YU49113B - Postupak za dobijanje klavulanat soli - Google Patents

Postupak za dobijanje klavulanat soli

Info

Publication number
YU49113B
YU49113B YU24796A YU24796A YU49113B YU 49113 B YU49113 B YU 49113B YU 24796 A YU24796 A YU 24796A YU 24796 A YU24796 A YU 24796A YU 49113 B YU49113 B YU 49113B
Authority
YU
Yugoslavia
Prior art keywords
clavulanic acid
preparation
ester
pharmaceutically acceptable
acceptable salt
Prior art date
Application number
YU24796A
Other languages
English (en)
Other versions
YU24796A (sh
Inventor
Capuder Egidij Dr.
Original Assignee
Lek Pharmaceutical And Chemical Co. Dd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lek Pharmaceutical And Chemical Co. Dd. filed Critical Lek Pharmaceutical And Chemical Co. Dd.
Publication of YU24796A publication Critical patent/YU24796A/sh
Publication of YU49113B publication Critical patent/YU49113B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Abstract

Postupak za dobijanje i/ili prečišćavanje klavulanske kiseline ili njene farmaceutski prihvatljive soli ili estra, naznačen time, što obuhvata stupnjeve: a) dodavanje dodatnog rastvarača izabranog iz C1 do C6 alkohola i njihovih smeša, suvom rastvoru klavulanske kiseline u rastvaraču nemešljivom sa vodom, b) kontaktiranje rastvora sa N, N'-diizopropiletilen diaminom, c) izolovanje aminske soli klavulanske kiseline koja je nagrađena; i d) prevođenje aminske soli u klavulansku kiselinu ili njenu farmaceutski prihvatljivu so ili estar. Prijava sadrži još 1 nezavisan i 4 zavisna zahteva.
YU24796A 1995-04-20 1996-04-19 Postupak za dobijanje klavulanat soli YU49113B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SI9500134A SI9500134B (sl) 1995-04-20 1995-04-20 Postopek za pripravo čistih alkalijskih soli klavulanske kisline

Publications (2)

Publication Number Publication Date
YU24796A YU24796A (sh) 1998-09-18
YU49113B true YU49113B (sh) 2004-03-12

Family

ID=20431603

Family Applications (1)

Application Number Title Priority Date Filing Date
YU24796A YU49113B (sh) 1995-04-20 1996-04-19 Postupak za dobijanje klavulanat soli

Country Status (29)

Country Link
US (2) US6180782B1 (sh)
EP (1) EP0821687B1 (sh)
JP (1) JPH11503744A (sh)
KR (1) KR19990007892A (sh)
CN (1) CN1118469C (sh)
AT (1) ATE239736T1 (sh)
BG (1) BG63395B1 (sh)
CA (1) CA2218648A1 (sh)
CZ (1) CZ293279B6 (sh)
DE (1) DE69628002T2 (sh)
DK (1) DK0821687T3 (sh)
DZ (1) DZ2024A1 (sh)
EE (1) EE9700263A (sh)
EG (1) EG21091A (sh)
ES (1) ES2199286T3 (sh)
HR (1) HRP960186A2 (sh)
HU (1) HUP9901055A3 (sh)
JO (1) JO1902B1 (sh)
PL (1) PL183465B1 (sh)
PT (1) PT821687E (sh)
RO (1) RO116195B1 (sh)
RU (1) RU2166506C2 (sh)
SI (1) SI9500134B (sh)
SK (1) SK143797A3 (sh)
TN (1) TNSN96061A1 (sh)
UA (1) UA54389C2 (sh)
WO (1) WO1996033197A1 (sh)
YU (1) YU49113B (sh)
ZA (1) ZA963119B (sh)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9500134B (sl) * 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
SI9500265A1 (en) 1995-08-28 1997-02-28 Lek Tovarna Farmacevtskih Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
EP0937084A1 (en) * 1996-11-11 1999-08-25 Gist-Brocades B.V. Process for the preparation of salts and esters of clavulanic acid
AT404728B (de) * 1996-11-27 1999-02-25 Biochemie Gmbh Verfahren zur herstellung von clavulansäure-aminsalzen
AR015825A1 (es) * 1997-05-28 2001-05-30 Gist Brocades Bv Produccion fermentativa de acido clavulanico bajo condiciones controladas de fosfato
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
US20040146918A1 (en) * 2000-02-18 2004-07-29 Weiner Michael L. Hybrid nucleic acid assembly
CN1222528C (zh) 2000-05-13 2005-10-12 史密斯克莱·比奇曼公司 提纯克拉布兰酸盐的方法
CN105384758B (zh) * 2015-12-01 2018-05-01 国药集团威奇达药业有限公司 克拉维酸胺盐的制备方法
CN109305978A (zh) * 2017-07-26 2019-02-05 山东睿鹰先锋制药有限公司 一种制备克拉维酸盐的新方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110165A (en) 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
US4144242A (en) 1975-02-07 1979-03-13 Glaxo Laboratories Limited Process for the purification of clavulanic acid
GB1578739A (en) 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
US4454069A (en) 1979-08-24 1984-06-12 Beecham Group Limited Clavulanic acid salts and their preparation from the tertiary butyl amine salt
DE3063683D1 (en) 1979-08-24 1983-07-14 Beecham Group Plc Amine salt of clavulanic acid, its preparation and use
MX7417E (es) 1984-10-27 1988-10-14 Antibioticos Sa Metodo para la preparacion de acido clavulanico y sus derivados
AT399155B (de) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) * 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
KR100200239B1 (ko) * 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
GB9305565D0 (en) 1993-03-18 1993-05-05 Smithkline Beecham Plc Novel compounds and processes
AU682030B2 (en) 1993-03-26 1997-09-18 Dsm N.V. Diamine salts of clavulanic acid
GB9401969D0 (en) 1994-02-02 1994-03-30 Smithkline Beecham Plc Process
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9426261D0 (en) 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
AP9701116A0 (en) * 1995-02-25 1997-10-31 Spurcourt Ltd Clavulanic acid salts
SI9500074A (en) * 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
SI9500134B (sl) * 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
EP0937084A1 (en) * 1996-11-11 1999-08-25 Gist-Brocades B.V. Process for the preparation of salts and esters of clavulanic acid

Also Published As

Publication number Publication date
KR19990007892A (ko) 1999-01-25
CA2218648A1 (en) 1996-10-24
EP0821687B1 (en) 2003-05-07
SI9500134B (sl) 2004-04-30
BG63395B1 (bg) 2001-12-29
PT821687E (pt) 2003-09-30
US20010025104A1 (en) 2001-09-27
RO116195B1 (ro) 2000-11-30
PL183465B1 (pl) 2002-06-28
DZ2024A1 (fr) 2002-10-21
SI9500134A1 (en) 1996-10-31
HRP960186A2 (en) 1997-12-31
AU5340196A (en) 1996-11-07
TNSN96061A1 (fr) 2005-03-15
AU692091B2 (en) 1998-05-28
HUP9901055A3 (en) 2000-02-28
HUP9901055A2 (hu) 1999-08-30
EP0821687A1 (en) 1998-02-04
SK143797A3 (en) 1998-05-06
CN1185158A (zh) 1998-06-17
CZ293279B6 (cs) 2004-03-17
ATE239736T1 (de) 2003-05-15
PL322888A1 (en) 1998-03-02
RU2166506C2 (ru) 2001-05-10
YU24796A (sh) 1998-09-18
DK0821687T3 (da) 2003-08-18
ZA963119B (en) 1996-10-24
ES2199286T3 (es) 2004-02-16
CZ331897A3 (cs) 1998-03-18
UA54389C2 (uk) 2003-03-17
EG21091A (en) 2000-10-31
US6369219B2 (en) 2002-04-09
US6180782B1 (en) 2001-01-30
WO1996033197A1 (en) 1996-10-24
CN1118469C (zh) 2003-08-20
JPH11503744A (ja) 1999-03-30
EE9700263A (et) 1998-04-15
JO1902B1 (en) 1996-07-25
DE69628002D1 (de) 2003-06-12
DE69628002T2 (de) 2004-03-04
BG102043A (en) 1998-11-30

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