MA39247B1 - 2-(4-guanidinophenyl)-2-oxo-ethyle substitues inhibiteurs d'enteropeptidase utiles pour le traitement ou la prevention, par ex. L'obesite, le diabete sucre, les troubles de l'alimentation, l'hyperlipidemie, l'hypertension, l'insuffisance cardiaque - Google Patents
2-(4-guanidinophenyl)-2-oxo-ethyle substitues inhibiteurs d'enteropeptidase utiles pour le traitement ou la prevention, par ex. L'obesite, le diabete sucre, les troubles de l'alimentation, l'hyperlipidemie, l'hypertension, l'insuffisance cardiaqueInfo
- Publication number
- MA39247B1 MA39247B1 MA39247A MA39247A MA39247B1 MA 39247 B1 MA39247 B1 MA 39247B1 MA 39247 A MA39247 A MA 39247A MA 39247 A MA39247 A MA 39247A MA 39247 B1 MA39247 B1 MA 39247B1
- Authority
- MA
- Morocco
- Prior art keywords
- obesity
- treatment
- diabetes mellitus
- guanidinophenyl
- hyperlipidemia
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
- C07D261/04—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/42—Oxazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/541—Non-condensed thiazines containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Child & Adolescent Psychology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
L'invention concerne un composé hétérocyclique fusionné ayant une action inhibitrice de l'entéropeptidase et une utilisation du composé en tant que médicament pour le traitement ou la prophylaxie de l'obésité, du diabète sucré, etc.. Plus particulièrement, elle concerne un composé représenté par la formule suivante (i) : dans laquelle chaque symbole est tel que défini dans la description, ou un sel de celui-ci et l'utilisation du composé en tant que médicament pour le traitement ou la prophylaxie de l'obésité, du diabète sucré, etc..
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2014025944 | 2014-02-13 | ||
PCT/JP2015/000640 WO2015122188A1 (fr) | 2014-02-13 | 2015-02-12 | Composé hétérocyclique |
Publications (2)
Publication Number | Publication Date |
---|---|
MA39247A1 MA39247A1 (fr) | 2017-11-30 |
MA39247B1 true MA39247B1 (fr) | 2018-04-30 |
Family
ID=52589730
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA39247A MA39247B1 (fr) | 2014-02-13 | 2015-02-12 | 2-(4-guanidinophenyl)-2-oxo-ethyle substitues inhibiteurs d'enteropeptidase utiles pour le traitement ou la prevention, par ex. L'obesite, le diabete sucre, les troubles de l'alimentation, l'hyperlipidemie, l'hypertension, l'insuffisance cardiaque |
Country Status (22)
Country | Link |
---|---|
US (2) | US9428470B2 (fr) |
EP (1) | EP3105228B1 (fr) |
JP (1) | JP6458054B2 (fr) |
KR (1) | KR20160113299A (fr) |
CN (1) | CN106170487A (fr) |
AR (1) | AR099399A1 (fr) |
AU (1) | AU2015216439A1 (fr) |
BR (1) | BR112016018548A2 (fr) |
CA (1) | CA2939675A1 (fr) |
CL (1) | CL2016002023A1 (fr) |
CR (1) | CR20160368A (fr) |
EA (1) | EA201691624A1 (fr) |
EC (1) | ECSP16067163A (fr) |
IL (1) | IL247018A0 (fr) |
MA (1) | MA39247B1 (fr) |
MX (1) | MX2016010561A (fr) |
PE (1) | PE20161396A1 (fr) |
PH (1) | PH12016501614A1 (fr) |
SG (1) | SG11201606176YA (fr) |
TW (1) | TW201609677A (fr) |
UY (1) | UY35995A (fr) |
WO (1) | WO2015122188A1 (fr) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9969709B2 (en) | 2013-03-13 | 2018-05-15 | Takeda Pharmaceutical Company Limited | Guanidinobenzoic acid ester compound |
US9346776B2 (en) | 2014-02-13 | 2016-05-24 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound |
WO2015123437A1 (fr) | 2014-02-13 | 2015-08-20 | Incyte Corporation | Cyclopropylamines en tant qu'inhibiteurs de lsd1 |
US9428470B2 (en) * | 2014-02-13 | 2016-08-30 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
DK3105226T3 (da) | 2014-02-13 | 2019-10-14 | Incyte Corp | Cyclopropylaminer som lsd1-inhibitorer |
PE20161573A1 (es) | 2014-02-13 | 2017-01-19 | Incyte Corp | Ciclopropilamina como inhibidor de la lsd1 |
TW201613925A (en) | 2014-07-10 | 2016-04-16 | Incyte Corp | Imidazopyrazines as LSD1 inhibitors |
WO2016007722A1 (fr) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Triazolopyridines et triazolopyrazines utilisables comme inhibiteurs de lsd1 |
WO2016007731A1 (fr) | 2014-07-10 | 2016-01-14 | Incyte Corporation | Imidazopyridines et imidazopyrazines à utiliser en tant qu'inhibiteurs de lsd1 |
JP2018080109A (ja) * | 2015-03-16 | 2018-05-24 | 武田薬品工業株式会社 | 治療剤 |
EP3275874B1 (fr) * | 2015-03-27 | 2019-10-30 | Takeda Pharmaceutical Company Limited | Composé hétérocyclique fusionné |
CN107660205B (zh) | 2015-04-03 | 2021-08-27 | 因赛特公司 | 作为lsd1抑制剂的杂环化合物 |
CN110402244B (zh) | 2015-08-12 | 2023-02-03 | 因赛特公司 | Lsd1抑制剂的盐 |
BR112020008676A2 (pt) | 2017-11-02 | 2020-10-27 | Ube Industries, Ltd. | composto, e, composição farmacêutica. |
JOP20200282A1 (ar) | 2018-05-09 | 2020-11-08 | Lg Chemical Ltd | مركب جديد ينطوي على نشاط مثبط للإنتيروببتيداز |
TW202024028A (zh) * | 2018-08-27 | 2020-07-01 | 日商思可海雅藥品股份有限公司 | 苯甲酸酯化合物 |
US10968200B2 (en) | 2018-08-31 | 2021-04-06 | Incyte Corporation | Salts of an LSD1 inhibitor and processes for preparing the same |
WO2021013742A1 (fr) | 2019-07-19 | 2021-01-28 | Janssen Pharmaceutica Nv | Dérivés de [1,2,4]triazolo[1,5-a]pyridinyle 5,8-disubstitués et d'imidazo[1,2-a]pyridine 5,8-disubstitués utiles en tant qu'inhibiteurs de l'entéropeptidase |
JP7327788B2 (ja) * | 2019-08-06 | 2023-08-16 | 学校法人福岡大学 | 糖化産物生成抑制剤及び医薬組成物 |
EP4054593A1 (fr) * | 2019-11-04 | 2022-09-14 | Faraday Pharmaceuticals, Inc. | Utilisation de composés d'iodure pour le traitement et la prévention d'une cardiotoxicité et d'une cachexie associées à une chimiothérapie |
WO2021166899A1 (fr) * | 2020-02-17 | 2021-08-26 | 宇部興産株式会社 | Médicament contenant un inhibiteur de protéase gastrique destiné à être utilisé en association avec un mimétique d'incrétine |
CN111803652B (zh) * | 2020-08-04 | 2021-09-14 | 南通康是美生物科技有限公司 | 治疗痤疮的化合物在制备治疗痤疮的药物组合物或化妆品组合物中的用途 |
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US9428470B2 (en) | 2014-02-13 | 2016-08-30 | Takeda Pharmaceutical Company Limited | Heterocyclic compound |
PE20161573A1 (es) | 2014-02-13 | 2017-01-19 | Incyte Corp | Ciclopropilamina como inhibidor de la lsd1 |
DK3105226T3 (da) | 2014-02-13 | 2019-10-14 | Incyte Corp | Cyclopropylaminer som lsd1-inhibitorer |
US9346776B2 (en) | 2014-02-13 | 2016-05-24 | Takeda Pharmaceutical Company Limited | Fused heterocyclic compound |
-
2015
- 2015-02-11 US US14/619,464 patent/US9428470B2/en not_active Expired - Fee Related
- 2015-02-12 TW TW104104692A patent/TW201609677A/zh unknown
- 2015-02-12 US US15/117,539 patent/US10023544B2/en not_active Expired - Fee Related
- 2015-02-12 JP JP2016569124A patent/JP6458054B2/ja not_active Expired - Fee Related
- 2015-02-12 BR BR112016018548A patent/BR112016018548A2/pt not_active Application Discontinuation
- 2015-02-12 MA MA39247A patent/MA39247B1/fr unknown
- 2015-02-12 PE PE2016001481A patent/PE20161396A1/es not_active Application Discontinuation
- 2015-02-12 EA EA201691624A patent/EA201691624A1/ru unknown
- 2015-02-12 CA CA2939675A patent/CA2939675A1/fr not_active Abandoned
- 2015-02-12 AU AU2015216439A patent/AU2015216439A1/en not_active Abandoned
- 2015-02-12 EP EP15706547.5A patent/EP3105228B1/fr active Active
- 2015-02-12 CN CN201580019434.9A patent/CN106170487A/zh active Pending
- 2015-02-12 SG SG11201606176YA patent/SG11201606176YA/en unknown
- 2015-02-12 MX MX2016010561A patent/MX2016010561A/es unknown
- 2015-02-12 CR CR20160368A patent/CR20160368A/es unknown
- 2015-02-12 AR ARP150100410A patent/AR099399A1/es unknown
- 2015-02-12 WO PCT/JP2015/000640 patent/WO2015122188A1/fr active Application Filing
- 2015-02-12 KR KR1020167024873A patent/KR20160113299A/ko not_active Application Discontinuation
- 2015-02-12 UY UY0001035995A patent/UY35995A/es not_active Application Discontinuation
-
2016
- 2016-07-31 IL IL247018A patent/IL247018A0/en unknown
- 2016-08-10 CL CL2016002023A patent/CL2016002023A1/es unknown
- 2016-08-11 EC ECIEPI201667163A patent/ECSP16067163A/es unknown
- 2016-08-12 PH PH12016501614A patent/PH12016501614A1/en unknown
Also Published As
Publication number | Publication date |
---|---|
BR112016018548A2 (pt) | 2019-01-15 |
EP3105228B1 (fr) | 2018-09-26 |
US20160347724A1 (en) | 2016-12-01 |
WO2015122188A1 (fr) | 2015-08-20 |
TW201609677A (zh) | 2016-03-16 |
CR20160368A (es) | 2016-12-01 |
CN106170487A (zh) | 2016-11-30 |
AR099399A1 (es) | 2016-07-20 |
CL2016002023A1 (es) | 2017-03-24 |
PH12016501614A1 (en) | 2017-02-06 |
ECSP16067163A (es) | 2017-10-31 |
MX2016010561A (es) | 2016-11-16 |
US9428470B2 (en) | 2016-08-30 |
JP6458054B2 (ja) | 2019-01-23 |
US20150225354A1 (en) | 2015-08-13 |
IL247018A0 (en) | 2016-09-29 |
UY35995A (es) | 2015-08-31 |
AU2015216439A1 (en) | 2016-08-11 |
CA2939675A1 (fr) | 2015-08-20 |
MA39247A1 (fr) | 2017-11-30 |
EA201691624A1 (ru) | 2017-05-31 |
SG11201606176YA (en) | 2016-08-30 |
JP2017505823A (ja) | 2017-02-23 |
KR20160113299A (ko) | 2016-09-28 |
PE20161396A1 (es) | 2017-01-10 |
US10023544B2 (en) | 2018-07-17 |
EP3105228A1 (fr) | 2016-12-21 |
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