BG64642B1 - Фармацевтичен състав с продължително освобождаване на лекарствени средства, капсулирани в микрочастици на хиалуронова киселина - Google Patents

Фармацевтичен състав с продължително освобождаване на лекарствени средства, капсулирани в микрочастици на хиалуронова киселина Download PDF

Info

Publication number
BG64642B1
BG64642B1 BG102969A BG10296998A BG64642B1 BG 64642 B1 BG64642 B1 BG 64642B1 BG 102969 A BG102969 A BG 102969A BG 10296998 A BG10296998 A BG 10296998A BG 64642 B1 BG64642 B1 BG 64642B1
Authority
BG
Bulgaria
Prior art keywords
microparticles
hgh
hyaluronic acid
release
group
Prior art date
Application number
BG102969A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG102969A (en
Inventor
Myung-Jin Kim
Sun-Jin Kim
Oh-Ryong KWON
Original Assignee
Lg Chemical Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=19501732&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG64642(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Lg Chemical Ltd. filed Critical Lg Chemical Ltd.
Publication of BG102969A publication Critical patent/BG102969A/xx
Publication of BG64642B1 publication Critical patent/BG64642B1/bg

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
BG102969A 1997-04-01 1998-11-30 Фармацевтичен състав с продължително освобождаване на лекарствени средства, капсулирани в микрочастици на хиалуронова киселина BG64642B1 (bg)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019970012046A KR100236771B1 (ko) 1997-04-01 1997-04-01 히아루론산을 이용한 약물의 서방성 미세입자 제형

Publications (2)

Publication Number Publication Date
BG102969A BG102969A (en) 1999-09-30
BG64642B1 true BG64642B1 (bg) 2005-10-31

Family

ID=19501732

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102969A BG64642B1 (bg) 1997-04-01 1998-11-30 Фармацевтичен състав с продължително освобождаване на лекарствени средства, капсулирани в микрочастици на хиалуронова киселина

Country Status (26)

Country Link
US (3) US20080063727A1 (de)
EP (1) EP0918535B1 (de)
JP (1) JP3445283B2 (de)
KR (1) KR100236771B1 (de)
CN (1) CN1132625C (de)
AR (1) AR011208A1 (de)
AT (1) ATE285245T1 (de)
AU (1) AU721929B2 (de)
BG (1) BG64642B1 (de)
BR (1) BR9804802B1 (de)
CA (1) CA2256596C (de)
DE (1) DE69828252T2 (de)
DK (1) DK0918535T3 (de)
ES (1) ES2232939T3 (de)
HK (1) HK1020885A1 (de)
HU (1) HUP0000737A3 (de)
ID (1) ID20584A (de)
IL (1) IL127220A (de)
MY (1) MY132812A (de)
NZ (1) NZ333019A (de)
PL (1) PL195223B1 (de)
PT (1) PT918535E (de)
TR (1) TR199802500T1 (de)
TW (1) TW514532B (de)
WO (1) WO1998043664A1 (de)
ZA (1) ZA982533B (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6221854B1 (en) * 1996-03-05 2001-04-24 Orquest, Inc. Method of promoting bone growth with hyaluronic acid and growth factors
KR100236771B1 (ko) * 1997-04-01 2000-02-01 성재갑 히아루론산을 이용한 약물의 서방성 미세입자 제형
JP4234803B2 (ja) * 1997-10-27 2009-03-04 久光製薬株式会社 薬物放出速度が制御された医薬組成物
WO1999059543A1 (en) * 1998-05-20 1999-11-25 Highchem Company., Ltd. A pharmaceutical formulation for nasal administration
EP1091730A1 (de) * 1998-06-29 2001-04-18 White Spot AG Verwendung von wachstumsfaktoren zur arzneimittelherstellung
CN100374163C (zh) 1999-01-13 2008-03-12 阿尔凯米亚肿瘤学私人有限公司 增强药物功效的组合物
DK1071407T3 (da) * 1999-01-18 2014-10-20 Lg Life Sciences Ltd Lipofile mikropartikler indeholdende et proteinlægemiddel eller et antigen og formulering omhandlende samme
SE9904121D0 (sv) * 1999-11-15 1999-11-15 Gustaf Jederstroem Hydrophobe biomolecular structure
US7785625B2 (en) 2000-01-14 2010-08-31 Lg Life Sciences, Limited Lipophilic-coated microparticle containing a protein drug and formulation comprising same
AU4724401A (en) 2000-02-28 2001-09-12 Genesegues Inc Nanocapsule encapsulation system and method
GB0004827D0 (en) * 2000-02-29 2000-04-19 Quadrant Holdings Cambridge Compositions
AUPQ879500A0 (en) 2000-07-14 2000-08-10 Meditech Research Limited Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease
US9066919B2 (en) * 2000-07-14 2015-06-30 Alchemia Oncology Pty Limited Hyaluronan as a chemo-sensitizer in the treatment of cancer
JP4931282B2 (ja) * 2000-10-02 2012-05-16 日本ケミカルリサーチ株式会社 生理活性ペプチド含有粉末
EP1356809A4 (de) 2000-12-28 2008-05-14 Takeda Pharmaceutical Retardzubereitungen
WO2002085399A1 (en) * 2001-04-20 2002-10-31 Takeda Chemical Industries, Ltd. Peptide-containing preparations
JP2005505540A (ja) * 2001-08-27 2005-02-24 メディテック リサーチ リミテッド 改善された治療プロトコール
GB0129489D0 (en) * 2001-12-10 2002-01-30 Quadrant Healthcare Uk Ltd Sustained-release compositions
WO2005054301A1 (ja) * 2003-11-14 2005-06-16 Chugai Seiyaku Kabushiki Kaisha 架橋多糖微粒子およびその製造方法
WO2005116130A1 (en) * 2004-05-27 2005-12-08 Novozymes Biopolymer A/S A fast dissolving dried hyaluronic acid product
US8143391B2 (en) 2004-09-07 2012-03-27 Chugai Seiyaku Kabushiki Kaisha Process for producing water-soluble hyaluronic acid modification
MY139088A (en) 2005-02-21 2009-08-28 Lg Life Sciences Ltd Sustained release composition of protein drug
US8017152B2 (en) 2005-05-27 2011-09-13 Stratosphere Pharma Ab Cores and microcapsules suitable for parenteral administration as well as process for their manufacture
CN103784960A (zh) * 2005-07-27 2014-05-14 阿尔卡米亚肿瘤学股份有限公司 使用乙酰透明质酸的治疗方案
US8319625B2 (en) * 2005-09-01 2012-11-27 Simplexgrinnell Lp Fire alarm textual notification related application
CA2621279C (en) * 2005-09-07 2016-06-14 Alchemia Oncology Pty Limited Therapeutic compositions comprising hyaluronan and therapeutic antibodies as well as methods of treatment
JP2009521486A (ja) * 2005-12-23 2009-06-04 アルタス ファーマシューティカルズ インコーポレイテッド ポリカチオン錯化タンパク質結晶を含む組成物およびこれを使用した治療法
KR100939983B1 (ko) 2006-10-31 2010-02-03 주식회사 엘지생명과학 히아루론산-소수성 폴리 아미노산 공중합체
FR2931360B1 (fr) * 2008-05-20 2012-05-18 Centre Nat Rech Scient Nanoparticules contenant un peptide, vecteurs les contenant et utilisations pharmaceutiques desdits nanoparticules et vecteurs
KR101183262B1 (ko) 2009-04-22 2012-09-14 (주)알테오젠 체내 지속성을 유지함으로 체내 반감기가 증가된 단백질 또는 펩티드 융합체, 및 이를 이용하여 체내 반감기를 증가시키는 방법
ES2667025T3 (es) 2009-12-15 2018-05-09 Ascendis Pharma Endocrinology Division A/S Composición seca de hormona de crecimiento unida transitoriamente a un portador de polímero
MX341642B (es) * 2011-06-14 2016-08-29 Ipsen Pharma Sas Composicion de liberacion sostenida que contiene peptidos como ingredientes activos.
US9399019B2 (en) * 2012-05-09 2016-07-26 Evonik Corporation Polymorph compositions, methods of making, and uses thereof
JP6231559B2 (ja) 2012-06-05 2017-11-15 シージェイ ヘルスケア コーポレイションCj Healthcare Corporation 高グリコシル化された持続型ヒト成長ホルモンタンパク質の製造方法及び精製方法
WO2015018461A1 (fr) 2013-08-09 2015-02-12 Genbiotech Compositions therapeutiques comprenant d'acide hyaluronique
CN107072963B (zh) 2014-09-03 2020-07-07 吉倪塞思公司 治疗性纳米粒子和相关的组合物、方法和系统

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4971782A (en) * 1983-09-14 1990-11-20 Peroxydent Group Periodontal composition and method
US4851521A (en) * 1985-07-08 1989-07-25 Fidia, S.P.A. Esters of hyaluronic acid
JPH0725689B2 (ja) * 1986-10-07 1995-03-22 中外製薬株式会社 顆粒球コロニ−刺激因子を含有する徐放性製剤
JPH02213A (ja) * 1987-10-19 1990-01-05 Taiho Yakuhin Kogyo Kk 生理活性ペプチド持続製剤
JPH01287041A (ja) * 1988-05-13 1989-11-17 Rooman Kogyo:Kk 徐放性製剤
JPH03215430A (ja) * 1990-01-19 1991-09-20 Kita Kiyoshi 関節腔抗凝固剤
US5707644A (en) * 1989-11-04 1998-01-13 Danbiosyst Uk Limited Small particle compositions for intranasal drug delivery
IT1243390B (it) * 1990-11-22 1994-06-10 Vectorpharma Int Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione.
JPH04282322A (ja) * 1991-03-08 1992-10-07 Denki Kagaku Kogyo Kk 生物活性ペプチド製剤
JP3283288B2 (ja) * 1991-03-08 2002-05-20 電気化学工業株式会社 生理活性ペプチド製剤
JPH0565231A (ja) * 1991-03-12 1993-03-19 Takeda Chem Ind Ltd エリスロポエチンの持続性製剤
IT1247472B (it) * 1991-05-31 1994-12-17 Fidia Spa Processo per la preparazione di microsfere contenenti componenti biologicamente attivi.
JP3449738B2 (ja) * 1991-07-10 2003-09-22 武田薬品工業株式会社 水溶性組成物
JPH05186364A (ja) * 1991-08-01 1993-07-27 Takeda Chem Ind Ltd 水溶性組成物
DE69220317T2 (de) * 1991-10-01 1997-10-16 Takeda Chemical Industries Ltd Mikropartikeln-Zusammenfassung zur verlängerten Freigabe und Herstellung derselbe
JPH08198772A (ja) * 1994-11-25 1996-08-06 Kirin Brewery Co Ltd 顆粒球コロニー刺激因子含有粉末経鼻投与製剤
KR100201352B1 (ko) * 1995-03-16 1999-06-15 성재갑 단일주사 백신 제형
US5641749A (en) * 1995-11-29 1997-06-24 Amgen Inc. Method for treating retinal ganglion cell injury using glial cell line-derived neurothrophic factor (GDNF) protein product
KR100236771B1 (ko) * 1997-04-01 2000-02-01 성재갑 히아루론산을 이용한 약물의 서방성 미세입자 제형
US7276251B2 (en) * 1997-04-01 2007-10-02 Lg Life Sciences, Ltd., Inc. Sustained-release composition of drugs encapsulated in microparticles of hyaluronic acid
JPH09309843A (ja) * 1996-05-21 1997-12-02 Shiseido Co Ltd ヒアルロン酸含有経肺投与用製剤
US6113947A (en) * 1997-06-13 2000-09-05 Genentech, Inc. Controlled release microencapsulated NGF formulation
JP4234803B2 (ja) * 1997-10-27 2009-03-04 久光製薬株式会社 薬物放出速度が制御された医薬組成物
TW577758B (en) * 1997-10-27 2004-03-01 Ssp Co Ltd Intra-articular preparation for the treatment of arthropathy
DK1071407T3 (da) * 1999-01-18 2014-10-20 Lg Life Sciences Ltd Lipofile mikropartikler indeholdende et proteinlægemiddel eller et antigen og formulering omhandlende samme

Also Published As

Publication number Publication date
CA2256596C (en) 2005-12-13
WO1998043664A1 (en) 1998-10-08
CA2256596A1 (en) 1998-10-08
US20110020458A1 (en) 2011-01-27
CN1132625C (zh) 2003-12-31
KR100236771B1 (ko) 2000-02-01
NZ333019A (en) 1999-08-30
HUP0000737A2 (hu) 2000-09-28
EP0918535A1 (de) 1999-06-02
AR011208A1 (es) 2000-08-02
IL127220A0 (en) 1999-09-22
BR9804802A (pt) 1999-08-17
PL330230A1 (en) 1999-05-10
TR199802500T1 (xx) 1999-06-21
DE69828252D1 (de) 2005-01-27
AU6524198A (en) 1998-10-22
HK1020885A1 (en) 2000-05-26
DK0918535T3 (da) 2005-04-18
JPH11513047A (ja) 1999-11-09
DE69828252T2 (de) 2005-11-10
JP3445283B2 (ja) 2003-09-08
US20130230598A1 (en) 2013-09-05
PT918535E (pt) 2005-03-31
ZA982533B (en) 1998-09-30
ATE285245T1 (de) 2005-01-15
TW514532B (en) 2002-12-21
CN1222857A (zh) 1999-07-14
US20080063727A1 (en) 2008-03-13
BG102969A (en) 1999-09-30
PL195223B1 (pl) 2007-08-31
AU721929B2 (en) 2000-07-20
EP0918535B1 (de) 2004-12-22
KR19980075759A (ko) 1998-11-16
ID20584A (id) 1999-01-21
MY132812A (en) 2007-10-31
ES2232939T3 (es) 2005-06-01
IL127220A (en) 2004-12-15
HUP0000737A3 (en) 2003-05-28
BR9804802B1 (pt) 2011-04-19

Similar Documents

Publication Publication Date Title
BG64642B1 (bg) Фармацевтичен състав с продължително освобождаване на лекарствени средства, капсулирани в микрочастици на хиалуронова киселина
US6465425B1 (en) Microencapsulation and sustained release of biologically active acid-stable or free sulfhydryl-containing proteins
KR100356550B1 (ko) 펩티드의금속염을함유한서방성제제
US20030064105A1 (en) Lipophilic-coated microparticle containing a protein drug and formulation comprising same
US7785625B2 (en) Lipophilic-coated microparticle containing a protein drug and formulation comprising same
US7276251B2 (en) Sustained-release composition of drugs encapsulated in microparticles of hyaluronic acid
AU2002358831B2 (en) Prolonged release biodegradable microspheres and method for preparing same
KR100535319B1 (ko) 약물방출속도가제어된의약조성물
DE69838750T2 (de) Zeitverzögerte gelzusammensetzungen mit verlängerter wirkstoffverabreichung
EP0138216B1 (de) IFN-Präparat mit verzögerter Abgabe für parentale Verabreichung
JP2002533378A (ja) タンパク質の徐放用ポリオール/油懸濁液
EP0140255A2 (de) Injektionen mit verzögerter Abgabe
AU2004251456A1 (en) Use of ethanol as plasticizer for preparing subcutaneous implants containing thermolabile active principles dispersed in a PLGA matrix
JPH0436233A (ja) 生理活性物質含有生体内分解吸収性の徐放性製剤
MX2008008924A (es) Formulaciones farmaceuticas que comprenden dextrano con peso molecular de 1.0-100kda y procesos para su preparacion.
KR100329336B1 (ko) 히아루론산을 이용한 단백질 약물의 서방성 미세 입자 제형
JPH0512328B2 (de)
JPH08225454A (ja) マイクロスフェア製剤
JP2003531106A (ja) 新規なエリスロポイエチン刺激タンパク質を含む生分解性微粒子
MXPA99010284A (en) Sustained-release delayed gels
JPH0694418B2 (ja) 長期徐放性製剤