CN109963570A - 芍药苷-6’-o-苯磺酸酯在治疗干燥综合征的应用 - Google Patents
芍药苷-6’-o-苯磺酸酯在治疗干燥综合征的应用 Download PDFInfo
- Publication number
- CN109963570A CN109963570A CN201780069179.8A CN201780069179A CN109963570A CN 109963570 A CN109963570 A CN 109963570A CN 201780069179 A CN201780069179 A CN 201780069179A CN 109963570 A CN109963570 A CN 109963570A
- Authority
- CN
- China
- Prior art keywords
- drug
- application
- paeoniflorin
- group
- sjogren syndrome
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
Abstract
芍药苷‑6'‑O‑苯磺酸酯在治疗干燥综合征的药物中的应用,芍药苷‑6'‑O‑苯磺酸酯的分子式为C29H32O13S。
Description
PCT国内申请,说明书已公开。
Claims (10)
- PCT国内申请,权利要求书已公开。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2017071998 | 2017-01-21 | ||
CNPCT/CN2017/071998 | 2017-01-21 | ||
PCT/CN2017/073540 WO2018133139A1 (zh) | 2017-01-21 | 2017-02-14 | 芍药苷-6'-o-苯磺酸酯在治疗干燥综合征的应用 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN109963570A true CN109963570A (zh) | 2019-07-02 |
Family
ID=62907661
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201780069179.8A Pending CN109963570A (zh) | 2017-01-21 | 2017-02-14 | 芍药苷-6’-o-苯磺酸酯在治疗干燥综合征的应用 |
Country Status (6)
Country | Link |
---|---|
US (2) | US20180325931A1 (zh) |
EP (1) | EP3533451B1 (zh) |
JP (1) | JP6827113B2 (zh) |
CN (1) | CN109963570A (zh) |
AU (1) | AU2017394032B8 (zh) |
WO (1) | WO2018133139A1 (zh) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023125818A1 (zh) * | 2021-12-30 | 2023-07-06 | 广州白云山汉方现代药业有限公司 | 去苯甲酰芍药苷-6'-o-苯磺酸酯、及其制备方法与用途 |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN113713083A (zh) * | 2020-05-25 | 2021-11-30 | 南京帝昌医药科技有限公司 | 一种用于治疗脱发的药物组合 |
CN115677789A (zh) * | 2021-07-23 | 2023-02-03 | 广州白云山汉方现代药业有限公司 | 一种芍药苷-6-o′-苯磺酸酯的制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102603827A (zh) * | 2012-02-10 | 2012-07-25 | 魏伟 | 一种芍药苷芳香族酯衍生物、其制备方法及其用途 |
Family Cites Families (51)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7745140B2 (en) | 2002-01-03 | 2010-06-29 | The Trustees Of The University Of Pennsylvania | Activation and expansion of T-cells using an engineered multivalent signaling platform as a research tool |
AU2003304172A1 (en) * | 2003-05-30 | 2005-01-04 | Shen Zhen Lansen Medicine Co. Ltd. | The pharmaceutical use of total glucide of peony |
US20160355591A1 (en) | 2011-05-02 | 2016-12-08 | Immunomedics, Inc. | Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies |
WO2007092939A2 (en) | 2006-02-08 | 2007-08-16 | Morphotek, Inc. | Antigenic gm-csf peptides and antibodies to gm-csf |
CA3009680C (en) | 2006-03-16 | 2023-08-15 | Symthera Canada Ltd. | Combination of cytokine and cytokine receptor for altering immune system functioning |
EP1914242A1 (en) | 2006-10-19 | 2008-04-23 | Sanofi-Aventis | Novel anti-CD38 antibodies for the treatment of cancer |
LT2126054T (lt) | 2007-01-31 | 2016-10-10 | Yeda Research And Development Company Limited | Peradresuotos, genetiškai modifikuotos t reguliavimo ląstelės ir jų naudojimas autoimuninės ir uždegiminės ligos slopinimui |
JP2010531896A (ja) | 2007-06-26 | 2010-09-30 | チルドレンズ メディカル センター コーポレーション | 治療的投与のためのMetAP−2阻害剤ポリマーソーム |
CA2740077A1 (en) | 2008-10-08 | 2010-04-15 | Cambridge Enterprise Limited | Methods and compositions for diagnosis and treatment |
US8748103B2 (en) | 2008-11-07 | 2014-06-10 | Sequenta, Inc. | Monitoring health and disease status using clonotype profiles |
US8679474B2 (en) | 2010-08-04 | 2014-03-25 | StemBios Technologies, Inc. | Somatic stem cells |
EP2640420B1 (en) | 2010-11-19 | 2018-08-15 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (iro) compounds to modulate toll-like receptor based immune response |
TWI602820B (zh) | 2012-06-06 | 2017-10-21 | 星宿藥物公司 | 溴域抑制劑及其用途 |
EP2897638A1 (en) | 2012-09-24 | 2015-07-29 | Montana State University-Bozeman | Recombinant lactococcus lactis expressing escherichia coli colonization factor antigen i (cfa/i) fimbriae and their methods of use |
UY35212A (es) | 2012-12-21 | 2014-06-30 | Gilead Sciences Inc | Inhibidores de la quinasa que regula la señal de la apoptosis |
CA2903737C (en) | 2013-03-06 | 2021-05-18 | Janssen Pharmaceutica Nv | Benzoimidazol-2-yl pyrimidine modulators of the histamine h4 receptor |
US9394349B2 (en) | 2013-03-15 | 2016-07-19 | Therabron Therapeutics, Inc. | Modification and compositions of human secretoglobin proteins |
US9289461B2 (en) | 2013-03-15 | 2016-03-22 | Mead Johnson Nutrition Company | Reducing the risk of autoimmune disease |
WO2015058214A1 (en) | 2013-10-18 | 2015-04-23 | Trustees Of The University Of Pennsylvania | Oral delivery of angiotensin converting enzyme 2 (ace2) or angiotensin-(1-7) bioencapsulated in plant cells |
CR20160268A (es) | 2013-12-20 | 2016-08-16 | Gilead Sciences Inc | Inhibidores de la quinasa reguladora de la señal de apoptosis |
WO2015100246A1 (en) | 2013-12-24 | 2015-07-02 | Ossianix, Inc. | Baff selective binding compounds and related methods |
WO2015109245A1 (en) | 2014-01-17 | 2015-07-23 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Particle formulations of all-trans retinoic acid and transforming growth factor beta for the treatment of type 1 diabetes mellitus |
WO2015107140A1 (en) | 2014-01-17 | 2015-07-23 | Fundació Institut D'investigació En Ciències De La Salut Germans Trias I Pujol | Liposome-based immunotherapy |
JP2017505766A (ja) | 2014-01-17 | 2017-02-23 | デベヴェ・テクノロジーズ | 皮膚上でのイムノリバランス |
US10130650B2 (en) | 2014-01-27 | 2018-11-20 | The Children's Hospital Of Philadelphia | Compositions and methods for treating autoimmune and inflammatory diseases |
GB201401465D0 (en) | 2014-01-29 | 2014-03-12 | Roach Arthur H | Use of cladribine for treating autoimmune inflammatory disease |
WO2015123493A2 (en) | 2014-02-13 | 2015-08-20 | Northwestern University | Compositions and methods for modulatuion of immune response |
US10022443B2 (en) | 2014-04-08 | 2018-07-17 | Boston Pharmaceuticals Inc. | Antibodies specific for IL-21 and uses thereof |
US10308703B2 (en) | 2014-04-28 | 2019-06-04 | The National Institute For Biotechnology I | Variants of DR3 and use thereof |
KR101705446B1 (ko) | 2014-04-29 | 2017-02-09 | 가톨릭대학교 산학협력단 | 면역질환 치료효과를 갖는 신규한 화합물 및 이의 용도 |
RS64542B1 (sr) | 2014-04-30 | 2023-09-29 | Hanall Biopharma Co Ltd | Vezivanje antitela za fcrn za lečenje autoimunih bolesti |
JP2017516853A (ja) | 2014-05-23 | 2017-06-22 | ミングサイト ファーマシューティカルズ,インク. | 自己免疫性疾患の処置 |
JP7093612B2 (ja) | 2014-05-27 | 2022-06-30 | アカデミア シニカ | Bacteroides由来のフコシダーゼおよびそれを使用する方法 |
DK3151853T3 (da) | 2014-06-04 | 2020-07-27 | Diamyd Medical Ab | Glutaminsyre-decarboxylase (GAD) til anvendelse ved behandling af en autoimmun sygdom |
SG10201903578VA (en) | 2014-10-24 | 2019-05-30 | Bristol Myers Squibb Co | Indole carboxamides compounds useful as kinase inhibitors |
CN107921104A (zh) | 2015-02-22 | 2018-04-17 | 索伦托治疗有限公司 | 结合cd137的抗体疗法 |
US20160333409A1 (en) | 2015-03-09 | 2016-11-17 | Cb Biotechnologies, Inc. | Method for identifying disease-associated cdr3 patterns in an immune repertoire |
KR20160126734A (ko) | 2015-04-24 | 2016-11-02 | 한국생명공학연구원 | 자가면역질환 환자 특이적 유도만능줄기세포의 제조방법 및 이의 이용 |
US20180142211A1 (en) | 2015-05-20 | 2018-05-24 | Biokine Therapeutics Ltd | Methods of mesenchymal stem cell mobilization and expansion |
PL3297992T3 (pl) | 2015-05-22 | 2020-07-27 | Chong Kun Dang Pharmaceutical Corp. | Heterocykloalkilowe związki pochodne jako selektywne inhibitory deacetylazy histonowej oraz zawierające je kompozycje farmaceutyczne |
WO2016191545A1 (en) | 2015-05-26 | 2016-12-01 | Advaxis, Inc. | Personalized delivery vector-based immunotherapy and uses thereof |
US20180116988A1 (en) | 2015-05-28 | 2018-05-03 | The Regents Of The University Of Colorado A Body Corporate | Methods of preventing and treating autoimmunity |
WO2016196393A2 (en) | 2015-05-29 | 2016-12-08 | Presage Biosciences, Inc. | Autophagy-inhibiting compounds and uses thereof |
AU2016270587B2 (en) | 2015-05-29 | 2020-12-24 | Regeneron Pharmaceuticals, Inc. | Non-human animals having a disruption in a C9ORF72 locus |
JP6786526B2 (ja) | 2015-06-03 | 2020-11-18 | ザ メディカル カレッジ オブ ウィスコンシン インクThe Medical College Of Wisconsin, Inc. | 改変されたccl20ロックド二量体ポリペプチド |
US20160355464A1 (en) | 2015-06-07 | 2016-12-08 | Mark Quang Nguyen | Fumarate compounds, pharmaceutical compositions thereof, and methods of use |
WO2016200694A1 (en) | 2015-06-10 | 2016-12-15 | Hackensack University Medical Center | Use of telmisartan to prevent and treat graft versus host disease and other alloimmune and autoimmune diseases |
JP2018517774A (ja) | 2015-06-10 | 2018-07-05 | エリジウム・ヘルス・インコーポレイテッド | ニコチンアミドリボシドおよびプテロスチルベン組成物ならびに皮膚障害の処置のための方法 |
JP2018522833A (ja) | 2015-06-12 | 2018-08-16 | イミューノメディクス、インコーポレイテッドImmunomedics, Inc. | キメラ抗原受容体(car)コンストラクト、及びcarコンストラクトを発現するt細胞(car−t)またはnk細胞(car−nk)による疾患治療 |
WO2016204429A1 (ko) | 2015-06-18 | 2016-12-22 | 한국화학연구원 | 헤테로아릴 유도체 또는 이의 약학적으로 허용가능한 염, 이의 제조방법 및 이를 유효성분으로 포함하는 pi3 키나아제 관련 질환의 예방 또는 치료용 약학적 조성물. |
RU2601410C1 (ru) | 2015-11-13 | 2016-11-10 | ЗАО "Р-Фарм" | {3-[(7H-ПИРРОЛО[2,3-d]ПИРИМИДИН-4-ИЛ)АЗОЛИЛ]АЗЕТИДИН-3-ИЛ}АЦЕТОНИТРИЛЫ В КАЧЕСТВЕ ИНГИБИТОРОВ ЯНУС КИНАЗ |
-
2017
- 2017-02-14 CN CN201780069179.8A patent/CN109963570A/zh active Pending
- 2017-02-14 AU AU2017394032A patent/AU2017394032B8/en active Active
- 2017-02-14 EP EP17892917.0A patent/EP3533451B1/en active Active
- 2017-02-14 WO PCT/CN2017/073540 patent/WO2018133139A1/zh active Application Filing
- 2017-02-14 JP JP2019527134A patent/JP6827113B2/ja active Active
- 2017-02-14 US US15/513,050 patent/US20180325931A1/en not_active Abandoned
-
2020
- 2020-01-13 US US16/740,570 patent/US20200147116A1/en not_active Abandoned
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102603827A (zh) * | 2012-02-10 | 2012-07-25 | 魏伟 | 一种芍药苷芳香族酯衍生物、其制备方法及其用途 |
Non-Patent Citations (1)
Title |
---|
于静雅: "芍药苷对原发性干燥综合征患者外周血单个核细胞表面 P2X7R 表达及炎症细胞因子 IL-1、 IL-6 分泌的干预作用", 《万方学术期刊数据库 硕士学位论文》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2023125818A1 (zh) * | 2021-12-30 | 2023-07-06 | 广州白云山汉方现代药业有限公司 | 去苯甲酰芍药苷-6'-o-苯磺酸酯、及其制备方法与用途 |
Also Published As
Publication number | Publication date |
---|---|
AU2017394032A1 (en) | 2019-06-13 |
JP2019537615A (ja) | 2019-12-26 |
WO2018133139A1 (zh) | 2018-07-26 |
AU2017394032A8 (en) | 2020-10-22 |
EP3533451A4 (en) | 2020-01-15 |
EP3533451B1 (en) | 2022-07-27 |
US20200147116A1 (en) | 2020-05-14 |
AU2017394032B2 (en) | 2020-10-08 |
JP6827113B2 (ja) | 2021-02-10 |
US20180325931A1 (en) | 2018-11-15 |
AU2017394032B8 (en) | 2020-10-22 |
EP3533451A1 (en) | 2019-09-04 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US10201537B2 (en) | Use of levocetirizine and montelukast in the treatment of autoimmune disorders | |
US20160022684A1 (en) | Bet inhibitor and bruton's tyrosine kinase inhibitor combinations | |
US20080032989A1 (en) | Method of treating inflammatory diseases using tyroskine kinase inhibitors | |
CN109963570A (zh) | 芍药苷-6’-o-苯磺酸酯在治疗干燥综合征的应用 | |
TW201628622A (zh) | Tlr抑制劑與布魯頓氏(bruton's)酪胺酸激酶抑制劑之組合 | |
Zhang et al. | Protection against ulcerative colitis and colorectal cancer by evodiamine via anti‑inflammatory effects | |
CN102895661A (zh) | 靶向CysLT1的药物在制备用于预防或治疗自身免疫性疾病的药物中的用途 | |
KR19990044834A (ko) | 네가티브인자작용 억제제 | |
US11197860B2 (en) | Treatment of primary biliary cholangitis and primary sclerosing cholangitis with baricitinib | |
Song et al. | Berberine attenuates experimental autoimmune myasthenia gravis via rebalancing the T cell subsets | |
WO2018081090A1 (en) | Compositions and methods for the treatment of hbv infection | |
CN101048160B (zh) | 嘌呤和嘧啶cdk抑制剂及其在制备用于治疗自身免疫性疾病的药物中的用途 | |
JP2018534309A (ja) | 自己免疫疾患の処置 | |
CN101747414B (zh) | TNF-α结合肽和TNFR1封闭肽及其在治疗TNF相关疾病中的应用 | |
US7875616B2 (en) | Use of tyrosine kinase inhibitor to treat diabetes | |
CN109568430A (zh) | 一种免疫增强剂的制备方法和应用 | |
Friedlaender et al. | Effect of cortisone administered orally in bronchial asthma | |
CN104825455B (zh) | 依鲁替尼的用途 | |
CN104411309A (zh) | 阿可拉定在制备用于治疗原发性肝癌的药物中的用途 | |
CN1333044A (zh) | 消渴降糖宝 | |
RU2635968C1 (ru) | Способ лечения и профилактики состояний аллергического спектра | |
CN102321155A (zh) | Tnf结合肽和tnfr1封闭肽及其在治疗溃疡性结肠炎中的应用 | |
Miao | Clinical Efficacy of Lenalidomide Combined with Cyclophosphamide and Dexamethasone in the Treatment of Multiple Myeloma | |
CN116672367A (zh) | 鱼油在制备治疗荨麻疹药物的应用及其药物组合物 | |
CN104069097A (zh) | 去甲斑蝥素用于治疗类风湿关节炎的新用途 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20201117 Address after: 510970 No.8, Wenquan Avenue, Conghua, Guangzhou, Guangdong Province Applicant after: GUANGZHOU HANFANG PHARMACEUTICAL Co.,Ltd. Address before: 315194 Li Bing, Room 204, 2nd Floor, D Building, 655 Xueshi Road, Yinzhou District, Ningbo City, Zhejiang Province Applicant before: Ningbo Zhiming Biotechnology Co.,Ltd. Applicant before: Wei Wei |