RU2166506C2 - Способ получения и/или очистки клавулановой кислоты или ее фармацевтически приемлемой соли или эфира и способ ее отделения от содержащейся в отфильтрованном ферментационном бульоне примеси клавам-2-карбоновой кислоты - Google Patents

Способ получения и/или очистки клавулановой кислоты или ее фармацевтически приемлемой соли или эфира и способ ее отделения от содержащейся в отфильтрованном ферментационном бульоне примеси клавам-2-карбоновой кислоты Download PDF

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Publication number
RU2166506C2
RU2166506C2 RU97119069/04A RU97119069A RU2166506C2 RU 2166506 C2 RU2166506 C2 RU 2166506C2 RU 97119069/04 A RU97119069/04 A RU 97119069/04A RU 97119069 A RU97119069 A RU 97119069A RU 2166506 C2 RU2166506 C2 RU 2166506C2
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RU
Russia
Prior art keywords
clavulanic acid
amine
pharmaceutically acceptable
ester
acceptable salt
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Application number
RU97119069/04A
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English (en)
Russian (ru)
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RU97119069A (ru
Inventor
Эгидий ЦАПУДЕР (SI)
Эгидий Цапудер
Original Assignee
Лек Фармасьютикал энд Кемикал Ко. Д.Д.
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Publication of RU97119069A publication Critical patent/RU97119069A/ru
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D503/00—Heterocyclic compounds containing 4-oxa-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. oxapenicillins, clavulanic acid derivatives; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Cephalosporin Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
RU97119069/04A 1995-04-20 1996-04-17 Способ получения и/или очистки клавулановой кислоты или ее фармацевтически приемлемой соли или эфира и способ ее отделения от содержащейся в отфильтрованном ферментационном бульоне примеси клавам-2-карбоновой кислоты RU2166506C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SI9500134A SI9500134B (sl) 1995-04-20 1995-04-20 Postopek za pripravo čistih alkalijskih soli klavulanske kisline
SIP-9500134 1995-04-20

Publications (2)

Publication Number Publication Date
RU97119069A RU97119069A (ru) 1999-10-27
RU2166506C2 true RU2166506C2 (ru) 2001-05-10

Family

ID=20431603

Family Applications (1)

Application Number Title Priority Date Filing Date
RU97119069/04A RU2166506C2 (ru) 1995-04-20 1996-04-17 Способ получения и/или очистки клавулановой кислоты или ее фармацевтически приемлемой соли или эфира и способ ее отделения от содержащейся в отфильтрованном ферментационном бульоне примеси клавам-2-карбоновой кислоты

Country Status (29)

Country Link
US (2) US6180782B1 (de)
EP (1) EP0821687B1 (de)
JP (1) JPH11503744A (de)
KR (1) KR19990007892A (de)
CN (1) CN1118469C (de)
AT (1) ATE239736T1 (de)
BG (1) BG63395B1 (de)
CA (1) CA2218648A1 (de)
CZ (1) CZ293279B6 (de)
DE (1) DE69628002T2 (de)
DK (1) DK0821687T3 (de)
DZ (1) DZ2024A1 (de)
EE (1) EE9700263A (de)
EG (1) EG21091A (de)
ES (1) ES2199286T3 (de)
HR (1) HRP960186A2 (de)
HU (1) HUP9901055A3 (de)
JO (1) JO1902B1 (de)
PL (1) PL183465B1 (de)
PT (1) PT821687E (de)
RO (1) RO116195B1 (de)
RU (1) RU2166506C2 (de)
SI (1) SI9500134B (de)
SK (1) SK143797A3 (de)
TN (1) TNSN96061A1 (de)
UA (1) UA54389C2 (de)
WO (1) WO1996033197A1 (de)
YU (1) YU49113B (de)
ZA (1) ZA963119B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT400033B (de) 1992-03-10 1995-09-25 Biochemie Gmbh Neues verfahren zur isolierung und reinigung von clavulansäure und zur herstellung von pharmakologisch verträglichen salzen derselben
SI9500134B (sl) * 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
SI9500265A1 (en) 1995-08-28 1997-02-28 Lek Tovarna Farmacevtskih Process for purification of the aqueous fermented broth filtrate of streptomyces sp. p 6621 ferm p 2804 by ultrafiltration
AT403375B (de) * 1995-11-15 1998-01-26 Biochemie Gmbh Verfahren zur fällung von alkalisalzen der clavulansäure
PL333247A1 (en) * 1996-11-11 1999-11-22 Gist Brocades Bv Method of manufacturing of salts and esters of clavulan acid
AT404728B (de) * 1996-11-27 1999-02-25 Biochemie Gmbh Verfahren zur herstellung von clavulansäure-aminsalzen
AR015825A1 (es) * 1997-05-28 2001-05-30 Gist Brocades Bv Produccion fermentativa de acido clavulanico bajo condiciones controladas de fosfato
GB0003305D0 (en) 2000-02-15 2000-04-05 Zeneca Ltd Pyrimidine derivatives
US20040146918A1 (en) * 2000-02-18 2004-07-29 Weiner Michael L. Hybrid nucleic acid assembly
WO2001087891A1 (en) 2000-05-13 2001-11-22 Smithkline Beecham P.L.C. Process for the purification of a salt of clavulanic acid
CN105384758B (zh) * 2015-12-01 2018-05-01 国药集团威奇达药业有限公司 克拉维酸胺盐的制备方法
CN109305978A (zh) * 2017-07-26 2019-02-05 山东睿鹰先锋制药有限公司 一种制备克拉维酸盐的新方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4110165A (en) 1974-04-20 1978-08-29 Beecham Group Limited Process for the production of clavulanic acid
US4144242A (en) 1975-02-07 1979-03-13 Glaxo Laboratories Limited Process for the purification of clavulanic acid
GB1578739A (en) 1976-07-23 1980-11-05 Beecham Group Ltd Amine salts of clavulanic acid methods for their preparation and compositions containing them
US4454069A (en) 1979-08-24 1984-06-12 Beecham Group Limited Clavulanic acid salts and their preparation from the tertiary butyl amine salt
EP0026044B1 (de) 1979-08-24 1983-06-08 Beecham Group Plc Aminsalz der Clavulansäure, seine Herstellung und Verwendung
AU600655B2 (en) 1984-10-27 1990-08-23 Beecham Group Plc Preparation of clavulanic acid and its salts and esters
AT399155B (de) * 1992-03-26 1995-03-27 Lek Tovarna Farmacevtskih Neue alkylendiammonium-diclavulanat-derivate, verfahren zu deren herstellung sowie deren verwendung
SI9300296B (sl) 1992-06-11 1998-06-30 Smithkline Beecham P.L.C. Postopek in intermedianti za pripravo klavulanske kisline
KR100200239B1 (ko) 1992-10-21 1999-06-15 김충환 클라불란산 칼륨염의 제조방법
GB9305565D0 (en) 1993-03-18 1993-05-05 Smithkline Beecham Plc Novel compounds and processes
PL306371A1 (en) * 1993-03-26 1995-03-20 Gist Brocades Nv Diamine salts of clavulanic acid
GB9401969D0 (en) 1994-02-02 1994-03-30 Smithkline Beecham Plc Process
SI9400107A (en) * 1994-03-02 1995-10-31 Lek Tovarna Farmacevtskih New process of the isolation of clavulanic acid and its pharmaceutical salts from fermented broth of streptomyces sp.p 6621 ferm p 2804.
GB9426261D0 (en) 1994-12-24 1995-02-22 Spurcourt Ltd Clavulanic acid salts
EP0729961B1 (de) 1995-02-25 2001-12-19 Spurcourt Limited Clavulansäure Salz
SI9500074A (en) * 1995-03-10 1996-10-31 Lek Tovarna Farmacevtskih Process for preparation of alkani salts of clavulanic acid.
SI9500134B (sl) * 1995-04-20 2004-04-30 Lek, Postopek za pripravo čistih alkalijskih soli klavulanske kisline
PL333247A1 (en) * 1996-11-11 1999-11-22 Gist Brocades Bv Method of manufacturing of salts and esters of clavulan acid

Also Published As

Publication number Publication date
JO1902B1 (en) 1996-07-25
SI9500134B (sl) 2004-04-30
US6369219B2 (en) 2002-04-09
BG102043A (en) 1998-11-30
CA2218648A1 (en) 1996-10-24
YU49113B (sh) 2004-03-12
EP0821687A1 (de) 1998-02-04
DE69628002D1 (de) 2003-06-12
HUP9901055A3 (en) 2000-02-28
DZ2024A1 (fr) 2002-10-21
JPH11503744A (ja) 1999-03-30
EE9700263A (et) 1998-04-15
US20010025104A1 (en) 2001-09-27
PL183465B1 (pl) 2002-06-28
CZ293279B6 (cs) 2004-03-17
DE69628002T2 (de) 2004-03-04
WO1996033197A1 (en) 1996-10-24
RO116195B1 (ro) 2000-11-30
AU692091B2 (en) 1998-05-28
HRP960186A2 (en) 1997-12-31
UA54389C2 (uk) 2003-03-17
EP0821687B1 (de) 2003-05-07
DK0821687T3 (da) 2003-08-18
ATE239736T1 (de) 2003-05-15
PT821687E (pt) 2003-09-30
HUP9901055A2 (hu) 1999-08-30
BG63395B1 (bg) 2001-12-29
SK143797A3 (en) 1998-05-06
US6180782B1 (en) 2001-01-30
CZ331897A3 (cs) 1998-03-18
PL322888A1 (en) 1998-03-02
YU24796A (sh) 1998-09-18
AU5340196A (en) 1996-11-07
TNSN96061A1 (fr) 2005-03-15
CN1118469C (zh) 2003-08-20
CN1185158A (zh) 1998-06-17
SI9500134A1 (en) 1996-10-31
ES2199286T3 (es) 2004-02-16
EG21091A (en) 2000-10-31
ZA963119B (en) 1996-10-24
KR19990007892A (ko) 1999-01-25

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MM4A The patent is invalid due to non-payment of fees

Effective date: 20040418