BG64911B1 - Ген на streptomyces avermitilis насочващ съотношението b2:b1 авермектините - Google Patents

Ген на streptomyces avermitilis насочващ съотношението b2:b1 авермектините Download PDF

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Publication number
BG64911B1
BG64911B1 BG104759A BG10475900A BG64911B1 BG 64911 B1 BG64911 B1 BG 64911B1 BG 104759 A BG104759 A BG 104759A BG 10475900 A BG10475900 A BG 10475900A BG 64911 B1 BG64911 B1 BG 64911B1
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BG
Bulgaria
Prior art keywords
avec
avermitilis
cells
nucleotide sequence
polynucleotide molecule
Prior art date
Application number
BG104759A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG104759A (en
Inventor
Kim Stutzman-Engwall
Yoshihiro Katoh
Hamish Mcarthur
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of BG104759A publication Critical patent/BG104759A/xx
Publication of BG64911B1 publication Critical patent/BG64911B1/bg

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00Preparation of compounds containing saccharide radicals
    • C12P19/44Preparation of O-glycosides, e.g. glucosides
    • C12P19/60Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C12N15/76Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora for Actinomyces; for Streptomyces
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88Lyases (4.)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
BG104759A 1998-02-13 2000-09-12 Ген на streptomyces avermitilis насочващ съотношението b2:b1 авермектините BG64911B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US7463698P 1998-02-13 1998-02-13

Publications (2)

Publication Number Publication Date
BG104759A BG104759A (en) 2001-04-30
BG64911B1 true BG64911B1 (bg) 2006-08-31

Family

ID=22120706

Family Applications (1)

Application Number Title Priority Date Filing Date
BG104759A BG64911B1 (bg) 1998-02-13 2000-09-12 Ген на streptomyces avermitilis насочващ съотношението b2:b1 авермектините

Country Status (32)

Country Link
EP (1) EP1053335A1 (es)
JP (2) JP2002503473A (es)
KR (3) KR20040053390A (es)
CN (2) CN1297485A (es)
AP (1) AP9901463A0 (es)
AR (1) AR018085A1 (es)
AU (1) AU752343C (es)
BG (1) BG64911B1 (es)
BR (1) BR9907893A (es)
CA (2) CA2320031A1 (es)
CO (1) CO5070698A1 (es)
DZ (1) DZ2720A1 (es)
EA (1) EA003905B1 (es)
GT (1) GT199900014A (es)
HN (1) HN1999000008A (es)
HR (1) HRP20000539A2 (es)
HU (1) HUP0100784A3 (es)
IL (2) IL137610A0 (es)
IS (1) IS5567A (es)
MA (1) MA24760A1 (es)
NO (1) NO20004044L (es)
NZ (2) NZ505676A (es)
OA (1) OA11449A (es)
PA (1) PA8467601A1 (es)
PE (1) PE20000352A1 (es)
PL (1) PL194270B1 (es)
SK (1) SK11722000A3 (es)
TN (1) TNSN99017A1 (es)
TW (1) TW585910B (es)
WO (1) WO1999041389A1 (es)
YU (1) YU50900A (es)
ZA (1) ZA991138B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20040053390A (ko) * 1998-02-13 2004-06-23 화이자 프로덕츠 인코포레이티드 아베르멕틴의 비2:비1의 비를 제어할 수 있는 스트렙토마이세스 아베르미틸리스 유전자
US6248579B1 (en) * 1998-02-13 2001-06-19 Pfizer Inc Streptomyces avermitilis gene directing the ratio of B2:B1 avermectins
ES2272299T3 (es) 1999-08-12 2007-05-01 Pfizer Products Inc. Gen de streptomyces avermitilis que dirige la relacion de avermectinas b2:b1.
US7630836B2 (en) 2001-05-30 2009-12-08 The Kitasato Institute Polynucleotides
ME00472B (me) * 2002-02-12 2011-10-10 Zoetis Services Llc Streptomyces avermitilis gen koji određuje odnos b2:b1 avermektina
CN107338210B (zh) * 2017-09-05 2021-08-17 天津科技大学 一种阿维链霉菌合成培养基及其发酵液的制备方法
CN111269296B (zh) * 2020-03-06 2021-11-05 山东大学 一种nLsA蛋白及其结构基因和应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4310519A (en) * 1976-04-19 1982-01-12 Merck & Co., Inc. Novel substances and process for their production
US4429042A (en) * 1978-09-08 1984-01-31 Merck & Co., Inc. Strain of Streptomyces for producing antiparasitic compounds
EP0276103A2 (en) * 1987-01-23 1988-07-27 Pfizer Inc. Process for production of B avermectins and cultures therefor

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3881147T2 (de) * 1987-10-23 1993-09-02 Pfizer Verfahren zur herstellung von aglykonen von avermectin und sie enthaltende kulturen.
JPH0747171B2 (ja) * 1988-09-20 1995-05-24 株式会社東芝 圧延機の設定方法および装置
US5252474A (en) * 1989-03-31 1993-10-12 Merck & Co., Inc. Cloning genes from Streptomyces avermitilis for avermectin biosynthesis and the methods for their use
DE69023036T2 (de) * 1989-03-31 1996-06-13 Merck & Co Inc Klonierung von Streptomyces avermitilis Genen zur Biosynthese von Avermectin und Verfahren zu ihrer Verwendung.
JP2888586B2 (ja) * 1990-03-05 1999-05-10 社団法人北里研究所 エバーメクチンの特定成分を選択生産するための微生物およびその選択的製造法
FI942725A (fi) * 1993-12-16 1995-06-17 Pfizer Haaraketjuista alfaketohappodenydrogenaasikompleksia koodaavia geenejä Streptomyces avermitiliksesta
KR20040053390A (ko) * 1998-02-13 2004-06-23 화이자 프로덕츠 인코포레이티드 아베르멕틴의 비2:비1의 비를 제어할 수 있는 스트렙토마이세스 아베르미틸리스 유전자

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4310519A (en) * 1976-04-19 1982-01-12 Merck & Co., Inc. Novel substances and process for their production
US4429042A (en) * 1978-09-08 1984-01-31 Merck & Co., Inc. Strain of Streptomyces for producing antiparasitic compounds
EP0276103A2 (en) * 1987-01-23 1988-07-27 Pfizer Inc. Process for production of B avermectins and cultures therefor

Also Published As

Publication number Publication date
CO5070698A1 (es) 2001-08-28
NO20004044L (no) 2000-10-11
NO20004044D0 (no) 2000-08-11
TNSN99017A1 (fr) 2005-11-10
PL342468A1 (en) 2001-06-04
OA11449A (en) 2003-12-03
AU752343C (en) 2005-11-03
IL137610A0 (en) 2001-07-24
KR20010052166A (ko) 2001-06-25
PL194270B1 (pl) 2007-05-31
HRP20000539A2 (en) 2001-04-30
NZ505676A (en) 2003-02-28
HN1999000008A (es) 1999-10-29
KR20040099389A (ko) 2004-11-26
CA2320031A1 (en) 1999-08-19
IL183596A0 (es) 2007-09-20
PE20000352A1 (es) 2000-05-16
NZ518657A (en) 2003-10-31
TW585910B (en) 2004-05-01
EA200000758A1 (ru) 2001-04-23
HUP0100784A3 (en) 2004-10-28
EA003905B1 (ru) 2003-10-30
JP2002503473A (ja) 2002-02-05
JP4011036B2 (ja) 2007-11-21
MA24760A1 (fr) 1999-10-01
DZ2720A1 (fr) 2003-09-01
WO1999041389A1 (en) 1999-08-19
YU50900A (sh) 2004-03-12
SK11722000A3 (sk) 2001-04-09
AP9901463A0 (en) 1999-03-31
CA2521289A1 (en) 1999-08-19
HUP0100784A2 (hu) 2001-06-28
JP2004283174A (ja) 2004-10-14
BG104759A (en) 2001-04-30
ZA991138B (en) 2000-08-14
GT199900014A (es) 2000-07-25
AU752343B2 (en) 2002-09-19
EP1053335A1 (en) 2000-11-22
CN1297485A (zh) 2001-05-30
CN1521180A (zh) 2004-08-18
IS5567A (is) 2000-07-20
PA8467601A1 (es) 2000-09-29
KR100499214B1 (ko) 2005-07-07
KR20040053390A (ko) 2004-06-23
AU1887899A (en) 1999-08-30
AR018085A1 (es) 2001-10-31
BR9907893A (pt) 2000-11-14

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