BG63208B1 - Бициклични тахикининови антагонисти, тяхното приготовляване и използуване в фармацевтични състави - Google Patents

Бициклични тахикининови антагонисти, тяхното приготовляване и използуване в фармацевтични състави Download PDF

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Publication number
BG63208B1
BG63208B1 BG101849A BG10184997A BG63208B1 BG 63208 B1 BG63208 B1 BG 63208B1 BG 101849 A BG101849 A BG 101849A BG 10184997 A BG10184997 A BG 10184997A BG 63208 B1 BG63208 B1 BG 63208B1
Authority
BG
Bulgaria
Prior art keywords
cyclo
dap
seq
leu
asp
Prior art date
Application number
BG101849A
Other languages
Bulgarian (bg)
English (en)
Other versions
BG101849A (en
Inventor
Federico Arcamone
Carlo Maggi
Laura Quartara
Danilo Giannotti
Original Assignee
A. Menarini Industrie Farmaceutiche Riunite S.R.L.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11351134&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BG63208(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by A. Menarini Industrie Farmaceutiche Riunite S.R.L. filed Critical A. Menarini Industrie Farmaceutiche Riunite S.R.L.
Publication of BG101849A publication Critical patent/BG101849A/xx
Publication of BG63208B1 publication Critical patent/BG63208B1/bg

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/22—Tachykinins, e.g. Eledoisins, Substance P; Related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K9/00—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof
    • C07K9/006—Peptides having up to 20 amino acids, containing saccharide radicals and having a fully defined sequence; Derivatives thereof the peptide sequence being part of a ring structure

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Neurology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Virology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Oncology (AREA)
  • Pulmonology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
BG101849A 1995-03-13 1997-08-22 Бициклични тахикининови антагонисти, тяхното приготовляване и използуване в фармацевтични състави BG63208B1 (bg)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT95FI000044A IT1277835B1 (it) 1995-03-13 1995-03-13 Composti biciclici, loro preparazione ed uso in composizioni farmaceutiche
PCT/EP1996/001028 WO1996028467A1 (en) 1995-03-13 1996-03-11 Bicyclic tachykinins antagonists, preparation thereof and their use in pharmaceutical composition

Publications (2)

Publication Number Publication Date
BG101849A BG101849A (en) 1998-04-30
BG63208B1 true BG63208B1 (bg) 2001-06-29

Family

ID=11351134

Family Applications (1)

Application Number Title Priority Date Filing Date
BG101849A BG63208B1 (bg) 1995-03-13 1997-08-22 Бициклични тахикининови антагонисти, тяхното приготовляване и използуване в фармацевтични състави

Country Status (33)

Country Link
US (1) US6150325A (et)
EP (1) EP0815126B1 (et)
JP (1) JP4618821B2 (et)
KR (1) KR100405009B1 (et)
CN (1) CN1189477C (et)
AR (1) AR004476A1 (et)
AT (1) ATE198481T1 (et)
AU (1) AU696528B2 (et)
BG (1) BG63208B1 (et)
BR (1) BR9607348A (et)
CZ (1) CZ287372B6 (et)
DE (1) DE69611438T2 (et)
DK (1) DK0815126T3 (et)
EA (1) EA000697B1 (et)
EE (1) EE03618B1 (et)
ES (1) ES2155187T3 (et)
GE (1) GEP20002271B (et)
GR (1) GR3035676T3 (et)
HR (1) HRP960117B1 (et)
HU (1) HU222051B1 (et)
IL (1) IL117395A (et)
IT (1) IT1277835B1 (et)
MX (1) MX9706927A (et)
NO (1) NO319290B1 (et)
NZ (1) NZ303982A (et)
PL (1) PL184147B1 (et)
PT (1) PT815126E (et)
RO (1) RO118297B1 (et)
SK (1) SK281899B6 (et)
TW (1) TW565572B (et)
UA (1) UA48962C2 (et)
WO (1) WO1996028467A1 (et)
ZA (1) ZA961983B (et)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6017705A (en) * 1995-03-14 2000-01-25 Ludwig Institute For Cancer Research Isolated nucleic acid molecules which are members of the MAGE-B family and uses thereof
IT1291776B1 (it) * 1997-02-07 1999-01-21 Menarini Ricerche Spa Composti monociclici a quattro residui bifunzionali, aventi azione nk-2 antagonista
IT1304888B1 (it) * 1998-08-05 2001-04-05 Menarini Ricerche Spa Composti monociclici ad azione nk-2 antagonista e formulazioni che licontengono
AU7552401A (en) * 2000-06-12 2001-12-24 Univ Rochester Method of treating symptoms of hormonal variation, including hot flashes, using tachykinin receptor antagonist
EP1297826A1 (en) * 2001-09-27 2003-04-02 Menarini Ricerche S.p.A. Nasal pharmaceutical compositions containing a NK-2 antagonist
ITFI20020239A1 (it) * 2002-12-06 2004-06-07 Menarini Ricerche Spa Processo per la preparazione di composti peptidici biciclici.
ITFI20040221A1 (it) * 2004-10-27 2005-01-27 Guidotti & C Spa Composizioni farmaceutiche a base di nk2 antagonisti per uso pediatrico
ITRM20120331A1 (it) 2012-07-12 2014-01-13 Guidotti & C Spa Labor Composizioni pediatriche orali liquide contenenti nepadutant.

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1262902B (it) * 1992-04-15 1996-07-22 Menarini Farma Ind Composti triciclici antagonisti delle tachichinine, loro preparazione e loro uso in composizioni farmaceutiche.

Also Published As

Publication number Publication date
EA000697B1 (ru) 2000-02-28
HUP9801835A3 (en) 2000-05-29
SK281899B6 (sk) 2001-09-11
TW565572B (en) 2003-12-11
AR004476A1 (es) 1998-12-16
DK0815126T3 (da) 2001-05-07
EP0815126B1 (en) 2001-01-03
CZ286297A3 (cs) 1998-02-18
UA48962C2 (uk) 2002-09-16
HRP960117B1 (en) 2001-06-30
IL117395A (en) 1999-12-31
SK121297A3 (en) 1998-02-04
WO1996028467A1 (en) 1996-09-19
IL117395A0 (en) 1996-07-23
NO319290B1 (no) 2005-07-11
GR3035676T3 (en) 2001-06-29
EE9700230A (et) 1998-04-15
MX9706927A (es) 1997-11-29
IT1277835B1 (it) 1997-11-12
KR100405009B1 (ko) 2004-05-20
ZA961983B (en) 1997-09-29
HUP9801835A2 (hu) 1999-01-28
AU5105996A (en) 1996-10-02
CN1183786A (zh) 1998-06-03
ES2155187T3 (es) 2001-05-01
JP4618821B2 (ja) 2011-01-26
JPH11501643A (ja) 1999-02-09
ITFI950044A1 (it) 1996-09-13
ITFI950044A0 (it) 1995-03-13
BG101849A (en) 1998-04-30
PL322105A1 (en) 1998-01-05
CZ287372B6 (en) 2000-11-15
CN1189477C (zh) 2005-02-16
DE69611438T2 (de) 2001-06-13
PT815126E (pt) 2001-06-29
HU222051B1 (hu) 2003-04-28
NO974057L (no) 1997-11-07
EE03618B1 (et) 2002-02-15
KR19980703011A (ko) 1998-09-05
NO974057D0 (no) 1997-09-03
US6150325A (en) 2000-11-21
RO118297B1 (ro) 2003-04-30
AU696528B2 (en) 1998-09-10
DE69611438D1 (de) 2001-02-08
PL184147B1 (pl) 2002-09-30
ATE198481T1 (de) 2001-01-15
EA199700223A1 (ru) 1998-04-30
NZ303982A (en) 1998-04-27
HRP960117A2 (en) 1997-08-31
EP0815126A1 (en) 1998-01-07
BR9607348A (pt) 1997-12-30
GEP20002271B (en) 2000-10-25

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