MX366636B - Nuevo derivado de un análogo de insulina. - Google Patents

Nuevo derivado de un análogo de insulina.

Info

Publication number
MX366636B
MX366636B MX2016004325A MX2016004325A MX366636B MX 366636 B MX366636 B MX 366636B MX 2016004325 A MX2016004325 A MX 2016004325A MX 2016004325 A MX2016004325 A MX 2016004325A MX 366636 B MX366636 B MX 366636B
Authority
MX
Mexico
Prior art keywords
insulin analogue
novel derivative
derivative
novel
analogue
Prior art date
Application number
MX2016004325A
Other languages
English (en)
Spanish (es)
Other versions
MX2016004325A (es
Inventor
Naver Helle
Madsen Peter
Møller Tagmose Tina
Børglum Kjeldsen Thomas
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of MX2016004325A publication Critical patent/MX2016004325A/es
Publication of MX366636B publication Critical patent/MX366636B/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/62Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/28Insulins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MX2016004325A 2013-10-07 2014-10-03 Nuevo derivado de un análogo de insulina. MX366636B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP13187626 2013-10-07
PCT/EP2014/071236 WO2015052088A1 (en) 2013-10-07 2014-10-03 Novel derivative of an insulin analogue

Publications (2)

Publication Number Publication Date
MX2016004325A MX2016004325A (es) 2016-07-11
MX366636B true MX366636B (es) 2019-07-17

Family

ID=49301382

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016004325A MX366636B (es) 2013-10-07 2014-10-03 Nuevo derivado de un análogo de insulina.

Country Status (21)

Country Link
US (1) US9896496B2 (enExample)
EP (1) EP3055325B1 (enExample)
JP (1) JP6499184B2 (enExample)
KR (1) KR20160065126A (enExample)
CN (1) CN105636979B (enExample)
AU (1) AU2014333979B2 (enExample)
BR (1) BR112016007166A2 (enExample)
CA (1) CA2926701A1 (enExample)
DK (1) DK3055325T3 (enExample)
ES (1) ES2676065T3 (enExample)
HR (1) HRP20180468T1 (enExample)
HU (1) HUE036702T2 (enExample)
IL (1) IL244507B (enExample)
MX (1) MX366636B (enExample)
PL (1) PL3055325T3 (enExample)
PT (1) PT3055325T (enExample)
RS (1) RS57004B1 (enExample)
RU (1) RU2673185C2 (enExample)
SA (1) SA516370893B1 (enExample)
SI (1) SI3055325T1 (enExample)
WO (1) WO2015052088A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110004366A (ko) 2008-03-18 2011-01-13 노보 노르디스크 에이/에스 프로테아제 안정화되고, 아실화된 인슐린 유사체
AR105616A1 (es) 2015-05-07 2017-10-25 Lilly Co Eli Proteínas de fusión
WO2018083335A1 (en) 2016-11-07 2018-05-11 Novo Nordisk A/S Dchbs-active esters of peg compounds and their use
BR112019011761A2 (pt) * 2016-12-16 2019-11-05 Novo Nordisk As composições farmacêuticas contendo insulina
KR102612576B1 (ko) 2017-09-29 2023-12-12 한미약품 주식회사 링커로서 비펩타이드성 중합체 결합 지방산 유도체 화합물을 포함하는 단백질 결합체 및 이의 제조방법
TWI799680B (zh) * 2019-01-29 2023-04-21 美商美國禮來大藥廠 製備gip/glp1雙重促效劑之方法
CN111909255A (zh) * 2019-05-10 2020-11-10 宁波鲲鹏生物科技有限公司 胰岛素衍生物及其制备方法
CA3189527A1 (en) 2020-07-24 2022-01-27 Jiangsu Gensciences Inc. Insulin-fc fusion protein and application thereof
US20240374692A1 (en) 2021-05-24 2024-11-14 Sunshine Lake Pharma Co., Ltd. A novel acylated insulin analog
CN117342967A (zh) * 2023-09-28 2024-01-05 奥锐特药业(天津)有限公司 一种长链脂肪酸化合物的制备方法

Family Cites Families (134)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2832685A (en) 1952-05-24 1958-04-29 Crest Foods Co Inc Solubilization of milk proteins
US3528960A (en) 1968-10-07 1970-09-15 Lilly Co Eli N-carboxyaroyl insulins
US3719655A (en) 1969-12-05 1973-03-06 Lilly Co Eli Process for the crystallization of the ammonium and alkali metal salts in insulin
US3950517A (en) 1970-05-08 1976-04-13 National Research Development Corporation Insulin derivatives
US3869437A (en) 1970-05-08 1975-03-04 Nat Res Dev Mono-, di, and N{HD A1{B , N{HU B1{B , N{HU B29{B -tri-acylated insulin
US4179337A (en) 1973-07-20 1979-12-18 Davis Frank F Non-immunogenic polypeptides
US4033941A (en) 1975-12-17 1977-07-05 Eli Lilly And Company Process for purifying glucagon
GB1492997A (en) 1976-07-21 1977-11-23 Nat Res Dev Insulin derivatives
JPS5767548A (en) 1980-10-14 1982-04-24 Shionogi & Co Ltd Insulin analog and its preparation
PH25772A (en) 1985-08-30 1991-10-18 Novo Industri As Insulin analogues, process for their preparation
PH23446A (en) 1986-10-20 1989-08-07 Novo Industri As Peptide preparations
JPH01254699A (ja) 1988-04-05 1989-10-11 Kodama Kk インスリン誘導体及びその用途
DK257988D0 (da) 1988-05-11 1988-05-11 Novo Industri As Nye peptider
EP0425482B1 (en) 1988-07-20 1993-08-18 Novo Nordisk A/S Human insulin analogs and preparations containing them
US5225323A (en) 1988-11-21 1993-07-06 Baylor College Of Medicine Human high-affinity neurotransmitter uptake system
US5716927A (en) 1988-12-23 1998-02-10 Novo Nordisk A/S Insulin analogs having a modified B-chain
FI913037A7 (fi) 1988-12-23 1991-06-20 Novo Nordisk As Ihmisen insuliinianalogit
DE3844211A1 (de) 1988-12-29 1990-07-05 Hoechst Ag Neue insulinderivate, verfahren zu deren herstellung, ihre verwendung und eine sie enthaltende pharmazeutische zubereitung
DE69018461T2 (de) 1989-04-20 1995-08-03 Sinai School Medicine Hepatospezifische insulin-analoga.
CA1340994C (en) 1989-09-21 2000-05-16 Rudolf Edgar Dr. Falk Treatment of conditions and disease
KR930001305B1 (ko) 1989-10-19 1993-02-25 니뽕 유우시 가부시끼가이샤 당 응답형 고분자 복합체(Polymer Complexes of Sugar Response Type)
US5179189A (en) 1990-01-19 1993-01-12 Nova Pharmaceutical Corporation Fatty acid terminated polyanhydrides
DK45590D0 (enExample) 1990-02-21 1990-02-21 Novo Nordisk As
DK155690D0 (da) 1990-06-28 1990-06-28 Novo Nordisk As Nye peptider
DK158390D0 (da) 1990-07-02 1990-07-02 Novo Nordisk As Nye peptider
WO1992001476A1 (en) 1990-07-26 1992-02-06 University Of Iowa Research Foundation Novel drug delivery systems for proteins and peptides using albumin as a carrier molecule
DK10191D0 (da) 1991-01-22 1991-01-22 Novo Nordisk As Hidtil ukendte peptider
US5336782A (en) 1991-04-24 1994-08-09 Kuraray Co., Ltd. Long chain carboxylic acid imide ester
US6475795B1 (en) 1991-07-03 2002-11-05 Meditech Research, Ltd. Use of hyaluronan in gene therapy
US5268453A (en) 1991-08-08 1993-12-07 Scios Inc. Tissue-selective insulin analogs
NZ245170A (en) 1991-11-26 1994-07-26 Lilly Co Eli Insulin and proinsulin analogues with arg at b31, b32 and ao and pharmaceutical compositions
AU5171293A (en) 1992-10-14 1994-05-09 Regents Of The University Of Colorado, The Ion-pairing of drugs for improved efficacy and delivery
US5359030A (en) 1993-05-10 1994-10-25 Protein Delivery, Inc. Conjugation-stabilized polypeptide compositions, therapeutic delivery and diagnostic formulations comprising same, and method of making and using the same
US5506203C1 (en) 1993-06-24 2001-02-06 Astra Ab Systemic administration of a therapeutic preparation
US6869930B1 (en) 1993-09-17 2005-03-22 Novo Nordisk A/S Acylated insulin
SK282495B6 (sk) 1993-09-17 2002-02-05 Novo Nordisk A/S Acylovaný inzulínový derivát a farmaceutický prostriedok, ktorý ho obsahuje
GB9323588D0 (en) 1993-11-16 1994-01-05 Cortecs Ltd Hydrophobic preparation
BR9507023A (pt) 1994-03-07 1997-09-23 Inhale Therapeutic Syst Processos para aerossolização de uma dose de insulina para a liberação respiratória de insulina e para preparação de uma composição de insulina e composição de insulina
US6500645B1 (en) 1994-06-17 2002-12-31 Novo Nordisk A/S N-terminally extended proteins expressed in yeast
US5693609A (en) 1994-11-17 1997-12-02 Eli Lilly And Company Acylated insulin analogs
US5646242A (en) 1994-11-17 1997-07-08 Eli Lilly And Company Selective acylation of epsilon-amino groups
US6251856B1 (en) 1995-03-17 2001-06-26 Novo Nordisk A/S Insulin derivatives
CA2215694A1 (en) 1995-03-17 1996-09-26 Novo Nordisk A/S Insulin derivatives
US5824638A (en) 1995-05-22 1998-10-20 Shire Laboratories, Inc. Oral insulin delivery
US20030104981A1 (en) 1995-11-03 2003-06-05 Jelena Mandic Human insulin analogues
US6451970B1 (en) 1996-02-21 2002-09-17 Novo Nordisk A/S Peptide derivatives
WO1998001473A1 (en) 1996-07-05 1998-01-15 Novo Nordisk A/S Method for the production of precursors of insulin, precursors of insulin analogues, and insulin like peptides
JP3300368B2 (ja) 1996-07-11 2002-07-08 ノボ ノルディスク アクティーゼルスカブ 選択的アシル化方法
ATE264871T1 (de) 1996-07-26 2004-05-15 Aventis Pharma Gmbh Insulinderivate mit erhöhter zinkbindung
US5898067A (en) 1997-02-07 1999-04-27 Novo Nordisk A/S Crystallization of proteins
US6310038B1 (en) 1997-03-20 2001-10-30 Novo Nordisk A/S Pulmonary insulin crystals
PT1025125E (pt) 1997-10-24 2003-11-28 Novo Nordisk As Derivativos agregados da insulina humana
US6268335B1 (en) 1997-10-24 2001-07-31 Eli Lilly And Company Insoluble insulin compositions
ZA989744B (en) 1997-10-31 2000-04-26 Lilly Co Eli Method for administering acylated insulin.
DE69816325T2 (de) 1997-11-12 2004-04-22 Alza Corp., Palo Alto Gepufferte arzneistoffformulierungen zur transdermalen verabreichung durch elektrotransport
CO4970787A1 (es) 1997-12-23 2000-11-07 Lilly Co Eli Composiciones insolubles de insulina y derivados de insulina que controlan la glucosa sanguinea
AU8029798A (en) 1998-06-12 2000-01-05 Deutsches Wollforschungsinstitut Insulin analogue
GB9814172D0 (en) 1998-06-30 1998-08-26 Andaris Ltd Formulation for inhalation
AU758351B2 (en) 1998-08-25 2003-03-20 Alkermes, Inc. Stable spray-dried protein formulations
TW570805B (en) 1998-09-01 2004-01-11 Hoffmann La Roche Water-soluble pharmaceutical composition in an ionic complex
US7030083B2 (en) 1998-09-09 2006-04-18 University Of Washington Treatment of eclampsia and preeclampsia
CN1210058C (zh) 1998-10-16 2005-07-13 诺沃挪第克公司 用于肺送递的稳定的浓缩胰岛素制剂
US6660715B2 (en) 1998-11-19 2003-12-09 Massachusetts Institute Of Technology Nonaqueous solutions and suspensions of macromolecules for pulmonary delivery
ES2180511T3 (es) 1999-01-26 2003-02-16 Lilly Co Eli Formulaciones monodispersas de analogos de insulina acilados hexamericos.
WO2000061178A1 (en) 1999-04-13 2000-10-19 Inhale Therapeutics Systems, Inc. Pulmonary administration of dry powder formulations for treating infertility
WO2000064940A1 (en) 1999-04-27 2000-11-02 Eli Lilly And Company Insulin crystals for pulmonary administration
US6746853B1 (en) 1999-05-19 2004-06-08 Xencor, Inc. Proteins with insulin-like activity useful in the treatment of diabetes
AU5144400A (en) 1999-05-19 2000-12-05 Xencor, Inc. Novel proteins with insulin-like activity useful in the treatment of diabetes
US6309633B1 (en) 1999-06-19 2001-10-30 Nobex Corporation Amphiphilic drug-oligomer conjugates with hydroyzable lipophile components and methods for making and using the same
CN1141974C (zh) 2000-06-07 2004-03-17 张昊 结肠定位释放的口服生物制剂
US6867183B2 (en) 2001-02-15 2005-03-15 Nobex Corporation Pharmaceutical compositions of insulin drug-oligomer conjugates and methods of treating diseases therewith
CN1160122C (zh) 2001-04-20 2004-08-04 清华大学 一种制备口服胰岛素油相制剂的方法
OA13136A (en) 2001-05-21 2006-12-13 Nektar Therapeutics Pulmonary administration of chemically modified insulin.
US6828297B2 (en) 2001-06-04 2004-12-07 Nobex Corporation Mixtures of insulin drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
US6858580B2 (en) 2001-06-04 2005-02-22 Nobex Corporation Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same
JP2004537580A (ja) 2001-08-10 2004-12-16 エピックス メディカル, インコーポレイテッド 延長された循環半減期を有するポリペプチド結合体
US7030082B2 (en) 2001-09-07 2006-04-18 Nobex Corporation Pharmaceutical compositions of drug-oligomer conjugates and methods of treating disease therewith
US6770625B2 (en) 2001-09-07 2004-08-03 Nobex Corporation Pharmaceutical compositions of calcitonin drug-oligomer conjugates and methods of treating diseases therewith
PT1430082E (pt) 2001-09-07 2010-01-15 Biocon Ltd Métodos de síntese de conjugados de polipéptido de insulina-oligómero, e conjugados de polipéptido de pró-insulina-oligómero e método de síntese dos mesmos
WO2003048195A2 (en) 2001-12-02 2003-06-12 Novo Nordisk A/S Glucose dependant release of insulin from glucose sensing insulin derivatives
WO2003047493A2 (en) 2001-12-03 2003-06-12 Dor Biopharma Inc. Stabilized reverse micelle compositions and uses thereof
AU2002314790A1 (en) 2001-12-05 2003-06-23 Dow Global Technologies Inc. Method for immobilizing a biologic in a polyurethane-hydrogel composition, a composition prepared from the method, and biomedical applications
PL374949A1 (en) 2001-12-20 2005-11-14 Eli Lilly And Company Insulin molecule having protracted time action
WO2003094951A1 (en) 2002-05-07 2003-11-20 Novo Nordisk A/S Soluble formulations comprising insulin aspart and insulin detemir
JP5599543B2 (ja) 2002-05-07 2014-10-01 ノヴォ ノルディスク アー/エス 単量体インスリン及びアシル化インスリンを含む可溶性製剤
AU2003236521A1 (en) 2002-06-13 2003-12-31 Nobex Corporation Methods of reducing hypoglycemic episodes in the treatment of diabetes mellitus
CN1165549C (zh) 2002-06-15 2004-09-08 江苏万邦生化医药股份有限公司 胰岛素的纯化方法
EP1633391B1 (en) 2003-06-03 2011-10-19 Novo Nordisk A/S Stabilized pharmaceutical peptide compositions
EP1644411A2 (en) 2003-07-11 2006-04-12 Novo Nordisk A/S Stabilised insulin compositions
WO2005012346A1 (en) 2003-07-25 2005-02-10 Conjuchem, Inc. Long lasting insulin derivatives and methods thereof
JP4463814B2 (ja) 2003-08-05 2010-05-19 ノボ ノルディスク アクティーゼルスカブ 新規のインスリン誘導体
CA2535013C (en) 2003-08-13 2013-02-12 Nobex Corporation Micro-particle fatty acid salt solid dosage formulations for therapeutic agents
EP2932981B1 (en) * 2003-09-19 2021-06-16 Novo Nordisk A/S Albumin-binding derivatives of GLP-1
EP1687428A1 (en) 2003-11-14 2006-08-09 Novo Nordisk A/S Processes for making acylated insulin
CA2545034C (en) 2003-11-20 2013-03-05 Novo Nordisk A/S Propylene glycol-containing peptide formulations which are optimal for production and for use in injection devices
WO2005058961A2 (en) 2003-12-12 2005-06-30 Amgen Inc. Antibodies specific for human galanin, and uses thereof
DE10358387A1 (de) 2003-12-13 2005-07-07 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pulver enthaltend niedermolekulares Dextran und Verfahren zu deren Herstellung
US7625865B2 (en) 2004-03-26 2009-12-01 Universita Degli Studi Di Parma Insulin highly respirable microparticles
CN101151048A (zh) 2004-05-10 2008-03-26 纳斯泰克制药公司 增强甲状旁腺激素粘膜递送的组合物和方法
KR101276754B1 (ko) 2004-07-19 2013-06-19 바이오콘 리미티드 인슐린―올리고머 접합체,제형 및 이들의 용도
JP4990142B2 (ja) 2004-08-23 2012-08-01 マンカインド コーポレイション 薬物送達のためのジケトピペラジン塩、ジケトモルホリン塩、又はジケトジオキサン塩
AU2005311601B2 (en) 2004-12-03 2011-12-01 Rhode Island Hospital Diagnosis and treatment of Alzheimer's Disease
WO2006079641A2 (en) 2005-01-27 2006-08-03 Novo Nordisk A/S Insulin derivatives conjugated with structurally well defined branched polymers
JP4933455B2 (ja) 2005-02-02 2012-05-16 ノヴォ ノルディスク アー/エス 新規のインスリン誘導体
US20080171695A1 (en) 2005-02-02 2008-07-17 Novo Nordisk A/S Insulin Derivatives
EP1863840A1 (en) 2005-03-18 2007-12-12 Novo Nordisk A/S Pegylated single-chain insulin
WO2007006320A1 (en) 2005-07-12 2007-01-18 Sherine Hassan Abbas Helmy Drinkable oral insulin liquid and capsules
WO2007041481A1 (en) 2005-09-29 2007-04-12 Biodel, Inc. Rapid acting and prolonged acting insulin preparations
JP4710533B2 (ja) 2005-10-07 2011-06-29 株式会社豊田自動織機 牽引車両のドローバー装置
DE602006014990D1 (de) 2005-10-20 2010-07-29 Mdrna Inc Intranasale verabreichung von schnell wirkendem insulin
DK1969004T3 (da) 2005-12-28 2011-11-28 Novo Nordisk As Insulinsammensætninger og metode til at lave en sammensætning
WO2007081824A2 (en) 2006-01-06 2007-07-19 Case Western Reserve University Fibrillation resistant proteins
JP2009527526A (ja) 2006-02-21 2009-07-30 ノボ・ノルデイスク・エー/エス 単鎖インスリンのアナログとその製薬的製剤
DE602007009496D1 (de) 2006-02-27 2010-11-11 Novo Nordisk As Insulinderivate
WO2007104737A1 (en) 2006-03-13 2007-09-20 Novo Nordisk A/S Acylated single chain insulin
WO2007128815A1 (en) 2006-05-09 2007-11-15 Novo Nordisk A/S Insulin derivative
JP5269767B2 (ja) 2006-05-09 2013-08-21 ノボ・ノルデイスク・エー/エス インスリン誘導体
ES2542146T3 (es) 2006-07-31 2015-07-31 Novo Nordisk A/S Insulinas extendidas PEGiladas.
PL2074141T3 (pl) 2006-09-22 2017-02-28 Novo Nordisk A/S Analogi insuliny oporne na proteazę
US20100120660A1 (en) 2007-04-30 2010-05-13 Per Balschmidt Highly concentrated insulin solutions and compositions
US20100190706A1 (en) 2007-06-01 2010-07-29 Novo Nordisk A/S Stable Non-Aqueous Pharmaceutical Compositions
EP2167032B1 (en) * 2007-06-13 2019-08-07 Novo Nordisk A/S Pharmaceutical formulation comprising an insulin derivative
EP2170945A1 (en) 2007-07-16 2010-04-07 Novo Nordisk A/S Protease stabilized, pegylated insulin analogues
EP2178910B1 (en) 2007-08-15 2014-10-08 Novo Nordisk A/S Insulins with an acyl moiety comprising repeating units of alkylene glycol containing amino acids
WO2009022005A1 (en) 2007-08-15 2009-02-19 Novo Nordisk A/S Insulin analogues with an acyl and alkylene glycol moiety
WO2009060071A1 (en) * 2007-11-08 2009-05-14 Novo Nordisk A/S Insulin derivative
CN101970477B (zh) 2008-03-14 2014-12-31 诺沃-诺迪斯克有限公司 蛋白酶稳定的胰岛素类似物
KR20110004366A (ko) 2008-03-18 2011-01-13 노보 노르디스크 에이/에스 프로테아제 안정화되고, 아실화된 인슐린 유사체
WO2010049488A1 (en) 2008-10-30 2010-05-06 Novo Nordisk A/S Treating diabetes melitus using insulin injections with less than daily injection frequency
ES2612468T3 (es) * 2010-05-10 2017-05-17 Novo Nordisk A/S Procedimiento para la preparación de complejos de insulina-zinc
WO2011161124A1 (en) 2010-06-23 2011-12-29 Novo Nordisk A/S Insulin analogues containing additional disulfide bonds
JP5931857B2 (ja) 2010-06-23 2016-06-08 ノヴォ ノルディスク アー/エス 追加のジスルフィド結合を含有するインスリン誘導体
EP2632478B1 (en) * 2010-10-27 2019-07-24 Novo Nordisk A/S Treating diabetes melitus using insulin injections administered with varying injection intervals
AU2013247047A1 (en) 2012-04-11 2014-10-23 Novo Nordisk A/S Insulin formulations

Also Published As

Publication number Publication date
EP3055325B1 (en) 2018-01-03
CN105636979B (zh) 2020-01-10
AU2014333979A1 (en) 2016-03-24
IL244507B (en) 2018-05-31
BR112016007166A2 (pt) 2017-09-12
PL3055325T3 (pl) 2018-06-29
AU2014333979B2 (en) 2018-02-15
EP3055325A1 (en) 2016-08-17
SI3055325T1 (en) 2018-05-31
JP6499184B2 (ja) 2019-04-10
SA516370893B1 (ar) 2018-08-13
US20160215037A1 (en) 2016-07-28
JP2017502074A (ja) 2017-01-19
HUE036702T2 (hu) 2018-07-30
CN105636979A (zh) 2016-06-01
US9896496B2 (en) 2018-02-20
RU2016114098A3 (enExample) 2018-05-21
WO2015052088A1 (en) 2015-04-16
CA2926701A1 (en) 2015-04-16
ES2676065T3 (es) 2018-07-16
KR20160065126A (ko) 2016-06-08
RS57004B1 (sr) 2018-05-31
RU2016114098A (ru) 2017-11-15
MX2016004325A (es) 2016-07-11
RU2673185C2 (ru) 2018-11-22
DK3055325T3 (en) 2018-04-16
IL244507A0 (en) 2016-04-21
PT3055325T (pt) 2018-04-06
HRP20180468T1 (hr) 2018-05-04

Similar Documents

Publication Publication Date Title
MX366636B (es) Nuevo derivado de un análogo de insulina.
LT2916860T (lt) Diabeto gydymui skirta kompozicija, apimanti oksintomodulino analogą
TN2014000517A1 (en) Syringe
IN2014CN02616A (enExample)
PT3110840T (pt) A22k, desb27, b29r, des b30, na posição épsilon de análogo de insulina humana acilada de lisina 22
IL248668B (en) Pyrrolidine gpr40 modulators for the treatment of diseases such as diabetes
EP2970161B8 (en) Gpr120 agonists for the treatment of type ii diabetes
EP3192452A4 (en) Medical needle
PH12016501183A1 (en) Novel compound for treatment of severe hypoglycemia
IL248670A0 (en) Pyrrolidine gpr40 modulators for the treatment of diseases such as diabetes
PH12016501182A1 (en) Novel compound for treatment of severe hypoglycemia
PH12016501184A1 (en) Novel compound for treatment of severe hypoglycemia
MX2016013979A (es) Nuevas vias de administracion de insulina, analogos de insulina o derivados de insulina.
HK40006683A (en) Insulin analogs
AU2017901918A0 (en) Treatment of diabetes
UA103980C2 (ru) Способ консервативного лечения апоплексии яичника с минимальным гемоперитонеумом
AU2016902883A0 (en) Insulin Analogs
AU2016901862A0 (en) Treatment of diabetes
AU2015904246A0 (en) Treatment of diabetes
PH12014000104A1 (en) Therapeutic methods and compositions for treating diabetes
IN2013CH05395A (enExample)
UA88022U (ru) Способ получения вещества с потенциальными физиологическими свойствами 4,5,6,7-тетрагидро-3н-2-n-(пара-метоксифенациламино)-азепина гидрохлорида

Legal Events

Date Code Title Description
FG Grant or registration