MX2017006224A - Derivados heterociclicos y usos de los mismos. - Google Patents

Derivados heterociclicos y usos de los mismos.

Info

Publication number
MX2017006224A
MX2017006224A MX2017006224A MX2017006224A MX2017006224A MX 2017006224 A MX2017006224 A MX 2017006224A MX 2017006224 A MX2017006224 A MX 2017006224A MX 2017006224 A MX2017006224 A MX 2017006224A MX 2017006224 A MX2017006224 A MX 2017006224A
Authority
MX
Mexico
Prior art keywords
heterocyclic derivatives
activation
stat3 protein
stereoisomer
prevention
Prior art date
Application number
MX2017006224A
Other languages
English (en)
Inventor
Hee Park Chan
Hwi Lee Sang
Im Junhwan
Ok Lee Soon
Kim Jongmin
Seok Ko Kwang
Kim Byungho
Kong Minjung
Jo MOON Hyung
Sun KIM Mi
Original Assignee
C&C Res Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by C&C Res Lab filed Critical C&C Res Lab
Publication of MX2017006224A publication Critical patent/MX2017006224A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
    • A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/50—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D333/52—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes
    • C07D333/62—Benzo[b]thiophenes; Hydrogenated benzo[b]thiophenes with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D333/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D333/70—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Abstract

Se proporciona un derivado heterocíclico representado por la fórmula (I), o una sal o un estereoisómero farmacéuticamente aceptables del mismo, el cual tiene un efecto inhibidor sobre la activación de la proteína STAT3, y es útil para la prevención o tratamiento de enfermedades asociadas con la activación de la proteína STAT3.
MX2017006224A 2014-12-02 2015-11-30 Derivados heterociclicos y usos de los mismos. MX2017006224A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20140170860 2014-12-02
PCT/KR2015/012920 WO2016089060A2 (en) 2014-12-02 2015-11-30 Heterocyclic derivatives and use thereof

Publications (1)

Publication Number Publication Date
MX2017006224A true MX2017006224A (es) 2017-07-31

Family

ID=56092629

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2017006165A MX2017006165A (es) 2014-12-02 2015-11-30 Derivados heterociclicos y uso de los mismos.
MX2017006224A MX2017006224A (es) 2014-12-02 2015-11-30 Derivados heterociclicos y usos de los mismos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2017006165A MX2017006165A (es) 2014-12-02 2015-11-30 Derivados heterociclicos y uso de los mismos.

Country Status (16)

Country Link
US (2) US10633394B2 (es)
EP (2) EP3227270A4 (es)
JP (2) JP6648137B2 (es)
KR (3) KR20160066490A (es)
CN (2) CN107001345B (es)
AU (2) AU2015355841B2 (es)
BR (1) BR112017011316B1 (es)
CA (2) CA2966742A1 (es)
IL (1) IL252560B (es)
MX (2) MX2017006165A (es)
MY (1) MY194314A (es)
PH (1) PH12017550004B1 (es)
RU (2) RU2711502C2 (es)
SG (1) SG11201703296PA (es)
TW (2) TWI687423B (es)
WO (1) WO2016089060A2 (es)

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CN107973788B (zh) * 2018-01-09 2021-07-09 沈阳药科大学 Bbi608衍生物及其制备与用途
CN109045013A (zh) * 2018-06-20 2018-12-21 新乡医学院第附属医院 Nifuroxazide的医药新用途
US11485750B1 (en) 2019-04-05 2022-11-01 Kymera Therapeutics, Inc. STAT degraders and uses thereof
KR102426921B1 (ko) * 2019-09-24 2022-07-29 주식회사 이노보테라퓨틱스 헤테로아릴아미도피리딘올 유도체 및 이를 유효성분으로 포함하는 자가면역질환의 예방 또는 치료용 약학적 조성물
AU2020369568B2 (en) 2019-10-25 2024-03-21 Gilead Sciences, Inc. GLP-1R modulating compounds
WO2021100942A1 (ko) * 2019-11-22 2021-05-27 재단법인 한국파스퇴르연구소 항결핵 화합물인 티에노싸이아졸카박사아마이드 유도체
WO2021138694A1 (en) * 2020-01-02 2021-07-08 Accro Bioscience Inc. Heteroaryl compounds as inhibitors of programmed necrosis pathway, composition and method using the same
CN113150009B (zh) * 2020-01-07 2023-05-23 爱科诺生物医药(香港)有限公司 一类具有程序性细胞坏死通路抑制活性的杂环化合物及其应用
EP4247804A1 (en) 2020-11-20 2023-09-27 Gilead Sciences, Inc. Polyheterocyclic glp-1 r modulating compounds
CR20230495A (es) 2021-04-21 2023-11-30 Gilead Sciences Inc Compuestos moduladores del glp-ir carboxibenzimidazólicos.

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Also Published As

Publication number Publication date
MY194314A (en) 2022-11-28
PH12017550004A1 (en) 2017-10-18
PH12017550004B1 (en) 2017-10-18
CN107231802B (zh) 2021-02-12
AU2015355839B2 (en) 2020-01-16
WO2016089060A3 (en) 2016-08-25
MX2017006165A (es) 2017-07-19
EP3227271A2 (en) 2017-10-11
WO2016089060A2 (en) 2016-06-09
JP2017537110A (ja) 2017-12-14
US10023591B2 (en) 2018-07-17
BR112017011316B1 (pt) 2023-12-26
KR20160066490A (ko) 2016-06-10
EP3227270A4 (en) 2018-06-06
SG11201703296PA (en) 2017-05-30
IL252560B (en) 2021-04-29
RU2711502C2 (ru) 2020-01-17
CA2966742A1 (en) 2016-06-09
KR102534266B1 (ko) 2023-05-19
AU2015355841A1 (en) 2017-06-22
JP6648137B2 (ja) 2020-02-14
TW201629012A (zh) 2016-08-16
JP2017537111A (ja) 2017-12-14
KR20170081708A (ko) 2017-07-12
RU2017123170A3 (es) 2019-04-19
RU2734390C2 (ru) 2020-10-15
TWI687423B (zh) 2020-03-11
BR112017011316A2 (pt) 2018-01-02
AU2015355839A1 (en) 2017-05-25
CN107231802A (zh) 2017-10-03
TWI691484B (zh) 2020-04-21
CN107001345A (zh) 2017-08-01
CN107001345B (zh) 2021-03-02
US20170320889A1 (en) 2017-11-09
RU2017120973A3 (es) 2019-04-08
KR102534262B1 (ko) 2023-05-19
RU2017123170A (ru) 2019-01-09
EP3227271A4 (en) 2018-05-30
NZ731847A (en) 2021-11-26
TW201632529A (zh) 2016-09-16
EP3227270A2 (en) 2017-10-11
CA2966759A1 (en) 2016-06-09
AU2015355841B2 (en) 2019-12-19
US10633394B2 (en) 2020-04-28
IL252560A0 (en) 2017-07-31
JP6640222B2 (ja) 2020-02-05
KR20170081707A (ko) 2017-07-12
CA2966759C (en) 2024-01-23
US20190119297A1 (en) 2019-04-25
RU2017120973A (ru) 2019-01-09
BR112017011312A2 (pt) 2018-01-02

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