BR112014016810A8 - composições e métodos para tratamento de distúrbios metabólicos - Google Patents

composições e métodos para tratamento de distúrbios metabólicos

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Publication number
BR112014016810A8
BR112014016810A8 BR112014016810A BR112014016810A BR112014016810A8 BR 112014016810 A8 BR112014016810 A8 BR 112014016810A8 BR 112014016810 A BR112014016810 A BR 112014016810A BR 112014016810 A BR112014016810 A BR 112014016810A BR 112014016810 A8 BR112014016810 A8 BR 112014016810A8
Authority
BR
Brazil
Prior art keywords
metabolic disorders
methods
compositions
treating metabolic
biguanide compounds
Prior art date
Application number
BR112014016810A
Other languages
English (en)
Other versions
BR112014016810A2 (pt
Inventor
D Baron Alain
S Fineman Mark
R A Beeley Nigel
Original Assignee
Elcelyx Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48745545&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112014016810(A8) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US13/345,135 external-priority patent/US20120177730A1/en
Priority claimed from US13/547,022 external-priority patent/US8796338B2/en
Application filed by Elcelyx Therapeutics Inc filed Critical Elcelyx Therapeutics Inc
Publication of BR112014016810A2 publication Critical patent/BR112014016810A2/pt
Publication of BR112014016810A8 publication Critical patent/BR112014016810A8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
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    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
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    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
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    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
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Abstract

composições e métodos para tratamento de distúrbios metabólicos resumo são fornecidos métodos para melhorar a tolerabilidade gastrintestinal de compostos de biguanida e para tratamento de distúrbios metabólicos e/ou indução à perda de peso em pacientes que necessitem dos mesmos, especialmente em indivíduos que possuem uma contra-indicação para o tratamento com compostos de biguanida, compreendendo a administração de formulações de liberação retardada de tais compostos de biguanida, incluindo a metformina, direcionada ao intestino delgado.
BR112014016810A 2012-01-06 2013-01-05 composições e métodos para tratamento de distúrbios metabólicos BR112014016810A8 (pt)

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US13/345,135 US20120177730A1 (en) 2011-01-07 2012-01-06 Chemosensory Receptor Ligand-Based Therapies
US201261649171P 2012-05-18 2012-05-18
US13/547,022 US8796338B2 (en) 2011-01-07 2012-07-11 Biguanide compositions and methods of treating metabolic disorders
PCT/US2013/020420 WO2013103919A2 (en) 2012-01-06 2013-01-05 Compositions and methods for treating metabolic disorders

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