BR112012010762A2 - inibidores de prolil hidroxilalse - Google Patents
inibidores de prolil hidroxilalseInfo
- Publication number
- BR112012010762A2 BR112012010762A2 BR112012010762-3A BR112012010762A BR112012010762A2 BR 112012010762 A2 BR112012010762 A2 BR 112012010762A2 BR 112012010762 A BR112012010762 A BR 112012010762A BR 112012010762 A2 BR112012010762 A2 BR 112012010762A2
- Authority
- BR
- Brazil
- Prior art keywords
- disclosed
- inhibitors
- prolyl
- hydroxylalse
- hif
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title abstract 3
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 101001082567 Caenorhabditis elegans Hypoxia-inducible factor 1 Proteins 0.000 abstract 1
- 101100450705 Caenorhabditis elegans hif-1 gene Proteins 0.000 abstract 1
- 206010021143 Hypoxia Diseases 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 206010057249 Phagocytosis Diseases 0.000 abstract 1
- 102000004079 Prolyl Hydroxylases Human genes 0.000 abstract 1
- 108010043005 Prolyl Hydroxylases Proteins 0.000 abstract 1
- 230000024932 T cell mediated immunity Effects 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 230000007954 hypoxia Effects 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 210000002510 keratinocyte Anatomy 0.000 abstract 1
- 210000000440 neutrophil Anatomy 0.000 abstract 1
- 210000001539 phagocyte Anatomy 0.000 abstract 1
- 230000008782 phagocytosis Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
- C07D211/96—Sulfur atom
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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- A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
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Abstract
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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