BG64387B1 - Халоген заместени тетрациклени производни на тетрахидрофуран - Google Patents
Халоген заместени тетрациклени производни на тетрахидрофуран Download PDFInfo
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- BG64387B1 BG64387B1 BG104287A BG10428700A BG64387B1 BG 64387 B1 BG64387 B1 BG 64387B1 BG 104287 A BG104287 A BG 104287A BG 10428700 A BG10428700 A BG 10428700A BG 64387 B1 BG64387 B1 BG 64387B1
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- Prior art keywords
- formula
- hydrogen
- compounds
- alkyl
- halogen
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- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical class C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 title description 14
- 150000001875 compounds Chemical class 0.000 claims abstract description 114
- 150000003839 salts Chemical class 0.000 claims abstract description 26
- 229910052736 halogen Inorganic materials 0.000 claims abstract description 21
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract description 21
- 239000001257 hydrogen Substances 0.000 claims abstract description 21
- 150000002367 halogens Chemical class 0.000 claims abstract description 19
- 125000003118 aryl group Chemical group 0.000 claims abstract description 14
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims abstract description 13
- 125000001424 substituent group Chemical group 0.000 claims abstract description 11
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims abstract description 7
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract description 7
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 6
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 5
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- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 5
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- 238000000034 method Methods 0.000 claims description 20
- 125000004432 carbon atom Chemical group C* 0.000 claims description 19
- 239000002253 acid Substances 0.000 claims description 17
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- 239000002585 base Substances 0.000 claims description 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 11
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- 125000004122 cyclic group Chemical group 0.000 claims description 10
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
- C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Anesthesiology (AREA)
- Addiction (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP97203154 | 1997-10-10 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BG104287A BG104287A (en) | 2000-11-30 |
| BG64387B1 true BG64387B1 (bg) | 2004-12-30 |
Family
ID=8228817
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BG104287A BG64387B1 (bg) | 1997-10-10 | 2000-03-30 | Халоген заместени тетрациклени производни на тетрахидрофуран |
Country Status (36)
| Country | Link |
|---|---|
| US (2) | US6511976B1 (uk) |
| EP (1) | EP1021432B1 (uk) |
| JP (1) | JP3248902B2 (uk) |
| KR (1) | KR100366014B1 (uk) |
| CN (1) | CN100340554C (uk) |
| AP (1) | AP1239A (uk) |
| AR (1) | AR017325A1 (uk) |
| AT (1) | ATE235479T1 (uk) |
| AU (1) | AU737334B2 (uk) |
| BG (1) | BG64387B1 (uk) |
| BR (1) | BR9812871A (uk) |
| CA (1) | CA2305612C (uk) |
| CZ (1) | CZ296928B6 (uk) |
| DE (1) | DE69812668T2 (uk) |
| DK (1) | DK1021432T3 (uk) |
| EA (1) | EA003698B1 (uk) |
| EE (1) | EE04526B1 (uk) |
| ES (1) | ES2195403T3 (uk) |
| HK (1) | HK1029106A1 (uk) |
| HR (1) | HRP20000189A2 (uk) |
| HU (1) | HU225161B1 (uk) |
| ID (1) | ID23903A (uk) |
| IL (1) | IL135538A (uk) |
| MY (1) | MY117783A (uk) |
| NO (1) | NO317159B1 (uk) |
| NZ (1) | NZ503294A (uk) |
| OA (1) | OA11898A (uk) |
| PL (1) | PL339833A1 (uk) |
| PT (1) | PT1021432E (uk) |
| SI (1) | SI1021432T1 (uk) |
| SK (1) | SK284028B6 (uk) |
| TR (1) | TR200000918T2 (uk) |
| TW (1) | TW567186B (uk) |
| UA (1) | UA52778C2 (uk) |
| WO (1) | WO1999019317A1 (uk) |
| ZA (1) | ZA989204B (uk) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA79248C2 (en) * | 2001-11-09 | 2007-06-11 | Janssen Pharmaceutica Nv | Mandelate salts of substituted tetracyclic tetrahydrofuran derivatives |
| CA2468040A1 (en) | 2001-12-07 | 2003-06-12 | Janssen Pharmaceutica N.V. | Preparation of cis-fused 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives |
| ATE294168T1 (de) * | 2001-12-07 | 2005-05-15 | Janssen Pharmaceutica Nv | Herstellung von trans-kondensierte 3,3a,8,12b- tetrahydro-2h-dibenzo(3,4:6,7)cyclohepta(1,2- b)furan derivaten |
| HRP20020305A8 (en) | 2002-04-10 | 2009-03-31 | GlaxoSmithKline istra�iva�ki centar Zagreb d.o.o. | 2-thia-dibenzoazulenes as inhibitors of tumour necrosis factor production and intermediates for the preparation thereof |
| HRP20020441A2 (en) * | 2002-05-21 | 2003-12-31 | Pliva D D | 1-oxa-dibenzoazulen as inhibitor of production of tumor necrosis factors and intermediate for preparation thereof |
| HRP20030160A2 (en) * | 2003-03-06 | 2005-04-30 | Pliva-Istra�iva�ki institut d.o.o. | 1-thiadibenzoazulene derivatives and biological action thereof |
| HRP20030885A2 (en) * | 2003-11-03 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 2-THIA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYYTEM DISEASES AND DISORDERS |
| HRP20030956A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1,2-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANU |
| HRP20030953A2 (en) * | 2003-11-21 | 2005-10-31 | Pliva-Istra�iva�ki institut d.o.o. | PREPARATION OF 1-AZA-2-OXA-DIBENZO[e,h]AZULENES AND THEIR USE FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
| HRP20030959A2 (uk) * | 2003-11-21 | 2005-10-31 | Pliva-Istra�iva�ki institut d.o.o. | |
| HRP20030957A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1-THIA-3-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
| HRP20030954A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva D.D. | USE OF 1-AZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
| HRP20030955A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1-OXADIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF PHARMACEUTICAL FORMULATIONS FOR THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
| HRP20030958A2 (en) * | 2003-11-21 | 2005-08-31 | Pliva-Istra�iva�ki institut d.o.o. | USE OF 1,3-DIAZA-DIBENZO[e,h]AZULENES FOR THE MANUFACTURE OF THE TREATMENT AND PREVENTION OF CENTRAL NERVOUS SYSTEM DISEASES AND DISORDERS |
| HRP20040104A2 (en) * | 2004-01-30 | 2005-10-31 | Pliva-Istra�iva�ki institut d.o.o. | Use of benzonaphthoazulenes for the manufacture of pharmaceutical formulations for the treatment and prevention of central nervous system diseases and disorders |
| AR049512A1 (es) * | 2004-06-14 | 2006-08-09 | Janssen Pharmaceutica Nv | Derivados de tetrahidrofurano tetraciclicos. composiciones farmaceuticas |
| CA2568752C (en) * | 2004-06-23 | 2013-05-07 | Janssen Pharmaceutica N.V. | Novel unsaturated tetracyclic tetrahydrofuran derivatives |
| AU2005313325C1 (en) | 2004-12-07 | 2011-11-10 | Janssen Pharmaceutica N.V. | Substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives |
| AU2011202995B2 (en) * | 2004-12-07 | 2012-02-02 | Janssen Pharmaceutica N.V. | Substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives |
| US7915249B2 (en) | 2005-01-27 | 2011-03-29 | Janssen Pharmaceutical Nv | Heterocyclic tetracyclic tetrahydrofuran derivatives as 5HT2 inhibitors in the treatment of CNS disorders |
| US20080214572A1 (en) * | 2005-05-19 | 2008-09-04 | Francisco Javier Fernandez-Gadea | Selected Tetracyclic Tetrahydrofuran Derivatives Containing a Cyclic Amine Side Chain |
| CA2604165A1 (en) * | 2005-05-26 | 2006-11-30 | Janssen Pharmaceutica N.V. | Novel substituted tetracyclic tetrahydrofuran, pyrrolidine and tetrahydrothiophene derivatives and their use as a medicament |
| CA2611443C (en) * | 2005-06-17 | 2014-08-26 | Janssen Pharmaceutica N.V. | Novel tetracyclic tetrahydrofuran derivatives containing a cyclic amine side chain |
| US9125866B1 (en) | 2015-01-28 | 2015-09-08 | King Saud University | Antidepressant compounds |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996014321A1 (en) * | 1994-11-02 | 1996-05-17 | Janssen Pharmaceutica N.V. | Substituted tetracyclic oxazepine and thiazepine derivatives with 5-ht2 receptor affinity |
| WO1996014320A1 (en) * | 1994-11-02 | 1996-05-17 | Janssen Pharmaceutica N.V. | Substituted tetracyclic azepine derivatives which have affinity for 5-ht2 receptors |
| WO1997038991A1 (en) * | 1996-04-12 | 1997-10-23 | Janssen Pharmaceutica N.V. | Substituted tetracyclic tetrahydrofuran derivatives |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA48245C2 (uk) | 1996-08-28 | 2002-08-15 | Елі Ліллі Енд Компані | ЗАМІЩЕНІ 1,2,3,4-ТЕТРАГІДРО-2-ДИБЕНЗОФУРАНАМІНИ ТА 2-АМІНОЦИКЛОГЕПТА[B]БЕНЗОФУРАНИ, ФАРМАЦЕВТИЧНА ЛІКАРСЬКА ФОРМА ТА СПОСІБ ПІДВИЩЕННЯ АКТИВАЦІЇ 5-НТ<sub>1F</sub> РЕЦЕПТОРА У ССАВЦЯ |
-
1998
- 1998-06-10 UA UA2000041945A patent/UA52778C2/uk unknown
- 1998-10-06 AP APAP/P/2000/001784A patent/AP1239A/en active
- 1998-10-06 CN CNB98809956XA patent/CN100340554C/zh not_active Expired - Fee Related
- 1998-10-06 CA CA002305612A patent/CA2305612C/en not_active Expired - Fee Related
- 1998-10-06 KR KR1020007001926A patent/KR100366014B1/ko not_active IP Right Cessation
- 1998-10-06 JP JP2000515890A patent/JP3248902B2/ja not_active Expired - Fee Related
- 1998-10-06 WO PCT/EP1998/006352 patent/WO1999019317A1/en active IP Right Grant
- 1998-10-06 EP EP98950107A patent/EP1021432B1/en not_active Expired - Lifetime
- 1998-10-06 US US09/529,252 patent/US6511976B1/en not_active Expired - Fee Related
- 1998-10-06 NZ NZ503294A patent/NZ503294A/en not_active IP Right Cessation
- 1998-10-06 MY MYPI98004563A patent/MY117783A/en unknown
- 1998-10-06 TR TR2000/00918T patent/TR200000918T2/xx unknown
- 1998-10-06 AT AT98950107T patent/ATE235479T1/de active
- 1998-10-06 BR BR9812871-0A patent/BR9812871A/pt not_active Application Discontinuation
- 1998-10-06 OA OA00000105A patent/OA11898A/en unknown
- 1998-10-06 EA EA200000400A patent/EA003698B1/ru not_active IP Right Cessation
- 1998-10-06 ES ES98950107T patent/ES2195403T3/es not_active Expired - Lifetime
- 1998-10-06 DK DK98950107T patent/DK1021432T3/da active
- 1998-10-06 CZ CZ20001136A patent/CZ296928B6/cs not_active IP Right Cessation
- 1998-10-06 EE EEP200000161A patent/EE04526B1/xx not_active IP Right Cessation
- 1998-10-06 PT PT98950107T patent/PT1021432E/pt unknown
- 1998-10-06 SI SI9830430T patent/SI1021432T1/xx unknown
- 1998-10-06 DE DE69812668T patent/DE69812668T2/de not_active Expired - Lifetime
- 1998-10-06 ID IDW20000646A patent/ID23903A/id unknown
- 1998-10-06 PL PL98339833A patent/PL339833A1/xx not_active IP Right Cessation
- 1998-10-06 SK SK471-2000A patent/SK284028B6/sk unknown
- 1998-10-06 IL IL13553898A patent/IL135538A/xx not_active IP Right Cessation
- 1998-10-06 HU HU0003748A patent/HU225161B1/hu not_active IP Right Cessation
- 1998-10-06 AU AU96296/98A patent/AU737334B2/en not_active Ceased
- 1998-10-08 ZA ZA9809204A patent/ZA989204B/xx unknown
- 1998-10-09 AR ARP980105055A patent/AR017325A1/es unknown
- 1998-10-09 TW TW087116681A patent/TW567186B/zh not_active IP Right Cessation
-
2000
- 2000-03-30 BG BG104287A patent/BG64387B1/bg unknown
- 2000-04-05 HR HR20000189A patent/HRP20000189A2/hr not_active Application Discontinuation
- 2000-04-06 NO NO20001792A patent/NO317159B1/no not_active IP Right Cessation
- 2000-11-10 HK HK00107164A patent/HK1029106A1/xx not_active IP Right Cessation
-
2002
- 2002-11-12 US US10/292,270 patent/US6699858B2/en not_active Expired - Fee Related
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1996014321A1 (en) * | 1994-11-02 | 1996-05-17 | Janssen Pharmaceutica N.V. | Substituted tetracyclic oxazepine and thiazepine derivatives with 5-ht2 receptor affinity |
| WO1996014320A1 (en) * | 1994-11-02 | 1996-05-17 | Janssen Pharmaceutica N.V. | Substituted tetracyclic azepine derivatives which have affinity for 5-ht2 receptors |
| WO1997038991A1 (en) * | 1996-04-12 | 1997-10-23 | Janssen Pharmaceutica N.V. | Substituted tetracyclic tetrahydrofuran derivatives |
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