017-02-06
CR20160368A (es) 2016-12-01
BR112016018548A2 (pt) 2019-01-15
US20150225354A1 (en) 2015-08-13
MX2016010561A (es) 2016-11-16
WO2015122188A1 (en) 2015-08-20
IL247018A0 (en) 2016-09-29
ECSP16067163A (es) 2017-10-31

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