DE60203937D1 - Herstellung von trans-kondensierte 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivaten - Google Patents

Herstellung von trans-kondensierte 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivaten

Info

Publication number
DE60203937D1
DE60203937D1 DE60203937T DE60203937T DE60203937D1 DE 60203937 D1 DE60203937 D1 DE 60203937D1 DE 60203937 T DE60203937 T DE 60203937T DE 60203937 T DE60203937 T DE 60203937T DE 60203937 D1 DE60203937 D1 DE 60203937D1
Authority
DE
Germany
Prior art keywords
trans
preparation
cyclohepta
dibenzo
tetrahydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60203937T
Other languages
English (en)
Other versions
DE60203937T2 (de
Inventor
Yolande Lydia Lang
B P A M J Medaer
G J Hoornaert
Thierry Brossette
Frans J C Compernolle
Michel Joseph Mauric Guillaume
Hua Mao
Tomasz Kozlecki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Publication of DE60203937D1 publication Critical patent/DE60203937D1/de
Application granted granted Critical
Publication of DE60203937T2 publication Critical patent/DE60203937T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
DE60203937T 2001-12-07 2002-12-02 Herstellung von trans-kondensierte 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivaten Expired - Lifetime DE60203937T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP01204961 2001-12-07
EP01204961 2001-12-07
PCT/EP2002/013560 WO2003048146A1 (en) 2001-12-07 2002-12-02 PREPARATION OF TRANS-FUSED 3,3a,8,12b-TETRAHYDRO-2H-DIBENZO[3,4:6,7]CYCLOHEPTA[1,2-b]FURAN DERIVATIVES

Publications (2)

Publication Number Publication Date
DE60203937D1 true DE60203937D1 (de) 2005-06-02
DE60203937T2 DE60203937T2 (de) 2006-05-11

Family

ID=8181460

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60203937T Expired - Lifetime DE60203937T2 (de) 2001-12-07 2002-12-02 Herstellung von trans-kondensierte 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivaten

Country Status (21)

Country Link
US (2) US6998494B2 (de)
EP (1) EP1456193B1 (de)
JP (1) JP4516752B2 (de)
KR (1) KR20050044329A (de)
CN (1) CN1293066C (de)
AT (1) ATE294168T1 (de)
AU (1) AU2002342926B2 (de)
BR (1) BR0214068A (de)
CA (1) CA2468038C (de)
DE (1) DE60203937T2 (de)
ES (1) ES2242076T3 (de)
HK (1) HK1076461A1 (de)
HR (1) HRP20040490A2 (de)
HU (1) HUP0402152A3 (de)
IL (1) IL162349A0 (de)
MX (1) MXPA04005400A (de)
NO (1) NO20042884L (de)
NZ (1) NZ532806A (de)
PL (1) PL369585A1 (de)
WO (1) WO2003048146A1 (de)
ZA (1) ZA200404394B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60203937T2 (de) * 2001-12-07 2006-05-11 Janssen Pharmaceutica N.V. Herstellung von trans-kondensierte 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivaten
WO2005013969A1 (en) * 2003-07-15 2005-02-17 Janssen Pharmaceutica N.V. Antipsychotic agent with socializing properties
TW200612899A (en) * 2004-06-14 2006-05-01 Janssen Pharmaceutica Nv Novel tetracyclic tetrahydrofuran derivatives
CA2577305C (en) * 2004-08-31 2013-12-17 Janssen Pharmaceutica N.V. Process for the production of [2-(4-fluoro-benzyl)-phenyl]-acetic acid
RU2401257C2 (ru) 2004-12-07 2010-10-10 Янссен Фармацевтика Н.В. Новые замещенные тетрациклические производные тетрагидрофурана, пирролидина и тетрагидротиофена
MX2007009092A (es) 2005-01-27 2007-09-12 Janssen Pharmaceutica Nv Derivados de tetrahidrofurano tetraciclicos heterociclicos como inhibidores de 5ht2 en el tratamiento de trastornos del sistema nervioso central.
AU2006259020C1 (en) 2005-06-17 2012-01-19 Janssen Pharmaceutica N.V. Novel tetracyclic tetrahydrofuran derivatives containing a cyclic amine side chain

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69720709T2 (de) 1996-04-12 2004-03-11 Janssen Pharmaceutica N.V. Substituierte tetracyclische tetrahydrofuranderivate
UA52778C2 (uk) * 1997-10-10 2003-01-15 Янссен Фармацевтика Н.В. Галогенозаміщені тетрациклічні похідні тетрагідрофурану, спосіб їх отримання та композиція на їх основі
UA79248C2 (en) * 2001-11-09 2007-06-11 Janssen Pharmaceutica Nv Mandelate salts of substituted tetracyclic tetrahydrofuran derivatives
PL370440A1 (en) * 2001-12-07 2005-05-30 Janssen Pharmaceutica N.V. Preparation of cis-fused 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivatives
DE60203937T2 (de) * 2001-12-07 2006-05-11 Janssen Pharmaceutica N.V. Herstellung von trans-kondensierte 3,3a,8,12b-tetrahydro-2h-dibenzo[3,4:6,7]cyclohepta[1,2-b]furan derivaten

Also Published As

Publication number Publication date
EP1456193A1 (de) 2004-09-15
US20050014820A1 (en) 2005-01-20
US6998494B2 (en) 2006-02-14
WO2003048146A1 (en) 2003-06-12
AU2002342926A1 (en) 2003-06-17
KR20050044329A (ko) 2005-05-12
NZ532806A (en) 2006-01-27
CA2468038A1 (en) 2003-06-12
CN1293066C (zh) 2007-01-03
EP1456193B1 (de) 2005-04-27
JP2005511691A (ja) 2005-04-28
CN1602306A (zh) 2005-03-30
ATE294168T1 (de) 2005-05-15
ES2242076T3 (es) 2005-11-01
NO20042884L (no) 2004-07-07
HUP0402152A2 (hu) 2005-02-28
IL162349A0 (en) 2005-11-20
BR0214068A (pt) 2004-10-13
ZA200404394B (en) 2005-09-05
PL369585A1 (en) 2005-05-02
JP4516752B2 (ja) 2010-08-04
US20050228043A1 (en) 2005-10-13
AU2002342926B2 (en) 2009-02-26
MXPA04005400A (es) 2004-10-11
HK1076461A1 (en) 2006-01-20
DE60203937T2 (de) 2006-05-11
HRP20040490A2 (en) 2004-10-31
CA2468038C (en) 2011-04-26
HUP0402152A3 (en) 2007-03-28

Similar Documents

Publication Publication Date Title
HK1076461A1 (en) Preparation of trans-fused 3,3a,8,12b-tetrahydro-2h-dibenzoÄ3,4;6,7ÜcycloheptaÄ1,2-bÜfuran derivatives
HUP9701048A2 (hu) Új eljárás sildenafil előállítására és a felhasznált új köztitermékek
NZ522568A (en) Substituted bicyclic derivatives for the treatment of abnormal cell growth
SE0102616D0 (sv) Novel compounds
EP1256588A4 (de) Neue pyrazin-derivate oder salze davon, pharmazeutische zusammensetzungen, die die derivate oder deren salze enthalten und intermediate zu beider herstellung
TNSN07485A1 (fr) Derives de n-(arylalkyl)-1h-pyrrolopyridine -2- carboxamides, leur preparation et leur application en therapeutique
MXPA03011954A (es) Nuevos derivados de acido sulfonico.
EP1193256A8 (de) Pharmazeutisch aktive Benzolsulfonamidderivate als JNK-Proteininhibitoren
NO20023405D0 (no) Fremgangsmåte for fremstilling av 5-Cyanoftalid
MXPA04005399A (es) Preparacion de derivados cis-fusionados de 3, 3a, 8, 12b-tetrahidro-2h-dibenzo [3,4:6,7]ciclohepta[1,2-b]furano.
ATE239722T1 (de) Benzofurylpiperazine als serotonin-agonisten
WO2001056992A3 (en) Dibenzo (b,f) azepine intermediates
HUP0301942A2 (hu) Eljárás citalopram elżállítására
EA200001101A1 (ru) НОВЫЕ ДИГИДРОФУРО[3,4-b]ХИНОЛИН-1-ОНЫ, СПОСОБ ИХ ПОЛУЧЕНИЯ И СОДЕРЖАЩИЕ ИХ ФАРМАЦЕВТИЧЕСКИЕ КОМПОЗИЦИИ
MXPA04003278A (es) Derivados de 5-metoxi-8-aril-?1,2,4?triazolo?1,5-a?piridina como antagonistas del receptor de adenosina.
MXPA05008400A (es) Derivados de oxazolidinona n-sustituidos por un anillo triciclico, para su uso como agentes antibacterianos.
AU6594900A (en) Tricyclic dihydrobenzofuran derivatives, process for the preparation thereof andagents
BG106846A (en) Novel heteroaryl derivatives, their preparation and use
EE200300058A (et) Imidaso[1,2-c] [2,3] bensodiasepiinide valmistamismeetod ja vaheühendid nende valmistamisel
EP1148059A4 (de) Thiazolpyrimidin-verbindungen, verfahren zu ihrer herstellung und ihre anwendung
FI104078B (fi) Menetelmä terapeuttisesti käyttökelpoisten (3-(1-piperatsinyyli)tieno£2,3-b|- ja -£2,3-c|pyridiinijohdannaisten valmistamiseksi
ES2082202T3 (es) Derivados de biciclo(3.3.0)octano, procedimiento para su preparacion y su utilizacion farmaceutica.
DK1490391T3 (da) 11beta-langkædet substituerede 19-nor-17alfa-pregna-1,3,5(10)-trien-17beta-oler med en 21,2alfa-lactonring

Legal Events

Date Code Title Description
8364 No opposition during term of opposition