BR112014000857A2 - método para a produção de compostos de 177lu de alta pureza isentos de veículos e compostos de 177lu isentos de veículos - Google Patents

método para a produção de compostos de 177lu de alta pureza isentos de veículos e compostos de 177lu isentos de veículos

Info

Publication number
BR112014000857A2
BR112014000857A2 BR112014000857A BR112014000857A BR112014000857A2 BR 112014000857 A2 BR112014000857 A2 BR 112014000857A2 BR 112014000857 A BR112014000857 A BR 112014000857A BR 112014000857 A BR112014000857 A BR 112014000857A BR 112014000857 A2 BR112014000857 A2 BR 112014000857A2
Authority
BR
Brazil
Prior art keywords
compounds
vehicle
free
production
purity
Prior art date
Application number
BR112014000857A
Other languages
English (en)
Other versions
BR112014000857B1 (pt
Inventor
Zhernosekov Konstantin
Harfensteller Mark
Marx Sebastian
Nikula Tuomo
Original Assignee
Itm Isotopen Tech München Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Itm Isotopen Tech München Ag filed Critical Itm Isotopen Tech München Ag
Publication of BR112014000857A2 publication Critical patent/BR112014000857A2/pt
Publication of BR112014000857B1 publication Critical patent/BR112014000857B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/244—Lanthanides; Compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
    • C22B59/00—Obtaining rare earth metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
    • B01D15/166—Fluid composition conditioning, e.g. gradient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/001—Recovery of specific isotopes from irradiated targets
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/001—Recovery of specific isotopes from irradiated targets
    • G21G2001/0094—Other isotopes not provided for in the groups listed above

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Inorganic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • High Energy & Nuclear Physics (AREA)
  • General Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Geology (AREA)
  • Manufacturing & Machinery (AREA)
  • Materials Engineering (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Metallurgy (AREA)
  • Environmental & Geological Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

resumo patente de invenção: "método para a produção de compostos de 177lu de alta pureza isentos de veículos e compostos de 177lu isentos de veículos". a presente invenção refere-se a um método cromatográfico de coluna de produção de compostos de 177lu adicionados não transportadores de alta pureza para propostas medicinais. no método de acordo com a invenção, um trocador de cátion e um agente quelatante adequado são usados. com o método de acordo com a invenção, é possível pela primeira vez proporcionar compostos de 177lu adicionados não transportadores de alta pureza em quantidades em miligramas para proposta farmacêutico-medicinal de compostos 176yb irradiados com nêutrons térmicos, os radionuclídeos de 177lu e 176yb estando presentes em uma razão de massa apropriada de 1:102 a 1:1010 para purificação.
BR112014000857-4A 2011-07-15 2012-04-12 métodos para produção de compostos de 177lu de alta pureza isentos de veículos, e uso de cromatografia de troca catiônica para a produção dos referidos compostos BR112014000857B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102011051868A DE102011051868B4 (de) 2011-07-15 2011-07-15 Verfahren zur Herstellung trägerfreier hochreiner 177Lu-Verbindungen sowie trägerfreie 177Lu-Verbindungen
DE102011051868.1 2011-07-15
PCT/EP2012/056644 WO2013010686A1 (de) 2011-07-15 2012-04-12 Verfahren zur herstellung trägerfreier hochreiner 177lu-verbindungen sowie trägerfreie 177lu-verbindungen

Publications (2)

Publication Number Publication Date
BR112014000857A2 true BR112014000857A2 (pt) 2017-02-21
BR112014000857B1 BR112014000857B1 (pt) 2021-01-05

Family

ID=46000806

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014000857-4A BR112014000857B1 (pt) 2011-07-15 2012-04-12 métodos para produção de compostos de 177lu de alta pureza isentos de veículos, e uso de cromatografia de troca catiônica para a produção dos referidos compostos

Country Status (21)

Country Link
US (1) US9816156B2 (pt)
EP (1) EP2546839B1 (pt)
JP (2) JP6219276B2 (pt)
KR (1) KR101931521B1 (pt)
CN (1) CN103718250B (pt)
AU (1) AU2012202379B2 (pt)
BR (1) BR112014000857B1 (pt)
CA (1) CA2839968C (pt)
DE (1) DE102011051868B4 (pt)
DK (1) DK2546839T3 (pt)
ES (1) ES2558116T3 (pt)
HK (1) HK1190818A1 (pt)
HU (1) HUE026163T2 (pt)
PL (1) PL2546839T3 (pt)
PT (1) PT2546839E (pt)
RS (1) RS54508B1 (pt)
RU (1) RU2573475C2 (pt)
SI (1) SI2546839T1 (pt)
SM (1) SMT201600065B (pt)
WO (1) WO2013010686A1 (pt)
ZA (1) ZA201203027B (pt)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016011396A1 (en) * 2014-07-18 2016-01-21 Purdue Research Foundation Ligand-assisted chromatography for metal ion separation
CN105063382B (zh) * 2015-09-12 2017-06-13 北京科技大学 一种La、Ce、Pr、Nd混合稀土离子的分离方法
US10344314B2 (en) 2016-05-04 2019-07-09 Curium Us Llc Systems and methods for sterility testing of radionuclide generator column assemblies
EP3452112A2 (en) 2016-05-04 2019-03-13 Curium US LLC Column assembly transfer mechanism and systems and methods for sanitizing same
EP4022653A2 (en) * 2019-08-29 2022-07-06 CF Technologies, Inc. Systems and methods for selective recovery of metals from ion exchange resins
JP2022553073A (ja) 2019-10-25 2022-12-21 インテレクソン ゲゼルシャフト ミット ベシュレンクテル ハフツング 治療・診断標的としてのｈｌａ－ｈ， ｈｌａ－ｊおよびｈｌａ－ｌ
WO2021102167A1 (en) * 2019-11-20 2021-05-27 SHINE Medical Technologies, LLC Separation of rare earth elements
CN110828020A (zh) * 2019-11-21 2020-02-21 中国核动力研究设计院 一种含有载体氯化镥-177溶液的制备系统及其制备方法
PL4077288T3 (pl) 2019-12-20 2024-04-08 Nuclear Research And Consultancy Group Rozdział chromatograficzny metali z użyciem chelatorów na bazie DOTA
CN115836137A (zh) 2020-04-02 2023-03-21 阳光科技公司 稀土元素的分离
CN111440947B (zh) * 2020-04-17 2022-02-15 包头稀土研究院 采用氧化镱原料还原蒸馏制备金属镱的方法
RU2741009C9 (ru) 2020-09-11 2021-06-22 Линчевский Дмитрий Александрович Способ разделения лютеция и иттербия методом хроматографии
CN112176193B (zh) * 2020-09-29 2022-08-09 中国工程物理研究院核物理与化学研究所 一种镧系树脂循环洗脱分离Yb-176和Lu-177的方法
KR102266273B1 (ko) * 2020-12-24 2021-06-17 한국원자력연구원 크로마토그래피를 이용한 무담체 루테튬-177의 생산 및 정제 방법
DE102021109246B3 (de) 2021-04-13 2022-06-09 ITM Isotope Technologies Munich SE Radiopharmaka zu unterschiedlichen ARTs
CN115216652A (zh) * 2021-04-20 2022-10-21 赣江中药创新中心 一种从镱镥混合物中分离提纯镥的方法
RU2763745C1 (ru) * 2021-06-02 2022-01-10 Акционерное Общество "Государственный Научный Центр - Научно-Исследовательский Институт Атомных Реакторов" Способ катионообменного выделения радионуклида лютеция-177 из облученного в ядерном реакторе иттербия
US12090215B2 (en) 2022-02-04 2024-09-17 Westinghouse Electric Company Llc Method and device for direct production of radio-isotope based cancer treatment pharmaceuticals
US20240035118A1 (en) * 2022-07-26 2024-02-01 Shine Technologies, Llc Phase Change System and Phase Change Crucible for the Separation of Rare Earth Elements
US11894156B1 (en) * 2023-04-04 2024-02-06 CVF International LLC Separation of rare earth elements by means of physical chemistry for use in medical applications

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2925431A (en) 1956-04-17 1960-02-16 Gregory R Choppin Cationic exchange process for the separation of rare earths
US3228750A (en) 1962-06-07 1966-01-11 Roald E Lindstrom Process for separating rare-earth elements by ion exchange
JPS5845341A (ja) * 1981-09-11 1983-03-16 Agency Of Ind Science & Technol 希土類金属の分離方法
JPS62145164A (ja) * 1985-12-19 1987-06-29 Seitetsu Kagaku Co Ltd 希土類イオンの分離法
JPS63103825A (ja) * 1986-10-17 1988-05-09 Showa Denko Kk 希土類元素の分離方法
JPH03108661A (ja) * 1989-09-22 1991-05-08 Kurita Water Ind Ltd 核酸関連物質の分離方法
CN1054644C (zh) * 1995-11-08 2000-07-19 北京大学 铥、镱、镥的溶剂萃取分离方法
FI991197A0 (fi) * 1999-05-27 1999-05-27 Mart Saarma Neurotrooppiset tekijät lantionalueen ääreishermoston toimintahäiriön hoitamisessa
US6751280B2 (en) 2002-08-12 2004-06-15 Ut-Battelle, Llc Method of preparing high specific activity platinum-195m
US6716353B1 (en) 2002-10-30 2004-04-06 Ut-Battelle, Llc Method for preparing high specific activity 177Lu
US7226577B2 (en) * 2003-01-13 2007-06-05 Bracco Imaging, S. P. A. Gastrin releasing peptide compounds
EP1807844B1 (en) * 2004-09-28 2010-05-19 Soreq Nuclear Research Center Israel Atomic Energy Commission Method and system for production of radioisotopes
CN1796608A (zh) * 2004-12-21 2006-07-05 北京大学 一种纯化镱和富集铥镥的方法及设备
US9202600B2 (en) * 2005-01-14 2015-12-01 Paul Scherrer Institut Method for production of radioisotope preparations and their use in life science, research, medical application and industry
CA2724384A1 (en) * 2008-05-15 2009-11-19 Transmolecular, Inc. Treatment of metastatic tumors
RU2404922C2 (ru) * 2008-08-07 2010-11-27 Открытое акционерное общество "Государственный научный центр Научно-иследовательский институт атомных реакторов" Способ ионообменного выделения радионуклидов иттрия, редкоземельных и трансплутониевых элементов из растворов альфа-гидроксиизомасляной кислоты и ее солей
CA2742764A1 (en) * 2008-11-06 2010-05-14 The Curators Of The University Of Missouri Separation method for carrier-free radiolanthanides
JP5376130B2 (ja) * 2009-03-24 2013-12-25 独立行政法人日本原子力研究開発機構 抗体標識が可能な無担体１７７Ｌｕの分離精製法

Also Published As

Publication number Publication date
JP2014521076A (ja) 2014-08-25
KR20140071324A (ko) 2014-06-11
CA2839968C (en) 2019-02-26
SI2546839T1 (sl) 2016-02-29
CN103718250A (zh) 2014-04-09
RU2573475C2 (ru) 2016-01-20
EP2546839B1 (de) 2015-11-04
WO2013010686A1 (de) 2013-01-24
US9816156B2 (en) 2017-11-14
PL2546839T3 (pl) 2016-04-29
KR101931521B1 (ko) 2018-12-21
DE102011051868B4 (de) 2013-02-21
JP6219276B2 (ja) 2017-10-25
JP2017214355A (ja) 2017-12-07
AU2012202379A8 (en) 2014-01-16
RU2013155710A (ru) 2015-08-27
PT2546839E (pt) 2016-03-08
AU2012202379A1 (en) 2013-01-31
EP2546839A1 (de) 2013-01-16
DE102011051868A1 (de) 2013-01-17
HUE026163T2 (en) 2016-05-30
BR112014000857B1 (pt) 2021-01-05
JP6530007B2 (ja) 2019-06-12
SMT201600065B (it) 2016-04-29
RS54508B1 (en) 2016-06-30
CN103718250B (zh) 2016-06-01
US20140294700A1 (en) 2014-10-02
ES2558116T3 (es) 2016-02-02
HK1190818A1 (zh) 2014-07-11
DK2546839T3 (en) 2016-02-08
ZA201203027B (en) 2012-12-27
AU2012202379B2 (en) 2015-01-22
CA2839968A1 (en) 2013-01-24

Similar Documents

Publication Publication Date Title
BR112014000857A2 (pt) método para a produção de compostos de 177lu de alta pureza isentos de veículos e compostos de 177lu isentos de veículos
JP2014527996A5 (pt)
BR112012033402A2 (pt) moduladores de canais de íons conforme os compostos heterocíclicos fundidos
BR112015026325A2 (pt) dosagem oral de compostos glp-1
BR112015012295A8 (pt) Uso de um inibidor de wee1, e, kit para identificar um paciente com câncer
EA028156B9 (ru) Конденсированные гетероциклические соединения в качестве модуляторов ионных каналов
EA201491329A1 (ru) 4,4-дизамещенные 1,4-дигидропиримидины и их применение в качестве лекарственных препаратов для лечения гепатита b
BR112012021857A2 (pt) formas cristalinas para sal de sódio de 5-amino-2,3-di-hidro ftalazino-1,4-diona, preparações farmacêuticas contendo o mesmo e processo para a produção das ditas formas
BR112014007193A2 (pt) derivados de pirazoloquinolinona, preparação dos mesmos e uso terapêutico dos mesmos
BR112012019011A8 (pt) "processo para fazer zeólito de titânio- mww".
MX2020002113A (es) Composicion neuroprotectora anticolinergica y metodos.
BR112013027171A2 (pt) trocador de calor e método para sua produção
BR112015018168A2 (pt) inibidores de rock suaves
CU20130116A7 (es) Derivados de heteroarilo como moduladores de nachr alfa 7
BR112015016103A2 (pt) processo para preparar ésteres cíclicos e amidas cíclicas
BR112015026473A2 (pt) formulação de um meio de contraste e seu processo de preparação associado
BR112014024269A8 (pt) Anticorpo ou um fragmento de ligação a antígeno do anticorpo, fragmento de ligação a antígeno do anticorpo, composição farmacêutica, uso de um anticorpo ou um fragmento de ligação a antígeno, uso de uma composição, vetor, célula hospedeira transformada, e, método para produzir um anticorpo
NZ720651A (en) Fused heterocyclic compounds as ion channel modulators
BR112014018767A8 (pt) Compostos de pirroldicarboxamidas fundidas e composição farmacêutica que os compreende
WO2012097116A3 (en) Isotopologues of isoindole derivatives
WO2012031045A3 (en) Phosphonate ester derivatives and methods of synthesis thereof
BR112012021291A2 (pt) inibidores diméricos de iap.
BR112014010729A2 (pt) métodos para tratamento de ataques de gota
MY180320A (en) Chlorin derivative useful in photodynamic therapy and diagnosis
EA201391026A1 (ru) Кристаллическое производное оксазина и его применение в качестве ингибитора bace

Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 12/04/2012, OBSERVADAS AS CONDICOES LEGAIS.

B25A Requested transfer of rights approved

Owner name: ITM ISOTOPE TECHNOLOGIES MUNICH SE (DE)