CN103718250B - 生产无载体添加的高纯度177Lu化合物的方法和无载体添加的177Lu化合物 - Google Patents

生产无载体添加的高纯度177Lu化合物的方法和无载体添加的177Lu化合物 Download PDF

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CN103718250B
CN103718250B CN201280035257.XA CN201280035257A CN103718250B CN 103718250 B CN103718250 B CN 103718250B CN 201280035257 A CN201280035257 A CN 201280035257A CN 103718250 B CN103718250 B CN 103718250B
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cation exchange
exchange material
chelating agent
eluate
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CN103718250A (zh
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塞巴斯蒂安·马克斯
马克·哈尔芬施特勒
康斯坦丁·哲诺斯科夫
托墨·尼古拉
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Attemo Isotope Technologies Munich Europe Ag
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/244—Lanthanides; Compounds thereof
    • C—CHEMISTRY; METALLURGY
    • C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
    • C22B—PRODUCTION AND REFINING OF METALS; PRETREATMENT OF RAW MATERIALS
    • C22B59/00—Obtaining rare earth metals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/16—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the conditioning of the fluid carrier
    • B01D15/166—Fluid composition conditioning, e.g. gradient
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
    • B01D15/361—Ion-exchange
    • B01D15/362—Cation-exchange
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/001—Recovery of specific isotopes from irradiated targets
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21G—CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES
    • G21G1/00—Arrangements for converting chemical elements by electromagnetic radiation, corpuscular radiation or particle bombardment, e.g. producing radioactive isotopes
    • G21G1/001—Recovery of specific isotopes from irradiated targets
    • G21G2001/0094—Other isotopes not provided for in the groups listed above

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  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Pharmacology & Pharmacy (AREA)
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  • Inorganic Chemistry (AREA)
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  • High Energy & Nuclear Physics (AREA)
  • General Engineering & Computer Science (AREA)
  • Environmental & Geological Engineering (AREA)
  • Mechanical Engineering (AREA)
  • Metallurgy (AREA)
  • Materials Engineering (AREA)
  • Manufacturing & Machinery (AREA)
  • Geology (AREA)
  • General Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201280035257.XA 2011-07-15 2012-04-12 生产无载体添加的高纯度177Lu化合物的方法和无载体添加的177Lu化合物 Active CN103718250B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102011051868A DE102011051868B4 (de) 2011-07-15 2011-07-15 Verfahren zur Herstellung trägerfreier hochreiner 177Lu-Verbindungen sowie trägerfreie 177Lu-Verbindungen
DE102011051868.1 2011-07-15
PCT/EP2012/056644 WO2013010686A1 (de) 2011-07-15 2012-04-12 Verfahren zur herstellung trägerfreier hochreiner 177lu-verbindungen sowie trägerfreie 177lu-verbindungen

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CN103718250A CN103718250A (zh) 2014-04-09
CN103718250B true CN103718250B (zh) 2016-06-01

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US (1) US9816156B2 (https=)
EP (1) EP2546839B1 (https=)
JP (2) JP6219276B2 (https=)
KR (1) KR101931521B1 (https=)
CN (1) CN103718250B (https=)
AU (1) AU2012202379B2 (https=)
BR (1) BR112014000857B1 (https=)
CA (1) CA2839968C (https=)
DE (1) DE102011051868B4 (https=)
DK (1) DK2546839T3 (https=)
ES (1) ES2558116T3 (https=)
HU (1) HUE026163T2 (https=)
PL (1) PL2546839T3 (https=)
PT (1) PT2546839E (https=)
RS (1) RS54508B1 (https=)
RU (1) RU2573475C2 (https=)
SI (1) SI2546839T1 (https=)
SM (1) SMT201600065B (https=)
WO (1) WO2013010686A1 (https=)
ZA (1) ZA201203027B (https=)

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RU2763745C1 (ru) * 2021-06-02 2022-01-10 Акционерное Общество "Государственный Научный Центр - Научно-Исследовательский Институт Атомных Реакторов" Способ катионообменного выделения радионуклида лютеция-177 из облученного в ядерном реакторе иттербия

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US10344314B2 (en) * 2016-05-04 2019-07-09 Curium Us Llc Systems and methods for sterility testing of radionuclide generator column assemblies
CA3021879C (en) * 2016-05-04 2023-10-10 Mallinckrodt Nuclear Medicine Llc Column assembly transfer mechanism and systems and methods for sanitizing same
CN113748121B (zh) * 2019-04-29 2025-07-29 先正达农作物保护股份公司 用于蛋白质检测的组合物以及方法
EP4022653A2 (en) 2019-08-29 2022-07-06 CF Technologies, Inc. Systems and methods for selective recovery of metals from ion exchange resins
AU2020369092A1 (en) 2019-10-25 2022-05-12 Intellexon Gmbh HLA-H, HLA-J, HLA-L, HLA-V and HLA-Y as therapeutic and diagnostic targets
JP2023502987A (ja) 2019-11-20 2023-01-26 シャイン テクノロジーズ エルエルシー 希土類元素の分離
CN110828020A (zh) * 2019-11-21 2020-02-21 中国核动力研究设计院 一种含有载体氯化镥-177溶液的制备系统及其制备方法
BR112022012030A2 (pt) 2019-12-20 2022-09-06 Nuclear Res And Consultancy Group Uso de um composto, e, método de separação cromatográfica
CA3174318A1 (en) 2020-04-02 2021-10-07 Richard SISSON Separation of rare earth elements
CN111440947B (zh) * 2020-04-17 2022-02-15 包头稀土研究院 采用氧化镱原料还原蒸馏制备金属镱的方法
RU2741009C9 (ru) * 2020-09-11 2021-06-22 Линчевский Дмитрий Александрович Способ разделения лютеция и иттербия методом хроматографии
CN112176193B (zh) * 2020-09-29 2022-08-09 中国工程物理研究院核物理与化学研究所 一种镧系树脂循环洗脱分离Yb-176和Lu-177的方法
KR102266273B1 (ko) * 2020-12-24 2021-06-17 한국원자력연구원 크로마토그래피를 이용한 무담체 루테튬-177의 생산 및 정제 방법
DE102021109246B3 (de) 2021-04-13 2022-06-09 ITM Isotope Technologies Munich SE Radiopharmaka zu unterschiedlichen ARTs
CN115216652A (zh) * 2021-04-20 2022-10-21 赣江中药创新中心 一种从镱镥混合物中分离提纯镥的方法
US12090215B2 (en) 2022-02-04 2024-09-17 Westinghouse Electric Company Llc Method and device for direct production of radio-isotope based cancer treatment pharmaceuticals
US12540371B2 (en) 2022-07-26 2026-02-03 Shine Technologies, Llc Phase change system and phase change crucible for the separation of rare earth elements
US11894156B1 (en) * 2023-04-04 2024-02-06 CVF International LLC Separation of rare earth elements by means of physical chemistry for use in medical applications
US20240339233A1 (en) 2023-04-04 2024-10-10 CVF International LLC Separation of rare earth elements by means of physical chemistry
CN116864178A (zh) * 2023-07-19 2023-10-10 中国核动力研究设计院 一种无载体镥-177溶液制备系统及方法
CN117018864A (zh) * 2023-07-27 2023-11-10 中国核动力研究设计院 一种多级连续分离纯化制备无载体镥-177的方法
CN117448602B (zh) * 2023-09-07 2026-04-14 国电投核素同创(重庆)科技有限公司 一种从177Lu/176Yb混合物中分离177Lu的方法

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JP2010223827A (ja) * 2009-03-24 2010-10-07 Japan Atomic Energy Agency 抗体標識が可能な無担体１７７Ｌｕの分離精製法

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RU2763745C1 (ru) * 2021-06-02 2022-01-10 Акционерное Общество "Государственный Научный Центр - Научно-Исследовательский Институт Атомных Реакторов" Способ катионообменного выделения радионуклида лютеция-177 из облученного в ядерном реакторе иттербия

Also Published As

Publication number Publication date
SMT201600065B (it) 2016-04-29
KR20140071324A (ko) 2014-06-11
AU2012202379A8 (en) 2014-01-16
DK2546839T3 (en) 2016-02-08
DE102011051868A1 (de) 2013-01-17
WO2013010686A1 (de) 2013-01-24
JP2014521076A (ja) 2014-08-25
US9816156B2 (en) 2017-11-14
JP6530007B2 (ja) 2019-06-12
EP2546839A1 (de) 2013-01-16
RU2013155710A (ru) 2015-08-27
CN103718250A (zh) 2014-04-09
KR101931521B1 (ko) 2018-12-21
CA2839968C (en) 2019-02-26
JP6219276B2 (ja) 2017-10-25
CA2839968A1 (en) 2013-01-24
SI2546839T1 (sl) 2016-02-29
HK1190818A1 (zh) 2014-07-11
JP2017214355A (ja) 2017-12-07
AU2012202379B2 (en) 2015-01-22
RU2573475C2 (ru) 2016-01-20
BR112014000857B1 (pt) 2021-01-05
AU2012202379A1 (en) 2013-01-31
RS54508B1 (sr) 2016-06-30
ES2558116T3 (es) 2016-02-02
US20140294700A1 (en) 2014-10-02
PL2546839T3 (pl) 2016-04-29
EP2546839B1 (de) 2015-11-04
PT2546839E (pt) 2016-03-08
BR112014000857A2 (pt) 2017-02-21
ZA201203027B (en) 2012-12-27
DE102011051868B4 (de) 2013-02-21
HUE026163T2 (en) 2016-05-30

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