|
US2832685A
(en)
|
1952-05-24 |
1958-04-29 |
Crest Foods Co Inc |
Solubilization of milk proteins
|
|
US3528960A
(en)
|
1968-10-07 |
1970-09-15 |
Lilly Co Eli |
N-carboxyaroyl insulins
|
|
US3719655A
(en)
|
1969-12-05 |
1973-03-06 |
Lilly Co Eli |
Process for the crystallization of the ammonium and alkali metal salts in insulin
|
|
US3950517A
(en)
|
1970-05-08 |
1976-04-13 |
National Research Development Corporation |
Insulin derivatives
|
|
US3869437A
(en)
|
1970-05-08 |
1975-03-04 |
Nat Res Dev |
Mono-, di, and N{HD A1{B , N{HU B1{B , N{HU B29{B -tri-acylated insulin
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4033941A
(en)
|
1975-12-17 |
1977-07-05 |
Eli Lilly And Company |
Process for purifying glucagon
|
|
GB1492997A
(en)
|
1976-07-21 |
1977-11-23 |
Nat Res Dev |
Insulin derivatives
|
|
JPS5767548A
(en)
|
1980-10-14 |
1982-04-24 |
Shionogi & Co Ltd |
Insulin analog and its preparation
|
|
PH25772A
(en)
|
1985-08-30 |
1991-10-18 |
Novo Industri As |
Insulin analogues, process for their preparation
|
|
PH23446A
(en)
|
1986-10-20 |
1989-08-07 |
Novo Industri As |
Peptide preparations
|
|
JPH01254699A
(ja)
|
1988-04-05 |
1989-10-11 |
Kodama Kk |
インスリン誘導体及びその用途
|
|
DK257988D0
(da)
|
1988-05-11 |
1988-05-11 |
Novo Industri As |
Nye peptider
|
|
AU616205B2
(en)
|
1988-07-20 |
1991-10-24 |
Novo Nordisk A/S |
Human insulin analogs and preparations containing them
|
|
US5225323A
(en)
|
1988-11-21 |
1993-07-06 |
Baylor College Of Medicine |
Human high-affinity neurotransmitter uptake system
|
|
KR910700262A
(ko)
|
1988-12-23 |
1991-03-14 |
안네 제케르 |
사람 인슐린 유사체
|
|
US5716927A
(en)
|
1988-12-23 |
1998-02-10 |
Novo Nordisk A/S |
Insulin analogs having a modified B-chain
|
|
DE3844211A1
(de)
|
1988-12-29 |
1990-07-05 |
Hoechst Ag |
Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
|
|
ATE120762T1
(de)
|
1989-04-20 |
1995-04-15 |
Sinai School Medicine |
Hepatospezifische insulin-analoga.
|
|
CA1340994C
(en)
|
1989-09-21 |
2000-05-16 |
Rudolf Edgar Dr. Falk |
Treatment of conditions and disease
|
|
CA2027930C
(en)
|
1989-10-19 |
1998-06-30 |
Tsuyoshi Miyazaki |
Polymer complexes of a sugar response type
|
|
US5179189A
(en)
|
1990-01-19 |
1993-01-12 |
Nova Pharmaceutical Corporation |
Fatty acid terminated polyanhydrides
|
|
DK45590D0
(enExample)
|
1990-02-21 |
1990-02-21 |
Novo Nordisk As |
|
|
DK155690D0
(da)
|
1990-06-28 |
1990-06-28 |
Novo Nordisk As |
Nye peptider
|
|
DK158390D0
(da)
|
1990-07-02 |
1990-07-02 |
Novo Nordisk As |
Nye peptider
|
|
WO1992001476A1
(en)
|
1990-07-26 |
1992-02-06 |
University Of Iowa Research Foundation |
Novel drug delivery systems for proteins and peptides using albumin as a carrier molecule
|
|
DK10191D0
(da)
|
1991-01-22 |
1991-01-22 |
Novo Nordisk As |
Hidtil ukendte peptider
|
|
US5336782A
(en)
|
1991-04-24 |
1994-08-09 |
Kuraray Co., Ltd. |
Long chain carboxylic acid imide ester
|
|
WO1998017320A1
(en)
|
1991-07-03 |
1998-04-30 |
Hyal Pharmaceutical Corporation |
Use of hyaluronan in gene therapy
|
|
US5268453A
(en)
|
1991-08-08 |
1993-12-07 |
Scios Inc. |
Tissue-selective insulin analogs
|
|
CZ342492A3
(en)
|
1991-11-26 |
1993-06-16 |
Lilly Co Eli |
Derivatives of tri-arginine insulin, process of their preparation and a pharmaceutical composition in which said derivatives are comprised
|
|
WO1994008599A1
(en)
|
1992-10-14 |
1994-04-28 |
The Regents Of The University Of Colorado |
Ion-pairing of drugs for improved efficacy and delivery
|
|
US5359030A
(en)
|
1993-05-10 |
1994-10-25 |
Protein Delivery, Inc. |
Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
|
|
US5506203C1
(en)
|
1993-06-24 |
2001-02-06 |
Astra Ab |
Systemic administration of a therapeutic preparation
|
|
DE69428134T2
(de)
*
|
1993-09-17 |
2002-05-02 |
Novo Nordisk A/S, Bagsvaerd |
Acyliertes insulin
|
|
US6869930B1
(en)
|
1993-09-17 |
2005-03-22 |
Novo Nordisk A/S |
Acylated insulin
|
|
GB9323588D0
(en)
|
1993-11-16 |
1994-01-05 |
Cortecs Ltd |
Hydrophobic preparation
|
|
ATE264096T1
(de)
|
1994-03-07 |
2004-04-15 |
Nektar Therapeutics |
Verfahren und mittel zur verabreichung von insulin über die lunge
|
|
US6500645B1
(en)
|
1994-06-17 |
2002-12-31 |
Novo Nordisk A/S |
N-terminally extended proteins expressed in yeast
|
|
US5693609A
(en)
|
1994-11-17 |
1997-12-02 |
Eli Lilly And Company |
Acylated insulin analogs
|
|
US5646242A
(en)
|
1994-11-17 |
1997-07-08 |
Eli Lilly And Company |
Selective acylation of epsilon-amino groups
|
|
US6251856B1
(en)
|
1995-03-17 |
2001-06-26 |
Novo Nordisk A/S |
Insulin derivatives
|
|
CA2215694A1
(en)
|
1995-03-17 |
1996-09-26 |
Novo Nordisk A/S |
Insulin derivatives
|
|
US5824638A
(en)
|
1995-05-22 |
1998-10-20 |
Shire Laboratories, Inc. |
Oral insulin delivery
|
|
US20030104981A1
(en)
|
1995-11-03 |
2003-06-05 |
Jelena Mandic |
Human insulin analogues
|
|
US6451970B1
(en)
|
1996-02-21 |
2002-09-17 |
Novo Nordisk A/S |
Peptide derivatives
|
|
WO1998001473A1
(en)
|
1996-07-05 |
1998-01-15 |
Novo Nordisk A/S |
Method for the production of precursors of insulin, precursors of insulin analogues, and insulin like peptides
|
|
EP0938502B1
(en)
|
1996-07-11 |
2004-10-06 |
Novo Nordisk A/S |
Selective acylation method
|
|
EP0821006B1
(de)
|
1996-07-26 |
2004-04-21 |
Aventis Pharma Deutschland GmbH |
Insulinderivate mit erhöhter Zinkbindung
|
|
US5898067A
(en)
|
1997-02-07 |
1999-04-27 |
Novo Nordisk A/S |
Crystallization of proteins
|
|
US6310038B1
(en)
|
1997-03-20 |
2001-10-30 |
Novo Nordisk A/S |
Pulmonary insulin crystals
|
|
TR200001050T2
(tr)
|
1997-10-24 |
2000-08-21 |
Eli Lilly And Company |
Çözünmez insülin bileşimleri
|
|
JP2003525846A
(ja)
|
1997-10-24 |
2003-09-02 |
ノボ ノルディスク アクティーゼルスカブ |
ヒトインスリン誘導体の集合体
|
|
ZA989744B
(en)
|
1997-10-31 |
2000-04-26 |
Lilly Co Eli |
Method for administering acylated insulin.
|
|
AU1375199A
(en)
|
1997-11-12 |
1999-05-31 |
Alza Corporation |
Method for decreasing self-association of polypeptides
|
|
CO4970787A1
(es)
|
1997-12-23 |
2000-11-07 |
Lilly Co Eli |
Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea
|
|
CA2334859A1
(en)
|
1998-06-12 |
1999-12-23 |
Kings College London |
Insulin analogue
|
|
GB9814172D0
(en)
|
1998-06-30 |
1998-08-26 |
Andaris Ltd |
Formulation for inhalation
|
|
EP1107743B1
(en)
|
1998-08-25 |
2007-06-27 |
Advanced Inhalation Research, Inc. |
Stable spray-dried protein formulations
|
|
TW570805B
(en)
|
1998-09-01 |
2004-01-11 |
Hoffmann La Roche |
Water-soluble pharmaceutical composition in an ionic complex
|
|
US7030083B2
(en)
|
1998-09-09 |
2006-04-18 |
University Of Washington |
Treatment of eclampsia and preeclampsia
|
|
PL197504B1
(pl)
|
1998-10-16 |
2008-04-30 |
Novo Nordisk As |
Trwałe stężone preparaty insulinowe do podawania do płuc
|
|
US6660715B2
(en)
|
1998-11-19 |
2003-12-09 |
Massachusetts Institute Of Technology |
Nonaqueous solutions and suspensions of macromolecules for pulmonary delivery
|
|
ATE220917T1
(de)
|
1999-01-26 |
2002-08-15 |
Lilly Co Eli |
Monodisperse formulierungen, die hexamere acylierte insulinanaloge enthalten
|
|
WO2000061178A1
(en)
|
1999-04-13 |
2000-10-19 |
Inhale Therapeutics Systems, Inc. |
Pulmonary administration of dry powder formulations for treating infertility
|
|
JP2002543092A
(ja)
|
1999-04-27 |
2002-12-17 |
イーライ・リリー・アンド・カンパニー |
肺投与用インスリン結晶
|
|
JP2003518917A
(ja)
|
1999-05-19 |
2003-06-17 |
ゼンコー |
糖尿病の処置に有用なインシュリン様活性を有する新規タンパク質
|
|
US6746853B1
(en)
|
1999-05-19 |
2004-06-08 |
Xencor, Inc. |
Proteins with insulin-like activity useful in the treatment of diabetes
|
|
US6309633B1
(en)
|
1999-06-19 |
2001-10-30 |
Nobex Corporation |
Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
|
|
CN1141974C
(zh)
|
2000-06-07 |
2004-03-17 |
张昊 |
结肠定位释放的口服生物制剂
|
|
US6867183B2
(en)
|
2001-02-15 |
2005-03-15 |
Nobex Corporation |
Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
|
|
CN1160122C
(zh)
|
2001-04-20 |
2004-08-04 |
清华大学 |
一种制备口服胰岛素油相制剂的方法
|
|
MY137181A
(en)
|
2001-05-21 |
2009-01-30 |
Nektar Therapeutics |
Pulmonary administration of chemically modified insulin
|
|
US6828297B2
(en)
|
2001-06-04 |
2004-12-07 |
Nobex Corporation |
Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
US6858580B2
(en)
|
2001-06-04 |
2005-02-22 |
Nobex Corporation |
Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
|
|
EP1423136A4
(en)
|
2001-08-10 |
2007-07-25 |
Epix Pharm Inc |
POLYPEPTIDE CONJUGATES HAVING INCREASED CIRCULATION HALF-VIES
|
|
US6770625B2
(en)
|
2001-09-07 |
2004-08-03 |
Nobex Corporation |
Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
|
|
PT1430082E
(pt)
|
2001-09-07 |
2010-01-15 |
Biocon Ltd |
Métodos de síntese de conjugados de polipéptido de insulina-oligómero, e conjugados de polipéptido de pró-insulina-oligómero e método de síntese dos mesmos
|
|
US7030082B2
(en)
|
2001-09-07 |
2006-04-18 |
Nobex Corporation |
Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
|
|
WO2003048195A2
(en)
|
2001-12-02 |
2003-06-12 |
Novo Nordisk A/S |
Glucose dependant release of insulin from glucose sensing insulin derivatives
|
|
US8535650B2
(en)
|
2001-12-03 |
2013-09-17 |
Soligenix, Inc. |
Stabilized reverse micelle compositions and uses thereof
|
|
EP1456371A1
(en)
|
2001-12-05 |
2004-09-15 |
Dow Global Technologies Inc. |
Method for immobilizing a biologic in a polyurethane-hydrogel composition, a composition prepared from the method, and biomedical applications
|
|
EP1545460A4
(en)
|
2001-12-20 |
2005-11-16 |
Lilly Co Eli |
INSULIN MOLECULE WITH TEMPORARY EFFECT
|
|
EP1506003A1
(en)
|
2002-05-07 |
2005-02-16 |
Novo Nordisk A/S |
Soluble formulations comprising insulin aspart and insulin detemir
|
|
ATE496064T1
(de)
|
2002-05-07 |
2011-02-15 |
Novo Nordisk As |
Lösliche formulierungen, die monomeres insulin und acyliertes insulin enthalten
|
|
US7601688B2
(en)
|
2002-06-13 |
2009-10-13 |
Biocon Limited |
Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
|
|
CN1165549C
(zh)
|
2002-06-15 |
2004-09-08 |
江苏万邦生化医药股份有限公司 |
胰岛素的纯化方法
|
|
PL1633391T3
(pl)
|
2003-06-03 |
2012-03-30 |
Novo Nordisk As |
Stabilizowane farmaceutycznie kompozycje peptydowe
|
|
EP1644411A2
(en)
|
2003-07-11 |
2006-04-12 |
Novo Nordisk A/S |
Stabilised insulin compositions
|
|
AU2004261319B2
(en)
|
2003-07-25 |
2010-12-23 |
Conjuchem Biotechnologies Inc. |
Long lasting insulin derivatives and methods thereof
|
|
BRPI0413276B8
(pt)
|
2003-08-05 |
2021-05-25 |
Novo Nordisk As |
derivado de insulina, complexo de zinco do mesmo, e, composição farmacêutica
|
|
WO2005016312A1
(en)
|
2003-08-13 |
2005-02-24 |
Nobex Corporation |
Micro-particle fatty acid salt solid dosage formulations for therapeutic agents
|
|
TW200526254A
(en)
*
|
2003-09-19 |
2005-08-16 |
Novo Nordisk As |
Novel GLP-1 derivatives
|
|
EP1687428A1
(en)
|
2003-11-14 |
2006-08-09 |
Novo Nordisk A/S |
Processes for making acylated insulin
|
|
CN104826116A
(zh)
|
2003-11-20 |
2015-08-12 |
诺沃挪第克公司 |
对于生产和用于注射装置中是最佳的含有丙二醇的肽制剂
|
|
WO2005058961A2
(en)
|
2003-12-12 |
2005-06-30 |
Amgen Inc. |
Antibodies specific for human galanin, and uses thereof
|
|
DE10358387A1
(de)
|
2003-12-13 |
2005-07-07 |
Boehringer Ingelheim Pharma Gmbh & Co. Kg |
Pulver enthaltend niedermolekulares Dextran und Verfahren zu deren Herstellung
|
|
JP4792457B2
(ja)
|
2004-03-26 |
2011-10-12 |
ユニヴァーシタ’デグリ ステュディ ディ パルマ |
高度に呼吸に適したインスリンのマイクロ粒子
|
|
MXPA06012980A
(es)
|
2004-05-10 |
2007-06-12 |
Nastech Pharm Co |
Composiciones y metodos para el suministro mucosal mejorado de la hormona paratiroidea.
|
|
WO2006014673A2
(en)
|
2004-07-19 |
2006-02-09 |
Nobex Corporation |
Insulin-oligomer conjugates, formulations and uses thereof
|
|
EP2314298B1
(en)
|
2004-08-23 |
2015-05-27 |
MannKind Corporation |
Microparticles comprising diketopiperazine salts for drug delivery
|
|
EP1817050B1
(en)
|
2004-12-03 |
2015-04-15 |
Rhode Island Hospital |
Diagnosis and treatment of alzheimer's disease
|
|
WO2006079641A2
(en)
|
2005-01-27 |
2006-08-03 |
Novo Nordisk A/S |
Insulin derivatives conjugated with structurally well defined branched polymers
|
|
JP4933455B2
(ja)
|
2005-02-02 |
2012-05-16 |
ノヴォ ノルディスク アー/エス |
新規のインスリン誘導体
|
|
EP2292653B1
(en)
|
2005-02-02 |
2014-05-21 |
Novo Nordisk A/S |
Novel insulin derivatives
|
|
WO2006097521A1
(en)
|
2005-03-18 |
2006-09-21 |
Novo Nordisk A/S |
Pegylated single-chain insulin
|
|
WO2007006320A1
(en)
|
2005-07-12 |
2007-01-18 |
Sherine Hassan Abbas Helmy |
Drinkable oral insulin liquid and capsules
|
|
WO2007041481A1
(en)
|
2005-09-29 |
2007-04-12 |
Biodel, Inc. |
Rapid acting and prolonged acting insulin preparations
|
|
JP4710533B2
(ja)
|
2005-10-07 |
2011-06-29 |
株式会社豊田自動織機 |
牽引車両のドローバー装置
|
|
JP2009512709A
(ja)
|
2005-10-20 |
2009-03-26 |
エムディーアールエヌエー,インコーポレイテッド |
速効型インスリンの経鼻投与
|
|
PL1969004T3
(pl)
|
2005-12-28 |
2012-01-31 |
Novo Nordisk As |
Kompozycje zawierające acylowaną insulinę i cynk oraz sposób wytwarzania tych kompozycji
|
|
WO2007081824A2
(en)
|
2006-01-06 |
2007-07-19 |
Case Western Reserve University |
Fibrillation resistant proteins
|
|
US20090069216A1
(en)
|
2006-02-21 |
2009-03-12 |
Novo Nordisk A/S |
Single-Chain Insulin Analogues and Pharmaceutical Formulations Thereof
|
|
DE602007009496D1
(de)
|
2006-02-27 |
2010-11-11 |
Novo Nordisk As |
Insulinderivate
|
|
JP2009530242A
(ja)
|
2006-03-13 |
2009-08-27 |
ノボ・ノルデイスク・エー/エス |
アシル化単鎖インスリン
|
|
EP2386572B1
(en)
|
2006-05-09 |
2015-07-08 |
Novo Nordisk A/S |
Insulin derivative
|
|
EP2024390B1
(en)
|
2006-05-09 |
2015-08-19 |
Novo Nordisk A/S |
Insulin derivative
|
|
WO2008015099A2
(en)
|
2006-07-31 |
2008-02-07 |
Novo Nordisk A/S |
Pegylated, extended insulins
|
|
ES2601839T3
(es)
|
2006-09-22 |
2017-02-16 |
Novo Nordisk A/S |
Análogos de insulina resistentes a proteasas
|
|
EP2152243A2
(en)
|
2007-04-30 |
2010-02-17 |
Novo Nordisk A/S |
Highly concentrated insulin solutions and compositions
|
|
EP2497462A1
(en)
|
2007-06-01 |
2012-09-12 |
Novo Nordisk A/S |
Stable non-aqueous pharmaceutical compositions
|
|
WO2008152106A1
(en)
|
2007-06-13 |
2008-12-18 |
Novo Nordisk A/S |
Pharmaceutical formulation comprising an insulin derivative
|
|
WO2009010428A1
(en)
|
2007-07-16 |
2009-01-22 |
Novo Nordisk A/S |
Protease stabilized, pegylated insulin analogues
|
|
US8962794B2
(en)
|
2007-08-15 |
2015-02-24 |
Novo Nordisk A/S |
Insulins with an acyl moiety comprising repeating units of alkylene glycol containing amino acids
|
|
AU2008288413B2
(en)
|
2007-08-15 |
2013-09-26 |
Novo Nordisk A/S |
Insulin analogues with an acyl and aklylene glycol moiety
|
|
WO2009060071A1
(en)
*
|
2007-11-08 |
2009-05-14 |
Novo Nordisk A/S |
Insulin derivative
|
|
EP2254905B1
(en)
|
2008-03-14 |
2016-12-14 |
Novo Nordisk A/S |
Protease-stabilized insulin analogues
|
|
DK2254906T3
(en)
*
|
2008-03-18 |
2017-01-23 |
Novo Nordisk As |
Protease-stabilized acylated insulin analogues
|
|
WO2010049488A1
(en)
*
|
2008-10-30 |
2010-05-06 |
Novo Nordisk A/S |
Treating diabetes melitus using insulin injections with less than daily injection frequency
|
|
AU2011252127B2
(en)
*
|
2010-05-10 |
2014-02-20 |
Novo Nordisk A/S |
Process for the preparation of insulin-zinc complexes
|
|
CN102947331B
(zh)
|
2010-06-23 |
2016-08-03 |
诺沃—诺迪斯克有限公司 |
包含额外的二硫键的胰岛素类似物
|
|
AU2011269000C1
(en)
*
|
2010-06-23 |
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