AU2012275556B2 - MicroRNA biomarkers indicative of Alzheimer's Disease - Google Patents

MicroRNA biomarkers indicative of Alzheimer's Disease Download PDF

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Publication number
AU2012275556B2
AU2012275556B2 AU2012275556A AU2012275556A AU2012275556B2 AU 2012275556 B2 AU2012275556 B2 AU 2012275556B2 AU 2012275556 A AU2012275556 A AU 2012275556A AU 2012275556 A AU2012275556 A AU 2012275556A AU 2012275556 B2 AU2012275556 B2 AU 2012275556B2
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mir
mirna
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sample
alzheimer
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AU2012275556A1 (en
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Zoltan DEZSO
Pavan Kumar
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Eisai R&D Management Co Ltd
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Eisai R&D Management Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Pathology (AREA)
  • General Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
AU2012275556A 2011-06-27 2012-06-26 MicroRNA biomarkers indicative of Alzheimer's Disease Active AU2012275556B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2013204118A AU2013204118A1 (en) 2011-06-27 2012-06-26 MicroRNA biomarkers indicative of Alzheimer's Disease

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161501720P 2011-06-27 2011-06-27
US61/501,720 2011-06-27
PCT/US2012/044202 WO2013003350A2 (en) 2011-06-27 2012-06-26 Microrna biomarkers indicative of alzheimer's disease

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AU2013204118A Division AU2013204118A1 (en) 2011-06-27 2012-06-26 MicroRNA biomarkers indicative of Alzheimer's Disease

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AU2012275556A1 AU2012275556A1 (en) 2013-05-02
AU2012275556B2 true AU2012275556B2 (en) 2016-02-04

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US (1) US9771617B2 (enExample)
EP (1) EP2723894B1 (enExample)
JP (2) JP6154809B2 (enExample)
KR (1) KR102082016B1 (enExample)
CN (1) CN103781919B9 (enExample)
AU (1) AU2012275556B2 (enExample)
BR (1) BR112013033488B8 (enExample)
CA (1) CA2840196C (enExample)
ES (1) ES2580379T3 (enExample)
IL (1) IL230034B (enExample)
MX (1) MX341840B (enExample)
RU (1) RU2639509C2 (enExample)
WO (1) WO2013003350A2 (enExample)

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WO2016148073A1 (ja) 2015-03-13 2016-09-22 国立大学法人広島大学 アルツハイマー病又は軽度認知症の検出を補助する方法
US10358676B2 (en) * 2015-04-03 2019-07-23 Kaohsiung Chang Gung Memorial Hospital Methods and kits for detecting Kawasaki disease
KR101734645B1 (ko) * 2015-05-18 2017-05-11 (주)에이엔티랩스 초기 알츠하이머 병 또는 경도 인지 장애 진단 방법
EP3351939B1 (en) 2015-09-16 2020-11-04 Shimadzu Corporation Multiplex biomarker for use in evaluation of state of accumulation of amyloid b in brain, and analysis method for said evaluation
ES2734678T3 (es) * 2015-12-22 2019-12-11 Siemens Ag Firmas específicas en enfermedad de alzheimer por perfiles de miarn multicéntricos
US10262423B2 (en) * 2016-03-29 2019-04-16 Verily Life Sciences Llc Disease and fall risk assessment using depth mapping systems
WO2017186719A1 (en) * 2016-04-25 2017-11-02 Instytut Biologii Doswiadczalnej Im. Marcelego Nenckiego Polska Akademia Nauk Microrna biomarkers in blood for diagnosis of alzheimer's disease
KR101998457B1 (ko) * 2016-05-10 2019-07-10 조선대학교산학협력단 알츠하이머 질병의 진단을 위한 바이오마커
KR101992539B1 (ko) * 2016-10-21 2019-09-30 서울대학교산학협력단 miRNA 기반의 인지장애 질환 진단용 조성물 및 방법
WO2018228875A1 (en) * 2017-06-15 2018-12-20 Nestec S.A. Micro-rna biomarkers of blood-brain barrier dysfunction
EP3642366B1 (en) * 2017-06-19 2023-11-15 St. John's University Circulating serum microrna biomarkers and methods for alzheimer's disease diagnosis
AU2018300159A1 (en) 2017-07-12 2020-02-06 Texas Tech University System MicroRNA-455-3p as a peripheral biomarker for Alzheimer's disease
US11078535B2 (en) * 2017-07-18 2021-08-03 The Trustees Of Indiana University Presymptomatic micro RNA targets for treatment of neurodegeneration pathology
CN111511929A (zh) * 2017-10-25 2020-08-07 蜂鸟诊断有限责任公司 作为用于阿尔茨海默氏病的生物标志物的miRNA
CN111344409A (zh) * 2017-11-12 2020-06-26 加利福尼亚大学董事会 用于检测癌症的非编码rna
WO2019117306A1 (ja) 2017-12-14 2019-06-20 国立大学法人広島大学 アルツハイマー病の検出を補助する方法
CN108277271A (zh) * 2018-02-05 2018-07-13 范瑶飞 一种辅助检测阿兹海默疾病的miRNA
EP3754019B1 (en) * 2018-02-13 2024-01-31 Toray Industries, Inc. Use of a kit or device and method for detecting dementia
EP3807422B1 (en) 2018-06-15 2025-12-03 Universitat Autònoma de Barcelona Circulating mirnas as biomarkers for diagnosis of mild cognitive impairment and alzheimer´s disease
US20210292840A1 (en) * 2018-07-25 2021-09-23 Srnalytics, Inc. Small rna predictors for alzheimer's disease
JP6884810B2 (ja) * 2019-05-08 2021-06-09 キユーピー株式会社 情報提供装置、情報提供方法及びｍｉＲＮＡ重要度テーブル生成方法
AU2021313706A1 (en) * 2020-07-24 2023-02-23 Otago Innovation Limited Biomarkers for cognitive conditions
WO2022165205A1 (en) * 2021-01-29 2022-08-04 Arizona Board Of Regents On Behalf Of Arizona State University Systems and methods for diagnosing neurodegenerative diseases

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CN103781919B (zh) 2017-07-04
JP2014520529A (ja) 2014-08-25
US20140378439A1 (en) 2014-12-25
CA2840196A1 (en) 2013-01-03
KR102082016B1 (ko) 2020-02-26
JP2016214256A (ja) 2016-12-22
KR20140044375A (ko) 2014-04-14
CA2840196C (en) 2022-09-20
RU2639509C2 (ru) 2017-12-21
ES2580379T3 (es) 2016-08-23
AU2012275556A1 (en) 2013-05-02
BR112013033488A2 (pt) 2017-03-01
EP2723894A2 (en) 2014-04-30
RU2014102357A (ru) 2015-08-10
CN103781919B9 (zh) 2017-09-15
MX341840B (es) 2016-09-05
IL230034B (en) 2021-02-28
CN103781919A (zh) 2014-05-07
US9771617B2 (en) 2017-09-26
WO2013003350A2 (en) 2013-01-03
JP6154809B2 (ja) 2017-06-28
BR112013033488B8 (pt) 2022-11-22
EP2723894B1 (en) 2016-05-11
WO2013003350A3 (en) 2013-04-11
MX2013015392A (es) 2014-07-14
BR112013033488B1 (pt) 2022-03-03

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