ES2676065T3 - Nuevo derivado de un análogo de la insulina - Google Patents

Nuevo derivado de un análogo de la insulina Download PDF

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Publication number
ES2676065T3
ES2676065T3 ES14780512.1T ES14780512T ES2676065T3 ES 2676065 T3 ES2676065 T3 ES 2676065T3 ES 14780512 T ES14780512 T ES 14780512T ES 2676065 T3 ES2676065 T3 ES 2676065T3
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ES
Spain
Prior art keywords
compound
insulin
hexamer
nacl
ethoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
ES14780512.1T
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English (en)
Spanish (es)
Inventor
Peter Madsen
Tina Møller TAGMOSE
Helle Naver
Thomas Børglum KJELDSEN
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novo Nordisk AS
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Novo Nordisk AS
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Application filed by Novo Nordisk AS filed Critical Novo Nordisk AS
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Publication of ES2676065T3 publication Critical patent/ES2676065T3/es
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Anticipated expiration legal-status Critical

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/62—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ES14780512.1T 2013-10-07 2014-10-03 Nuevo derivado de un análogo de la insulina Active ES2676065T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP13187626 2013-10-07
EP13187626 2013-10-07
PCT/EP2014/071236 WO2015052088A1 (en) 2013-10-07 2014-10-03 Novel derivative of an insulin analogue

Publications (1)

Publication Number Publication Date
ES2676065T3 true ES2676065T3 (es) 2018-07-16

Family

ID=49301382

Family Applications (1)

Application Number Title Priority Date Filing Date
ES14780512.1T Active ES2676065T3 (es) 2013-10-07 2014-10-03 Nuevo derivado de un análogo de la insulina

Country Status (21)

Country Link
US (1) US9896496B2 (enExample)
EP (1) EP3055325B1 (enExample)
JP (1) JP6499184B2 (enExample)
KR (1) KR20160065126A (enExample)
CN (1) CN105636979B (enExample)
AU (1) AU2014333979B2 (enExample)
BR (1) BR112016007166A2 (enExample)
CA (1) CA2926701A1 (enExample)
DK (1) DK3055325T3 (enExample)
ES (1) ES2676065T3 (enExample)
HR (1) HRP20180468T1 (enExample)
HU (1) HUE036702T2 (enExample)
IL (1) IL244507B (enExample)
MX (1) MX366636B (enExample)
PL (1) PL3055325T3 (enExample)
PT (1) PT3055325T (enExample)
RS (1) RS57004B1 (enExample)
RU (1) RU2673185C2 (enExample)
SA (1) SA516370893B1 (enExample)
SI (1) SI3055325T1 (enExample)
WO (1) WO2015052088A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691759B2 (en) 2008-03-18 2014-04-08 Novo Nordisk A/S Protease stabilized, acylated insulin analogues
AR105616A1 (es) 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
EP3534962B1 (en) 2016-11-07 2020-08-19 Novo Nordisk A/S Dchbs-active esters of peg compounds and their use
SI3554534T1 (sl) * 2016-12-16 2021-09-30 Novo Nordisk A/S Farmacevtski sestavki, ki vsebujejo inzulin
CN111164128A (zh) 2017-09-29 2020-05-15 韩美药品株式会社 包含作为接头的非肽基聚合物偶联的脂肪酸衍生物化合物的蛋白复合物及其制备方法
TWI799680B (zh) * 2019-01-29 2023-04-21 美商美國禮來大藥廠 製備gip/glp1雙重促效劑之方法
CN111909255A (zh) * 2019-05-10 2020-11-10 宁波鲲鹏生物科技有限公司 胰岛素衍生物及其制备方法
EP4230216A4 (en) 2020-07-24 2025-02-19 Jiangsu Gensciences Inc. Insulin-fc fusion protein and application thereof
EP4347632A4 (en) 2021-05-24 2025-03-26 Sunshine Lake Pharma Co., Ltd. A novel acylated insulin analog
CN117342967A (zh) * 2023-09-28 2024-01-05 奥锐特药业(天津)有限公司 一种长链脂肪酸化合物的制备方法

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WO2011161124A1 (en) * 2010-06-23 2011-12-29 Novo Nordisk A/S Insulin analogues containing additional disulfide bonds
KR20130139297A (ko) * 2010-10-27 2013-12-20 노보 노르디스크 에이/에스 다양한 주사 간격으로 투여된 인슐린 주사를 이용한 진성 당뇨병의 치료
CN104364260B (zh) 2012-04-11 2017-02-22 诺和诺德股份有限公司 胰岛素制剂

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