ATE294168T1 - Herstellung von trans-kondensierte 3,3a,8,12b- tetrahydro-2h-dibenzo(3,4:6,7)cyclohepta(1,2- b)furan derivaten - Google Patents

Herstellung von trans-kondensierte 3,3a,8,12b- tetrahydro-2h-dibenzo(3,4:6,7)cyclohepta(1,2- b)furan derivaten

Info

Publication number
ATE294168T1
ATE294168T1 AT02779576T AT02779576T ATE294168T1 AT E294168 T1 ATE294168 T1 AT E294168T1 AT 02779576 T AT02779576 T AT 02779576T AT 02779576 T AT02779576 T AT 02779576T AT E294168 T1 ATE294168 T1 AT E294168T1
Authority
AT
Austria
Prior art keywords
trans
preparation
cyclohepta
dibenzo
tetrahydro
Prior art date
Application number
AT02779576T
Other languages
English (en)
Inventor
Yolande Lydia Lang
B P A M J Medaer
G J Hoornaert
Thierry Brossette
Frans J C Compernolle
Michel Joseph Mauric Guillaume
Hua Mao
Tomasz Kozlecki
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE294168T1 publication Critical patent/ATE294168T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D307/00Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/24Antidepressants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
AT02779576T 2001-12-07 2002-12-02 Herstellung von trans-kondensierte 3,3a,8,12b- tetrahydro-2h-dibenzo(3,4:6,7)cyclohepta(1,2- b)furan derivaten ATE294168T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP01204961 2001-12-07
PCT/EP2002/013560 WO2003048146A1 (en) 2001-12-07 2002-12-02 PREPARATION OF TRANS-FUSED 3,3a,8,12b-TETRAHYDRO-2H-DIBENZO[3,4:6,7]CYCLOHEPTA[1,2-b]FURAN DERIVATIVES

Publications (1)

Publication Number Publication Date
ATE294168T1 true ATE294168T1 (de) 2005-05-15

Family

ID=8181460

Family Applications (1)

Application Number Title Priority Date Filing Date
AT02779576T ATE294168T1 (de) 2001-12-07 2002-12-02 Herstellung von trans-kondensierte 3,3a,8,12b- tetrahydro-2h-dibenzo(3,4:6,7)cyclohepta(1,2- b)furan derivaten

Country Status (21)

Country Link
US (2) US6998494B2 (de)
EP (1) EP1456193B1 (de)
JP (1) JP4516752B2 (de)
KR (1) KR20050044329A (de)
CN (1) CN1293066C (de)
AT (1) ATE294168T1 (de)
AU (1) AU2002342926B2 (de)
BR (1) BR0214068A (de)
CA (1) CA2468038C (de)
DE (1) DE60203937T2 (de)
ES (1) ES2242076T3 (de)
HK (1) HK1076461A1 (de)
HR (1) HRP20040490A2 (de)
HU (1) HUP0402152A3 (de)
IL (1) IL162349A0 (de)
MX (1) MXPA04005400A (de)
NO (1) NO20042884L (de)
NZ (1) NZ532806A (de)
PL (1) PL369585A1 (de)
WO (1) WO2003048146A1 (de)
ZA (1) ZA200404394B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2468038C (en) * 2001-12-07 2011-04-26 Janssen Pharmaceutica Nv Preparation of trans-fused 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives
WO2005013969A1 (en) * 2003-07-15 2005-02-17 Janssen Pharmaceutica N.V. Antipsychotic agent with socializing properties
AU2005251948A1 (en) * 2004-06-14 2005-12-22 Janssen Pharmaceutica N.V. Novel tetracyclic tetrahydrofuran derivatives
CN100591652C (zh) * 2004-08-31 2010-02-24 詹森药业有限公司 生产2-(4-氟-苄基)-苯基-乙酸的方法
RU2401257C2 (ru) 2004-12-07 2010-10-10 Янссен Фармацевтика Н.В. Новые замещенные тетрациклические производные тетрагидрофурана, пирролидина и тетрагидротиофена
JP4937141B2 (ja) 2005-01-27 2012-05-23 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ Cns障害の処置における5ht2インヒビターとしての複素環式四環式テトラヒドロフラン誘導体
ES2342110T3 (es) 2005-06-17 2010-07-01 Janssen Pharmaceutica Nv Nuevos derivados tetraciclicos de tetrahidrofurano que contienen una cadena lateral de amina ciclica.

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUP9901613A3 (en) 1996-04-12 2001-08-28 Janssen Pharmaceutica Nv Substituted tetracyclic fused furanamine derivatives, process for their preparation, use thereof and pharmaceutical compositions containing them
UA52778C2 (uk) * 1997-10-10 2003-01-15 Янссен Фармацевтика Н.В. Галогенозаміщені тетрациклічні похідні тетрагідрофурану, спосіб їх отримання та композиція на їх основі
UA79248C2 (en) * 2001-11-09 2007-06-11 Janssen Pharmaceutica Nv Mandelate salts of substituted tetracyclic tetrahydrofuran derivatives
CA2468038C (en) * 2001-12-07 2011-04-26 Janssen Pharmaceutica Nv Preparation of trans-fused 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives
PL370440A1 (en) * 2001-12-07 2005-05-30 Janssen Pharmaceutica N.V. Preparation of cis-fused 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives

Also Published As

Publication number Publication date
HRP20040490A2 (en) 2004-10-31
JP2005511691A (ja) 2005-04-28
AU2002342926B2 (en) 2009-02-26
NO20042884L (no) 2004-07-07
WO2003048146A1 (en) 2003-06-12
NZ532806A (en) 2006-01-27
EP1456193A1 (de) 2004-09-15
BR0214068A (pt) 2004-10-13
US6998494B2 (en) 2006-02-14
ES2242076T3 (es) 2005-11-01
AU2002342926A1 (en) 2003-06-17
US20050228043A1 (en) 2005-10-13
HK1076461A1 (en) 2006-01-20
CA2468038A1 (en) 2003-06-12
US20050014820A1 (en) 2005-01-20
IL162349A0 (en) 2005-11-20
DE60203937T2 (de) 2006-05-11
HUP0402152A3 (en) 2007-03-28
HUP0402152A2 (hu) 2005-02-28
CN1293066C (zh) 2007-01-03
EP1456193B1 (de) 2005-04-27
ZA200404394B (en) 2005-09-05
DE60203937D1 (de) 2005-06-02
CA2468038C (en) 2011-04-26
MXPA04005400A (es) 2004-10-11
CN1602306A (zh) 2005-03-30
PL369585A1 (en) 2005-05-02
JP4516752B2 (ja) 2010-08-04
KR20050044329A (ko) 2005-05-12

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