BR112013033488B8 - Métodos para facilitar o diagnóstico do comprometimento cognitivo devido a doença de alzheimer ou comprometimento cognitivo leve (mci)e kit - Google Patents
Métodos para facilitar o diagnóstico do comprometimento cognitivo devido a doença de alzheimer ou comprometimento cognitivo leve (mci)e kitInfo
- Publication number
- BR112013033488B8 BR112013033488B8 BR112013033488A BR112013033488A BR112013033488B8 BR 112013033488 B8 BR112013033488 B8 BR 112013033488B8 BR 112013033488 A BR112013033488 A BR 112013033488A BR 112013033488 A BR112013033488 A BR 112013033488A BR 112013033488 B8 BR112013033488 B8 BR 112013033488B8
- Authority
- BR
- Brazil
- Prior art keywords
- cognitive impairment
- methods
- disease
- alzheimer
- mci
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 7
- 208000010877 cognitive disease Diseases 0.000 title abstract 6
- 238000000034 method Methods 0.000 title abstract 5
- 208000027061 mild cognitive impairment Diseases 0.000 title abstract 4
- 208000028698 Cognitive impairment Diseases 0.000 title abstract 2
- 238000003745 diagnosis Methods 0.000 title abstract 2
- 238000012544 monitoring process Methods 0.000 abstract 2
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161501720P | 2011-06-27 | 2011-06-27 | |
| US61/501,720 | 2011-06-27 | ||
| PCT/US2012/044202 WO2013003350A2 (en) | 2011-06-27 | 2012-06-26 | Microrna biomarkers indicative of alzheimer's disease |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| BR112013033488A2 BR112013033488A2 (pt) | 2017-03-01 |
| BR112013033488B1 BR112013033488B1 (pt) | 2022-03-03 |
| BR112013033488B8 true BR112013033488B8 (pt) | 2022-11-22 |
Family
ID=46724591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112013033488A BR112013033488B8 (pt) | 2011-06-27 | 2012-06-26 | Métodos para facilitar o diagnóstico do comprometimento cognitivo devido a doença de alzheimer ou comprometimento cognitivo leve (mci)e kit |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9771617B2 (enExample) |
| EP (1) | EP2723894B1 (enExample) |
| JP (2) | JP6154809B2 (enExample) |
| KR (1) | KR102082016B1 (enExample) |
| CN (1) | CN103781919B9 (enExample) |
| AU (1) | AU2012275556B2 (enExample) |
| BR (1) | BR112013033488B8 (enExample) |
| CA (1) | CA2840196C (enExample) |
| ES (1) | ES2580379T3 (enExample) |
| IL (1) | IL230034B (enExample) |
| MX (1) | MX341840B (enExample) |
| RU (1) | RU2639509C2 (enExample) |
| WO (1) | WO2013003350A2 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013022953A2 (en) * | 2011-08-08 | 2013-02-14 | Eugenia Wang | Biomarker for alzheimer's disease and/or mild cognitively impairment, and use thereof |
| WO2015050835A1 (en) * | 2013-10-01 | 2015-04-09 | Advanced Genomic Technology, Llc | Circulating biomarkers for alzheimer's disease and/or mild cognitive impairment |
| WO2015134551A1 (en) * | 2014-03-03 | 2015-09-11 | Banyan Biomarkers, Inc. | Micro rna markers for diagnosis of a neurological condition |
| KR101583450B1 (ko) * | 2014-12-01 | 2016-01-11 | 전주대학교 산학협력단 | 마이크로 rna id의 분석방법 및 이를 통해 도출한 대장암의 바이오마커 |
| WO2016148073A1 (ja) | 2015-03-13 | 2016-09-22 | 国立大学法人広島大学 | アルツハイマー病又は軽度認知症の検出を補助する方法 |
| US10358676B2 (en) * | 2015-04-03 | 2019-07-23 | Kaohsiung Chang Gung Memorial Hospital | Methods and kits for detecting Kawasaki disease |
| KR101734645B1 (ko) * | 2015-05-18 | 2017-05-11 | (주)에이엔티랩스 | 초기 알츠하이머 병 또는 경도 인지 장애 진단 방법 |
| EP3351939B1 (en) | 2015-09-16 | 2020-11-04 | Shimadzu Corporation | Multiplex biomarker for use in evaluation of state of accumulation of amyloid b in brain, and analysis method for said evaluation |
| ES2734678T3 (es) * | 2015-12-22 | 2019-12-11 | Siemens Ag | Firmas específicas en enfermedad de alzheimer por perfiles de miarn multicéntricos |
| US10262423B2 (en) * | 2016-03-29 | 2019-04-16 | Verily Life Sciences Llc | Disease and fall risk assessment using depth mapping systems |
| WO2017186719A1 (en) * | 2016-04-25 | 2017-11-02 | Instytut Biologii Doswiadczalnej Im. Marcelego Nenckiego Polska Akademia Nauk | Microrna biomarkers in blood for diagnosis of alzheimer's disease |
| KR101998457B1 (ko) * | 2016-05-10 | 2019-07-10 | 조선대학교산학협력단 | 알츠하이머 질병의 진단을 위한 바이오마커 |
| KR101992539B1 (ko) * | 2016-10-21 | 2019-09-30 | 서울대학교산학협력단 | miRNA 기반의 인지장애 질환 진단용 조성물 및 방법 |
| WO2018228875A1 (en) * | 2017-06-15 | 2018-12-20 | Nestec S.A. | Micro-rna biomarkers of blood-brain barrier dysfunction |
| EP3642366B1 (en) * | 2017-06-19 | 2023-11-15 | St. John's University | Circulating serum microrna biomarkers and methods for alzheimer's disease diagnosis |
| AU2018300159A1 (en) | 2017-07-12 | 2020-02-06 | Texas Tech University System | MicroRNA-455-3p as a peripheral biomarker for Alzheimer's disease |
| US11078535B2 (en) * | 2017-07-18 | 2021-08-03 | The Trustees Of Indiana University | Presymptomatic micro RNA targets for treatment of neurodegeneration pathology |
| CN111511929A (zh) * | 2017-10-25 | 2020-08-07 | 蜂鸟诊断有限责任公司 | 作为用于阿尔茨海默氏病的生物标志物的miRNA |
| CN111344409A (zh) * | 2017-11-12 | 2020-06-26 | 加利福尼亚大学董事会 | 用于检测癌症的非编码rna |
| WO2019117306A1 (ja) | 2017-12-14 | 2019-06-20 | 国立大学法人広島大学 | アルツハイマー病の検出を補助する方法 |
| CN108277271A (zh) * | 2018-02-05 | 2018-07-13 | 范瑶飞 | 一种辅助检测阿兹海默疾病的miRNA |
| EP3754019B1 (en) * | 2018-02-13 | 2024-01-31 | Toray Industries, Inc. | Use of a kit or device and method for detecting dementia |
| EP3807422B1 (en) | 2018-06-15 | 2025-12-03 | Universitat Autònoma de Barcelona | Circulating mirnas as biomarkers for diagnosis of mild cognitive impairment and alzheimer´s disease |
| US20210292840A1 (en) * | 2018-07-25 | 2021-09-23 | Srnalytics, Inc. | Small rna predictors for alzheimer's disease |
| JP6884810B2 (ja) * | 2019-05-08 | 2021-06-09 | キユーピー株式会社 | 情報提供装置、情報提供方法及びｍｉＲＮＡ重要度テーブル生成方法 |
| AU2021313706A1 (en) * | 2020-07-24 | 2023-02-23 | Otago Innovation Limited | Biomarkers for cognitive conditions |
| WO2022165205A1 (en) * | 2021-01-29 | 2022-08-04 | Arizona Board Of Regents On Behalf Of Arizona State University | Systems and methods for diagnosing neurodegenerative diseases |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5965364A (en) | 1990-10-09 | 1999-10-12 | Benner; Steven Albert | Method for selecting functional deoxyribonucleotide derivatives |
| US5432272A (en) | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
| US5767259A (en) | 1994-12-27 | 1998-06-16 | Naxcor | Oligonucleotides containing base-free linking groups with photoactivatable side chains |
| US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| DE69738687D1 (de) | 1996-04-12 | 2008-06-26 | Phri Properties Inc | Sonden, kits und assays |
| SE506700C2 (sv) | 1996-05-31 | 1998-02-02 | Mikael Kubista | Sond och förfaranden för analys av nukleinsyra |
| US6485901B1 (en) | 1997-10-27 | 2002-11-26 | Boston Probes, Inc. | Methods, kits and compositions pertaining to linear beacons |
| EP1025120B1 (en) | 1997-10-27 | 2010-08-18 | Boston Probes, Inc. | Methods, kits and compositions pertaining to pna molecular beacons |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US6383752B1 (en) | 1999-03-31 | 2002-05-07 | Hybridon, Inc. | Pseudo-cyclic oligonucleobases |
| EP1236173A2 (en) | 1999-10-27 | 2002-09-04 | Biowulf Technologies, LLC | Methods and devices for identifying patterns in biological systems |
| US6528254B1 (en) | 1999-10-29 | 2003-03-04 | Stratagene | Methods for detection of a target nucleic acid sequence |
| US6596490B2 (en) | 2000-07-14 | 2003-07-22 | Applied Gene Technologies, Inc. | Nucleic acid hairpin probes and uses thereof |
| KR101054732B1 (ko) | 2000-07-18 | 2011-08-05 | 더 유나이티드 스테이츠 오브 아메리카 애즈 리프리젠티드 바이 더 세크레터리 오브 더 디파트먼트 오브 헬쓰 앤드 휴먼 써비시즈 | 생물학적 데이터의 숨겨진 패턴에 근거한 생물학적 상태의 식별 방법 |
| US6350580B1 (en) | 2000-10-11 | 2002-02-26 | Stratagene | Methods for detection of a target nucleic acid using a probe comprising secondary structure |
| US7113896B2 (en) | 2001-05-11 | 2006-09-26 | Zhen Zhang | System and methods for processing biological expression data |
| WO2003020739A2 (en) | 2001-09-04 | 2003-03-13 | Exiqon A/S | Novel lna compositions and uses thereof |
| US6593091B2 (en) | 2001-09-24 | 2003-07-15 | Beckman Coulter, Inc. | Oligonucleotide probes for detecting nucleic acids through changes in flourescence resonance energy transfer |
| US20020193950A1 (en) | 2002-02-25 | 2002-12-19 | Gavin Edward J. | Method for analyzing mass spectra |
| US20030225031A1 (en) | 2002-05-21 | 2003-12-04 | Quay Steven C. | Administration of acetylcholinesterase inhibitors to the cerebral spinal fluid |
| JP2004161636A (ja) * | 2002-11-11 | 2004-06-10 | Takeda Chem Ind Ltd | 軽度認知障害または注意欠陥多動性障害治療剤 |
| EP1618214A4 (en) | 2003-04-25 | 2008-02-13 | Becton Dickinson Co | DETECTION OF TYPES 1 AND 2 OF HERPES SIMPLEX VIRUS BY AMPLIFICATION OF NUCLEIC ACID |
| US9119846B2 (en) | 2003-04-29 | 2015-09-01 | Neurim Pharmaceuticals (1991) Ltd. | Method and composition for enhancing cognition in alzheimer's patients |
| EP1774025A4 (en) | 2004-07-09 | 2009-09-16 | Univ Pittsburgh | IDENTIFYING MARKERS IN LUNG AND BREAST CANCER |
| US20060078894A1 (en) | 2004-10-12 | 2006-04-13 | Winkler Matthew M | Methods and compositions for analyzing nucleic acids |
| JP2006176503A (ja) | 2004-11-26 | 2006-07-06 | Tohoku Univ | 脳血管障害を伴うアルツハイマー病治療薬 |
| RU2418068C2 (ru) * | 2005-08-17 | 2011-05-10 | Сирна Терапьютикс, Инк. | Молекулы химически модифицированной короткой интерферирующей нуклеиновой кислоты, которые опосредуют интерференцию рнк |
| WO2007044937A2 (en) * | 2005-10-13 | 2007-04-19 | President And Fellows Of Harvard College | Compositions and methods to modulate memory |
| AU2007286855A1 (en) * | 2006-08-21 | 2008-02-28 | Novartis Ag | Biomarkers for Alzheimer's Disease progression |
| US20100167948A1 (en) | 2007-05-22 | 2010-07-01 | The Brigham And Women's Hospital, Inc. | MicroRNA Expression Profiling of Cerebrospinal Fluid |
| US8841267B2 (en) | 2007-05-23 | 2014-09-23 | Ge Healthcare Dharmacon, Inc. | Micro-RNA scaffolds, non-naturally occurring micro-RNAs, and methods for optimizing non-naturally occurring micro-RNAs |
| US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| WO2009009457A1 (en) * | 2007-07-06 | 2009-01-15 | University Of Louisville Research Foundation, Inc. | Alzheimer's disease-specific micro-rna microarray and related methods |
| US8551703B2 (en) | 2007-07-06 | 2013-10-08 | The Regents Of The University Of California | SNPs associated with fatty acid composition of bovine meat and milk |
| CA2676113C (en) * | 2007-07-25 | 2014-07-08 | University Of Louisville Research Foundation, Inc. | Exosome-associated microrna as a diagnostic marker |
| JP5889529B2 (ja) | 2007-07-27 | 2016-03-22 | ヤンセン・サイエンシズ・アイルランド・ユーシー | アミロイド原性疾患の処置 |
| CN101861399B (zh) * | 2007-08-22 | 2015-11-25 | 特罗瓦基因公司 | 使用miRNA检测体内细胞死亡情况的方法 |
| US8455199B2 (en) * | 2007-09-14 | 2013-06-04 | The Ohio State University Research Foundation | MicroRNA expression in human peripheral blood microvesicles and uses thereof |
| CA2709354C (en) | 2007-12-21 | 2014-06-17 | Amgen Inc. | Anti-amyloid antibodies and uses thereof |
| US20110160290A1 (en) | 2008-05-21 | 2011-06-30 | Muneesh Tewari | Use of extracellular rna to measure disease |
| CN101386848A (zh) | 2008-08-12 | 2009-03-18 | 南京大学 | 细胞微粒子所载微小核糖核酸及其制备研究方法和应用 |
| EP3181705A1 (en) | 2008-11-12 | 2017-06-21 | Caris Life Sciences Switzerland Holdings GmbH | Methods and systems of using exosomes for determining phenotypes |
| US8637525B2 (en) | 2009-07-31 | 2014-01-28 | Bristol-Myers Squibb Company | Compounds for the reduction of beta-amyloid production |
| EP2287336A1 (fr) * | 2009-07-31 | 2011-02-23 | Exhonit Therapeutics SA | Procédés et méthodes de diagnostic de la maladie d'Alzheimer |
| EP2475372B2 (en) * | 2009-09-10 | 2020-10-21 | Velin-Pharma A/S | Method for the preparation of micro-rna and its therapeutic application |
| EP3118334A1 (en) | 2009-11-04 | 2017-01-18 | DiamiR, LLC | Methods of using small rna from bodily fluids for diagnosis and monitoring of neurodegenerative diseases |
| GB201011420D0 (en) | 2010-07-06 | 2010-08-18 | United Arab Emirates Universit | Method for diagnosis |
| JP5797756B2 (ja) | 2010-09-22 | 2015-10-21 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプＪａｎｓｓｅｎ Ｐｈａｒｍａｃｅｕｔｉｃａ Ｎａａｍｌｏｚｅ Ｖｅｎｎｏｏｔｓｃｈａｐ | ベータ−セクレターゼ（ＢＡＣＥ）の阻害剤として有用な４，７−ジヒドロ−ピラゾロ［１，５−ａ］ピラジン−６−イルアミン誘導体 |
| KR20190002733A (ko) | 2010-12-30 | 2019-01-08 | 파운데이션 메디신 인코포레이티드 | 종양 샘플의 다유전자 분석의 최적화 |
| US8945829B2 (en) | 2011-03-22 | 2015-02-03 | Cornell University | Distinguishing benign and malignant indeterminate thyroid lesions |
| US9023359B1 (en) | 2014-07-15 | 2015-05-05 | Kymab Limited | Targeting rare human PCSK9 variants for cholesterol treatment |
-
2012
- 2012-06-26 US US14/128,888 patent/US9771617B2/en active Active
- 2012-06-26 KR KR1020147001923A patent/KR102082016B1/ko active Active
- 2012-06-26 BR BR112013033488A patent/BR112013033488B8/pt active IP Right Grant
- 2012-06-26 MX MX2013015392A patent/MX341840B/es active IP Right Grant
- 2012-06-26 CA CA2840196A patent/CA2840196C/en active Active
- 2012-06-26 ES ES12750628.5T patent/ES2580379T3/es active Active
- 2012-06-26 JP JP2014518915A patent/JP6154809B2/ja active Active
- 2012-06-26 RU RU2014102357A patent/RU2639509C2/ru active
- 2012-06-26 EP EP12750628.5A patent/EP2723894B1/en active Active
- 2012-06-26 AU AU2012275556A patent/AU2012275556B2/en active Active
- 2012-06-26 WO PCT/US2012/044202 patent/WO2013003350A2/en not_active Ceased
- 2012-06-26 CN CN201280041358.8A patent/CN103781919B9/zh active Active
-
2013
- 2013-12-19 IL IL230034A patent/IL230034B/en active IP Right Grant
-
2016
- 2016-08-01 JP JP2016150989A patent/JP2016214256A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN103781919B (zh) | 2017-07-04 |
| JP2014520529A (ja) | 2014-08-25 |
| US20140378439A1 (en) | 2014-12-25 |
| CA2840196A1 (en) | 2013-01-03 |
| KR102082016B1 (ko) | 2020-02-26 |
| JP2016214256A (ja) | 2016-12-22 |
| KR20140044375A (ko) | 2014-04-14 |
| CA2840196C (en) | 2022-09-20 |
| RU2639509C2 (ru) | 2017-12-21 |
| ES2580379T3 (es) | 2016-08-23 |
| AU2012275556A1 (en) | 2013-05-02 |
| BR112013033488A2 (pt) | 2017-03-01 |
| AU2012275556B2 (en) | 2016-02-04 |
| EP2723894A2 (en) | 2014-04-30 |
| RU2014102357A (ru) | 2015-08-10 |
| CN103781919B9 (zh) | 2017-09-15 |
| MX341840B (es) | 2016-09-05 |
| IL230034B (en) | 2021-02-28 |
| CN103781919A (zh) | 2014-05-07 |
| US9771617B2 (en) | 2017-09-26 |
| WO2013003350A2 (en) | 2013-01-03 |
| JP6154809B2 (ja) | 2017-06-28 |
| EP2723894B1 (en) | 2016-05-11 |
| WO2013003350A3 (en) | 2013-04-11 |
| MX2013015392A (es) | 2014-07-14 |
| BR112013033488B1 (pt) | 2022-03-03 |
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