BR112015021463A2 - moduladores de benzoimidazol-2-il pirimidina do receptor histamínico h4 - Google Patents

moduladores de benzoimidazol-2-il pirimidina do receptor histamínico h4

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Publication number
BR112015021463A2
BR112015021463A2 BR112015021463A BR112015021463A BR112015021463A2 BR 112015021463 A2 BR112015021463 A2 BR 112015021463A2 BR 112015021463 A BR112015021463 A BR 112015021463A BR 112015021463 A BR112015021463 A BR 112015021463A BR 112015021463 A2 BR112015021463 A2 BR 112015021463A2
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BR
Brazil
Prior art keywords
benzoimidazol
histamine receptor
modulators
pyrimidine
pyrimidine modulators
Prior art date
Application number
BR112015021463A
Other languages
English (en)
Other versions
BR112015021463A8 (pt
Inventor
Matteo Conza
B Hickey Magali
Horns Stefan
Lochner Susanne
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of BR112015021463A2 publication Critical patent/BR112015021463A2/pt
Publication of BR112015021463A8 publication Critical patent/BR112015021463A8/pt

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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Abstract

resumo patente de invenção: "moduladores de benzoimidazol-2-il pirimidina do receptor histamínico h4". benzoimidazol-2-il pirimidinas, métodos de purificação das mesmas, e composições farmacêuticas e métodos para o tratamento de estados patológicos, distúrbios e condições mediadas pela atividade do receptor h4, incluindo alergia, asma, doenças autoimunes e prurido.
BR112015021463A 2013-03-06 2014-03-06 moduladores de benzoimidazol-2-il pirimidina do receptor histamínico h4,seu uso e composição faramacêutica BR112015021463A8 (pt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361773706P 2013-03-06 2013-03-06
US201361776260P 2013-03-11 2013-03-11
US201361784909P 2013-03-14 2013-03-14
PCT/US2014/021130 WO2014138368A1 (en) 2013-03-06 2014-03-06 Benzoimidazol-2-yl pyrimidine modulators of the histamine h4 receptor

Publications (2)

Publication Number Publication Date
BR112015021463A2 true BR112015021463A2 (pt) 2017-07-18
BR112015021463A8 BR112015021463A8 (pt) 2019-11-19

Family

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BR112015021463A BR112015021463A8 (pt) 2013-03-06 2014-03-06 moduladores de benzoimidazol-2-il pirimidina do receptor histamínico h4,seu uso e composição faramacêutica

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US (4) US8859575B2 (pt)
EP (2) EP3660011A1 (pt)
JP (1) JP6471103B2 (pt)
KR (1) KR102230383B1 (pt)
CN (1) CN105025898B (pt)
AU (1) AU2014225675B2 (pt)
BR (1) BR112015021463A8 (pt)
CA (1) CA2903737C (pt)
CL (1) CL2015002434A1 (pt)
CR (1) CR20150435A (pt)
CY (1) CY1122545T1 (pt)
DK (1) DK2964229T3 (pt)
DO (1) DOP2016000027A (pt)
EA (1) EA201591648A1 (pt)
ES (1) ES2773543T3 (pt)
GT (1) GT201500243A (pt)
HK (1) HK1218513A1 (pt)
HR (1) HRP20200253T1 (pt)
HU (1) HUE047681T2 (pt)
IL (1) IL240247B (pt)
JO (1) JO3516B1 (pt)
LT (1) LT2964229T (pt)
MX (1) MX2015011688A (pt)
MY (1) MY180726A (pt)
NZ (1) NZ710640A (pt)
PE (1) PE20151536A1 (pt)
PH (1) PH12015501731A1 (pt)
PL (1) PL2964229T3 (pt)
PT (1) PT2964229T (pt)
RS (1) RS59909B1 (pt)
SA (1) SA515360981B1 (pt)
SG (1) SG11201507117XA (pt)
SI (1) SI2964229T1 (pt)
TW (1) TWI617554B (pt)
UA (1) UA118754C2 (pt)
UY (1) UY35370A (pt)
WO (1) WO2014138368A1 (pt)
ZA (1) ZA201507351B (pt)

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DE602007008545D1 (de) 2006-03-31 2010-09-30 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyridine und pyrazine als modulatoren des histamin-h4-rezeptors
US9371311B2 (en) 2008-06-30 2016-06-21 Janssen Pharmaceutica Nv Benzoimidazol-2-yl pyrimidine derivatives
EP3660011A1 (en) 2013-03-06 2020-06-03 Janssen Pharmaceutica NV Benzoimidazol-2-yl pyrimidine modulators of the histamine h4 receptor
JO3509B1 (ar) 2013-03-14 2020-07-05 Janssen Pharmaceutica Nv معدلات p2x7
TWI644671B (zh) 2013-03-14 2018-12-21 比利時商健生藥品公司 Ｐ２ｘ７調節劑
US10053463B2 (en) 2013-03-14 2018-08-21 Janssen Pharmaceutica Nv Substituted [1,2,4]triazolo[4,3-a]pyrazines as P2X7 modulators
US9096596B2 (en) 2013-03-14 2015-08-04 Janssen Pharmaceutica Nv P2X7 modulators
EP3191492B1 (en) 2014-09-12 2019-01-09 Janssen Pharmaceutica NV P2x7 modulators
CN109963570A (zh) 2017-01-21 2019-07-02 宁波知明生物科技有限公司 芍药苷-6’-o-苯磺酸酯在治疗干燥综合征的应用
WO2020065613A1 (en) 2018-09-28 2020-04-02 Janssen Pharmaceutica Nv Monoacylglycerol lipase modulators
MX2021003661A (es) 2018-09-28 2021-08-19 Janssen Pharmaceutica Nv Moduladores de la monoacilglicerol lipasa.
US11839663B2 (en) 2019-09-30 2023-12-12 Janssen Pharmaceutica Nv Radiolabelled MGL pet ligands
WO2021191359A1 (en) 2020-03-26 2021-09-30 Janssen Pharmaceutica Nv Monoacylglycerol lipase modulators

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