BR112014000857B1 - métodos para produção de compostos de 177lu de alta pureza isentos de veículos, e uso de cromatografia de troca catiônica para a produção dos referidos compostos - Google Patents
métodos para produção de compostos de 177lu de alta pureza isentos de veículos, e uso de cromatografia de troca catiônica para a produção dos referidos compostos Download PDFInfo
- Publication number
- BR112014000857B1 BR112014000857B1 BR112014000857-4A BR112014000857A BR112014000857B1 BR 112014000857 B1 BR112014000857 B1 BR 112014000857B1 BR 112014000857 A BR112014000857 A BR 112014000857A BR 112014000857 B1 BR112014000857 B1 BR 112014000857B1
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- Brazil
- Prior art keywords
- column
- cation exchange
- exchange material
- compounds
- chelating agent
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 53
- 238000005277 cation exchange chromatography Methods 0.000 title claims abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract description 5
- 239000002738 chelating agent Substances 0.000 claims abstract description 38
- 238000004519 manufacturing process Methods 0.000 claims abstract description 29
- 239000000463 material Substances 0.000 claims description 74
- 238000005341 cation exchange Methods 0.000 claims description 53
- 239000002253 acid Substances 0.000 claims description 39
- -1 ammonium ions Chemical class 0.000 claims description 39
- 229910001868 water Inorganic materials 0.000 claims description 38
- BWLBGMIXKSTLSX-UHFFFAOYSA-N 2-hydroxyisobutyric acid Chemical compound CC(C)(O)C(O)=O BWLBGMIXKSTLSX-UHFFFAOYSA-N 0.000 claims description 32
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 claims description 27
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 27
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 27
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 24
- 239000011707 mineral Substances 0.000 claims description 24
- 230000000694 effects Effects 0.000 claims description 17
- 238000011068 loading method Methods 0.000 claims description 17
- 238000010828 elution Methods 0.000 claims description 14
- 230000002378 acidificating effect Effects 0.000 claims description 13
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims description 12
- 235000019270 ammonium chloride Nutrition 0.000 claims description 12
- 238000005406 washing Methods 0.000 claims description 12
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- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 9
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims description 9
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims description 9
- 230000001143 conditioned effect Effects 0.000 claims description 9
- DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 claims description 9
- 229910017604 nitric acid Inorganic materials 0.000 claims description 9
- 229910052765 Lutetium Inorganic materials 0.000 claims description 8
- 238000009834 vaporization Methods 0.000 claims description 7
- 230000008016 vaporization Effects 0.000 claims description 7
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims description 6
- 150000007513 acids Chemical class 0.000 claims description 6
- 230000015572 biosynthetic process Effects 0.000 claims description 6
- OHSVLFRHMCKCQY-UHFFFAOYSA-N lutetium atom Chemical compound [Lu] OHSVLFRHMCKCQY-UHFFFAOYSA-N 0.000 claims description 6
- 239000006200 vaporizer Substances 0.000 claims description 6
- 239000003729 cation exchange resin Substances 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 229940023913 cation exchange resins Drugs 0.000 claims description 4
- 239000003480 eluent Substances 0.000 claims description 4
- 229910021645 metal ion Inorganic materials 0.000 claims description 4
- 150000007524 organic acids Chemical class 0.000 claims description 4
- 235000005985 organic acids Nutrition 0.000 claims description 4
- 239000004793 Polystyrene Substances 0.000 claims description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 3
- 150000002500 ions Chemical class 0.000 claims description 3
- 229920002223 polystyrene Polymers 0.000 claims description 3
- 235000011149 sulphuric acid Nutrition 0.000 claims description 3
- NWUYHJFMYQTDRP-UHFFFAOYSA-N 1,2-bis(ethenyl)benzene;1-ethenyl-2-ethylbenzene;styrene Chemical compound C=CC1=CC=CC=C1.CCC1=CC=CC=C1C=C.C=CC1=CC=CC=C1C=C NWUYHJFMYQTDRP-UHFFFAOYSA-N 0.000 claims description 2
- BPQQTUXANYXVAA-UHFFFAOYSA-N Orthosilicate Chemical compound [O-][Si]([O-])([O-])[O-] BPQQTUXANYXVAA-UHFFFAOYSA-N 0.000 claims description 2
- 230000033228 biological regulation Effects 0.000 claims description 2
- 150000007522 mineralic acids Chemical class 0.000 claims description 2
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- 239000011159 matrix material Substances 0.000 claims 1
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- 238000000746 purification Methods 0.000 abstract description 4
- 125000002091 cationic group Chemical group 0.000 abstract description 3
- 238000004587 chromatography analysis Methods 0.000 abstract description 2
- 238000000926 separation method Methods 0.000 description 41
- 229910052769 Ytterbium Inorganic materials 0.000 description 12
- 239000000047 product Substances 0.000 description 11
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- NAWDYIZEMPQZHO-UHFFFAOYSA-N ytterbium Chemical compound [Yb] NAWDYIZEMPQZHO-UHFFFAOYSA-N 0.000 description 10
- 230000008901 benefit Effects 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 8
- 229910052747 lanthanoid Inorganic materials 0.000 description 7
- 150000002602 lanthanoids Chemical group 0.000 description 7
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 6
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 6
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- 229910021529 ammonia Inorganic materials 0.000 description 2
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- SEGLCEQVOFDUPX-UHFFFAOYSA-N di-(2-ethylhexyl)phosphoric acid Chemical compound CCCCC(CC)COP(O)(=O)OCC(CC)CCCC SEGLCEQVOFDUPX-UHFFFAOYSA-N 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 238000001095 inductively coupled plasma mass spectrometry Methods 0.000 description 2
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- XMIIGOLPHOKFCH-UHFFFAOYSA-N 3-phenylpropionic acid Chemical compound OC(=O)CCC1=CC=CC=C1 XMIIGOLPHOKFCH-UHFFFAOYSA-N 0.000 description 1
- 229910052692 Dysprosium Inorganic materials 0.000 description 1
- 229910052691 Erbium Inorganic materials 0.000 description 1
- 229910052693 Europium Inorganic materials 0.000 description 1
- 229910052688 Gadolinium Inorganic materials 0.000 description 1
- 229910052689 Holmium Inorganic materials 0.000 description 1
- 229910052771 Terbium Inorganic materials 0.000 description 1
- 229910052775 Thulium Inorganic materials 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
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- UZLYXNNZYFBAQO-UHFFFAOYSA-N oxygen(2-);ytterbium(3+) Chemical compound [O-2].[O-2].[O-2].[Yb+3].[Yb+3] UZLYXNNZYFBAQO-UHFFFAOYSA-N 0.000 description 1
- 238000011349 peptide receptor radionuclide therapy Methods 0.000 description 1
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- 238000003860 storage Methods 0.000 description 1
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- 239000003053 toxin Substances 0.000 description 1
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- 229940075624 ytterbium oxide Drugs 0.000 description 1
- 229910003454 ytterbium oxide Inorganic materials 0.000 description 1
- KUBYTSCYMRPPAG-UHFFFAOYSA-N ytterbium(3+);trinitrate Chemical compound [Yb+3].[O-][N+]([O-])=O.[O-][N+]([O-])=O.[O-][N+]([O-])=O KUBYTSCYMRPPAG-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
- C22B59/00—Obtaining rare earth metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/244—Lanthanides; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
- B01D15/166—Fluid composition conditioning, e.g. gradient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
- B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
- B01D15/361—Ion-exchange
- B01D15/362—Cation-exchange
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
- G21G2001/0094—Other isotopes not provided for in the groups listed above
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Physics & Mathematics (AREA)
- High Energy & Nuclear Physics (AREA)
- General Engineering & Computer Science (AREA)
- Environmental & Geological Engineering (AREA)
- Mechanical Engineering (AREA)
- Metallurgy (AREA)
- Materials Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Geology (AREA)
- General Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102011051868A DE102011051868B4 (de) | 2011-07-15 | 2011-07-15 | Verfahren zur Herstellung trägerfreier hochreiner 177Lu-Verbindungen sowie trägerfreie 177Lu-Verbindungen |
| DE102011051868.1 | 2011-07-15 | ||
| PCT/EP2012/056644 WO2013010686A1 (de) | 2011-07-15 | 2012-04-12 | Verfahren zur herstellung trägerfreier hochreiner 177lu-verbindungen sowie trägerfreie 177lu-verbindungen |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112014000857A2 BR112014000857A2 (pt) | 2017-02-21 |
| BR112014000857B1 true BR112014000857B1 (pt) | 2021-01-05 |
Family
ID=46000806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014000857-4A BR112014000857B1 (pt) | 2011-07-15 | 2012-04-12 | métodos para produção de compostos de 177lu de alta pureza isentos de veículos, e uso de cromatografia de troca catiônica para a produção dos referidos compostos |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9816156B2 (https=) |
| EP (1) | EP2546839B1 (https=) |
| JP (2) | JP6219276B2 (https=) |
| KR (1) | KR101931521B1 (https=) |
| CN (1) | CN103718250B (https=) |
| AU (1) | AU2012202379B2 (https=) |
| BR (1) | BR112014000857B1 (https=) |
| CA (1) | CA2839968C (https=) |
| DE (1) | DE102011051868B4 (https=) |
| DK (1) | DK2546839T3 (https=) |
| ES (1) | ES2558116T3 (https=) |
| HU (1) | HUE026163T2 (https=) |
| PL (1) | PL2546839T3 (https=) |
| PT (1) | PT2546839E (https=) |
| RS (1) | RS54508B1 (https=) |
| RU (1) | RU2573475C2 (https=) |
| SI (1) | SI2546839T1 (https=) |
| SM (1) | SMT201600065B (https=) |
| WO (1) | WO2013010686A1 (https=) |
| ZA (1) | ZA201203027B (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016011396A1 (en) * | 2014-07-18 | 2016-01-21 | Purdue Research Foundation | Ligand-assisted chromatography for metal ion separation |
| CN105063382B (zh) * | 2015-09-12 | 2017-06-13 | 北京科技大学 | 一种La、Ce、Pr、Nd混合稀土离子的分离方法 |
| US10344314B2 (en) * | 2016-05-04 | 2019-07-09 | Curium Us Llc | Systems and methods for sterility testing of radionuclide generator column assemblies |
| CA3021879C (en) * | 2016-05-04 | 2023-10-10 | Mallinckrodt Nuclear Medicine Llc | Column assembly transfer mechanism and systems and methods for sanitizing same |
| CN113748121B (zh) * | 2019-04-29 | 2025-07-29 | 先正达农作物保护股份公司 | 用于蛋白质检测的组合物以及方法 |
| EP4022653A2 (en) | 2019-08-29 | 2022-07-06 | CF Technologies, Inc. | Systems and methods for selective recovery of metals from ion exchange resins |
| AU2020369092A1 (en) | 2019-10-25 | 2022-05-12 | Intellexon Gmbh | HLA-H, HLA-J, HLA-L, HLA-V and HLA-Y as therapeutic and diagnostic targets |
| JP2023502987A (ja) | 2019-11-20 | 2023-01-26 | シャイン テクノロジーズ エルエルシー | 希土類元素の分離 |
| CN110828020A (zh) * | 2019-11-21 | 2020-02-21 | 中国核动力研究设计院 | 一种含有载体氯化镥-177溶液的制备系统及其制备方法 |
| BR112022012030A2 (pt) | 2019-12-20 | 2022-09-06 | Nuclear Res And Consultancy Group | Uso de um composto, e, método de separação cromatográfica |
| CA3174318A1 (en) | 2020-04-02 | 2021-10-07 | Richard SISSON | Separation of rare earth elements |
| CN111440947B (zh) * | 2020-04-17 | 2022-02-15 | 包头稀土研究院 | 采用氧化镱原料还原蒸馏制备金属镱的方法 |
| RU2741009C9 (ru) * | 2020-09-11 | 2021-06-22 | Линчевский Дмитрий Александрович | Способ разделения лютеция и иттербия методом хроматографии |
| CN112176193B (zh) * | 2020-09-29 | 2022-08-09 | 中国工程物理研究院核物理与化学研究所 | 一种镧系树脂循环洗脱分离Yb-176和Lu-177的方法 |
| KR102266273B1 (ko) * | 2020-12-24 | 2021-06-17 | 한국원자력연구원 | 크로마토그래피를 이용한 무담체 루테튬-177의 생산 및 정제 방법 |
| DE102021109246B3 (de) | 2021-04-13 | 2022-06-09 | ITM Isotope Technologies Munich SE | Radiopharmaka zu unterschiedlichen ARTs |
| CN115216652A (zh) * | 2021-04-20 | 2022-10-21 | 赣江中药创新中心 | 一种从镱镥混合物中分离提纯镥的方法 |
| RU2763745C1 (ru) * | 2021-06-02 | 2022-01-10 | Акционерное Общество "Государственный Научный Центр - Научно-Исследовательский Институт Атомных Реакторов" | Способ катионообменного выделения радионуклида лютеция-177 из облученного в ядерном реакторе иттербия |
| US12090215B2 (en) | 2022-02-04 | 2024-09-17 | Westinghouse Electric Company Llc | Method and device for direct production of radio-isotope based cancer treatment pharmaceuticals |
| US12540371B2 (en) | 2022-07-26 | 2026-02-03 | Shine Technologies, Llc | Phase change system and phase change crucible for the separation of rare earth elements |
| US11894156B1 (en) * | 2023-04-04 | 2024-02-06 | CVF International LLC | Separation of rare earth elements by means of physical chemistry for use in medical applications |
| US20240339233A1 (en) | 2023-04-04 | 2024-10-10 | CVF International LLC | Separation of rare earth elements by means of physical chemistry |
| CN116864178A (zh) * | 2023-07-19 | 2023-10-10 | 中国核动力研究设计院 | 一种无载体镥-177溶液制备系统及方法 |
| CN117018864A (zh) * | 2023-07-27 | 2023-11-10 | 中国核动力研究设计院 | 一种多级连续分离纯化制备无载体镥-177的方法 |
| CN117448602B (zh) * | 2023-09-07 | 2026-04-14 | 国电投核素同创(重庆)科技有限公司 | 一种从177Lu/176Yb混合物中分离177Lu的方法 |
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| WO2010054168A1 (en) * | 2008-11-06 | 2010-05-14 | The Curators Of The University Of Missouri | Separation method for carrier-free radiolanthanides |
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