DK3055325T3 - New derivative of an insulin analogue - Google Patents
New derivative of an insulin analogue Download PDFInfo
- Publication number
- DK3055325T3 DK3055325T3 DK14780512.1T DK14780512T DK3055325T3 DK 3055325 T3 DK3055325 T3 DK 3055325T3 DK 14780512 T DK14780512 T DK 14780512T DK 3055325 T3 DK3055325 T3 DK 3055325T3
- Authority
- DK
- Denmark
- Prior art keywords
- insulin
- compound
- ethoxy
- hexamer
- day
- Prior art date
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title description 217
- 239000004026 insulin derivative Substances 0.000 title description 16
- PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical class C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 abstract description 36
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP13187626 | 2013-10-07 | ||
| PCT/EP2014/071236 WO2015052088A1 (en) | 2013-10-07 | 2014-10-03 | Novel derivative of an insulin analogue |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3055325T3 true DK3055325T3 (en) | 2018-04-16 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK14780512.1T DK3055325T3 (en) | 2013-10-07 | 2014-10-03 | New derivative of an insulin analogue |
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|---|---|
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| EP (1) | EP3055325B1 (enExample) |
| JP (1) | JP6499184B2 (enExample) |
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| CN (1) | CN105636979B (enExample) |
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| BR (1) | BR112016007166A2 (enExample) |
| CA (1) | CA2926701A1 (enExample) |
| DK (1) | DK3055325T3 (enExample) |
| ES (1) | ES2676065T3 (enExample) |
| HR (1) | HRP20180468T1 (enExample) |
| HU (1) | HUE036702T2 (enExample) |
| IL (1) | IL244507B (enExample) |
| MX (1) | MX366636B (enExample) |
| PL (1) | PL3055325T3 (enExample) |
| PT (1) | PT3055325T (enExample) |
| RS (1) | RS57004B1 (enExample) |
| RU (1) | RU2673185C2 (enExample) |
| SA (1) | SA516370893B1 (enExample) |
| SI (1) | SI3055325T1 (enExample) |
| WO (1) | WO2015052088A1 (enExample) |
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| JP5749155B2 (ja) | 2008-03-18 | 2015-07-15 | ノボ・ノルデイスク・エー／エス | プロテアーゼ安定化アシル化インスリンアナログ |
| AR105616A1 (es) | 2015-05-07 | 2017-10-25 | Lilly Co Eli | Proteínas de fusión |
| JP7076442B2 (ja) | 2016-11-07 | 2022-05-27 | ノヴォ ノルディスク アー／エス | Ｐｅｇ化合物のｄｃｈｂｓ活性エステル及びその使用 |
| HUE060149T2 (hu) * | 2016-12-16 | 2023-02-28 | Novo Nordisk As | Inzulint tartalmazó gyógyászati készítmények |
| US11357861B2 (en) | 2017-09-29 | 2022-06-14 | Hanmi Pharm. Co., Ltd | Protein complex comprising non-peptidyl polymer-coupled fatty acid derivative compound as linker and preparation method therefor |
| TWI799680B (zh) * | 2019-01-29 | 2023-04-21 | 美商美國禮來大藥廠 | 製備gip/glp1雙重促效劑之方法 |
| CN111909255A (zh) * | 2019-05-10 | 2020-11-10 | 宁波鲲鹏生物科技有限公司 | 胰岛素衍生物及其制备方法 |
| WO2022017309A1 (zh) | 2020-07-24 | 2022-01-27 | 江苏晟斯生物制药有限公司 | 胰岛素-Fc融合蛋白及其应用 |
| JP2024521757A (ja) | 2021-05-24 | 2024-06-04 | サンシャイン・レイク・ファーマ・カンパニー・リミテッド | 新規なアシル化インスリンアナログ |
| CN117586376A (zh) * | 2022-08-10 | 2024-02-23 | 成都奥达生物科技有限公司 | 一种长效胰岛素化合物 |
| CN117342967A (zh) * | 2023-09-28 | 2024-01-05 | 奥锐特药业(天津)有限公司 | 一种长链脂肪酸化合物的制备方法 |
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| JPH01254699A (ja) | 1988-04-05 | 1989-10-11 | Kodama Kk | インスリン誘導体及びその用途 |
| DK257988D0 (da) | 1988-05-11 | 1988-05-11 | Novo Industri As | Nye peptider |
| ATE93238T1 (de) | 1988-07-20 | 1993-09-15 | Novo Nordisk As | Menschliche insulinanalage und zubereitungen daraus. |
| US5225323A (en) | 1988-11-21 | 1993-07-06 | Baylor College Of Medicine | Human high-affinity neurotransmitter uptake system |
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| FI914898A0 (fi) | 1989-04-20 | 1991-10-17 | Sinai School Medicine | Leverspecifika insulinanaloger. |
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| DK45590D0 (enExample) | 1990-02-21 | 1990-02-21 | Novo Nordisk As | |
| DK155690D0 (da) | 1990-06-28 | 1990-06-28 | Novo Nordisk As | Nye peptider |
| DK158390D0 (da) | 1990-07-02 | 1990-07-02 | Novo Nordisk As | Nye peptider |
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| GB9323588D0 (en) | 1993-11-16 | 1994-01-05 | Cortecs Ltd | Hydrophobic preparation |
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| HUP9800523A3 (en) | 1995-03-17 | 1998-09-28 | Novo Nordisk As | Insulin derivatives |
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-
2014
- 2014-10-03 ES ES14780512.1T patent/ES2676065T3/es active Active
- 2014-10-03 DK DK14780512.1T patent/DK3055325T3/en active
- 2014-10-03 WO PCT/EP2014/071236 patent/WO2015052088A1/en not_active Ceased
- 2014-10-03 CA CA2926701A patent/CA2926701A1/en not_active Withdrawn
- 2014-10-03 CN CN201480055375.6A patent/CN105636979B/zh not_active Expired - Fee Related
- 2014-10-03 AU AU2014333979A patent/AU2014333979B2/en not_active Ceased
- 2014-10-03 PL PL14780512T patent/PL3055325T3/pl unknown
- 2014-10-03 EP EP14780512.1A patent/EP3055325B1/en not_active Not-in-force
- 2014-10-03 US US15/023,872 patent/US9896496B2/en not_active Expired - Fee Related
- 2014-10-03 HR HRP20180468TT patent/HRP20180468T1/hr unknown
- 2014-10-03 BR BR112016007166A patent/BR112016007166A2/pt not_active IP Right Cessation
- 2014-10-03 JP JP2016546167A patent/JP6499184B2/ja not_active Expired - Fee Related
- 2014-10-03 PT PT147805121T patent/PT3055325T/pt unknown
- 2014-10-03 MX MX2016004325A patent/MX366636B/es active IP Right Grant
- 2014-10-03 HU HUE14780512A patent/HUE036702T2/hu unknown
- 2014-10-03 SI SI201430644T patent/SI3055325T1/en unknown
- 2014-10-03 RS RS20180322A patent/RS57004B1/sr unknown
- 2014-10-03 KR KR1020167010201A patent/KR20160065126A/ko not_active Withdrawn
- 2014-10-03 RU RU2016114098A patent/RU2673185C2/ru not_active IP Right Cessation
-
2016
- 2016-03-08 IL IL244507A patent/IL244507B/en not_active IP Right Cessation
- 2016-04-07 SA SA516370893A patent/SA516370893B1/ar unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL3055325T3 (pl) | 2018-06-29 |
| JP6499184B2 (ja) | 2019-04-10 |
| PT3055325T (pt) | 2018-04-06 |
| SA516370893B1 (ar) | 2018-08-13 |
| RU2016114098A (ru) | 2017-11-15 |
| HRP20180468T1 (hr) | 2018-05-04 |
| IL244507A0 (en) | 2016-04-21 |
| IL244507B (en) | 2018-05-31 |
| SI3055325T1 (en) | 2018-05-31 |
| RU2016114098A3 (enExample) | 2018-05-21 |
| MX366636B (es) | 2019-07-17 |
| AU2014333979A1 (en) | 2016-03-24 |
| US9896496B2 (en) | 2018-02-20 |
| RS57004B1 (sr) | 2018-05-31 |
| KR20160065126A (ko) | 2016-06-08 |
| RU2673185C2 (ru) | 2018-11-22 |
| CN105636979B (zh) | 2020-01-10 |
| CA2926701A1 (en) | 2015-04-16 |
| EP3055325A1 (en) | 2016-08-17 |
| JP2017502074A (ja) | 2017-01-19 |
| BR112016007166A2 (pt) | 2017-09-12 |
| CN105636979A (zh) | 2016-06-01 |
| HUE036702T2 (hu) | 2018-07-30 |
| US20160215037A1 (en) | 2016-07-28 |
| WO2015052088A1 (en) | 2015-04-16 |
| AU2014333979B2 (en) | 2018-02-15 |
| MX2016004325A (es) | 2016-07-11 |
| ES2676065T3 (es) | 2018-07-16 |
| EP3055325B1 (en) | 2018-01-03 |
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