BR112014006684A2 - análogos de glucagon - Google Patents
análogos de glucagonInfo
- Publication number
- BR112014006684A2 BR112014006684A2 BR112014006684A BR112014006684A BR112014006684A2 BR 112014006684 A2 BR112014006684 A2 BR 112014006684A2 BR 112014006684 A BR112014006684 A BR 112014006684A BR 112014006684 A BR112014006684 A BR 112014006684A BR 112014006684 A2 BR112014006684 A2 BR 112014006684A2
- Authority
- BR
- Brazil
- Prior art keywords
- glucagon peptides
- glucagon
- glucagon analogs
- hyperglycemia
- obesity
- Prior art date
Links
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical class C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 title abstract 2
- 102000051325 Glucagon Human genes 0.000 abstract 6
- 108060003199 Glucagon Proteins 0.000 abstract 6
- 208000008589 Obesity Diseases 0.000 abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 abstract 2
- 201000001421 hyperglycemia Diseases 0.000 abstract 2
- 235000020824 obesity Nutrition 0.000 abstract 2
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229960004666 glucagon Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/2278—Vasoactive intestinal peptide [VIP]; Related peptides (e.g. Exendin)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Emergency Medicine (AREA)
- Addiction (AREA)
- Urology & Nephrology (AREA)
- Child & Adolescent Psychology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Psychiatry (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11182476 | 2011-09-23 | ||
| US201161539148P | 2011-09-26 | 2011-09-26 | |
| PCT/EP2012/068649 WO2013041678A1 (en) | 2011-09-23 | 2012-09-21 | Novel glucagon analogues |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014006684A2 true BR112014006684A2 (pt) | 2017-03-28 |
Family
ID=47911932
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014006684A BR112014006684A2 (pt) | 2011-09-23 | 2012-09-21 | análogos de glucagon |
Country Status (17)
| Country | Link |
|---|---|
| US (4) | US8541368B2 (enExample) |
| EP (1) | EP2758426B1 (enExample) |
| JP (2) | JP6352806B2 (enExample) |
| KR (1) | KR20140070612A (enExample) |
| CN (1) | CN104093735B (enExample) |
| AR (1) | AR088161A1 (enExample) |
| AU (1) | AU2012311484B2 (enExample) |
| BR (1) | BR112014006684A2 (enExample) |
| CA (1) | CA2849673A1 (enExample) |
| IL (1) | IL231199A0 (enExample) |
| IN (1) | IN2014CN02448A (enExample) |
| MX (1) | MX354705B (enExample) |
| MY (1) | MY167234A (enExample) |
| RU (2) | RU2610175C2 (enExample) |
| TW (1) | TWI596110B (enExample) |
| WO (1) | WO2013041678A1 (enExample) |
| ZA (1) | ZA201401603B (enExample) |
Families Citing this family (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1765408B1 (en) * | 2004-07-08 | 2015-12-09 | Novo Nordisk A/S | Polypeptide protracting tags comprising a tetrazole moiety |
| DK2454282T3 (en) | 2009-07-13 | 2015-05-04 | Zealand Pharma As | acetylated glucagonanaloger |
| US8541368B2 (en) | 2011-09-23 | 2013-09-24 | Novo Nordisk A/S | Glucagon analogues |
| JP6228187B2 (ja) | 2012-05-03 | 2017-11-08 | ジーランド ファーマ アクティーゼルスカブ | Ｇｉｐ−ｇｌｐ−１デュアルアゴニスト化合物及び方法 |
| UA117103C2 (uk) | 2012-07-23 | 2018-06-25 | Зіленд Фарма А/С | Сполука, яка має активність агоніста глюкагону |
| TWI608013B (zh) | 2012-09-17 | 2017-12-11 | 西蘭製藥公司 | 升糖素類似物 |
| UA116217C2 (uk) | 2012-10-09 | 2018-02-26 | Санофі | Пептидна сполука як подвійний агоніст рецепторів glp1-1 та глюкагону |
| JP6408998B2 (ja) | 2012-12-21 | 2018-10-17 | サノフイＳａｎｏｆｉ | 二重ｇｌｐ１／ｇｉｐまたは三方ｇｌｐ１／ｇｉｐ／グルカゴンアゴニスト |
| ES2754048T3 (es) * | 2013-04-18 | 2020-04-15 | Novo Nordisk As | Coagonistas de receptores de GLP-1/glucagón prolongados y estables para uso médico |
| AU2014255608B2 (en) * | 2013-04-18 | 2018-01-25 | Novo Nordisk A/S | Stable, protracted GLP-1/glucagon receptor co-agonists for medical use |
| ES2646538T3 (es) | 2013-06-20 | 2017-12-14 | Novo Nordisk A/S | Derivados de GLP-1 y sus usos |
| US9988429B2 (en) | 2013-10-17 | 2018-06-05 | Zealand Pharma A/S | Glucagon analogues |
| BR112016008115B1 (pt) | 2013-10-17 | 2024-03-12 | Boehringer Ingelheim International Gmbh | Análogos de glucagon acilados |
| WO2015067716A1 (en) | 2013-11-06 | 2015-05-14 | Zealand Pharma A/S | Glucagon-glp-1-gip triple agonist compounds |
| CA2929459C (en) | 2013-11-06 | 2022-05-03 | Zealand Pharma A/S | Gip-glp-1 dual agonist compounds and methods |
| TW201609799A (zh) | 2013-12-13 | 2016-03-16 | 賽諾菲公司 | 雙重ｇｌｐ－１／ｇｉｐ受體促效劑 |
| WO2015086728A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| EP3080149A1 (en) | 2013-12-13 | 2016-10-19 | Sanofi | Dual glp-1/glucagon receptor agonists |
| WO2015086730A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Non-acylated exendin-4 peptide analogues |
| AU2015220909A1 (en) | 2014-02-18 | 2016-07-14 | Novo Nordisk A/S | Stable glucagon analogues and use for treatment of hypoglycaemia |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| JP2017525656A (ja) | 2014-06-04 | 2017-09-07 | ノヴォ ノルディスク アー／エス | 医療用のｇｌｐ−１／グルカゴン受容体コアゴニスト |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| CN104926934B (zh) | 2014-09-23 | 2016-11-09 | 蒋先兴 | 胃泌酸调节素类似物 |
| WO2016055610A1 (en) * | 2014-10-10 | 2016-04-14 | Novo Nordisk A/S | Stable glp-1 based glp-1/glucagon receptor co-agonists |
| US10253078B2 (en) | 2014-10-29 | 2019-04-09 | Zealand Pharma A/S | GIP agonist compounds and methods |
| CN106999602B (zh) | 2014-11-27 | 2022-02-01 | 诺和诺德股份有限公司 | Glp-1衍生物及其用途 |
| US10392428B2 (en) | 2014-12-17 | 2019-08-27 | Novo Nordisk A/S | GLP-1 derivatives and uses thereof |
| JOP20200119A1 (ar) * | 2015-01-09 | 2017-06-16 | Lilly Co Eli | مركبات مساعد مشترك من gip وglp-1 |
| ES2763329T3 (es) | 2015-04-16 | 2020-05-28 | Zealand Pharma As | Análogo de glucagón acilado |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| TW201706291A (zh) | 2015-07-10 | 2017-02-16 | 賽諾菲公司 | 作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物 |
| WO2017015538A1 (en) | 2015-07-22 | 2017-01-26 | Purdue Research Foundation | Modified glucagon molecules |
| TWI622596B (zh) | 2015-10-26 | 2018-05-01 | 美國禮來大藥廠 | 升糖素受體促效劑 |
| HRP20220720T1 (hr) * | 2016-01-13 | 2022-09-30 | Novo Nordisk A/S | Analozi egf(a) s masnim kiselinama kao supstituentima |
| KR20200028399A (ko) * | 2017-07-13 | 2020-03-16 | 후지세유 그룹 혼샤 가부시키가이샤 | 펩타이드 |
| BR112020001286A2 (pt) | 2017-07-19 | 2020-07-28 | Novo Nordisk A/S | composto, e, método de tratamento da diabetes, sobrepeso e/ou doenças cardiovasculares |
| CN111164128A (zh) | 2017-09-29 | 2020-05-15 | 韩美药品株式会社 | 包含作为接头的非肽基聚合物偶联的脂肪酸衍生物化合物的蛋白复合物及其制备方法 |
| JOP20190150A1 (ar) | 2018-06-21 | 2019-12-21 | Merck Sharp & Dohme | مركبات مناهضة لـ pcsk9 |
| CA3128922A1 (en) * | 2019-02-05 | 2020-08-13 | Eli Lilly And Company | Glucagon analog agonists and methods of using the same |
| EP4076492A4 (en) * | 2019-12-20 | 2024-01-17 | Merck Sharp & Dohme LLC | PCSK9 ANTAGONIST COMPOUNDS |
| TWI850611B (zh) * | 2020-12-18 | 2024-08-01 | 丹麥商諾佛 儂迪克股份有限公司 | Glp-1及澱粉素受體之共促效劑 |
| CN116710462A (zh) | 2021-01-20 | 2023-09-05 | 维京治疗公司 | 用于治疗代谢病症和肝病的组合物和方法 |
| EP4259647A4 (en) | 2021-09-15 | 2025-03-26 | Viking Therapeutics, Inc. | COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC AND LIVER DISEASES |
| CN113759048B (zh) * | 2021-10-14 | 2022-06-21 | 成都普康唯新生物科技有限公司 | 一种十八烷二酸单叔丁酯检验方法 |
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-
2012
- 2012-09-21 US US13/624,387 patent/US8541368B2/en active Active
- 2012-09-21 RU RU2014114434A patent/RU2610175C2/ru not_active IP Right Cessation
- 2012-09-21 BR BR112014006684A patent/BR112014006684A2/pt not_active Application Discontinuation
- 2012-09-21 AU AU2012311484A patent/AU2012311484B2/en not_active Ceased
- 2012-09-21 RU RU2017101333A patent/RU2017101333A/ru unknown
- 2012-09-21 IN IN2448CHN2014 patent/IN2014CN02448A/en unknown
- 2012-09-21 WO PCT/EP2012/068649 patent/WO2013041678A1/en not_active Ceased
- 2012-09-21 TW TW101134663A patent/TWI596110B/zh not_active IP Right Cessation
- 2012-09-21 CN CN201280057736.1A patent/CN104093735B/zh not_active Expired - Fee Related
- 2012-09-21 EP EP12759773.0A patent/EP2758426B1/en active Active
- 2012-09-21 JP JP2014531245A patent/JP6352806B2/ja not_active Expired - Fee Related
- 2012-09-21 AR ARP120103494A patent/AR088161A1/es unknown
- 2012-09-21 KR KR1020147010449A patent/KR20140070612A/ko not_active Withdrawn
- 2012-09-21 MY MYPI2014000627A patent/MY167234A/en unknown
- 2012-09-21 MX MX2014003312A patent/MX354705B/es active IP Right Grant
- 2012-09-21 CA CA2849673A patent/CA2849673A1/en not_active Withdrawn
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2013
- 2013-07-09 US US13/937,674 patent/US9486505B2/en active Active
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2014
- 2014-02-27 IL IL231199A patent/IL231199A0/en unknown
- 2014-03-03 ZA ZA2014/01603A patent/ZA201401603B/en unknown
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2015
- 2015-02-24 US US14/629,682 patent/US9486506B2/en active Active
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2016
- 2016-08-16 US US15/237,958 patent/US20160347812A1/en not_active Abandoned
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- 2017-11-06 JP JP2017213869A patent/JP2018021081A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| RU2014114434A (ru) | 2015-10-27 |
| RU2610175C2 (ru) | 2017-02-08 |
| ZA201401603B (en) | 2015-02-25 |
| US9486505B2 (en) | 2016-11-08 |
| US8541368B2 (en) | 2013-09-24 |
| WO2013041678A1 (en) | 2013-03-28 |
| JP2018021081A (ja) | 2018-02-08 |
| US20130288958A1 (en) | 2013-10-31 |
| MY167234A (en) | 2018-08-14 |
| CN104093735B (zh) | 2018-07-06 |
| IN2014CN02448A (enExample) | 2015-06-19 |
| US20150182594A1 (en) | 2015-07-02 |
| RU2017101333A (ru) | 2018-12-19 |
| TWI596110B (zh) | 2017-08-21 |
| JP2014527975A (ja) | 2014-10-23 |
| KR20140070612A (ko) | 2014-06-10 |
| CA2849673A1 (en) | 2013-03-28 |
| JP6352806B2 (ja) | 2018-07-04 |
| US20130079278A1 (en) | 2013-03-28 |
| TW201329102A (zh) | 2013-07-16 |
| IL231199A0 (en) | 2014-04-30 |
| MX354705B (es) | 2018-03-16 |
| US20160347812A1 (en) | 2016-12-01 |
| EP2758426B1 (en) | 2019-08-07 |
| AR088161A1 (es) | 2014-05-14 |
| EP2758426A1 (en) | 2014-07-30 |
| US9486506B2 (en) | 2016-11-08 |
| AU2012311484A1 (en) | 2014-03-06 |
| MX2014003312A (es) | 2014-04-25 |
| AU2012311484B2 (en) | 2017-04-13 |
| CN104093735A (zh) | 2014-10-08 |
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