IL230034B - MicroRNA biomarkers that indicate Alzheimer's disease - Google Patents
MicroRNA biomarkers that indicate Alzheimer's diseaseInfo
- Publication number
- IL230034B IL230034B IL230034A IL23003413A IL230034B IL 230034 B IL230034 B IL 230034B IL 230034 A IL230034 A IL 230034A IL 23003413 A IL23003413 A IL 23003413A IL 230034 B IL230034 B IL 230034B
- Authority
- IL
- Israel
- Prior art keywords
- alzheimer
- disease
- biomarkers indicative
- microrna biomarkers
- microrna
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title 1
- 239000000090 biomarker Substances 0.000 title 1
- 108091070501 miRNA Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Pathology (AREA)
- General Engineering & Computer Science (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161501720P | 2011-06-27 | 2011-06-27 | |
| PCT/US2012/044202 WO2013003350A2 (en) | 2011-06-27 | 2012-06-26 | Microrna biomarkers indicative of alzheimer's disease |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| IL230034B true IL230034B (en) | 2021-02-28 |
Family
ID=46724591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL230034A IL230034B (en) | 2011-06-27 | 2013-12-19 | MicroRNA biomarkers that indicate Alzheimer's disease |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9771617B2 (enExample) |
| EP (1) | EP2723894B1 (enExample) |
| JP (2) | JP6154809B2 (enExample) |
| KR (1) | KR102082016B1 (enExample) |
| CN (1) | CN103781919B9 (enExample) |
| AU (1) | AU2012275556B2 (enExample) |
| BR (1) | BR112013033488B8 (enExample) |
| CA (1) | CA2840196C (enExample) |
| ES (1) | ES2580379T3 (enExample) |
| IL (1) | IL230034B (enExample) |
| MX (1) | MX341840B (enExample) |
| RU (1) | RU2639509C2 (enExample) |
| WO (1) | WO2013003350A2 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013022953A2 (en) * | 2011-08-08 | 2013-02-14 | Eugenia Wang | Biomarker for alzheimer's disease and/or mild cognitively impairment, and use thereof |
| WO2015050835A1 (en) * | 2013-10-01 | 2015-04-09 | Advanced Genomic Technology, Llc | Circulating biomarkers for alzheimer's disease and/or mild cognitive impairment |
| WO2015134551A1 (en) * | 2014-03-03 | 2015-09-11 | Banyan Biomarkers, Inc. | Micro rna markers for diagnosis of a neurological condition |
| KR101583450B1 (ko) * | 2014-12-01 | 2016-01-11 | 전주대학교 산학협력단 | 마이크로 rna id의 분석방법 및 이를 통해 도출한 대장암의 바이오마커 |
| EP3269823B1 (en) | 2015-03-13 | 2019-06-05 | Hiroshima University | Method for assisting detection of alzheimer's disease or mild cognitive impairment |
| US10358676B2 (en) * | 2015-04-03 | 2019-07-23 | Kaohsiung Chang Gung Memorial Hospital | Methods and kits for detecting Kawasaki disease |
| KR101734645B1 (ko) * | 2015-05-18 | 2017-05-11 | (주)에이엔티랩스 | 초기 알츠하이머 병 또는 경도 인지 장애 진단 방법 |
| EP4424704A3 (en) | 2015-09-16 | 2024-12-25 | Shimadzu Corporation | Multiplex biomarker for use in evaluation of state of accumulation of amyloid b in brain, and analysis method for said evaluation |
| EP3184646B1 (de) * | 2015-12-22 | 2019-04-17 | Siemens Aktiengesellschaft | Spezifische signaturen in alzheimer durch multizentrische mirna-profile |
| US10262423B2 (en) * | 2016-03-29 | 2019-04-16 | Verily Life Sciences Llc | Disease and fall risk assessment using depth mapping systems |
| WO2017186719A1 (en) * | 2016-04-25 | 2017-11-02 | Instytut Biologii Doswiadczalnej Im. Marcelego Nenckiego Polska Akademia Nauk | Microrna biomarkers in blood for diagnosis of alzheimer's disease |
| KR101998457B1 (ko) * | 2016-05-10 | 2019-07-10 | 조선대학교산학협력단 | 알츠하이머 질병의 진단을 위한 바이오마커 |
| KR101992539B1 (ko) * | 2016-10-21 | 2019-09-30 | 서울대학교산학협력단 | miRNA 기반의 인지장애 질환 진단용 조성물 및 방법 |
| WO2018228875A1 (en) * | 2017-06-15 | 2018-12-20 | Nestec S.A. | Micro-rna biomarkers of blood-brain barrier dysfunction |
| JP2020524509A (ja) * | 2017-06-19 | 2020-08-20 | セント・ジョーンズ・ユニバーシティＳｔ． Ｊｏｈｎｓ Ｕｎｉｖｅｒｓｉｔｙ | アルツハイマー病の診断のための循環血清マイクロｒｎａバイオマーカー及び方法 |
| CA3069445A1 (en) * | 2017-07-12 | 2019-01-17 | Texas Tech University System | Microrna-455-3p as a peripheral biomarker for alzheimer's disease |
| US11078535B2 (en) * | 2017-07-18 | 2021-08-03 | The Trustees Of Indiana University | Presymptomatic micro RNA targets for treatment of neurodegeneration pathology |
| CN111511929A (zh) * | 2017-10-25 | 2020-08-07 | 蜂鸟诊断有限责任公司 | 作为用于阿尔茨海默氏病的生物标志物的miRNA |
| WO2019094780A2 (en) * | 2017-11-12 | 2019-05-16 | The Regents Of The University Of California | Non-coding rna for detection of cancer |
| WO2019117306A1 (ja) | 2017-12-14 | 2019-06-20 | 国立大学法人広島大学 | アルツハイマー病の検出を補助する方法 |
| CN108277271A (zh) * | 2018-02-05 | 2018-07-13 | 范瑶飞 | 一种辅助检测阿兹海默疾病的miRNA |
| WO2019159884A1 (ja) * | 2018-02-13 | 2019-08-22 | 東レ株式会社 | 認知症の検出のためのキット又はデバイス及び方法 |
| US12054779B2 (en) | 2018-06-15 | 2024-08-06 | Universitat Autònoma De Barcelona | Circulating miRNAs as biomarkers for diagnosis of mild cognitive impairment and Alzheimer's disease |
| KR20210038585A (ko) * | 2018-07-25 | 2021-04-07 | 에스알엔에이리틱스, 인크. | 알츠하이머병에 대한 작은 rna 예측인자 |
| JP6884810B2 (ja) * | 2019-05-08 | 2021-06-09 | キユーピー株式会社 | 情報提供装置、情報提供方法及びｍｉＲＮＡ重要度テーブル生成方法 |
| US20240093297A1 (en) * | 2020-07-24 | 2024-03-21 | Otago Innovation Limited | Biomarkers For Cognitive Conditions |
| WO2022165205A1 (en) * | 2021-01-29 | 2022-08-04 | Arizona Board Of Regents On Behalf Of Arizona State University | Systems and methods for diagnosing neurodegenerative diseases |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5432272A (en) | 1990-10-09 | 1995-07-11 | Benner; Steven A. | Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases |
| US5965364A (en) | 1990-10-09 | 1999-10-12 | Benner; Steven Albert | Method for selecting functional deoxyribonucleotide derivatives |
| US5767259A (en) | 1994-12-27 | 1998-06-16 | Naxcor | Oligonucleotides containing base-free linking groups with photoactivatable side chains |
| US5925517A (en) | 1993-11-12 | 1999-07-20 | The Public Health Research Institute Of The City Of New York, Inc. | Detectably labeled dual conformation oligonucleotide probes, assays and kits |
| US5538848A (en) | 1994-11-16 | 1996-07-23 | Applied Biosystems Division, Perkin-Elmer Corp. | Method for detecting nucleic acid amplification using self-quenching fluorescence probe |
| AU713667B2 (en) | 1996-04-12 | 1999-12-09 | Phri Properties, Inc. | Detection probes, kits and assays |
| SE506700C2 (sv) | 1996-05-31 | 1998-02-02 | Mikael Kubista | Sond och förfaranden för analys av nukleinsyra |
| AU1366299A (en) | 1997-10-27 | 1999-05-17 | Boston Probes, Inc. | Methods, kits and compositions pertaining to pna molecular beacons |
| US6485901B1 (en) | 1997-10-27 | 2002-11-26 | Boston Probes, Inc. | Methods, kits and compositions pertaining to linear beacons |
| US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
| US6383752B1 (en) | 1999-03-31 | 2002-05-07 | Hybridon, Inc. | Pseudo-cyclic oligonucleobases |
| JP5064625B2 (ja) | 1999-10-27 | 2012-10-31 | バイオウルフ テクノロジーズ エルエルスィー | パターンを同定するための方法及び機械 |
| US6528254B1 (en) | 1999-10-29 | 2003-03-04 | Stratagene | Methods for detection of a target nucleic acid sequence |
| US6596490B2 (en) | 2000-07-14 | 2003-07-22 | Applied Gene Technologies, Inc. | Nucleic acid hairpin probes and uses thereof |
| WO2002006829A2 (en) | 2000-07-18 | 2002-01-24 | Correlogic Systems, Inc. | A process for discriminating between biological states based on hidden patterns from biological data |
| US6350580B1 (en) | 2000-10-11 | 2002-02-26 | Stratagene | Methods for detection of a target nucleic acid using a probe comprising secondary structure |
| US7113896B2 (en) | 2001-05-11 | 2006-09-26 | Zhen Zhang | System and methods for processing biological expression data |
| US7060809B2 (en) | 2001-09-04 | 2006-06-13 | Exiqon A/S | LNA compositions and uses thereof |
| US6593091B2 (en) | 2001-09-24 | 2003-07-15 | Beckman Coulter, Inc. | Oligonucleotide probes for detecting nucleic acids through changes in flourescence resonance energy transfer |
| US20020193950A1 (en) | 2002-02-25 | 2002-12-19 | Gavin Edward J. | Method for analyzing mass spectra |
| US20030225031A1 (en) * | 2002-05-21 | 2003-12-04 | Quay Steven C. | Administration of acetylcholinesterase inhibitors to the cerebral spinal fluid |
| JP2004161636A (ja) | 2002-11-11 | 2004-06-10 | Takeda Chem Ind Ltd | 軽度認知障害または注意欠陥多動性障害治療剤 |
| EP2267166B1 (en) | 2003-04-25 | 2016-01-13 | Becton Dickinson and Company | Detection of herpes simplex virus types 1 and 2 by nucleic acid amplification |
| US9119846B2 (en) | 2003-04-29 | 2015-09-01 | Neurim Pharmaceuticals (1991) Ltd. | Method and composition for enhancing cognition in alzheimer's patients |
| AU2005271961B8 (en) | 2004-07-09 | 2011-11-24 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Identification of markers in esophageal cancer, colon cancer, head and neck cancer and melanoma |
| US20060078894A1 (en) | 2004-10-12 | 2006-04-13 | Winkler Matthew M | Methods and compositions for analyzing nucleic acids |
| JP2006176503A (ja) | 2004-11-26 | 2006-07-06 | Tohoku Univ | 脳血管障害を伴うアルツハイマー病治療薬 |
| RU2418068C2 (ru) * | 2005-08-17 | 2011-05-10 | Сирна Терапьютикс, Инк. | Молекулы химически модифицированной короткой интерферирующей нуклеиновой кислоты, которые опосредуют интерференцию рнк |
| WO2007044937A2 (en) * | 2005-10-13 | 2007-04-19 | President And Fellows Of Harvard College | Compositions and methods to modulate memory |
| EP2056876A1 (en) * | 2006-08-21 | 2009-05-13 | Novartis AG | Biomarkers for alzheimer's disease progression |
| WO2008153692A2 (en) * | 2007-05-22 | 2008-12-18 | The Brigham And Women's Hospital, Inc. | Microrna expression profiling of cerebrospinal fluid |
| WO2008147839A1 (en) | 2007-05-23 | 2008-12-04 | Dharmacon, Inc. | Micro-rna scaffolds and non-naturally occurring micro-rnas |
| US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
| WO2009009457A1 (en) * | 2007-07-06 | 2009-01-15 | University Of Louisville Research Foundation, Inc. | Alzheimer's disease-specific micro-rna microarray and related methods |
| US8551703B2 (en) | 2007-07-06 | 2013-10-08 | The Regents Of The University Of California | SNPs associated with fatty acid composition of bovine meat and milk |
| GB2459228B (en) * | 2007-07-25 | 2012-06-20 | Univ Louisville Res Found | Exosome-associated microrna as a diagnostic marker |
| ES2498040T3 (es) | 2007-07-27 | 2014-09-24 | Janssen Alzheimer Immunotherapy | Tratamiento de enfermedades amiloidogénicas con anticuerpos anti-beta humanizados |
| WO2009025852A2 (en) * | 2007-08-22 | 2009-02-26 | Xenomics, Inc. | Methods of using mirna for detection of in vivo cell death |
| BRPI0816852A2 (pt) * | 2007-09-14 | 2017-06-06 | Univ Ohio State Res Found | método de diagnosticar ou prognosticar doença ou desordem em sujeito, biomarcador, método para determinar e/ou prever se sujeito tem diferenciação da desordem, biomarcador para desordem pulmonar, método para diagnosticar se sujeito tem, ou está em risco de desenvolver doença ou desordem, método de inibir a proliferação de doença ou desordem e método para identificar agente terapêutico do câncer. |
| WO2009085200A2 (en) | 2007-12-21 | 2009-07-09 | Amgen Inc. | Anti-amyloid antibodies and uses thereof |
| US20110160290A1 (en) | 2008-05-21 | 2011-06-30 | Muneesh Tewari | Use of extracellular rna to measure disease |
| CN101386848A (zh) | 2008-08-12 | 2009-03-18 | 南京大学 | 细胞微粒子所载微小核糖核酸及其制备研究方法和应用 |
| EP2350320A4 (en) | 2008-11-12 | 2012-11-14 | Caris Life Sciences Luxembourg Holdings | METHOD AND SYSTEMS FOR USE OF EXOSOMES FOR THE DETERMINATION OF PHENOTYPES |
| US8637525B2 (en) | 2009-07-31 | 2014-01-28 | Bristol-Myers Squibb Company | Compounds for the reduction of beta-amyloid production |
| EP2287336A1 (fr) | 2009-07-31 | 2011-02-23 | Exhonit Therapeutics SA | Procédés et méthodes de diagnostic de la maladie d'Alzheimer |
| AU2010294197C9 (en) * | 2009-09-10 | 2018-09-13 | Velin-Pharma A/S | Method for the preparation of micro-RNA and its therapeutic application |
| WO2011057003A2 (en) | 2009-11-04 | 2011-05-12 | Samuil Umansky | Methods of using small rna from bodily fluids for diagnosis and monitoring of neurodegenerative diseases |
| GB201011420D0 (en) | 2010-07-06 | 2010-08-18 | United Arab Emirates Universit | Method for diagnosis |
| EP2619207B1 (en) | 2010-09-22 | 2014-11-12 | Janssen Pharmaceutica, N.V. | 4,7-Dihydro-pyrazolo[1,5-a]pyrazin-6-ylamine derivatives useful as inhibitors of beta secretase (BACE) |
| EP3225697A3 (en) | 2010-12-30 | 2017-11-22 | Foundation Medicine, Inc. | Optimization of multigene analysis of tumor samples |
| US8945829B2 (en) | 2011-03-22 | 2015-02-03 | Cornell University | Distinguishing benign and malignant indeterminate thyroid lesions |
| US9023359B1 (en) | 2014-07-15 | 2015-05-05 | Kymab Limited | Targeting rare human PCSK9 variants for cholesterol treatment |
-
2012
- 2012-06-26 CA CA2840196A patent/CA2840196C/en active Active
- 2012-06-26 JP JP2014518915A patent/JP6154809B2/ja active Active
- 2012-06-26 ES ES12750628.5T patent/ES2580379T3/es active Active
- 2012-06-26 MX MX2013015392A patent/MX341840B/es active IP Right Grant
- 2012-06-26 RU RU2014102357A patent/RU2639509C2/ru active
- 2012-06-26 KR KR1020147001923A patent/KR102082016B1/ko active Active
- 2012-06-26 WO PCT/US2012/044202 patent/WO2013003350A2/en not_active Ceased
- 2012-06-26 AU AU2012275556A patent/AU2012275556B2/en active Active
- 2012-06-26 BR BR112013033488A patent/BR112013033488B8/pt active IP Right Grant
- 2012-06-26 US US14/128,888 patent/US9771617B2/en active Active
- 2012-06-26 EP EP12750628.5A patent/EP2723894B1/en active Active
- 2012-06-26 CN CN201280041358.8A patent/CN103781919B9/zh active Active
-
2013
- 2013-12-19 IL IL230034A patent/IL230034B/en active IP Right Grant
-
2016
- 2016-08-01 JP JP2016150989A patent/JP2016214256A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BR112013033488A2 (pt) | 2017-03-01 |
| WO2013003350A2 (en) | 2013-01-03 |
| ES2580379T3 (es) | 2016-08-23 |
| AU2012275556B2 (en) | 2016-02-04 |
| BR112013033488B8 (pt) | 2022-11-22 |
| MX341840B (es) | 2016-09-05 |
| CA2840196C (en) | 2022-09-20 |
| RU2014102357A (ru) | 2015-08-10 |
| MX2013015392A (es) | 2014-07-14 |
| KR102082016B1 (ko) | 2020-02-26 |
| CN103781919B (zh) | 2017-07-04 |
| RU2639509C2 (ru) | 2017-12-21 |
| EP2723894A2 (en) | 2014-04-30 |
| JP2016214256A (ja) | 2016-12-22 |
| WO2013003350A3 (en) | 2013-04-11 |
| CN103781919A (zh) | 2014-05-07 |
| KR20140044375A (ko) | 2014-04-14 |
| US9771617B2 (en) | 2017-09-26 |
| AU2012275556A1 (en) | 2013-05-02 |
| EP2723894B1 (en) | 2016-05-11 |
| CN103781919B9 (zh) | 2017-09-15 |
| BR112013033488B1 (pt) | 2022-03-03 |
| CA2840196A1 (en) | 2013-01-03 |
| JP6154809B2 (ja) | 2017-06-28 |
| US20140378439A1 (en) | 2014-12-25 |
| JP2014520529A (ja) | 2014-08-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA201307591B (en) | Micro-devices for disease detection | |
| IL239025A0 (en) | Treatment of lung disease | |
| EP2665696A4 (en) | PROCESS FOR THE PREPARATION OF 2,3,3,3-TETRAFLUOR-2-PROPENE | |
| EP2552874A4 (en) | PROCESS FOR PREPARING HEXAFLUOR-2 BUTENE | |
| IL226846B (en) | Micro-devices for disease detection | |
| ZA201404500B (en) | Methods for diagnosing alzheimer's disease | |
| ZA201403995B (en) | Stereoselective total synthesis of noribogaine | |
| PL2531286T3 (pl) | Sposób syntezy metanolu | |
| IL230441A0 (en) | Diagnosis of Alzheimer's disease | |
| EP2558432A4 (en) | METHOD FOR THE PRODUCTION OF TETRAFLUOROLEFINES | |
| IL231620A0 (en) | A method for diagnosing Alzheimer's disease | |
| ZA201404440B (en) | Process for the preparation of travoprost | |
| PT2739750T (pt) | Doença cardiovascular | |
| GB201206382D0 (en) | Parkinson's disease biomarker | |
| PL2673387T3 (pl) | Bezpośredni proces topnienia | |
| PT2603319E (pt) | Processo para a preparação de uretanos | |
| EP2791349A4 (en) | SYNTHESIS OF N-ACETYL-D-NEURAMIC ACID | |
| PL2526422T3 (pl) | Sposób diagnozowania choroby Sjogrena | |
| GB201403183D0 (en) | Detection of neurodegenerative disease | |
| AP2013006853A0 (en) | Biomarker for vavular heart disease | |
| GB201114112D0 (en) | Huntington's disease | |
| GB201117244D0 (en) | 20's dress design | |
| GB201118269D0 (en) | Treatment of cardiovascular disease | |
| GB201107988D0 (en) | Treatment of cardiovascular disease | |
| GB201005905D0 (en) | Disease determination |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FF | Patent granted | ||
| KB | Patent renewed |