ES2558116T3 - Procedimiento para la producción de compuestos de 177Lu de alta pureza sin portador así como compuestos de 177Lu sin portador - Google Patents
Procedimiento para la producción de compuestos de 177Lu de alta pureza sin portador así como compuestos de 177Lu sin portador Download PDFInfo
- Publication number
- ES2558116T3 ES2558116T3 ES12163203.8T ES12163203T ES2558116T3 ES 2558116 T3 ES2558116 T3 ES 2558116T3 ES 12163203 T ES12163203 T ES 12163203T ES 2558116 T3 ES2558116 T3 ES 2558116T3
- Authority
- ES
- Spain
- Prior art keywords
- column
- compounds
- cation exchange
- exchange material
- mineral acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 238000000034 method Methods 0.000 title abstract description 11
- 238000004519 manufacturing process Methods 0.000 title abstract description 6
- 150000001875 compounds Chemical class 0.000 title 1
- -1 ammonium ions Chemical class 0.000 abstract description 9
- 238000000926 separation method Methods 0.000 abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract description 4
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 abstract description 2
- 235000019270 ammonium chloride Nutrition 0.000 abstract description 2
- 239000002253 acid Substances 0.000 abstract 7
- 238000005341 cation exchange Methods 0.000 abstract 6
- 229910052500 inorganic mineral Inorganic materials 0.000 abstract 6
- 239000000463 material Substances 0.000 abstract 6
- 239000011707 mineral Substances 0.000 abstract 6
- 239000008139 complexing agent Substances 0.000 abstract 4
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 abstract 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 abstract 3
- 239000007858 starting material Substances 0.000 abstract 3
- BWLBGMIXKSTLSX-UHFFFAOYSA-N 2-hydroxyisobutyric acid Chemical compound CC(C)(O)C(O)=O BWLBGMIXKSTLSX-UHFFFAOYSA-N 0.000 abstract 2
- 238000005406 washing Methods 0.000 abstract 2
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 abstract 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 abstract 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 230000009918 complex formation Effects 0.000 abstract 1
- 238000010828 elution Methods 0.000 abstract 1
- DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 229910021645 metal ion Inorganic materials 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 238000002347 injection Methods 0.000 description 4
- 239000007924 injection Substances 0.000 description 4
- 108090000765 processed proteins & peptides Proteins 0.000 description 4
- 238000004128 high performance liquid chromatography Methods 0.000 description 3
- 102000004196 processed proteins & peptides Human genes 0.000 description 3
- XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 238000004440 column chromatography Methods 0.000 description 2
- 238000011194 good manufacturing practice Methods 0.000 description 2
- 238000002372 labelling Methods 0.000 description 2
- 229920001184 polypeptide Polymers 0.000 description 2
- DBXBTMSZEOQQDU-UHFFFAOYSA-N 3-hydroxyisobutyric acid Chemical compound OCC(C)C(O)=O DBXBTMSZEOQQDU-UHFFFAOYSA-N 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 229920005372 Plexiglas® Polymers 0.000 description 1
- 241000736892 Thujopsis dolabrata Species 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 238000006073 displacement reaction Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000012467 final product Substances 0.000 description 1
- 239000011261 inert gas Substances 0.000 description 1
- 238000001819 mass spectrum Methods 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 230000002572 peristaltic effect Effects 0.000 description 1
- 239000004926 polymethyl methacrylate Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 239000012217 radiopharmaceutical Substances 0.000 description 1
- 229940121896 radiopharmaceutical Drugs 0.000 description 1
- 230000002799 radiopharmaceutical effect Effects 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/244—Lanthanides; Compounds thereof
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
- C22B59/00—Obtaining rare earth metals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
- B01D15/166—Fluid composition conditioning, e.g. gradient
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
- B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
- B01D15/361—Ion-exchange
- B01D15/362—Cation-exchange
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
-
- G—PHYSICS
- G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
- G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
- G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
- G21G1/001—Recovery of specific isotopes from irradiated targets
- G21G2001/0094—Other isotopes not provided for in the groups listed above
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Physics & Mathematics (AREA)
- High Energy & Nuclear Physics (AREA)
- General Engineering & Computer Science (AREA)
- Environmental & Geological Engineering (AREA)
- Mechanical Engineering (AREA)
- Metallurgy (AREA)
- Materials Engineering (AREA)
- Manufacturing & Machinery (AREA)
- Geology (AREA)
- General Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102011051868A DE102011051868B4 (de) | 2011-07-15 | 2011-07-15 | Verfahren zur Herstellung trägerfreier hochreiner 177Lu-Verbindungen sowie trägerfreie 177Lu-Verbindungen |
| DE102011051868 | 2011-07-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2558116T3 true ES2558116T3 (es) | 2016-02-02 |
Family
ID=46000806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES12163203.8T Active ES2558116T3 (es) | 2011-07-15 | 2012-04-04 | Procedimiento para la producción de compuestos de 177Lu de alta pureza sin portador así como compuestos de 177Lu sin portador |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US9816156B2 (https=) |
| EP (1) | EP2546839B1 (https=) |
| JP (2) | JP6219276B2 (https=) |
| KR (1) | KR101931521B1 (https=) |
| CN (1) | CN103718250B (https=) |
| AU (1) | AU2012202379B2 (https=) |
| BR (1) | BR112014000857B1 (https=) |
| CA (1) | CA2839968C (https=) |
| DE (1) | DE102011051868B4 (https=) |
| DK (1) | DK2546839T3 (https=) |
| ES (1) | ES2558116T3 (https=) |
| HU (1) | HUE026163T2 (https=) |
| PL (1) | PL2546839T3 (https=) |
| PT (1) | PT2546839E (https=) |
| RS (1) | RS54508B1 (https=) |
| RU (1) | RU2573475C2 (https=) |
| SI (1) | SI2546839T1 (https=) |
| SM (1) | SMT201600065B (https=) |
| WO (1) | WO2013010686A1 (https=) |
| ZA (1) | ZA201203027B (https=) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016011396A1 (en) * | 2014-07-18 | 2016-01-21 | Purdue Research Foundation | Ligand-assisted chromatography for metal ion separation |
| CN105063382B (zh) * | 2015-09-12 | 2017-06-13 | 北京科技大学 | 一种La、Ce、Pr、Nd混合稀土离子的分离方法 |
| US10344314B2 (en) * | 2016-05-04 | 2019-07-09 | Curium Us Llc | Systems and methods for sterility testing of radionuclide generator column assemblies |
| CA3021879C (en) * | 2016-05-04 | 2023-10-10 | Mallinckrodt Nuclear Medicine Llc | Column assembly transfer mechanism and systems and methods for sanitizing same |
| CN113748121B (zh) * | 2019-04-29 | 2025-07-29 | 先正达农作物保护股份公司 | 用于蛋白质检测的组合物以及方法 |
| EP4022653A2 (en) | 2019-08-29 | 2022-07-06 | CF Technologies, Inc. | Systems and methods for selective recovery of metals from ion exchange resins |
| AU2020369092A1 (en) | 2019-10-25 | 2022-05-12 | Intellexon Gmbh | HLA-H, HLA-J, HLA-L, HLA-V and HLA-Y as therapeutic and diagnostic targets |
| JP2023502987A (ja) | 2019-11-20 | 2023-01-26 | シャイン テクノロジーズ エルエルシー | 希土類元素の分離 |
| CN110828020A (zh) * | 2019-11-21 | 2020-02-21 | 中国核动力研究设计院 | 一种含有载体氯化镥-177溶液的制备系统及其制备方法 |
| BR112022012030A2 (pt) | 2019-12-20 | 2022-09-06 | Nuclear Res And Consultancy Group | Uso de um composto, e, método de separação cromatográfica |
| CA3174318A1 (en) | 2020-04-02 | 2021-10-07 | Richard SISSON | Separation of rare earth elements |
| CN111440947B (zh) * | 2020-04-17 | 2022-02-15 | 包头稀土研究院 | 采用氧化镱原料还原蒸馏制备金属镱的方法 |
| RU2741009C9 (ru) * | 2020-09-11 | 2021-06-22 | Линчевский Дмитрий Александрович | Способ разделения лютеция и иттербия методом хроматографии |
| CN112176193B (zh) * | 2020-09-29 | 2022-08-09 | 中国工程物理研究院核物理与化学研究所 | 一种镧系树脂循环洗脱分离Yb-176和Lu-177的方法 |
| KR102266273B1 (ko) * | 2020-12-24 | 2021-06-17 | 한국원자력연구원 | 크로마토그래피를 이용한 무담체 루테튬-177의 생산 및 정제 방법 |
| DE102021109246B3 (de) | 2021-04-13 | 2022-06-09 | ITM Isotope Technologies Munich SE | Radiopharmaka zu unterschiedlichen ARTs |
| CN115216652A (zh) * | 2021-04-20 | 2022-10-21 | 赣江中药创新中心 | 一种从镱镥混合物中分离提纯镥的方法 |
| RU2763745C1 (ru) * | 2021-06-02 | 2022-01-10 | Акционерное Общество "Государственный Научный Центр - Научно-Исследовательский Институт Атомных Реакторов" | Способ катионообменного выделения радионуклида лютеция-177 из облученного в ядерном реакторе иттербия |
| US12090215B2 (en) | 2022-02-04 | 2024-09-17 | Westinghouse Electric Company Llc | Method and device for direct production of radio-isotope based cancer treatment pharmaceuticals |
| US12540371B2 (en) | 2022-07-26 | 2026-02-03 | Shine Technologies, Llc | Phase change system and phase change crucible for the separation of rare earth elements |
| US11894156B1 (en) * | 2023-04-04 | 2024-02-06 | CVF International LLC | Separation of rare earth elements by means of physical chemistry for use in medical applications |
| US20240339233A1 (en) | 2023-04-04 | 2024-10-10 | CVF International LLC | Separation of rare earth elements by means of physical chemistry |
| CN116864178A (zh) * | 2023-07-19 | 2023-10-10 | 中国核动力研究设计院 | 一种无载体镥-177溶液制备系统及方法 |
| CN117018864A (zh) * | 2023-07-27 | 2023-11-10 | 中国核动力研究设计院 | 一种多级连续分离纯化制备无载体镥-177的方法 |
| CN117448602B (zh) * | 2023-09-07 | 2026-04-14 | 国电投核素同创(重庆)科技有限公司 | 一种从177Lu/176Yb混合物中分离177Lu的方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2925431A (en) | 1956-04-17 | 1960-02-16 | Gregory R Choppin | Cationic exchange process for the separation of rare earths |
| US3228750A (en) | 1962-06-07 | 1966-01-11 | Roald E Lindstrom | Process for separating rare-earth elements by ion exchange |
| JPS5845341A (ja) * | 1981-09-11 | 1983-03-16 | Agency Of Ind Science & Technol | 希土類金属の分離方法 |
| JPS62145164A (ja) * | 1985-12-19 | 1987-06-29 | Seitetsu Kagaku Co Ltd | 希土類イオンの分離法 |
| JPS63103825A (ja) * | 1986-10-17 | 1988-05-09 | Showa Denko Kk | 希土類元素の分離方法 |
| JPH03108661A (ja) * | 1989-09-22 | 1991-05-08 | Kurita Water Ind Ltd | 核酸関連物質の分離方法 |
| CN1054644C (zh) * | 1995-11-08 | 2000-07-19 | 北京大学 | 铥、镱、镥的溶剂萃取分离方法 |
| FI991197A0 (fi) * | 1999-05-27 | 1999-05-27 | Mart Saarma | Neurotrooppiset tekijät lantionalueen ääreishermoston toimintahäiriön hoitamisessa |
| US6751280B2 (en) * | 2002-08-12 | 2004-06-15 | Ut-Battelle, Llc | Method of preparing high specific activity platinum-195m |
| US6716353B1 (en) | 2002-10-30 | 2004-04-06 | Ut-Battelle, Llc | Method for preparing high specific activity 177Lu |
| US7226577B2 (en) * | 2003-01-13 | 2007-06-05 | Bracco Imaging, S. P. A. | Gastrin releasing peptide compounds |
| EP1807844B1 (en) * | 2004-09-28 | 2010-05-19 | Soreq Nuclear Research Center Israel Atomic Energy Commission | Method and system for production of radioisotopes |
| CN1796608A (zh) * | 2004-12-21 | 2006-07-05 | 北京大学 | 一种纯化镱和富集铥镥的方法及设备 |
| GB2436508C (en) * | 2005-01-14 | 2011-01-26 | Europ Organisation For Nuclear Res Cern | Method for production of radioisotope preparationsand their use in life science, research, medical application and industry. |
| US8227439B2 (en) * | 2008-05-15 | 2012-07-24 | Morphotek, Inc. | Treatment of metastatic tumors |
| RU2404922C2 (ru) * | 2008-08-07 | 2010-11-27 | Открытое акционерное общество "Государственный научный центр Научно-иследовательский институт атомных реакторов" | Способ ионообменного выделения радионуклидов иттрия, редкоземельных и трансплутониевых элементов из растворов альфа-гидроксиизомасляной кислоты и ее солей |
| WO2010054168A1 (en) * | 2008-11-06 | 2010-05-14 | The Curators Of The University Of Missouri | Separation method for carrier-free radiolanthanides |
| JP5376130B2 (ja) * | 2009-03-24 | 2013-12-25 | 独立行政法人日本原子力研究開発機構 | 抗体標識が可能な無担体１７７Ｌｕの分離精製法 |
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2011
- 2011-07-15 DE DE102011051868A patent/DE102011051868B4/de active Active
-
2012
- 2012-04-04 DK DK12163203.8T patent/DK2546839T3/en active
- 2012-04-04 EP EP12163203.8A patent/EP2546839B1/de active Active
- 2012-04-04 SI SI201230436T patent/SI2546839T1/sl unknown
- 2012-04-04 RS RS20150886A patent/RS54508B1/sr unknown
- 2012-04-04 ES ES12163203.8T patent/ES2558116T3/es active Active
- 2012-04-04 PL PL12163203T patent/PL2546839T3/pl unknown
- 2012-04-04 HU HUE12163203A patent/HUE026163T2/en unknown
- 2012-04-04 PT PT121632038T patent/PT2546839E/pt unknown
- 2012-04-12 JP JP2014519460A patent/JP6219276B2/ja active Active
- 2012-04-12 CN CN201280035257.XA patent/CN103718250B/zh active Active
- 2012-04-12 CA CA2839968A patent/CA2839968C/en active Active
- 2012-04-12 WO PCT/EP2012/056644 patent/WO2013010686A1/de not_active Ceased
- 2012-04-12 KR KR1020147002410A patent/KR101931521B1/ko active Active
- 2012-04-12 US US14/232,205 patent/US9816156B2/en active Active
- 2012-04-12 BR BR112014000857-4A patent/BR112014000857B1/pt active IP Right Grant
- 2012-04-12 RU RU2013155710/05A patent/RU2573475C2/ru active
- 2012-04-24 AU AU2012202379A patent/AU2012202379B2/en active Active
- 2012-04-25 ZA ZA2012/03027A patent/ZA201203027B/en unknown
-
2016
- 2016-03-04 SM SM201600065T patent/SMT201600065B/xx unknown
-
2017
- 2017-04-28 JP JP2017090065A patent/JP6530007B2/ja active Active
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