BG63395B1 - Метод за получаване и/или пречистване на клавуланова киселина или нейна фармацевтично приемлива солили естер - Google Patents

Метод за получаване и/или пречистване на клавуланова киселина или нейна фармацевтично приемлива солили естер Download PDF

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Publication number
BG63395B1
BG63395B1 BG102043A BG10204397A BG63395B1 BG 63395 B1 BG63395 B1 BG 63395B1 BG 102043 A BG102043 A BG 102043A BG 10204397 A BG10204397 A BG 10204397A BG 63395 B1 BG63395 B1 BG 63395B1
Authority
BG
Bulgaria
Prior art keywords
clavulanic acid
methanol
amine
solution
salt
Prior art date
Application number
BG102043A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG102043A (en
Inventor
Egidij Capuder
Original Assignee
Lek Pharmaceutical And Chemical Co. D.D.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Pharmaceutical And Chemical Co. D.D. filed Critical Lek Pharmaceutical And Chemical Co. D.D.
Publication of BG102043A publication Critical patent/BG102043A/xx
Publication of BG63395B1 publication Critical patent/BG63395B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)
BG102043A 1995-04-20 1997-11-14 Метод за получаване и/или пречистване на клавуланова киселина или нейна фармацевтично приемлива солили естер BG63395B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI9500134A SI9500134B (sl) 1995-04-20 1995-04-20 Postopek za pripravo čistih alkalijskih soli klavulanske kisline
PCT/GB1996/000921 WO1996033197A1 (en) 1995-04-20 1996-04-17 Preparation of clavulanate salts

Publications (2)

Publication Number Publication Date
BG102043A BG102043A (en) 1998-11-30
BG63395B1 true BG63395B1 (bg) 2001-12-29

Family

ID=20431603

Family Applications (1)

Application Number Title Priority Date Filing Date
BG102043A BG63395B1 (bg) 1995-04-20 1997-11-14 Метод за получаване и/или пречистване на клавуланова киселина или нейна фармацевтично приемлива солили естер

Country Status (29)

Country Link
US (2) US6180782B1 (de)
EP (1) EP0821687B1 (de)
JP (1) JPH11503744A (de)
KR (1) KR19990007892A (de)
CN (1) CN1118469C (de)
AT (1) ATE239736T1 (de)
BG (1) BG63395B1 (de)
CA (1) CA2218648A1 (de)
CZ (1) CZ293279B6 (de)
DE (1) DE69628002T2 (de)
DK (1) DK0821687T3 (de)
DZ (1) DZ2024A1 (de)
EE (1) EE9700263A (de)
EG (1) EG21091A (de)
ES (1) ES2199286T3 (de)
HR (1) HRP960186A2 (de)
HU (1) HUP9901055A3 (de)
JO (1) JO1902B1 (de)
PL (1) PL183465B1 (de)
PT (1) PT821687E (de)
RO (1) RO116195B1 (de)
RU (1) RU2166506C2 (de)
SI (1) SI9500134B (de)
SK (1) SK143797A3 (de)
TN (1) TNSN96061A1 (de)
UA (1) UA54389C2 (de)
WO (1) WO1996033197A1 (de)
YU (1) YU49113B (de)
ZA (1) ZA963119B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9500134B (sl) * 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
SI9500265A1 (en) * 1995-08-28 1997-02-28 Lek Tovarna Farmacevtskih Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
EP0937084A1 (de) * 1996-11-11 1999-08-25 Gist-Brocades B.V. Verfahren zur herstellung von clavulansäure-salzen und estern
AT404728B (de) * 1996-11-27 1999-02-25 Biochemie Gmbh Verfahren zur herstellung von clavulansäure-aminsalzen
AR015825A1 (es) * 1997-05-28 2001-05-30 Gist Brocades Bv Produccion fermentativa de acido clavulanico bajo condiciones controladas de fosfato
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
US20040146918A1 (en) * 2000-02-18 2004-07-29 Weiner Michael L. Hybrid nucleic acid assembly
EP1284978B2 (de) 2000-05-13 2008-09-10 Smithkline Beecham Plc Verfahren zur reinigung eines salzes der clavulansäure
CN105384758B (zh) * 2015-12-01 2018-05-01 国药集团威奇达药业有限公司 克拉维酸胺盐的制备方法
CN109305978A (zh) * 2017-07-26 2019-02-05 山东睿鹰先锋制药有限公司 一种制备克拉维酸盐的新方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110165A (en) 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
US4144242A (en) 1975-02-07 1979-03-13 Glaxo Laboratories Limited Process for the purification of clavulanic acid
GB1578739A (en) 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
DE3063683D1 (en) 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
US4454069A (en) 1979-08-24 1984-06-12 Beecham Group Limited Clavulanic acid salts and their preparation from the tertiary butyl amine salt
AR245221A1 (es) * 1984-10-27 1993-12-30 Beecham Group Plc Un metodo para la produccion de acido clavulanico por fermentacion de s. clavuligerus
AT399155B (de) 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
GB9305565D0 (en) * 1993-03-18 1993-05-05 Smithkline Beecham Plc Novel compounds and processes
SK279918B6 (sk) * 1993-03-26 1999-05-07 Gist-Brocades N.V. Soli kyseliny klavulánovej s diamínmi, spôsob ich
GB9401969D0 (en) 1994-02-02 1994-03-30 Smithkline Beecham Plc Process
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9426261D0 (en) 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
EE9700186A (et) 1995-02-25 1998-02-16 Spurcourt Limited Klavulaanhappe soolad
SI9500074A (en) * 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
SI9500134B (sl) * 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
EP0937084A1 (de) * 1996-11-11 1999-08-25 Gist-Brocades B.V. Verfahren zur herstellung von clavulansäure-salzen und estern

Also Published As

Publication number Publication date
US20010025104A1 (en) 2001-09-27
PT821687E (pt) 2003-09-30
JO1902B1 (en) 1996-07-25
WO1996033197A1 (en) 1996-10-24
ATE239736T1 (de) 2003-05-15
JPH11503744A (ja) 1999-03-30
BG102043A (en) 1998-11-30
DZ2024A1 (fr) 2002-10-21
CZ293279B6 (cs) 2004-03-17
ZA963119B (en) 1996-10-24
CZ331897A3 (cs) 1998-03-18
UA54389C2 (uk) 2003-03-17
SI9500134B (sl) 2004-04-30
PL183465B1 (pl) 2002-06-28
CN1118469C (zh) 2003-08-20
TNSN96061A1 (fr) 2005-03-15
AU5340196A (en) 1996-11-07
YU24796A (sh) 1998-09-18
RU2166506C2 (ru) 2001-05-10
SK143797A3 (en) 1998-05-06
EP0821687B1 (de) 2003-05-07
SI9500134A1 (en) 1996-10-31
HUP9901055A2 (hu) 1999-08-30
PL322888A1 (en) 1998-03-02
DE69628002D1 (de) 2003-06-12
CN1185158A (zh) 1998-06-17
HUP9901055A3 (en) 2000-02-28
ES2199286T3 (es) 2004-02-16
CA2218648A1 (en) 1996-10-24
KR19990007892A (ko) 1999-01-25
DK0821687T3 (da) 2003-08-18
YU49113B (sh) 2004-03-12
EP0821687A1 (de) 1998-02-04
RO116195B1 (ro) 2000-11-30
HRP960186A2 (en) 1997-12-31
EG21091A (en) 2000-10-31
EE9700263A (et) 1998-04-15
DE69628002T2 (de) 2004-03-04
US6180782B1 (en) 2001-01-30
US6369219B2 (en) 2002-04-09
AU692091B2 (en) 1998-05-28

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