BR112014016810A8 - composições e métodos para tratamento de distúrbios metabólicos - Google Patents
composições e métodos para tratamento de distúrbios metabólicosInfo
- Publication number
- BR112014016810A8 BR112014016810A8 BR112014016810A BR112014016810A BR112014016810A8 BR 112014016810 A8 BR112014016810 A8 BR 112014016810A8 BR 112014016810 A BR112014016810 A BR 112014016810A BR 112014016810 A BR112014016810 A BR 112014016810A BR 112014016810 A8 BR112014016810 A8 BR 112014016810A8
- Authority
- BR
- Brazil
- Prior art keywords
- metabolic disorders
- methods
- compositions
- treating metabolic
- biguanide compounds
- Prior art date
Links
Classifications
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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- A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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Abstract
composições e métodos para tratamento de distúrbios metabólicos resumo são fornecidos métodos para melhorar a tolerabilidade gastrintestinal de compostos de biguanida e para tratamento de distúrbios metabólicos e/ou indução à perda de peso em pacientes que necessitem dos mesmos, especialmente em indivíduos que possuem uma contra-indicação para o tratamento com compostos de biguanida, compreendendo a administração de formulações de liberação retardada de tais compostos de biguanida, incluindo a metformina, direcionada ao intestino delgado.
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US13/547,022 US8796338B2 (en) | 2011-01-07 | 2012-07-11 | Biguanide compositions and methods of treating metabolic disorders |
PCT/US2013/020420 WO2013103919A2 (en) | 2012-01-06 | 2013-01-05 | Compositions and methods for treating metabolic disorders |
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BR112014016810A BR112014016810A8 (pt) | 2012-01-06 | 2013-01-05 | composições e métodos para tratamento de distúrbios metabólicos |
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