HUP0000737A2 - Hialuronsav mikrorészecskékbe foglalt hatóanyagokat tartalmazó nyújtott hatóanyagleadású készítmény - Google Patents
Hialuronsav mikrorészecskékbe foglalt hatóanyagokat tartalmazó nyújtott hatóanyagleadású készítményInfo
- Publication number
- HUP0000737A2 HUP0000737A2 HU0000737A HUP0000737A HUP0000737A2 HU P0000737 A2 HUP0000737 A2 HU P0000737A2 HU 0000737 A HU0000737 A HU 0000737A HU P0000737 A HUP0000737 A HU P0000737A HU P0000737 A2 HUP0000737 A2 HU P0000737A2
- Authority
- HU
- Hungary
- Prior art keywords
- microparticles
- sustained
- hyaluronic acid
- release composition
- drugs encapsulated
- Prior art date
Links
- 239000011859 microparticle Substances 0.000 title abstract 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 title abstract 2
- 229920002674 hyaluronan Polymers 0.000 title abstract 2
- 229960003160 hyaluronic acid Drugs 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- 238000013268 sustained release Methods 0.000 title 1
- 239000012730 sustained-release form Substances 0.000 title 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 239000003405 delayed action preparation Substances 0.000 abstract 1
- 229910017053 inorganic salt Inorganic materials 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Abstract
Nyújtőtt hatóanyag-leadású készítmény, amely a hialűrőnsavnak vagyszervetlen sójának mikrőrészecskéit és a mikrőrészecskékbe főglaltfehérje vagy peptid hatóanyagőt tartalmaz, ahől a mikrőrészecskékátlagős mérete 0,1 és 40 mm közötti. ŕ
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1019970012046A KR100236771B1 (ko) | 1997-04-01 | 1997-04-01 | 히아루론산을 이용한 약물의 서방성 미세입자 제형 |
PCT/KR1998/000062 WO1998043664A1 (en) | 1997-04-01 | 1998-03-26 | Sustained-release composition of drugs encapsulated in microparticles of hyaluronic acid |
Publications (2)
Publication Number | Publication Date |
---|---|
HUP0000737A2 true HUP0000737A2 (hu) | 2000-09-28 |
HUP0000737A3 HUP0000737A3 (en) | 2003-05-28 |
Family
ID=19501732
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HU0000737A HUP0000737A3 (en) | 1997-04-01 | 1998-03-26 | Sustained-release composition of drugs encapsulated in microparticles of hyaluronic acid |
Country Status (26)
Country | Link |
---|---|
US (3) | US20080063727A1 (hu) |
EP (1) | EP0918535B1 (hu) |
JP (1) | JP3445283B2 (hu) |
KR (1) | KR100236771B1 (hu) |
CN (1) | CN1132625C (hu) |
AR (1) | AR011208A1 (hu) |
AT (1) | ATE285245T1 (hu) |
AU (1) | AU721929B2 (hu) |
BG (1) | BG64642B1 (hu) |
BR (1) | BR9804802B1 (hu) |
CA (1) | CA2256596C (hu) |
DE (1) | DE69828252T2 (hu) |
DK (1) | DK0918535T3 (hu) |
ES (1) | ES2232939T3 (hu) |
HK (1) | HK1020885A1 (hu) |
HU (1) | HUP0000737A3 (hu) |
ID (1) | ID20584A (hu) |
IL (1) | IL127220A (hu) |
MY (1) | MY132812A (hu) |
NZ (1) | NZ333019A (hu) |
PL (1) | PL195223B1 (hu) |
PT (1) | PT918535E (hu) |
TR (1) | TR199802500T1 (hu) |
TW (1) | TW514532B (hu) |
WO (1) | WO1998043664A1 (hu) |
ZA (1) | ZA982533B (hu) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6221854B1 (en) * | 1996-03-05 | 2001-04-24 | Orquest, Inc. | Method of promoting bone growth with hyaluronic acid and growth factors |
KR100236771B1 (ko) * | 1997-04-01 | 2000-02-01 | 성재갑 | 히아루론산을 이용한 약물의 서방성 미세입자 제형 |
JP4234803B2 (ja) * | 1997-10-27 | 2009-03-04 | 久光製薬株式会社 | 薬物放出速度が制御された医薬組成物 |
EP1079801A1 (en) | 1998-05-20 | 2001-03-07 | Highchem Company., Ltd. | A pharmaceutical formulation for nasal administration |
EP1091730A1 (de) * | 1998-06-29 | 2001-04-18 | White Spot AG | Verwendung von wachstumsfaktoren zur arzneimittelherstellung |
NZ512676A (en) | 1999-01-13 | 2003-01-31 | Meditech Res Ltd | A composition and method for the enhancement of the efficacy of drugs |
NZ506975A (en) * | 1999-01-18 | 2004-01-30 | Lg Chemical Ltd | Lipophilic microparticles containing a protein drug or antigen and formulation comprising same |
SE9904121D0 (sv) | 1999-11-15 | 1999-11-15 | Gustaf Jederstroem | Hydrophobe biomolecular structure |
US7785625B2 (en) | 2000-01-14 | 2010-08-31 | Lg Life Sciences, Limited | Lipophilic-coated microparticle containing a protein drug and formulation comprising same |
CA2400172C (en) | 2000-02-28 | 2010-04-20 | Genesegues, Inc. | Nanocapsule encapsulation system and method |
GB0004827D0 (en) * | 2000-02-29 | 2000-04-19 | Quadrant Holdings Cambridge | Compositions |
US9066919B2 (en) * | 2000-07-14 | 2015-06-30 | Alchemia Oncology Pty Limited | Hyaluronan as a chemo-sensitizer in the treatment of cancer |
AUPQ879500A0 (en) | 2000-07-14 | 2000-08-10 | Meditech Research Limited | Hyaluronan as cytotoxic agent, drug presensitizer and chemo-sensitizer in the treatment of disease |
JP4931282B2 (ja) * | 2000-10-02 | 2012-05-16 | 日本ケミカルリサーチ株式会社 | 生理活性ペプチド含有粉末 |
US8637077B2 (en) | 2000-12-28 | 2014-01-28 | Takeda Pharmaceutical Company Limited | Sustained-release preparation |
WO2002085399A1 (en) * | 2001-04-20 | 2002-10-31 | Takeda Chemical Industries, Ltd. | Peptide-containing preparations |
CN1578677A (zh) * | 2001-08-27 | 2005-02-09 | 美迪泰克研究有限公司 | 改良的治疗方案 |
GB0129489D0 (en) * | 2001-12-10 | 2002-01-30 | Quadrant Healthcare Uk Ltd | Sustained-release compositions |
JP4745826B2 (ja) * | 2003-11-14 | 2011-08-10 | 中外製薬株式会社 | 架橋多糖微粒子およびその製造方法 |
WO2005116130A1 (en) * | 2004-05-27 | 2005-12-08 | Novozymes Biopolymer A/S | A fast dissolving dried hyaluronic acid product |
US8143391B2 (en) | 2004-09-07 | 2012-03-27 | Chugai Seiyaku Kabushiki Kaisha | Process for producing water-soluble hyaluronic acid modification |
TW200640492A (en) * | 2005-02-21 | 2006-12-01 | Lg Life Sciences Ltd | Sustained release composition of protein drug |
US8017152B2 (en) | 2005-05-27 | 2011-09-13 | Stratosphere Pharma Ab | Cores and microcapsules suitable for parenteral administration as well as process for their manufacture |
CN103784960A (zh) * | 2005-07-27 | 2014-05-14 | 阿尔卡米亚肿瘤学股份有限公司 | 使用乙酰透明质酸的治疗方案 |
US8319625B2 (en) * | 2005-09-01 | 2012-11-27 | Simplexgrinnell Lp | Fire alarm textual notification related application |
AU2006289651B2 (en) * | 2005-09-07 | 2012-07-26 | Alchemia Oncology Pty Limited | Therapeutic compositions comprising hyaluronan and therapeutic antibodies as well as methods of treatment |
AU2006330833A1 (en) * | 2005-12-23 | 2007-07-05 | Altus Pharmaceuticals Inc. | Compositions comprising polycation-complexed protein crystals and methods of treatment using them |
KR100939983B1 (ko) | 2006-10-31 | 2010-02-03 | 주식회사 엘지생명과학 | 히아루론산-소수성 폴리 아미노산 공중합체 |
FR2931360B1 (fr) * | 2008-05-20 | 2012-05-18 | Centre Nat Rech Scient | Nanoparticules contenant un peptide, vecteurs les contenant et utilisations pharmaceutiques desdits nanoparticules et vecteurs |
KR101183262B1 (ko) | 2009-04-22 | 2012-09-14 | (주)알테오젠 | 체내 지속성을 유지함으로 체내 반감기가 증가된 단백질 또는 펩티드 융합체, 및 이를 이용하여 체내 반감기를 증가시키는 방법 |
SG181648A1 (en) | 2009-12-15 | 2012-07-30 | Ascendis Pharma As | Dry growth hormone composition transiently linked to a polymer carrier |
US9415012B2 (en) * | 2011-06-14 | 2016-08-16 | Ipsen Pharma S.A.S. | Sustained-release composition containing peptides as active ingredient |
US9399019B2 (en) | 2012-05-09 | 2016-07-26 | Evonik Corporation | Polymorph compositions, methods of making, and uses thereof |
WO2013183948A1 (ko) | 2012-06-05 | 2013-12-12 | 씨제이제일제당 (주) | 고당화된 지속형 인간 성장호르몬 단백질 및 이의 제조방법 |
WO2015018461A1 (fr) | 2013-08-09 | 2015-02-12 | Genbiotech | Compositions therapeutiques comprenant d'acide hyaluronique |
SG10201902499VA (en) | 2014-09-03 | 2019-04-29 | Genesegues Inc | Therapeutic nanoparticles and related compositions, methods and systems |
Family Cites Families (25)
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US4971782A (en) * | 1983-09-14 | 1990-11-20 | Peroxydent Group | Periodontal composition and method |
US4851521A (en) * | 1985-07-08 | 1989-07-25 | Fidia, S.P.A. | Esters of hyaluronic acid |
JPH0725689B2 (ja) * | 1986-10-07 | 1995-03-22 | 中外製薬株式会社 | 顆粒球コロニ−刺激因子を含有する徐放性製剤 |
JPH02213A (ja) * | 1987-10-19 | 1990-01-05 | Taiho Yakuhin Kogyo Kk | 生理活性ペプチド持続製剤 |
JPH01287041A (ja) * | 1988-05-13 | 1989-11-17 | Rooman Kogyo:Kk | 徐放性製剤 |
JPH03215430A (ja) * | 1990-01-19 | 1991-09-20 | Kita Kiyoshi | 関節腔抗凝固剤 |
US5707644A (en) * | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
IT1243390B (it) * | 1990-11-22 | 1994-06-10 | Vectorpharma Int | Composizioni farmaceutiche in forma di particelle atte al rilascio controllato di sostanze farmacologicamente attive e procedimento per la loro preparazione. |
JPH04282322A (ja) * | 1991-03-08 | 1992-10-07 | Denki Kagaku Kogyo Kk | 生物活性ペプチド製剤 |
JP3283288B2 (ja) * | 1991-03-08 | 2002-05-20 | 電気化学工業株式会社 | 生理活性ペプチド製剤 |
JPH0565231A (ja) * | 1991-03-12 | 1993-03-19 | Takeda Chem Ind Ltd | エリスロポエチンの持続性製剤 |
IT1247472B (it) * | 1991-05-31 | 1994-12-17 | Fidia Spa | Processo per la preparazione di microsfere contenenti componenti biologicamente attivi. |
JP3449738B2 (ja) * | 1991-07-10 | 2003-09-22 | 武田薬品工業株式会社 | 水溶性組成物 |
JPH05186364A (ja) * | 1991-08-01 | 1993-07-27 | Takeda Chem Ind Ltd | 水溶性組成物 |
EP0535937B2 (en) * | 1991-10-01 | 2008-05-21 | Takeda Chemical Industries, Ltd. | Prolonged release microparticle preparation and production of the same |
JPH08198772A (ja) * | 1994-11-25 | 1996-08-06 | Kirin Brewery Co Ltd | 顆粒球コロニー刺激因子含有粉末経鼻投与製剤 |
KR100201352B1 (ko) * | 1995-03-16 | 1999-06-15 | 성재갑 | 단일주사 백신 제형 |
US5641749A (en) * | 1995-11-29 | 1997-06-24 | Amgen Inc. | Method for treating retinal ganglion cell injury using glial cell line-derived neurothrophic factor (GDNF) protein product |
KR100236771B1 (ko) * | 1997-04-01 | 2000-02-01 | 성재갑 | 히아루론산을 이용한 약물의 서방성 미세입자 제형 |
US7276251B2 (en) * | 1997-04-01 | 2007-10-02 | Lg Life Sciences, Ltd., Inc. | Sustained-release composition of drugs encapsulated in microparticles of hyaluronic acid |
JPH09309843A (ja) * | 1996-05-21 | 1997-12-02 | Shiseido Co Ltd | ヒアルロン酸含有経肺投与用製剤 |
US6113947A (en) * | 1997-06-13 | 2000-09-05 | Genentech, Inc. | Controlled release microencapsulated NGF formulation |
JP4234803B2 (ja) * | 1997-10-27 | 2009-03-04 | 久光製薬株式会社 | 薬物放出速度が制御された医薬組成物 |
TW577758B (en) * | 1997-10-27 | 2004-03-01 | Ssp Co Ltd | Intra-articular preparation for the treatment of arthropathy |
NZ506975A (en) * | 1999-01-18 | 2004-01-30 | Lg Chemical Ltd | Lipophilic microparticles containing a protein drug or antigen and formulation comprising same |
-
1997
- 1997-04-01 KR KR1019970012046A patent/KR100236771B1/ko not_active IP Right Cessation
-
1998
- 1998-03-25 MY MYPI98001281A patent/MY132812A/en unknown
- 1998-03-25 ZA ZA982533A patent/ZA982533B/xx unknown
- 1998-03-26 HU HU0000737A patent/HUP0000737A3/hu unknown
- 1998-03-26 TR TR1998/02500T patent/TR199802500T1/xx unknown
- 1998-03-26 AT AT98911246T patent/ATE285245T1/de active
- 1998-03-26 DK DK98911246T patent/DK0918535T3/da active
- 1998-03-26 EP EP98911246A patent/EP0918535B1/en not_active Revoked
- 1998-03-26 NZ NZ333019A patent/NZ333019A/xx not_active IP Right Cessation
- 1998-03-26 AU AU65241/98A patent/AU721929B2/en not_active Expired
- 1998-03-26 IL IL12722098A patent/IL127220A/en not_active IP Right Cessation
- 1998-03-26 PL PL98330230A patent/PL195223B1/pl not_active IP Right Cessation
- 1998-03-26 DE DE69828252T patent/DE69828252T2/de not_active Revoked
- 1998-03-26 WO PCT/KR1998/000062 patent/WO1998043664A1/en active IP Right Grant
- 1998-03-26 CN CN988004003A patent/CN1132625C/zh not_active Expired - Lifetime
- 1998-03-26 PT PT98911246T patent/PT918535E/pt unknown
- 1998-03-26 ID IDW980121D patent/ID20584A/id unknown
- 1998-03-26 CA CA002256596A patent/CA2256596C/en not_active Expired - Lifetime
- 1998-03-26 BR BRPI9804802-3A patent/BR9804802B1/pt not_active IP Right Cessation
- 1998-03-26 ES ES98911246T patent/ES2232939T3/es not_active Expired - Lifetime
- 1998-03-26 JP JP54148898A patent/JP3445283B2/ja not_active Expired - Lifetime
- 1998-03-30 TW TW087104742A patent/TW514532B/zh not_active IP Right Cessation
- 1998-04-01 AR ARP980101469A patent/AR011208A1/es active IP Right Grant
- 1998-11-30 BG BG102969A patent/BG64642B1/bg unknown
-
1999
- 1999-12-30 HK HK99106197A patent/HK1020885A1/xx not_active IP Right Cessation
-
2007
- 2007-10-31 US US11/979,148 patent/US20080063727A1/en not_active Abandoned
-
2010
- 2010-09-29 US US12/893,203 patent/US20110020458A1/en not_active Abandoned
-
2013
- 2013-02-20 US US13/771,722 patent/US20130230598A1/en not_active Abandoned
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD9A | Lapse of provisional protection due to non-payment of fees |